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  • 大澤 康次, 幡野 恵, 西宮 一尋, 岡崎 彬, 太田 真一, 宇田 文昭, 柳田 由紀, 檜垣 洋子, 吉田 知江里
    薬物動態
    1988年 3 巻 4 号 441-446
    発行日: 1988年
    公開日: 2007/03/29
    ジャーナル フリー
    ラットに
    3H
    -CU-
    83
    (S)を25μg/kgで静脈内あるいは経口投与し,血液中濃度および尿糞中排泄を検討した.
    静脈内投与後の血液中濃度推移は投与後
    5
    分より上昇し,投与後45分に25.74ng eq./mlのCmaxを示し,それ以後t1/2
    3
    .05時間とt1/2 33.09時間の二相で減少した.投与後72時間までのAUCは135.42ng eq.·hr/mlであった.
    経口投与では,投与後
    3
    時間でCmax 4.10ng eq./mlに達し,以後t1/2α 4.46時間とt1/2β 26.
    83
    時間の二相で減少した.投与後72時間までのAUCは48.62ng eq.·hr/mlであった.
    静脈内投与と経口投与のいずれの場合も,尿および糞中への放射能の排泄は,投与後48時間でほぼ終了した.静脈内投与では,投与後72時間までに投与量の30.52%が尿中に,60.42%が糞中に排泄された.経口投与では,同じく72時間までに40.34%が尿中に,69.24%が糞中に排泄された.
  • 梶谷 剛, 川瀬 智博, 山田 和芳, 平林 真
    日本金属学会誌
    1986年 50 巻 9 号 769-777
    発行日: 1986年
    公開日: 2008/04/04
    ジャーナル フリー
    A structure analysis of
    Ti5Si3D0.9
    has been carried out to determine the deuterium trap sites by neutron powder diffraction with the Rietveld profile analysis. It is revealed that the deuterium atoms are located at octahedral (
    2b
    ) sites surrounded by six Ti atoms in the crystal structure of
    Ti5Si3D0.9
    , space group P63/mcm. Local vibration spectra of hydrogen in
    Ti5Si3H0.83
    measured by neutron inelastic scattering support this result; the energy eigenvalue of the primary vibration mode is found at 7.53 kJ/mol (78 meV). The hole radius and the spring constant of the Ti-H(D) bond are discussed.
  • E. camaldulensis, E. globulus における容積重, および材形質含量の樹幹内変異と標準値を示す位置について
    小名 俊博, 園田 哲也, 伊藤 一弥, 柴田 勝
    紙パ技協誌
    1995年 49 巻 8 号 1227-1234
    発行日: 1995/08/01
    公開日: 2009/11/16
    ジャーナル フリー
    Within-tree variations, whole-tree values and the representative heights for the whole tree value of basic density, and contents of wood components per volume were analysed for two trees of Eucalyptus camaldulensis and
    E
    . globulus
    respectively, grown at the seed orchard in Western Australia to do quality breeding.
    Within-tree variation of
    E
    . camaldulensis
    was rather uniform as 500±40, 532 ±34 kg/
    m3
    , but that of
    E
    . globulus
    was large as 595 ± 69, 616 ± 79 kg/
    m3
    and the basic density was higher in bark side and upper part in the trunk, to be expected to have higher pulp productivity.
    The whole-tree values of
    E
    . camaldulensis
    were 501, 520 kg/
    m3
    and those of
    E
    . globulus
    were 594, 640 kg/
    m3
    and the difference of the species was observed.
    Representative heights for the whole-tree contents ±
    5
    % were
    0
    .32.
    8
    m on
    E
    . camaldulensis
    , and
    0
    .
    8
    and 2.
    8
    m on
    E
    . globulus
    regardless the differences in the whole-tree height and the within-tree variation when they were chosen below
    3
    .
    3
    m height for sampling an increment core.
    Representative heights were also determined for contents of wood components per volume as follows ; for
    E
    . camaldulensis
    , holocellulose : 1.
    3
    , 2.
    8
    m, cellulose : 2.
    83
    .
    3
    m, hemicellulose :
    0
    .
    82
    .
    8
    m, lignin :
    0
    .81.
    3
    , 2.
    8
    m, extractives : 2.
    3
    m, alkali-extractives : 1.
    3
    m, and total-extractives : 2.32.
    8
    m, for
    E
    . globulus
    , 2.
    8
    m, 2.32.
    8
    m, 2.
    8
    m,
    0
    .30.
    8
    m, 2.
    83
    .
    3
    m, 2.
    83
    .
    3
    m and 2.
    8
    m in the same manner.
    It is expected that whole-tree pulp properties including pulp productivity are predicted by the increment core taken from these representative heights.
  • 高木 徹, 林 賢治, 板橋 豊
    日本水産学会誌
    1984年 50 巻 8 号 1413-1418
    発行日: 1984/08/25
    公開日: 2008/02/29
    ジャーナル フリー
    The acetone extracts from three samples of the hepatopancreas of the poisonous scallops obtained on the Okhotsk Coast of Hokkaido Island were fractionated into two parts, hexane soluble fraction (fraction H) and 85% aqueous ethanol soluble fraction (fraction
    E
    ) by partition to two layers. The majortoxic components in the mouse assay of “diarrheic shellfish toxin” by intra-peritoneal injection were found to be free unsaturated fatty acids showed the following toxicity in MU per g, 18:1 n-
    9
    35, 18:2 n-6
    83
    , 18:
    3
    n-
    3
    167, 18:4 n-
    3
    83
    , 20:
    5
    n-
    3
    167, and
    22
    :6 n-
    3
    83
    , respectively. Toxicity of the fraction Hin MUper g was much lower than that of the fraction
    E
    . However, the toxicity of the fraction H per 1 g of the hepatopancreas was about twice that of the fraction
    E
    , since the fraction Hwas much more abundant than the fraction
    E
    in the hepatopancreas. The method for the assay of the diarrhetic shellfish toxin must be reexamined by considering the toxic effect of the free unsaturated fatty acids.
  • 山口 昭彦
    日本中東学会年報
    1994年 9 巻 37-65
    発行日: 1994/03/31
    公開日: 2018/03/30
    ジャーナル フリー
    L'entree en Iran des armees britannique et sovietique s'est produite en aout 1941. Elle ebranla du coup le regime de la dynastie pahlavi qui etait au pouvoir depuis 16 ans, et mena le pays vers l'instabilite politique et le chaos social. La defaite de l'arme gouvernementale, qui etait le pivot du regime de Reza Shah, reduisit considerablement le controle du gouvernement central dans le pays. Cette situation politico-sociale confuse permit le developpement de differents mouvements politiques en Iran. C'est ainsi que le 16 aout 1942 le parti clandestin Komeley Jiyanewey Kurdistan (J-K) est ne a Mehabad, une ville au nord-ouest de l' Iran. Des sa formation, ce parti a su etendre sa sphere d'activite et, en une courte periode de temps, a fini par mettre sous son influence la ville et ses alentours. A la fin de la Seconde Guerre mondiale, en ete 1945, le J-K etait devenu une organisation representant le mouvement nationaliste kurde en Iran. C'est a ce moment-la qu'un autre parti politique, le Hizbi Dimokratiki Kurdistan (HDK), fonde par Qazi Mihemed a Mehabad aussi, devait remplacer le J-K. Des le
    22
    janvier 1946, le HDK proclama l'instauration de la≪Republique de Kurdistan≫. Cependant, les troupes sovietiques qui avaient pris sous leur protection la Republique evacuerent les terres iraniennes, en mai 1946. Six mois plus tard, sous la pression militaire du gouvernement central iranien, la republique s'ecroula. Deux theories tentent d'expliquer le passage du J-K au HDK. William Eagleton Jr., par exemple, affirme dans The Kurdish Republic of 1946 que le HDK a ete cree sur le conseil des autorites sovietiques. L'ex-secretaire general du Parti Democratique du Kurdistan d'Iran, 'Ebd el-Rehman Qasimlu maintient par contre que Qazi Mihemed a etabli le nouveau parti de sa propre initiative, eu regard a la situation politique de cette epoque-la. Il considere que la passage du J-K au HDK comme etant l'evolution d'un parti nationaliste clandestin en un parti democratique. En analysant ces deux theories et en se basant sur les autobiographies des personages qui se sont engages dans cet evenement, cette etude tentera d'examiner le principe directeur et les activites du J-K et de mieux comprendre les raisons pour lesquelles le J-K devait etre remplace par le HDK. La conclusion generale portera sur les differents objectifs politiques du J-K et du HDK. Le J-K visait l'elevation du niveau culturel du peuple tout en luttant contre le tribalisme, qui etait, selon lui, le probleme majeur de≪la nation kurde≫, et cela en ecartant toute idee de revolte militaire. Le J-K a aussi exclu de son cadre les elites sociales telles que les leaders des tribus et dirigeants religieux de peur qu'ils n'excercent une influence sur les membres du parti. L'automne de 1944 fut le debut d'une nouvelle ere pour le mouvement kurde. Alors que l'espoir de l'autodetermination augmentait parmi le peuple a mesure que s'approchait la fin de la guerre, la necessite de la force militaire a commence a se faire sentir dans le J-K. C'est pour cela que s'est produite au sein du parti une tendance a compter sur l'aide militaire des sovietiques et a recourir au leadership de Qazi Mihemed, qui avait une certaine influence meme sur les leaders tribaux. Mais cette tendance etait essentiellement incompatible avec la ligne fondamentale du J-K et, graduellement, a prive ce parti de sa raison d'etre. Ainsi, le HDK se substitua au J-K en tant que≪parti democratique≫visant a rallier d'abord les elites sociales sous sa banniere, en s'appuyant sur l'autorite personnelle de Qazi Mihemed.
  • Tsuyoshi Kajitani, Tomohiro Kawase, Kazuyoshi Yamada, Makoto Hirabayashi
    Transactions of the Japan Institute of Metals
    1986年 27 巻 9 号 639-647
    発行日: 1986年
    公開日: 2007/06/01
    ジャーナル フリー
    A structure analysis of
    Ti5Si3D0.9
    has been carried out to determine the deuterium trap sites by neutron powder diffraction with the Rietveld profile analysis. It is revealed that the deuterium atoms are located at octahedral (2
    b
    ) sites surrounded by six Ti atoms in the crystal structure of
    Ti5Si3D0.9
    , space group P63/mcm. Local vibration spectrum of hydrogen in
    Ti5Si3H0.83
    measured by neutron inelastic scattering supports this result; the energy eigenvalue of the primary vibration mode is found at 7.53 kJ/mol (78 meV). The hole radius and the spring constant of the Ti–H(D) bond are discussed.
  • 榎 明潔, 八木 則男, 矢田部 龍一, 一本 英三郎
    土質工学会論文報告集
    1991年 31 巻 2 号 1-13
    発行日: 1991/06/15
    公開日: 2008/02/29
    ジャーナル フリー
    It has been shown after mathematical and mechanical investigation that Limit Equilibrium Method (LEM) can be considered as a method to obtain the necessary condition of Slip Line Method (SLM), and that the solution can be obtained under the condition that Fs=1 and ∂Fs/∂θ=O, where Fs is the safety factor and θ is the inclination of the plane on which the safety factor is defined. Next, the generalized LEM (GLEM) is proposed, dealing with the following points : (1) Triangular or quadrangular blocks can be treated; (2) Safety factors are defined also on interblock planes; and (
    3
    ) All types of plastic problems, slope stability, bearing capacity, and earth pressure are identically formulated. Two situations regarding treatment of the moment equilibrium condition are discussed. GLEM is applied to well-known problems. The results agree well with those obtained by theoretical methods. GLEM can be used to obtain the distribution of earth pressure or bearing capacity. GLEM, Iike ordinary LEM, is very effective for the practical problems, but GLEM is more theoretical and it can result in more accurate solutions.
  • Yosizo YAMAMOTO
    Nippon Sugaku-Buturigakkwai Kizi Dai
    3
    Ki

    1940年 22 巻 12 号 1048-1052
    発行日: 1940年
    公開日: 2009/06/09
    ジャーナル フリー
    The numerical values of the intervals betrween optieal levels are competed for the configurations
    1s22s22p83s23p83
    *94s,
    5
    s, 6s and 7s of Cu+, according to the general expression of energy-levels derived in the previous paper The self-consistent field radial functions computed by Hartree adn Hartree are used for1s, 2s, 2p,
    3
    s,
    3
    p and
    3
    d. Those of 4s,
    5
    s,
    e
    .s and are ealenlated from Hartree Hartree's core-functions by the numerical integrations. The calculated results are shown in Table I.The agreement with experiment is satisfactory
  • 西日本皮膚科
    2021年 83 巻 3 号 Index3_1-Index3_2
    発行日: 2021/06/01
    公開日: 2021/07/22
    ジャーナル 認証あり
  • CHINGCHUAN HUANG, LILING HONG
    地盤工学会論文報告集
    2000年 40 巻 5 号 65-73
    発行日: 2000/10/15
    公開日: 2008/02/29
    ジャーナル フリー
    The applicability of a method for predicting 'bearing capacity increase'in reinforced sandy ground was examined using tests performed under various test conditions. It was found that the present method predicted, with reasonable accuracy, the bearing capacity increase in sandy ground, reinforced with stiff reinforcement. This method may not be applicable for sandy ground reinforced with extensible reinforcement due to the unsuccessful formation of a semirigid zone under the footing. An investigation into the settlement of a footing on reinforced sandy ground, at ultimate footing load condition, suggested that the settlement of footing for reaching peak footing load may be correlated to the 'deep-footing'and the 'wide-slab'mechanisms. That is, the ultimate settlement ratio between reinforced and unreinforced model sandy ground, SRf, may be linearly correlated to 'BCRD'and 'BCRs', which represent 'deep-footing' and 'wide-slab'effects, respectively, on the ultimate bearing capacity increase in reinforced sandy ground.
  • H. K. Mahanty
    CYTOLOGIA
    1970年 35 巻 1 号 13-49
    発行日: 1970/03/25
    公開日: 2009/03/19
    ジャーナル フリー
    1. The chromosome numbers of 64 species have been studied on which 56 are investigated for the first time.
    2. Morphological, anatomical and cytological findings on the Musaceae in the broad sense are considered from a phylogenetical standpoint and three distinct groups:
    a) Musa-Ensete,
    b
    ) Ravenala-Strelitzia-Phenakospermum and c) Holiconia are recognised as suggested by some authors. For these groups sub-familial status is proposed.
    3
    . Lowiaceae have been studied for the first time cytologically and their chromosome morphology, distinct from that of any other group of Zingiberales, confirms their claim to familial status.
    4. Consideration of the conflicting theories proposed to account for the higher chromosome number in genera like Globba, Alpinia, and Phaemeria, etc. leads to rejection of Chakravorti's hypothesis of wholesale fragmentation of chromosomes and the acceptance of the opposed view of Raghavan and Venkatasubban and others.
    5
    . Holttum's transference of the genus Zingiber to the tribe Hedychieae has been given cytological support on the following points:
    a) the basic number in the genus Zingiber correlates with that of Kaempferia.
    b
    ) the new tribe Alpinieae (which is infact Zingibereae without Zingiber) have consistently 48 chromosomes in their somatic complements.
    6. It is suggested that the African representatives of Kaempferia should be given the status of genus; Cienkowskya on the following points:
    a) the difference in floral morphology
    b
    ) geographical separateness and
    c) the difference in the number and morphology of the chromosomes. By comparing the present and past findings, various lines of evolution of the chromosome complements within each group are discussed.
    7. The basic number 11 is considered to be probably the original one for the Zingiberales as a whole, being present in Ravenala which is the most primitive member in the order. From this secondary basic numbers have arisen through evolution.
  • 百目鬼 郁男, 中原 達夫, 山内 亮
    家畜繁殖研究會誌
    1974年 20 巻 2 号 76-80
    発行日: 1974/08/30
    公開日: 2008/05/15
    ジャーナル フリー
    性周期における牛の末梢血中遊離estrogen測定にITTRICH螢光法を応用して次の成績を得た。
    Ittrich colorの最大波長をspectrofluorometer Hitachi MPF-2AおよびType203で測定した結果,励起光538nm,螢光552.
    5
    nmであった。この螢光特性は
    E1
    ,
    E2
    および
    E3
    にそれぞれ共通であった。実際の測定では最大波長が接近しているので感度は若干低下するが510~520nmで励起し•螢光側552•
    5
    ±
    22
    5nm
    を読み,ALLENの補正を行なった。この条件において
    E1
    ,
    E2
    および
    E3
    -methyletherの最少検出量は1ngであった。回収率補正の目的で加えた6,7-
    3H
    -
    E2
    -17βの全過程における回収率は平均60.
    3
    ±11.7%であった。正常性周期を示す黒毛和種2頭の頸静脈血についてestrogenを分画測定した。その結果,両牛共
    E1
    ,
    E2
    の各消長型は性周期の全期間を通じてほぼ同じ傾向を示したが,
    E2
    E1
    にくらべ全般に高値であった。また
    E3
    は検出されなかった。これらの牛のtotalestrogenは発情前期に増加し,排卵前に鋭いピーク(35.
    3
    および
    99.8ng
    /l;
    E15.9
    および
    16.0ng
    /l,
    E229.4
    および
    83.8ng
    /l)を形成し,排卵後は急激に減少して最低値(
    3
    .
    8
    ~
    5.3ng
    /l;
    E11.6
    および
    1.9ng
    /l,
    E22.2
    および
    3.4ng
    /l)を示した。黄体期の最高値(10.1および
    27.0ng
    /l;
    E12.4
    および
    3.4ng
    /l,
    E27.7
    および23.6ng/l)は排卵後6~
    8
    日に認めた。すなわちestrogenの血中濃度は性周期の間に2つのピークを形成することを認めた。
  • Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE
    Agricultural and Biological Chemistry
    1988年 52 巻 12 号 3217-3218
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • 橘 健太郎, 木田 博太, 上野山 充, 中村 年宏, 山田 貴久, 林 晃正
    日本透析医学会雑誌
    2019年 52 巻 4 号 227-232
    発行日: 2019年
    公開日: 2019/05/18
    ジャーナル フリー

    本検討は, 経皮的冠動脈形成術 (PCI) 後の翌日血液透析 (HD) 時における透析中低血圧 (IDH) の発生因子について検討した. 対象は待機的PCI後, 翌日HDを施行した慢性HD患者連続

    83
    名 (年齢70±7歳, 男性64名). IDHの定義は, 収縮期血圧20mmHg以上の低下で, 症状を伴いかつHD中断を要したものとした. また, HD記録よりIDHを後方視的に調査し, Logistic回帰分析にてIDHの予測因子を検討した. IDH群 (12名) は非IDH群 (71名) に比して, 有意に低体重 (52.
    0
    ±
    3
    .
    8
    vs. 62.
    9
    ±1.
    5
    kg; p=
    0
    .007), 造影剤量/体重が多く (2.
    5
    ±
    0
    .
    3
    vs. 1.
    8
    ±
    0
    .1mL/kg; p=
    0
    .018), 低左室駆出率で (45.
    8
    ±4.2 vs. 56.
    0
    ±1.
    8
    % ; p=
    0
    .030),
    E
    /
    e
    ’ が高値 (
    22
    .
    9
    ±
    3
    .
    8
    vs. 17.2±
    0
    .
    9
    cm/sec; p=
    0
    .038) であった. また, 冠動脈病変や侵襲的な治療について有意差は認めなかった. Logistic回帰分析では, 造影剤量/体重 (OR, 6.87; 95%CI, 1.
    83
    -25.
    8
    ; p=
    0
    .004) がIDHの有意な予測因子であった. 造影剤使用量が多い症例は, IDHを生じる危険性が高いことが示唆された.

  • Keishi Hata, Fuyuki Sugawara, Naganori Ohisa, Saori Takahashi, Kazuyuki Hori
    Biological and Pharmaceutical Bulletin
    2002年 25 巻 8 号 1040-1044
    発行日: 2002年
    公開日: 2002/08/01
    ジャーナル フリー
    We screened the differentiation-inducing activities of 39 mushroom extracts from Akita prefecture, Japan, on the mouse osteoblastic cell line, MC
    3
    T
    3
    -
    E
    1. Sixteen phosphate buffered saline (PBS),
    8
    boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MC
    3
    T
    3
    -
    E
    1 cell differentiation. The enzyme activities were markedly induced by extracts of Tricholoma auratum, and we isolated the active compound from methanol extracts of this mushroom. Physical data for the isolated active compound were identical to those for (
    22E
    ,24R)-ergosta-7,
    22
    -diene-
    ,
    ,6β-triol (1). 1 induced ALP activities of MC
    3
    T
    3
    -
    E
    1 cells and promoted cell proliferation. To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MC
    3
    T
    3
    -
    E
    1 cells by 1, ergosterol (2), ergocalciferol (
    3
    ), cholesta-
    ,
    ,6β-triol (4), 7-dehydrocholesterol (
    5
    ) and cholecalciferol (6) were tested. The enzyme activities of MC
    3
    T
    3
    -
    E
    1 cells were increased
    3
    .
    0
    -fold by 10 μM 1 and 2.4-fold by 10 μM 4. However, 2,
    3
    ,
    5
    and 6 did not induce MC
    3
    T
    3
    -
    E
    1 cell ALP activity at
    0
    .1—10 μM. These results suggested that the OH groups at C-
    5
    and/or C-6 of 1 and 4 played an important role in their differentiation-inducing activities on MC
    3
    T
    3
    -
    E
    1 cells. Furthermore, 1 suppressed induction of MC
    3
    T
    3
    -
    E
    1 cell apoptosis by serum starvation.
  • Philippe Biane
    Publications of the Research Institute for Mathematical Sciences
    1995年 31 巻 1 号 63-79
    発行日: 1995年
    公開日: 2009/04/24
    ジャーナル フリー
  • Daria Kurguzova, Svetlana Serebrova, Alexey Prokofiev, Ludmila Krasnykh, Galina Vasilenko, Marina Zhuravleva, Elena Smolyarchuk, Anton Barkov
    日本薬理学会年会要旨集
    2018年 WCP2018 巻 WCP2018_PO3-5-27
    発行日: 2018年
    公開日: 2020/09/10
    会議録・要旨集 オープンアクセス

    Background

    The differences in conditions of enteric-coated acid-labile drug release and absorption between healthy subjects in bioequivalence studies and gastrointestinal patients in clinical practice can lead to significant differences in gastric stability of original PPIs and generics. Thus, pathologic duodenogastric reflux (PDGR) and the pH increasing within PPIs administration still remain unaccounted for.

    Methods

    Two-stage modified comparative dissolution testing of original omeprazole (OO) and four generics (G1;2;

    3
    ;4) was performed. At first, we moved drugs from solution with pH 1.2 (1.2±
    0
    .05) to pH 7.
    0
    (7.
    0
    ±
    0
    .05) and measure concentration of omeprazole in solution by high-performance liquid chromatography. According to our self-developed formula, pH 7 exposure time of resistance to PDGR for omeprazole is 4 minutes, i.
    e
    . the active substance should not be released within 4 minutes at pH 7. The exposure at the second stage was conducted with pH 4 (4.
    0
    ±
    0
    .05), that imitated gastric pH after PPI administration. And then we also moved drugs to pH 7 with the subsequent measurement of omeprazole concentration.

    Results

    Omeprazole concentrations after 4, 10, 15, 20, 30, 45, 60 minutes in pH 7 solution at the first stage were different for OO and generics. For OO, these values were 4,7±

    0
    ,7%; 41,4±
    3
    ,
    0
    %; 62,
    8
    ±4,
    0
    %; 79,
    5
    ±2,
    9
    %;
    83
    ,
    5
    ±2,
    9
    %; 81,6±2,
    9
    %; 80,6±4,4%; for Generic1 -
    0
    ; 49,
    3
    ±
    9
    ,
    9
    %; 88,
    8
    ±2,
    8
    %; 90,4±
    3
    ,7%; 88, 2±2,2%; 87,
    3
    ±2,
    0
    %; 85,
    9
    ±1,1%; for Generic2 -
    0
    ; 30,6±6,
    3
    %; 66,7±
    8
    ,2%; 76,4±7,4%;
    82
    ,
    8
    ±
    5
    ,
    3
    %; 86,
    0
    ±
    3
    ,7%; 84,6±
    3
    ,
    3
    %: for Generic
    3
    - 80,
    8
    ±
    3
    ,6%;
    83
    ,
    5
    ±1,
    9
    %;
    83
    ,
    8
    ±
    3
    ,2%;
    83
    ,
    3
    ±2,7%; 81,
    9
    ±2,1%;
    82
    ,1±2,
    0
    %;
    82
    ,
    0
    ±2,4%; for Generic4 -
    82
    ,
    5
    ±1,7%; 84,4±
    0
    ,
    8
    %; 84,2±1,2%;
    82
    ,
    9
    ±
    0
    ,
    9
    %;
    82
    ,
    9
    ±
    0
    ,
    9
    %;
    82
    ,
    9
    ±
    0
    ,
    9
    %;
    82
    ,
    8
    ±1,1%, respectively.

    An analysis of the omeprazole concentration in pH 7 solution at the second stage revealed the following parameters after the same time: for OO - 4,4±

    0
    ,6%; 40,
    5
    ±
    3
    ,
    0
    %; 62,
    8
    ±2,
    0
    %; 80,
    0
    ±
    3
    ,1%; 85,4±2,
    9
    %;
    82
    ,
    8
    ±
    3
    ,4%; 80,
    9
    ±
    3
    ,
    5
    %; for Generic1 -
    0
    ; 67,
    0
    ±7,
    8
    %; 89,7±2,
    3
    %; 91,
    9
    ±4,
    3
    %; 89,1±1,6%; 88,
    3
    ±1,4%; 87,
    8
    ±1,2%; for Generic2 -
    0
    ; 42,2±
    5
    ,6%; 75,1±7,
    3
    %; 81,
    0
    ±6,
    0
    %; 88,4±
    3
    ,2%; 88, 6±1,
    3
    %; 87,
    9
    ±1,
    0
    %; for Generic4 - 85,
    5
    ±
    0
    ,
    5
    %; 85,6±
    0
    ,
    5
    %; 84,7±
    0
    ,
    9
    %;
    82
    ,7±
    3
    ,
    0
    %; 84,4±
    0
    ,
    3
    %; 84,4±
    0
    ,
    3
    %; 84,
    3
    ±
    0
    ,4%, respectively. Generic
    3
    release and degradation were completely realized at pH 4.

    Conclusion

    Decreased gastric stability of Generic

    3
    and Generic4 makes PDGR and inhibited gastric acid secretion due to PPIs administration the potential causes of decreased enteric-coated acid-labile drugs stability.

  • ―St. Jude Medical valveの抗血栓性について―
    藤田 康雄, 林 純一, 山崎 芳彦, 江口 昭治, 大谷 信一
    人工臓器
    1988年 17 巻 3 号 1133-1136
    発行日: 1988/06/15
    公開日: 2011/10/07
    ジャーナル フリー
    SJM弁の抗血栓性についてS-
    E
    ボール弁との比較検討を行った。S-
    E
    ボール弁で単弁置換をうけた132例と、SJM弁で単弁置換をうけた135例を対象とした。僧帽弁置換群の血栓塞栓症の発生頻度は、S-
    E
    非被覆弁2.14%/患者・年、S-
    E
    被覆弁1.
    82
    %/患者・年、SJM弁1.69%/患者・年であった。術後7年のThrombo-embolism Free RateはS-
    E
    非被覆弁で60.
    5
    ±7.
    5
    %、S-
    E
    被覆弁で
    83
    .
    9
    ±
    5
    .2%、SJM弁で92.4±
    3
    .1%であった。大動脈弁置換群の血栓塞栓症の発生頻度は、S-
    E
    非被覆弁1.36%/患者・年、S-
    E
    被覆弁、SJM弁では
    0
    であった。術後7年のThromboembolism Free RateはS-
    E
    非被覆弁75.6±10.6%、S-
    E
    被覆弁80.
    0
    ±10.
    3
    %、SJM弁96.7±
    3
    .
    3
    %であった。SJM弁の抗血栓性はS-
    E
    非被覆弁に比し良好であったが、S-
    E
    被覆弁に比べ著しく向上したとはいえず、近年における血栓塞栓症の減少には厳重な抗凝固療法の施行も寄与していると考えられる。
  • Hiroshi Xavier Chiura, Masataka Umitsu
    Microbes and Environments
    2004年 19 巻 1 号 20-30
    発行日: 2004年
    公開日: 2004/04/21
    ジャーナル フリー
    Virus-like particles (VLPs) were collected from geothermal vent water samples in the drift-way at Toyoha Mine, Hokkaido, Japan (−500 m level, 63.
    5
    °C) whose VLP and bacterial abundance was (No/ml±SD, n: 500), VLP:
    9
    .60±
    0
    .29×108 and bacteria:
    3
    .61±
    0
    .14×106. VLPs ranged in diameter from 30 to 320 nm, and the major size distribution (ca 62%) was
    83
    .33.
    3
    nm (n: 843). Ultrafiltration followed by CsCl density equilibrium ultracentrifugation gave purified TY-VLPs: 6.64×1013. Regardless of UV treatment, TY-VLP reduced the efficiency of plating to 68.6-
    83
    .4% at a multiplicity of infection of ca
    0
    .
    3
    on Escherichia coli AB1157. Generalised transduction was observed on
    E
    . coli
    AB1157 with a frequency between 10-4 and 10-
    5
    cells/particle using TY-VLPs without UV-treatment. The growth of generated
    E
    . coli
    transductants (TY-
    E
    -trans) was compared to that of an
    E
    . coli
    transductant (ST-
    E
    -trans) generated by Aquificales originating VLP (Chiura, 2002). The extent of the maximum growth of both transductants was ca 40% of the parental
    E
    . coli
    used as a recipient. TY-
    E
    -trans acquired "budding-like" particle productivity, which has been demonstrated for ST-
    E
    -trans. ST-
    E
    -trans produced five different size particles, whose DNA content ranged between 291.6 and 382.
    0
    kb, and TY-
    E
    -trans produced ten different size particles between 68.
    5
    and 190.2 kb, respectively.
  • ―特にアポ蛋白Eの変化について―
    本間 康彦, 三神 美和, 佐藤 美智子, 石原 仁一, 吉川 広, 木下 栄治, 田川 隆介, 星合 充基, 古屋 秀夫, 井出 満, 田辺 晃久, 玉地 寛光, 兼本 成斌, 友田 春夫, 中谷 矩章, 五島 雄一郎
    動脈硬化
    1984年 12 巻 3 号 599-603
    発行日: 1984/08/01
    公開日: 2011/09/21
    ジャーナル フリー
    Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL2 and
    HDL3
    were estimated on the
    0
    th, 7th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
    B
    , C-II,
    E
    levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL2 and
    HDL3
    were 15.
    9
    ±7.
    5
    mg/dl (mean±SD), 150.
    9
    ±58.1mg/dl 43.
    8
    ±
    9
    .6mg/dl, 16.4±
    5
    .
    8
    mg/dl and 24.
    9
    ±6.
    3
    mg/dl respectively. Plasma apoprotein A-I, A-II,
    B
    , C-II and
    E
    levels were 81.7±
    22
    .
    0
    mg/dl, 15.1±
    5
    .4mg/dl, 93.7±36.
    0
    mg/dl,
    3
    .
    83
    ±1.00mg/dl and 4.29±1.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-C (r=
    0
    .348), HDL2-C (r=
    0
    .612) and
    HDL3
    (r=
    0
    .569). Apoprotein
    B
    correlated with total cholesterol (TC) (r=
    0
    .610), VLDL-C (r=
    0
    .341), LDL-C (r=
    0
    .726), HDL-C (r=
    0
    .432) and HDL2-C (r=
    0
    .465). Apoprotein C-II correlated with TC (r=
    0
    .765), TG (r=
    0
    .679), VLDL-C (r=
    0
    .651), LDL-C (r=
    0
    .461) and HDL2-C (r=
    0
    .326). Apoprotein
    E
    correlated with TC (r=
    0
    .580), TG (r=
    0
    .575) and VLDL-C (r=
    0
    .666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=
    0
    .468). Apoprotein
    B
    correlated with apoprotein C-II (r=
    0
    .393). Apoprotein C-II correlated with apoprotein
    B
    (r=
    0
    .393) and
    E
    (r=
    0
    .549). Apoprotein
    E
    only correlated with apoprotein C-II (r=
    0
    .549).
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