Static characteristics of two different structured InAlGaAs/InAlAs superlattice avalanche photodiodes (SLAPDs) cooled by liquid nitrogen were evaluated at a wavelength of 1.5 μm. The dark current of the SLAPD having a thick superlattice layer of 0.504 μm was 5×10^-13 A. This was successively reduced by four orders of magnitude compared to that of the thin layer SLAPD of 0.231 μm at a breakdown voltage of around 20 V. The thickened layer was effective in suppressing tunneling dark current. An output current of 1.7×10^-12 A at a bias voltage of 15 V was measured for an optical input with a wavelength of 1.5 μm and a signal power of 1×10^-12 W. This showed a sharp distinction from the dark current.

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Two new polyacetylene compounds (, 6, 12)-1-acetoxy--isovaleryloxytetradeca-, 6, 12-trien-, 10-diyn-14-ol (B), and (, 6, 12)-1-acetoxy--(2-methylbutyryloxy)tetradeca-, 6, 12-trien-, 10-diyn-14-ol (C) have been isolated along with (, 6, 12)-1-acetoxy--senecioyloxytetradeca-, 6, 12-trien-, 10-diyn-14-ol (A) from Atractylodes Rhizome (Karabyakujutu). The structures of these compounds were determined on the basis of their spectral data.

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The association between apolipoprotein (Apo-) polymorphism and the response of plasma cholesterol to dietary therapy (cholesterol intake of less than 300mg/day) was investigated for about weeks in 208 nonfamilial hypercholesterolemia patients (/ 161, / 47). The baseline lipoprotein concentration and the intake of energy and lipids were not significantly different between subjects with / and those with / phenotypes. After the dietary therapy plasma total cholesterol and low density lipoprotein cholesterol were significantly decreased in both phenotype groups (p<0.05). The patients with / had significantly smaller reductions of LDL-C than the patients with /. The changes of LDL-C showed a significant difference between the patients with / and / by the Kruskal Wallis test (p=0.041). The presence of / predicted the degree of cholesterol reduction following dietary therapy.

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The syntheses of (S)-13-hydroxy-(2, , )-tetradecatrienoic acid (1) and (2, , Z-tetradecatrienoic acid (2) were carried out by using the Wittig reaction as the key step. The asymmetric center at C-13 and the double bond between C- and C- for natural compound 1 were reconfirmed as being of (S) configuration and , respectively. The relationship between the structure of the unsaturated hydroxy fatty acids and their inhibitory effect on the growth of lettuce was investigated.

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The leaning tower of Pisa is a famous historical structure, especially in the field of soil mechanics. In this paper, the historical development of the inclination is reconstructed considering that a ground failure took place after each of the three construction phases. Model tests (scale 1 : 130) were carried out in order to predict that the tower will fail definitely, i.. without any further disturbances, at an angle of inclination of 5.7°, which is dramatically close to the actual value of 5.5°. The estimated probability of failure rises very quickly with an increase in the angle of inclination. Conservation of the tower should be done therefore with utmost caution.

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The performance of single pitch and multi pitch screw anchors during the application of installation torque is presented. An experimental testing program was conducted using five models of screw anchors with different geometry. The effect of the shape of the screw element, sand properties, and installation depth on the required installation torque value was examined. A theoretical model was developed from which the required installation torque value can be calculated in terms of the influencing factors. The required installation torque can be determined in terms of the ultimate uplift resistance calculated from any of the available theories. Based on the actual installation torque value measured in the field, the anticipated pullout capacity can be back calculated from the present theory. A comparison between theoretical and experimental results showed good agreement. Also, good agreement was observed when the present theoretical results were compared with the available field results reported in the literature.

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In the seismic analysis of pile foundations the soil is often assumed to be an elastic material and the pressure at the soil pile interface is not limited during the analysis. This may result in a considerable error, as the computed pressure from an elastic analysis may go well beyond the ultimate lateral pressure of real soil. In fact, significant yielding at the soil-pile interface has been observed during real earthquakes, and also in laboratory tests. The yield zone is usually near the ground surface where the effect of inertial force due to the superstructure is higher. This yielding redefines the pile response, and in general cannot be ignored. In order to examine the effects of soil yielding on the internal pile response during earthquakes an approximate analysis is described in this paper which is an extension of a static method developed by the second author (1982) for the analysis of piles subjected to lateral soil movement. This method is then used to investigate the effects of soil yielding on the internal response of piles through a comparative study in which real earthquakes are used. It is shown that for strong earthquakes and heavily loaded piles the soil yielding may considerably increase the amount of maximum pile moment developed in the pile. A marked difference in the effects of yielding on the pile moment and shear is observed and discussed.

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The interaction between a penetrating shaft and the surrounding soil media under impact loading is a frequently encountered phenomenon in geotechnical engineering. Examples of such dynamic soil/shaft interaction would include dynamic pile driving, standard penetration testing (SPT), and dynamic driven rod test. Presented in this paper is a novel approach, based on the principle of dynamic system identification, which enables identification of dynamic soil-pile interaction model parameters. The analytical transfer function, relating the output stress wave forms to the input stress wave forms in the soil/shaft system, is derived using the Laplace and Fourier Transform techniques and the one-dimensional wave propagation theories. A numerical solution algorithm based on a variation of gradient method is coded into a micro-computer based program to solve the frequency-dependent soil-pile interaction parameters (Smith model) : soil damping and soil spring stiffness. To further reduce the amount of computational effort required in the solution of the frequency-dependent dynamic soil properties, it is suggested that the solution be obtained for the first-mode natural frequency of the measured stress waves. The results obtained from this simplified solution algorithm, when compared with both numerical simulations and controlled laboratory tests, are reasonably acceptable. The proposed parameter identification technique offers a viable alternative data interpretation procedure for deducing pertinent Smith model parameters used frequently in pile driving analysis.

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A biosynthetic pathway for (

)-methyl cinnamate formation was evaluated in Tricholoma matsutake by tracer experiments using ¹³C- and ²H-labeled precursors. One hundred percent selective ¹³C incorporation was observed when L-[1,2,,,5,6,7,,-

13C₉

, ^15/N]phenylalanine was converted to (

E

)-[1,2,

3

,

4

,5,6,7,

8

,

9

-

13C₉

]cinnamate and (

E

)-[1,2,

3

,

4

,5,6,7,

8

,

9

-

13C₉

]methyl cinnamate. Similarly, 100% selective ¹³C incorporation was observed when (

E

)-[1,2,

3

,

4

,5,6,7,

8

,

9

-

13C₉

]cinnamate was converted to (

E

)-[1,2,

3

,

4

,5,6,7,

8

,

9

-

13C₉

]methyl cinnamate. In contrast, the ²H incorporation selectivities were 82.1% and

81

.

4

% when L-[2,

3

,

4

,5,6,7,7,

8

-

2H₈

]phenylalanine was converted to (

E

)-[2,

3

,

4

,5,6,7,

8

-²H₇]cinnamate and (

E

)-[2,

3

,

4

,5,6,7,

8

-²H₇]methyl cinnamate, respectively. Thus, T. matsutake synthesizes (

E

)-methyl cinnamate from L-phenylalanine via (

E

)-cinnamate. (

E

)-cinnamate was likely formed through two pathways: one was major and the other was a minor.

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Purpose: The purpose of this study was to determine if the optical properties of zirconia and glass–ceramic (

.max) were affected by low-temperature degradation (aging).

Methods: Experiment samples were fabricated with seven zirconia brands (n=10): Zenostar, Zirlux, Katana, Bruxzir, DD-BioZX², DD-cubeX², NexxZr; and

.max were used as a control. This resulted in a total of 80 samples in the experiment. The L*, a* and b* were measured for each sample, and then the optical properties including translucency parameter (TP), contrast ratio (CR), and opalescence parameter (OP) were calculated. The samples were aged (20, 40, 60, 80, 100h), and the optical properties were calculated after each interval.

Results: Most zirconia brands had lower L*, higher a*, higher b* with increased aging, which visually corresponds to darker, redder, and more yellow. Aging also increased CR, lowered TP, and lowered OP.

.max was also affected by aging but still had the highest TP (23.±2.), L* (.7±.), and lowest CR (0.41±0.05) compared to any zirconia. The Zenostar had the closest TP (24.1±0.), and L* (.2±0.5) values to .max before aging. However, after 100h of aging, the DD-cubeX² was least effected and had the highest TP (.2±0.6) and lowest CR (0.43±0.01) compared with other zirconia samples and highest OP (11.±0.2) of all ceramic samples.

Conclusions: The optical properties of zirconia and

.max materials were affected by aging with the effects increasing with time. The magnitude of change was affected by seven brands of dental zirconia.

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Results of model loading tests on dense sand were reviewed to assess the variation in bearing capacity factors N_γ and N_q relative to the width of the foundation base. Consequently, it is confirmed that N_γ decreases non-linearly with increase in the width of foundation base and that N_q decreases more sharply than N_γ does as the width increase. It is also found that N_q decreases as the ratio of burried depth to the width increase. The cause of decrease in N_γ or N_q with increase in the width is regarded to be the rise of stress level which induces lowering of the angle of internal friction φ and volume reduction in the bearing sand by compression.

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Thirty-six patients (19 males, 17 females: atypical schizophrenia; , typical schizophrenia; , depression; 11, neurosis and other psychiatric disorders; ) were operated on according to orbitoventromedial undercutting by Hirose. In all cases, the Rorschach test was carried out and daily behaviors were studied. Thirty-one scales of the test were subjected to multivariate analysis whereas the behaviors were evaluated according to the following criteria, i.., A: recovered or symptom free, B: markedly improved, C: moderately improved, : slightly improved and : not improved. The following results were obtained.
1) The evaluation of behaviors is as follows. A: 12 cases, B: , C: , : 6, : none.
2) It was found that scores of +106% and R+106% scales were significantly higher after the operation than before; that correlation coefficients between the scores before and after the operation were considerably high.
) Factor analysis followed by varimax rotation was carried out. Six factors were extracted, i.., (1) sensitivity to emotional stimuli, (2) ego-strength, () obsessional rigidity, () reaction time, (5) anxiety and tension and (6) empathy. It was revealed that 2 was high in atypical schizophrenia, depression and neurosis, and that 2 and 6 were significantly different in terms of the factor scores among the four groups A, B, C and ; 2 was highest in A, and lowest in regardless of whether it was before or after the operation. 6 showed high scores in both A and C, and low in .
) Multiple discriminant analysis was applied to the data of the Rorschach test before the operation, by classifying 36 subjects into the four groups A, B, C and . As a result, high rates of correct diagnosis were obtained, i.., 100% for A, 78% for B, 56% for C and 100% for . When the groups C and were combined into one group (C+) the highest percentage (100%) was seen in A, followed by B (89%) and C+ group (87%). When the groups A and B were combined into one group (A+B), the percentages of correct diagnosis were % for A+B, and 93% for C+.
In conclusion, it can be said that scales of the Rorschach test have been proved to be valid for predicting mental and physical states after the orbito-ventromedial undercutting.

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Chemical synthesis of (, 24R)- and (, 24S)-1, 24-dihydroxy--vitamin has been achieved starting with the commercially available dinorcholenic acid acetate. Synthesis involved introduction of the 1-hydroxy group by a reduction of the 1, 2-epoxide generated by epoxidation of the 1, , 6-trien--one. The side chain on the steroid was then constructed by means of a Wittig reaction followed by introduction of the Δ⁷ bond by standard methods and its protection with 1-phenyl-1, 2, -triazoline-, 5-dione. Subsequent reduction of the hydroxy groups in the steroid side chain followed by reduction of the Diels-Alder addition products yielded the both 24-isomers. The 5, 7-dienes were irradiated and the corresponding vitamin compounds isolated. Nuclear magnetic resonance was used to identify individual isomers. The (, 24S)-1, 24-hydroxyvitamin compound bound equally well to the chick intestinal cytosol receptor as 1, 25-dihydroxyvitamin , while the 24R-isomer was approximately ten times less active. In vivo, both isomers were less active than 1, 25-dihydroxyvitamin ; however, the 24S-isomer was considerably more active than the 24R-isomer approaching the activity of 1, 25-dihydroxyvitamin .

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In order to clarify the physiological role of antidiuretic hormone (ADH) in regulating the renal water handling, a bioassay for ADH in urine was devised, and urinary excretion of ADH was determined in 21 normal subjects, 14 patients with central diabetes insipidus, and patients with inappropriate secretion of ADH (SIADH). Under normally hydrated states, 12 normal subjects and 7 patients with central diabetes insipidus excreted .±.2mU of ADH/day (12.±2.0μU/ml) (mean±s. .), and less than .2mU/day (2.0μU/ml), respectively. patients with SIADH excreted ADH ranging from 15.6 to 808.2mU/day. Under dehydrated states, ADH excretion increased to .0±0.5mU/hr (137.±/ml) (mean±S. .) in normal subjects. At that time, plasma and urine osmolality increased to 282.5±1.1 and 1004±43mOsm/kg (mean±S. .), respectively. In all of 7 patients with central diabetes insipidus, urinary ADH could be detected when plasma osmolality increased to 298.±1.7 mOsm/kg (mean±S. .) after water deprivation. In normal subjects, urinary ADH excretion decreased after water loading from .0±0.5 mU/hr to below 0.6mU/ hr (0.6μU/ml) with a concurrent reduction of plasma and urine osmolality to 274.±1. and ±7mOsm/kg (mean±S. .), respectively. Two types of daily urinary excretion patterns of ADH were found in patients with SIADH. One of them had ectopic ADH producing tumor and excreted a relatively large amount of ADH, and the other was a non-tumor case which excreted a normal amount of ADH. However, either case showed no suppressibility of ADH in the face of an expansion of body fluid with hypo-osmolality of the plasma.

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A rapid flat gel isoelectric focusing method has been developed for the determination of VLDL apolipoprotein (apo) isoform patterns. Isoelectric focusing in 5% polyacrylamide flat gel with M urea and 2.% pharmalyte (PH -6.5)(Pharmacia) was carried out at 3000 V and ° for 1 hr under a constant power of 30 W, using a flat bed apparatus FBE 3000 (Pharmacia) and an electrophoresis constant power supply ECPS 3000/150 (Pharmacia).The separation of apo isoform bands was good, and isoelectric points were determined 5.95 for apo , 5. for apo and 5.68 for apo 2 in our focusing system. We analyzed apo isoform patterns in our population (n=123) using this focusing method.
The results obtained were as follows;
1) The apo phenotype frequencies were 0.0% for 2/2, 6.5% for /2, 71.6% for /, 0.% for /2, 19.5% for / and 1.6% for /, indicating that Japanese have a higher frequency of allele and a lower frequency of ε2 allele than either German or Americans.
2) Two phenotypes, apo / and /2 were differentiated on the basis of the apo 2/ ratios. The ratio was 0.38±0.02 for group / and 1.12±0.04 for group /2. No overlap was observed between the two groups. The cut-off point between the two groups was assumed to be approximately 0. in our focusing system.
This method is useful for the analysis of apo isoform patterns.

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Nアルキル,:,10-ペリレンテトラカルボン酸モノアンヒドリド=モノイミド[a～]と芳香族アミン(アニリン,p-トルイジン,p-アニシジン,,5-キシリジン,-アミノナゾベンゼン,およびo-フェニレンジアミン)を縮合して非対称型,:,10-ペリレンビス(ジカルボキシミド)誘導体-N-アルキル-N'-アリール-,:,10-ペリレンビス(ジカルボキシミド)(〔5a～〕,〔6a～〕,〔7a～〕,〔a～〕,〔a～〕,および〔10a～b〕)を合成した. これらの各誘導体はすべて赤色系の色相を示し, 顔料試験の結果N-ブチル-N'-アリール-,:,10-ペリレンビス(ジカルボキシミド)(たとえば〔5〕や〔6〕)がとくにすぐれた耐光性を示した.

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Enterococcus faecalis is a frequent cause of hospital-acquired infection. Two hundred fifty one

E

. faecalis isolates from patients with urinary tract infection at Okayama University Hospital over an -year period from 1991 through 1998 were collected. The presence of the asaI, cylA, aac (6')-aph (2''), and aph (

3

')-III genes was analyzed by PCR methods. Of the 251 isolates, 205 (.7%) were positive for asaI. The .5% (167/205) of asaI-positive isolates also possessed either cylA or aminoglycoside resistance genes, compared to only 15.2% of (7/46) asaI-negative isolates (p<0.0001). The incidence of asaI gradually increased from 69.2% in 1991 to .7% in 1998. The number of isolates that contain asaI, cylA and aminoglycoside resistance gene (s) also increased. Pulsed-field gel electrophoresis (PFGE) analyses of 28 asaI-positive and hemolysin-producing isolates revealed different banding patterns, including 6 pairs with similar patterns. The plasmid analyses of these isolates showed different patterns except for 1 pair with similar PFGE pattern. These results suggest that

E

. faecalis possessing the asaI gene may play an important role in the exchange of genetic information among enterococci in the urinary tract.

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