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  • Philippe Biane
    Publications of the Research Institute for Mathematical Sciences
    1995年 31 巻 1 号 63-79
    発行日: 1995年
    公開日: 2009/04/24
    ジャーナル フリー
  • 川又 紀彦, 渡部 良平
    臨床血液
    2019年 60 巻 7 号 767-772
    発行日: 2019年
    公開日: 2019/08/06
    ジャーナル 認証あり

    BCR-ABL1 International Scale(IS)測定はチロシンキナーゼ阻害剤で治療されている慢性骨髄性白血病(CML)患者の治療効果をモニターする上で重要な検査法である。稀ではあるが,BCR-ABL1 IS測定ができないCMLが存在することが知られている。本研究において,我々は,そのようなBCR-ABL1 IS測定のできないCML患者を経験し,分子生物学的な方法で,その原因を解明した。本例ではABL1遺伝子における切断点がa2エクソン内にあることが分かり,そのことがABL1のa2エクソンを欠いた

    e
    14a
    3
    b
    3
    a
    3
    )キメラ遺伝子のmRNAのみの発現を誘導していた。a2エクソンは本邦における検査部でのIS測定において重要な要素であり,これが欠損することが測定不能の原因であった。このようなIS測定ができない稀なCML症例をさらに集積して,その分子構造を解明することが待たれる。

  • 山口 昭彦
    日本中東学会年報
    1994年 9 巻 37-65
    発行日: 1994/03/31
    公開日: 2018/03/30
    ジャーナル フリー
    L'entree en Iran des armees britannique et sovietique s'est produite en aout 1941. Elle ebranla du coup le regime de la dynastie pahlavi qui etait au pouvoir depuis 16 ans, et mena le pays vers l'instabilite politique et le chaos social. La defaite de l'arme gouvernementale, qui etait le pivot du regime de Reza Shah, reduisit considerablement le controle du gouvernement central dans le pays. Cette situation politico-sociale confuse permit le developpement de differents mouvements politiques en Iran.
    C'est
    ainsi que le 16 aout 1942 le parti clandestin Komeley Jiyanewey Kurdistan (J-K) est ne a Mehabad, une ville au nord-ouest de l' Iran. Des sa formation, ce parti a su etendre sa sphere d'activite et, en une courte periode de temps, a fini par mettre sous son influence la ville et ses alentours. A la fin de la Seconde Guerre mondiale, en ete 1945, le J-K etait devenu une organisation representant le mouvement nationaliste kurde en Iran.
    C'est
    a ce moment-la qu'un autre parti politique, le Hizbi Dimokratiki Kurdistan (HDK), fonde par Qazi Mihemed a Mehabad aussi, devait remplacer le J-K. Des le
    22
    janvier 1946, le HDK proclama l'instauration de la≪Republique de Kurdistan≫. Cependant, les troupes sovietiques qui avaient pris sous leur protection la Republique evacuerent les terres iraniennes, en mai 1946. Six mois plus tard, sous la pression militaire du gouvernement central iranien, la republique s'ecroula. Deux theories tentent d'expliquer le passage du J-K au HDK. William Eagleton Jr., par exemple, affirme dans The Kurdish Republic of 1946 que le HDK a ete cree sur le conseil des autorites sovietiques. L'ex-secretaire general du Parti Democratique du Kurdistan d'Iran, 'Ebd el-Rehman Qasimlu maintient par contre que Qazi Mihemed a etabli le nouveau parti de sa propre initiative, eu regard a la situation politique de cette epoque-la. Il considere que la passage du J-K au HDK comme etant l'evolution d'un parti nationaliste clandestin en un parti democratique. En analysant ces deux theories et en se basant sur les autobiographies des personages qui se sont engages dans cet evenement, cette etude tentera d'examiner le principe directeur et les activites du J-K et de mieux comprendre les raisons pour lesquelles le J-K devait etre remplace par le HDK. La conclusion generale portera sur les differents objectifs politiques du J-K et du HDK. Le J-K visait l'elevation du niveau culturel du peuple tout en luttant contre le tribalisme, qui etait, selon lui, le probleme majeur de≪la nation kurde≫, et cela en ecartant toute idee de revolte militaire. Le J-K a aussi exclu de son cadre les elites sociales telles que les leaders des tribus et dirigeants religieux de peur qu'ils n'excercent une influence sur les membres du parti. L'automne de 1944 fut le debut d'une nouvelle ere pour le mouvement kurde. Alors que l'espoir de l'autodetermination augmentait parmi le peuple a mesure que s'approchait la fin de la guerre, la necessite de la force militaire a commence a se faire sentir dans le J-K.
    C'est
    pour cela que s'est produite au sein du parti une tendance a compter sur l'aide militaire des sovietiques et a recourir au leadership de Qazi Mihemed, qui avait une certaine influence meme sur les leaders tribaux. Mais cette tendance etait essentiellement incompatible avec la ligne fondamentale du J-K et, graduellement, a prive ce parti de sa raison d'etre. Ainsi, le HDK se substitua au J-K en tant que≪parti democratique≫visant a rallier d'abord les elites sociales sous sa banniere, en s'appuyant sur l'autorite personnelle de Qazi Mihemed.
  • H. K. Mahanty
    CYTOLOGIA
    1970年 35 巻 1 号 13-49
    発行日: 1970/03/25
    公開日: 2009/03/19
    ジャーナル フリー
    1. The chromosome numbers of 64 species have been studied on which 56 are investigated for the first time.
    2. Morphological, anatomical and cytological findings on the Musaceae in the broad sense are considered from a phylogenetical standpoint and three distinct groups:
    a) Musa-Ensete,
    b
    ) Ravenala-Strelitzia-Phenakospermum and
    c
    ) Holiconia are recognised as suggested by some authors. For these groups sub-familial status is proposed.
    3
    . Lowiaceae have been studied for the first time cytologically and their chromosome morphology, distinct from that of any other group of Zingiberales, confirms their claim to familial status.
    4
    . Consideration of the conflicting theories proposed to account for the higher chromosome number in genera like Globba, Alpinia, and Phaemeria, etc. leads to rejection of Chakravorti's hypothesis of wholesale fragmentation of chromosomes and the acceptance of the opposed view of Raghavan and Venkatasubban and others.
    5. Holttum's transference of the genus Zingiber to the tribe Hedychieae has been given cytological support on the following points:
    a) the basic number in the genus Zingiber correlates with that of Kaempferia.
    b
    ) the new tribe Alpinieae (which is infact Zingibereae without Zingiber) have consistently 48 chromosomes in their somatic complements.
    6
    . It is suggested that the African representatives of Kaempferia should be given the status of genus; Cienkowskya on the following points:
    a) the difference in floral morphology
    b
    ) geographical separateness and
    c
    ) the difference in the number and morphology of the chromosomes. By comparing the present and past findings, various lines of evolution of the chromosome complements within each group are discussed.
    7
    . The basic number 11 is considered to be probably the original one for the Zingiberales as a whole, being present in Ravenala which is the most primitive member in the order. From this secondary basic numbers have arisen through evolution.
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • 布施川 雄一, 多田 博己, 小熊 利明, 椎名 豊, 玉地 寛光, 半田 俊之介
    動脈硬化
    1996年 23 巻 9 号 545-551
    発行日: 1996/04/10
    公開日: 2011/09/21
    ジャーナル フリー
    The association between apolipoprotein
    E
    (Apo-
    E
    ) polymorphism and the response of plasma cholesterol to dietary therapy (cholesterol intake of less than 300mg/day) was investigated for about
    8
    weeks in 208 nonfamilial hypercholesterolemia patients (
    E
    3
    /
    3
    161,
    E
    4
    /
    3
    47). The baseline lipoprotein concentration and the intake of energy and lipids were not significantly different between subjects with
    E
    3
    /
    3
    and those with
    E
    4
    /
    3
    phenotypes. After the dietary therapy plasma total cholesterol and low density lipoprotein cholesterol were significantly decreased in both phenotype groups (p<0.05). The patients with
    E
    4
    /
    3
    had significantly smaller reductions of LDL-
    C
    than the patients with
    E
    3
    /
    3
    . The changes of LDL-
    C
    showed a significant difference between the patients with
    E
    3
    /
    3
    and
    E
    4
    /
    3
    by the Kruskal Wallis test (p=0.041). The presence of
    E
    4
    /
    3
    predicted the degree of cholesterol reduction following dietary therapy.
  • M. L. GHOSH
    Journal of Physics of the Earth
    1972年 20 巻 2 号 165-186
    発行日: 1972年
    公開日: 2009/04/30
    ジャーナル フリー
    The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • JAN FAJKOS, Jiri Joska, Frantisek Sorm
    International Symposium on the Chemistry of Natural Products
    1964年 1964 巻 E-10-3
    発行日: 1964/04/12
    公開日: 2017/08/18
    会議録・要旨集 フリー
  • 増大する資源
    E
    . F. Boswell
    紙パ技協誌
    1998年 52 巻 7 号 885-889
    発行日: 1998/07/01
    公開日: 2009/11/19
    ジャーナル フリー
    The world is in the midst of a huge fundamental shift in fibre supply, demand balances, and policy changes. Governments around the world are introducing policy changes which influence the supply demand balance as the politicians' thoughts are uttered. Government agencies and their bureaucrats are imposing changes on industry even before the legislation is passed by the government in question.
    This ad hoc change process will continue for a time to come until the countries in question show a tough-mindedness with regard to their land use policies. Policies affecting forest areas such as protection areas, Native land claims, the protection of biodiversity and a true goal of sustainable development ; which addresses the combined issues of cultural, environmental, social and economic matters.
    Eventually all of these difficult issues will reach essential closure. Then there will be great new opportunities for investment to meet the growing demand for forest products ; leading to a strengthening competitive position in the more traditional producing areas such as Canada.
  • 米田 文郎, 大高 孝之, 新田 義博
    Chemical and Pharmaceutical Bulletin
    1963年 11 巻 7 号 954-956
    発行日: 1963/07/25
    公開日: 2008/03/31
    ジャーナル フリー
  • MATTHIAS KRONEN, PETER KLEINWÄCHTER, BRIGITTE SCHLEGEL, ALBERT HÄRTL, UDO GRÄFE
    The Journal of Antibiotics
    2001年 54 巻 2 号 175-178
    発行日: 2001/02/25
    公開日: 2008/09/19
    ジャーナル フリー
  • 琴尾 幸徳, 石川 成実, 田辺 順子, 御園 生尭久
    日本化学会誌(化学と工業化学)
    1980年 1980 巻 9 号 1391-1396
    発行日: 1980/09/10
    公開日: 2011/05/30
    ジャーナル フリー
    Nアルキル
    3
    ,
    4
    :
    9
    ,10-ペリレンテトラカルボン酸モノアンヒドリド=モノイミド[
    4
    a~
    e
    ]と芳香族アミン(アニリン,p-トルイジン,p-アニシジン,
    3
    ,5-キシリジン,
    4
    -アミノナゾベンゼン,およびo-フェニレンジアミン)を縮合して非対称型
    3
    ,
    4
    :
    9
    ,10-ペリレンビス(ジカルボキシミド)誘導体-N-アルキル-N'-アリール-
    3
    ,
    4
    :
    9
    ,10-ペリレンビス(ジカルボキシミド)(〔5a~
    e
    〕,〔
    6
    a~
    e
    〕,〔
    7
    a~
    e
    〕,〔
    8
    a~
    e
    〕,〔
    9
    a~
    e
    〕,および〔10a~
    b
    〕)を合成した. これらの各誘導体はすべて赤色系の色相を示し, 顔料試験の結果N-ブチル-N'-アリール-
    3
    ,
    4
    :
    9
    ,10-ペリレンビス(ジカルボキシミド)(たとえば〔5
    e
    〕や〔
    6
    e
    〕)がとくにすぐれた耐光性を示した.
  • MARIE LAVAULT, ALAIN FOURNET, HELENE GUINAUDEAU, JEAN BRUNETON
    Chemical and Pharmaceutical Bulletin
    1986年 34 巻 3 号 1148-1152
    発行日: 1986/03/25
    公開日: 2008/03/31
    ジャーナル フリー
    Nine isoquinoline alkaloids belonging to the protoberberine, proaporphine and bisbenzyl-isoquinoline series were isolated from Caryomene olivascens (Menispermaceae). Four compounds are new : (-)-2-norlimacine (
    4
    ), (-)-caryolivine (
    6
    ), (+)-1, 2-dehydro-2-norlimacusine (
    9
    ) and N-formylstepharine (
    3
    ). The last one is the first N-formyl derivative to be reported in the proaporphine group. Its biogenetic origin is discussed. Structures were established on the basis of 360 MHz (FT) nuclear magnetic resonance measurements and also by chemical correlation in the case of
    3
    .
  • Yasushi Ono, TS-
    3
    /
    4
    Group
    電気学会論文誌A(基礎・材料・共通部門誌)
    2005年 125 巻 11 号 958-959
    発行日: 2005年
    公開日: 2006/02/01
    ジャーナル フリー
    The high-power reconnection heating of spherical tokamak (ST) has been studied in the TS-
    3
    experiment by use of axial merging of two STs. In this method, the merging/ magnetic reconnection transformed a part of magnetic energy of merging STs into their thermal energy within short reconnection time. Our present low-field merging (0.
    3
    -0.5kG, R-0.2m) attained the maximum heating power of
    4
    -10MW and increased the beta-values of STs by factor 2-
    3
    transiently. The ion heating energy was found to increase inversely with the q-value (Bt component) of two STs. The most probable cause for this dependence is fast reconnection speed/ outflow speed due to large anomalous resistivity of current sheet in low-q state. After merging startup, decrease in beta was observed especially in low-q STs, indicating that the final beta value of ST increased with the q-value.
  • 馬場 輝郎
    照明学会雑誌
    1968年 52 巻 3 号 107-111
    発行日: 1968/03/25
    公開日: 2011/07/19
    ジャーナル フリー
  • Jessica J. PRENGER, Hyeon-Hye KIM, Jeff T. RICHARDS, Oscar MONJE, Howard G. LEVINE, Neil YORIO, Gary STUTTE, Ray WHEELER, John SAGER
    農業気象
    2005年 60 巻 5 号 385-390
    発行日: 2005年
    公開日: 2016/12/30
    ジャーナル フリー
     Human space exploration missions require life support systems to sustain the crew. Plants help regulate the earth’s atmospheric and terrestrial environment; similarly, plants could be used in a closed system in space: cleaning carbon dioxide from the air, breaking down liquid and solid wastes, and producing fresh food. Advanced Life Support systems would use plants as part of a bioregenerative system. For space flight applications, the systems must be low in mass and energy consumption, and must be designed for reduced gravity operations. Four areas of research are reviewed in this article related to ALS system design, crop physiology and biology. The Water Offset Nutrient Delivery ExpeRiment (WONDER) will be conducted on the Space Shuttle to evaluate gravity-independent hydroponic systems and optimum water content targets for microgravity crop production. The Photosynthesis Experiment and System Testing and Operation (PESTO) project studied the photosynthesis rates and physiological responses of crops germinated and grown in microgravity. A project to study crop production systems in closed, controlled environments for multiple crops in the same root and aerial environment (International Space Station baseline conditions) is described. Finally, efficient light emitting diode (LED) lighting is being studied to determine plant photobiological responses to different light qualities.
  • JURGEN GRABE, GERD GUDEHUS
    土質工学会論文報告集
    1992年 32 巻 3 号 130-136
    発行日: 1992/09/15
    公開日: 2008/02/29
    ジャーナル フリー
    The leaning tower of Pisa is a famous historical structure, especially in the field of soil mechanics. In this paper, the historical development of the inclination is reconstructed considering that a ground failure took place after each of the three construction phases. Model tests (scale 1 : 130) were carried out in order to predict that the tower will fail definitely, i.
    e
    . without any further disturbances, at an angle of inclination of 5.
    7
    °, which is dramatically close to the actual value of 5.5°. The estimated probability of failure rises very quickly with an increase in the angle of inclination. Conservation of the tower should be done therefore with utmost caution.
  • ASHRAF GHALY, ADEL HANNA, MIKHAIL HANNA
    土質工学会論文報告集
    1991年 31 巻 2 号 77-92
    発行日: 1991/06/15
    公開日: 2008/02/29
    ジャーナル フリー
    The performance of single pitch and multi pitch screw anchors during the application of installation torque is presented. An experimental testing program was conducted using five models of screw anchors with different geometry. The effect of the shape of the screw element, sand properties, and installation depth on the required installation torque value was examined. A theoretical model was developed from which the required installation torque value can be calculated in terms of the influencing factors. The required installation torque can be determined in terms of the ultimate uplift resistance calculated from any of the available theories. Based on the actual installation torque value measured in the field, the anticipated pullout capacity can be back calculated from the present theory. A comparison between theoretical and experimental results showed good agreement. Also, good agreement was observed when the present theoretical results were compared with the available field results reported in the literature.
  • ―特にアポ蛋白Eの変化について―
    本間 康彦, 三神 美和, 佐藤 美智子, 石原 仁一, 吉川 広, 木下 栄治, 田川 隆介, 星合 充基, 古屋 秀夫, 井出 満, 田辺 晃久, 玉地 寛光, 兼本 成斌, 友田 春夫, 中谷 矩章, 五島 雄一郎
    動脈硬化
    1984年 12 巻 3 号 599-603
    発行日: 1984/08/01
    公開日: 2011/09/21
    ジャーナル フリー
    Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL2 and
    HDL3
    were estimated on the 0th,
    7
    th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
    B
    ,
    C
    -II,
    E
    levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL2 and
    HDL3
    were 15.
    9
    ±
    7
    .5mg/dl (mean±SD), 150.
    9
    ±58.1mg/dl 43.
    8
    ±
    9
    .
    6
    mg/dl, 16.
    4
    ±5.
    8
    mg/dl and 24.
    9
    ±
    6
    .
    3
    mg/dl respectively. Plasma apoprotein A-I, A-II,
    B
    ,
    C
    -II and
    E
    levels were
    81
    .
    7
    ±
    22
    .0 mg/dl, 15.1±5.
    4
    mg/dl, 93.
    7
    ±36.0mg/dl,
    3
    .
    83
    ±1.00mg/dl and
    4
    .29±1.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-
    C
    (r=0.348), HDL2-
    C
    (r=0.612) and
    HDL3
    (r=0.569). Apoprotein
    B
    correlated with total cholesterol (TC) (r=0.610), VLDL-
    C
    (r=0.341), LDL-
    C
    (r=0.726), HDL-
    C
    (r=0.432) and HDL2-
    C
    (r=0.465). Apoprotein
    C
    -II correlated with TC (r=0.765), TG (r=0.679), VLDL-
    C
    (r=0.651), LDL-
    C
    (r=0.461) and HDL2-
    C
    (r=0.326). Apoprotein
    E
    correlated with TC (r=0.580), TG (r=0.575) and VLDL-
    C
    (r=0.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=0.468). Apoprotein
    B
    correlated with apoprotein
    C
    -II (r=0.393). Apoprotein
    C
    -II correlated with apoprotein
    B
    (r=0.393) and
    E
    (r=0.549). Apoprotein
    E
    only correlated with apoprotein
    C
    -II (r=0.549).
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