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  • 小田切 孝人, 田代 眞人
    ウイルス
    2013年 63 巻 2 号 233-240
    発行日: 2013/12/25
    公開日: 2014/10/31
    ジャーナル フリー
  • LIVIO SIROVICH
    地盤工学会論文報告集
    1996年 36 巻 4 号 23-34
    発行日: 1996/12/15
    公開日: 2008/02/29
    ジャーナル フリー
    Repetitive liquefactions in angular and subangular gravels from an alluvial fan, in the case of two earthquakes with accelerations lower than that of a former which had caused liquefaction some months before, are described. The liquefaction took place from the surface, down to a depth of approximately 10 m. Water laden with sediments spouted out for some tens of minutes after the strong motion ceased. Knowledge of the grain size distribution of the sediments inside the body of the alluvial fan roughly defines the areas of the fan prone to future liquefaction. Non-repetitive liquefaction in overconsolidated fine fluvio-lacustrine sand of glacial origin at the unusual depth of 14 m to 16 m is also described. From the observation of sand lifted up for 10 m inside a large diameter well, and of that which spouted out from several microvents, it was estimated that extra-pore pressure was close to lithostatic conditions. Nevertheless, modeling of intrinsic pore pressure buildup on the DESRA2 programme gives lower values than the experimental one. Geotechnical characteristics of the 12 m-thick sandy stratum indicate that the upper part is unusually soft, either due to water circulation or past repetitive liquefactions which prevented reconsolidation. It is suggested that excess pore pressure generated by the earthquake was also due to redistribution of pressure from adjacent sediments.
  • Mohd Suhail, Mohd Faizul Suhail, Hina Khan
    Journal of Clinical Biochemistry and Nutrition
    2008年 43 巻 3 号 210-220
    発行日: 2008年
    公開日: 2008/10/31
    ジャーナル フリー
    We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group
    B
    which comprised preeclamptics who were supplemented their diets with vitamins
    C
    and
    E
    . MDA increased from 6.
    22
     ± 2.
    8
    (placebo) to
    8
    .48 ± 1.2 (A) and
    8
    .02 ± 1.
    8
     nmol/gHb (
    B
    ). NO concentrations were enhanced from 19.3 ± 
    4
    .2 (P) to 23.
    8
     ± 6.
    4
    (A) and 24.1 ± 
    5
    .
    4
     μmol/L (
    B
    ). GSH contents were decreased from 10.42 ± 2.81 (P) to
    8
    .02 ± 2.92 (A) and
    9
    .39 ± 1.02 μmol/g Hb (
    B
    ), whereas GSSG concentrations increased from
    0
    .
    98
     ± 
    0
    .28 (P) to 1.24 ± 
    0
    .29 (A) and 1.08 ± 
    0
    .12 μmol/g Hb (
    B
    ). SOD activity decreased 23% in A and 14% in
    B
    ; GRx decreased 27% in A and
    5
    .
    5
    % in
    B
    ; GPx decreased 12% in A and
    9
    .6% in
    B
    . Catalase activity, however, increased 27% in A and 29% in
    B
    as compared to control. Thus, we conclude that the use of vitamins
    C
    and
    E
    should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.
  • FRANÇOIS LE GOFFIC, FRÉDÉRIC TANGY, BERNARD MOREAU
    The Journal of Antibiotics
    1979年 32 巻 12 号 1288-1292
    発行日: 1979年
    公開日: 2006/04/12
    ジャーナル フリー
    A sample of [3H] tobrarnycin (
    5
    , 000 Ci/Mole) has been synthetized and incubated with
    the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
    two types of binding sites. The primary one is probably responsible for the inhibition of
    protein synthesis whereas the secondary one is probably related to the misreading and reading
    tiirough of the messenger RNA.
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with 7 kinds of factors, as follows ; A^^〜=
    B
    +
    C
    +
    D
    +K+aE+
    bF
    +cG. A^^〜=estimated values of the readership score. 1)
    B
    ,
    C
    ,
    D
    , K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into 7 categories.
    C
    =pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories.
    D
    =kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2)
    E
    , F, G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into 6 kinds of area (2.
    5
    , 3.
    5
    ,
    5
    , 7, 10, 15) and 15 column means a whole page, about 2,000cm^2.
    E
    , F are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement. F=the marks obtained on the whole effect of the design. 3) a,
    b
    ,
    c
    : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+
    bF
    =A-(
    B
    +
    C
    +
    D
    +K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was 3,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is
    0
    .951. The table 2^* shows the contribution indexes of each factor by 3 kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, (3) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of
    E
    , F.
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _1+
    E
    _2+
    E
    _3+
    E
    _
    4
    . design elements [table]
    E
    _1,
    E
    _2,
    E
    _3,
    E
    _
    4
    , these values have the
    5
    grades, as
    0
    , 1, 2, 3,
    4
    and
    0
    is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of
    0
    to
    9
    grades as the sum of them. The values of F have also
    5
    grades,
    0
    to
    4
    . The principles to determine the values of
    E
    , F are as follows : a) The marks obtained of
    E
    , F must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula.
    c
    ) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    , F values, as the table
    5
    -
    4
    , and
    5
    -
    5
    in the thesis in Japanese.
  • 堀 幹夫, 片岡 貞, 清水 洋, 小野木 和弘
    YAKUGAKU ZASSHI
    1978年 98 巻 9 号 1189-1197
    発行日: 1978/09/25
    公開日: 2008/05/30
    ジャーナル フリー
    As a fundamental study on dibenzothiepins, reaction of 11-phenyl-6, 11-dihydrodibenzo [
    b
    ,
    e
    ] thiepin-11-ol (10) or 11-chloro-11-phenyl-6, 11-dihydrodibenzo [
    b
    ,
    e
    ] thiepin (14) with triphenylmethyl cation or
    SbCl5
    was examined under various conditions. 11-Phenyl-6, 11-dihydrodibenzo [
    b
    ,
    e
    ] thiepin-11-ylium salt (
    8
    ) was isolated as a black powder (perchlorate) and a green powder (hexachloroantimonate), but
    BF4
    salt was obtained only as a solution. Treatment of the hexachloroantimonate with excess of
    SbCl5
    was found to result in a novel dehydrocyclization reaction to give selectively
    9
    , 13
    b
    -dihydrofluoreno [1,
    9
    a,
    9
    -
    c
    ,
    d
    ] [2]-benzothiepin-13
    b
    -ylium hexachloroantimonate (19). Some discussions were made on the mechanism of the formation of 19.
  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in 95 (
    22
    .2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-2 (
    22
    ), blaCTX-M-3 (16), blaCTX-M-1 (15), blaOXA-1 (
    9
    ) and blaSHV-12 (3) alone or in combination. The most frequently encountered phylogenetic group was group A1 (35.
    8
    %), followed by group
    D2
    (
    22
    .1%),
    B
    1 (15.
    8
    %),
    D1
    (
    9
    .
    5
    %),
    A0
    (7.
    4
    %),
    B22
    (
    5
    .3%) and
    B23
    (
    4
    .2%), respectively. PMQR genes, aac(6’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.3, 10.
    5
    and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.
    0
    % for tobramycin to 56.
    8
    % for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE, f17a-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • 山本 雅史, 久保 達也, 冨永 茂人
    園芸学会雑誌
    2005年 74 巻 6 号 476-478
    発行日: 2005年
    公開日: 2006/02/24
    ジャーナル フリー
    わが国における主要中晩生および香酸カンキツ染色体のクロモマイシンA3 (CMA) 染色を行った. 染色体はCMA(+) バンドの有無および位置から
    5
    種類に区分できた. すなわち, CMA(+) をA: 両端および動原体近傍に有する,
    B
    : 一方の端部と動原体近傍に有する,
    C
    : 両端に有する,
    D
    : 一方の端部に有する,
    E
    : CMA(+) がない, である. 各種はこれらのうち
    4
    ,
    5
    種類の染色体を有し, 独自のCMAバンドパターンを示した. ハッサクでは1A+1
    C
    +
    8
    D
    +
    8
    E
    , ヒュウガナツでは2A+2
    C
    +
    5
    D
    +
    9
    E
    , ‘川野なつだいだい’では1A+2
    C
    +7
    D
    +
    8
    E
    , ‘宮内伊予柑’では1A+1
    B
    +1
    C
    +
    8
    D
    +7
    E
    , タンカン‘垂水1号’では1A+1
    B
    +1
    C
    +
    8
    D
    +7
    E
    , カボスでは3
    B
    +2
    C
    +
    5
    D
    +
    8
    E
    , スダチでは1
    B
    +2
    C
    +
    9
    D
    +6
    E
    およびユズ‘山根’では2
    B
    +1
    C
    +11
    D
    +
    4
    E
    であった. 以上の結果, 本研究においても近縁の種間では似通ったCMAバンドパターンが観察された.
  • 香山 滉一郎, 森下 政夫, 張 国鋒
    粉体および粉末冶金
    2006年 53 巻 5 号 419-429
    発行日: 2006年
    公開日: 2006/12/19
    ジャーナル オープンアクセス
    The phase diagrams of the Ni-Mo-
    B
    and Ni-W-
    B
    ternary systems in the region of less than 50mol%
    B
    were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
    E1
    :L (1365K, 71.
    5
    mol%Ni-6.
    0
    mol%Mo-
    22
    .
    5
    mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiMo2B2

    E2
    :L (1355K, 62.
    5
    mol%Ni-2.
    5
    mol%Mo-30.
    5
    mol%
    B
    )=
    Ni3B
    +
    Ni2B
    +
    NiMo2B2

    E3
    :L (1445K, 42.
    0
    mol%Ni-30.6mol%Mo-10.3mol%
    B
    )=(Ni)+NiMo+
    NiMo2B2

    P1:L (1812K, 34.
    9
    mol%Ni-42.3mol%Mo-
    22
    .
    8
    mol%
    B
    )+MoB=
    Mo2B
    +
    NiMo2B2

    P2:L (1633K, 42.3mol%Ni-40.
    4
    mol%Mo-17.3mol%
    B
    )+Mo=
    Mo2B
    +
    NiMo2B2

    P3:L (1812K, 53.
    5
    mol%Ni-33.7mol%Mo-12.
    8
    mol%
    B
    )+Mo=NiMo+
    NiMo2B2

    E1
    :L (1622K, 51.
    0
    mol%Ni-31.6mol%W-17.
    4
    mol%
    B
    )=(Ni)+W+
    NiW2B2

    E2
    :L (1260K, 71.
    0
    mol%Ni-7.
    0
    mol%W-
    22
    .
    0
    mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiW2B2

    E3
    :L (1291K, 65.
    4
    mol%Ni-
    4
    .
    8
    mol%W-29.
    8
    mol%
    B
    )=
    Ni2B
    +
    Ni3B
    +
    NiW2B2

    P1:L (2115K, 23.
    8
    mol%Ni-43.1mol%W-33.1mol%
    B
    )+WB=
    W2B
    +
    NiW2B2

    P2:L (1657K, 48.
    9
    mol%Ni-33.1mol%W-18.
    0
    mol%
    B
    )+
    W2B
    =W+
    NiW2B2

    The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
  • R.G. WAN, P.J. GUO
    地盤工学会論文報告集
    1999年 39 巻 6 号 1-11
    発行日: 1999/12/15
    公開日: 2008/02/29
    ジャーナル フリー
    This paper outlines a mathematical description of the stress dilatancy behaviour of granular materials which accounts for stress level and void ratio dependencies. The consideration of these aspects has important implications in the modelling of granular material behaviour. In fact, granular material mechanical response is largely dominated by the evolution of dilatancy, fabric and void ratio histories. The starting point in this study is the well established Rowe's theory which is revisited and ultimately modified by introducing a factor linked to governing state parameters in order to describe the complete behaviour of granular materials during deformation. Numerical simulations of triaxial tests on granular materials at different void ratios and stress levels are herein presented to illustrate the model.
  • 東坂 諒哉, 城 克己, 林 侑加子, 津村 ゆかり
    日本法科学技術学会誌
    2023年 28 巻 2 号 197-203
    発行日: 2023年
    公開日: 2023/07/31
    [早期公開] 公開日: 2023/04/20
    ジャーナル フリー

     The stability of

    Δ9
    ‒tetrahydrocannabinol acetate (
    Δ9
    ‒THC‒OAc) and
    Δ8
    ‒tetrahydrocannabinol acetate (
    Δ8
    ‒THC‒OAc) in
    e
    -liquid during storage was investigated.
    Δ9
    ‒THC‒OAc liquids in cartridges were stored at 80℃ or 30℃ for 28 days. The relative concentrations of cannabinoids in the liquids were measured by gas chromatography with flame ionization detection.
    Δ9
    ‒THC‒OAc decreased during storage at either temperature.
    Δ9
    ‒THC, a minor impurity, also decreased.
    Δ8
    ‒THC‒OAc liquid in a cartridge was stored at 80℃ for 57 days. The concentration of
    Δ8
    ‒THC‒OAc and
    Δ8
    ‒THC, a minor impurity, did not change during that time. Cannabinol acetate increased in all liquids, and unknown products were also detected by gas chromatography/mass spectrometry (GC/MS). The
    Δ9
    ‒THC‒OAc and
    Δ8
    ‒THC‒OAc liquids were subjected to GC/MS to detect representative diluents, glycerol, propylene glycol, and polyethylene glycol 400, but none of these were detected.

  • 木村 聖路, 田中 正則, 福田 眞作
    日本大腸肛門病学会雑誌
    2019年 72 巻 6 号 395-404
    発行日: 2019年
    公開日: 2019/05/31
    ジャーナル フリー

    フォローアップ検査がなされた2,740例(61.

    9
    ±37.7月,3.33±1.64回)を初回所見別にA群:正常大腸633例,
    B
    群:微小腺腫放置721例,
    C
    群:低異型度腺腫切除622例,
    D
    群:高異型度腺腫,粘膜内癌切除307例,
    E
    群:浸潤癌切除457例に分類し後ろ向きに検討した.異時性の低異型度腺腫,高異型度腺腫または癌(Index lesion)の累積発生率は,Kaplan-Meier法によるLogrank検定にて,両者ともA群,
    B
    群,
    C
    群,
    D
    群の順に段階的に有意に増加した.しかし低異型度腺腫は
    E
    群で有意に減少した.3年未満,
    5
    年未満のIndex lesion発生率はA群1.
    9
    %,1.7%,
    B
    群2.3%,3.2%,
    C
    群3.2%,3.
    8
    %,
    D
    4
    .
    0
    %,
    5
    .3%,
    E
    群6.
    9
    %,7.
    8
    %であった.
    4
    %を許容頻度とすれば,A,
    B
    C
    群は
    5
    年間は許容され
    D
    群は
    5
    年間,
    E
    群は3年間で許容頻度を超えた.

  • その1.乳歯について
    日本小児歯科学会, 有田 憲司, 阿部 洋子, 仲野 和彦, 齊藤 正人, 島村 和宏, 大須賀 直人, 清水 武彦, 石通 宏行, 松村 誠士, 尾崎 正雄, 石谷 徳人, 濱田 義彦, 渥美 信子, 小平 裕恵, 高風 亜由美, 長谷川 大子, 林 文子, 藤岡 万里, 茂木 瑞穂, 八若 保孝, 田中 光郎, 福本 敏, 早﨑 治明, 関本 恒夫, 渡部 茂, 新谷 誠康, 井上 美津子, 白川 哲夫, 宮新 美智世, 苅部 洋行, 朝田 芳信, 木本 茂成, 福田 理, 飯沼 光生, 仲野 道代, 香西 克之, 岩本 勉, 野中 和明, 牧 憲司, 藤原 卓, 山﨑 要一
    小児歯科学雑誌
    2019年 57 巻 1 号 45-53
    発行日: 2019/02/25
    公開日: 2020/01/31
    ジャーナル フリー

    日本人乳歯の萌出時期および萌出順序を明らかにし,乳歯の萌出に変化が生じているか否かを検討する目的で,全国的に3 か月から3 歳11 か月の小児

    8
    ,724 名を調査し,以下の結果を得た。

    1 .男児の乳歯萌出は,A が

    5
    か月-
    9
    か月,A が7 か月-11 か月,
    B
    9
    か月-1 歳2 か月,
    B
    9
    か月-1 歳3 か月,
    D
    が1 歳1 か月-1 歳6 か月,
    D
    が1 歳1 か月-1 歳7 か月,
    C
    が1 歳2 か月-1 歳
    8
    か月,
    C
    が1 歳2 か月-1 歳
    9
    か月,
    E
    が1 歳11 か月-2 歳7 か月,
    E
    が2 歳
    0
    か月-2 歳11 か月の順だったが,BB 間と
    D
    ,
    D
    ,
    C
    および
    C
    の間には有意な差は認められなかった。

    2 .女児の乳歯萌出は,A が6 か月-

    9
    か月,A が7 か月-11 か月,
    B
    9
    か月-1 歳1 か月,
    B
    9
    か月-1 歳2 か月,
    D
    が1 歳1 か月-1 歳7 か月,
    D
    が1 歳1 か月-1 歳7 か月,
    C
    が1 歳3 か月-1 歳
    9
    か月,
    C
    が1 歳
    4
    か月-1 歳
    9
    か月,
    E
    が1 歳11 か月-2 歳7 か月,
    E
    が2 歳1 か月-2 歳10 か月の順だったが,
    AA
    間,AB 間,BB 間,DD 間,CC 間には有意な差は認められなかった。

    3 .性差は大部分の歯で認めず,

    C
    C
    の萌出時期にのみ有意な差を認め,いずれも男児が1 か月早く萌出していた。

    4
    .前回報告(1988 年)に比べて,男児はA, A,
    C
    ,
    D
    の,女児はA と
    D
    の,萌出時期が有意に早くなっていることを認めた。

  • CHANIDNUN POTHIRAKSANON, DENNES T. BERGADO, HOSSAM M. ABUEL-NAGA
    SOILS AND FOUNDATIONS
    2010年 50 巻 5 号 599-608
    発行日: 2010年
    公開日: 2010/12/28
    ジャーナル フリー
    In this study the field feasibility of an innovative thermal technique to improve the performance of prefabricated vertical drains (PVD) used in conjunction with the preloading ground improvement method is investigated. For this purpose, two identical 6.
    0
    m high full-scale test embankments for preloading were constructed over the soft Bangkok clay where a conventional PVD system was installed underneath one embankment and a novel prefabricated vertical thermo-drain (PVTD) system was utilized for the other. The PVTD unit consists of a U-tube made of cross-linked polyethylene plastic (PEX) that is attached to a conventional PVD unit. Preheated water at about 90°
    C
    is circulated through the attached U-tube to raise the soil temperature underneath the PVTD embankment. The behavior of the two test embankments were compared in terms of excess pore water pressure and consolidation results. The comparison shows the advantage of a PVTD system over a conventional PVD system. The rate of consolidation increases significantly in the PVTD system due to the temperature effect on the hydraulic conductivity. Moreover, the embankment with the PVTD system generates more settlement due to the thermally induced irreversible contraction of saturated normally consolidated soft Bangkok clay.
  • 山本 松男
    口腔病学会雑誌
    1996年 63 巻 1 号 174-187
    発行日: 1996/03/31
    公開日: 2010/10/08
    ジャーナル フリー
    Oral Actinobacillus actinomycetemcomitans strains have been classified into five serotypes. The aim of this study was to determine the compositions of A. actinomycetemcomitans serotype
    d
    - and
    e
    - specific antigens. The serodistribution of clinical isolates from the patients with periodontitis were also investigated. Serotype-specific polysaccharide antigens of A. actinomycetemcomitans IDH 781 (serotype
    d
    ) and OMZ 534 (serotype
    e
    ) were extracted from whole cells by autoclaving. The extracts were purified by chromatography on DEAE-Sepharose CL-6
    B
    and Sephacryl S-300HR columns. The serotype
    d
    antigen was composed of rhamnose (17. 1%), mannose (45.
    5
    %), galactose (2.
    0
    %) and glucose (35.
    5
    %) . On the other hand, the serotype
    e
    antigen was composed of rhamnose (23.
    9
    %), mannose (29.1%), galactose (11.
    0
    %), glucose (13.
    5
    %) and unidentified sugar (
    22
    .
    5
    %) . Immunodiffusion tests revealed that the purified polysaccharide antigen form a single precipitin line with the corresponding rabbit antiserum. A total of 157 A. actinomycetemcomitans clinical isolates from diseased sites of 39 patients with periodontitis were serotyped by using serotype-specific rabbit antisera against A. actinomycetemcomitans serotype a,
    b
    ,
    c
    ,
    d
    and
    e
    strains. In the immunodiffusion assay, the autoclaved extracts of 42, 12, 34,
    8
    and 41 A. actinomycetemcomitans clinical isolates reacted with serotype a,
    b
    ,
    c
    ,
    d
    and
    e
    antisera, respectively. These findings indicate that the extraction of serotype antigens by autoclaving is useful and definite for the serotyping of A. actinomycetemcomitans clinical isolates.
  • 辻川 健治, 川上 貴大, 荒木 渉, 佐藤 高広, 伊藤 さよ, 和泉 要, 保戸田 滉樹, 岩田 祐子
    日本法科学技術学会誌
    2023年 28 巻 2 号 145-157
    発行日: 2023年
    公開日: 2023/07/31
    [早期公開] 公開日: 2023/04/20
    ジャーナル フリー

     We examined the stability of

    Δ9
    -tetrahydrocannabinol acetate (
    Δ9
    -THC-OAc) and
    Δ8
    -tetrahydrocannabinol acetate (
    Δ8
    -THC-OAc) in
    e
    -liquid products. Eight samples were heated at 30℃ for 28 days and one of them was heated at 70℃ for 2,
    4
    ,
    8
    , 10, and 15 days. Residual ratios of
    Δ9
    -THC-OAc and
    Δ8
    -THC-OAc were evaluated by gas chromatography with flame ion detection and their degradation products were examined by gas chromatography/mass spectrometry (GC/MS). Some samples were tested for solubility in hexane and were submitted to GC/MS analysis to detect propylene glycol and glycerol. After a 28-day incubation at 30℃,
    Δ9
    -THC-OAc was slightly decomposed (residual ratio: 84.
    5
    –94.2%) but
    Δ8
    -THC-OAc was almost stable (residual ratio: 95.2–108.
    9
    %). Heating at 70℃ decomposed not only
    Δ9
    -THC-OAc but also
    Δ8
    -THC-OAc. The decomposition proceeded rapidly in the initial 2 days then slowly until 15 days later. The degradation products, four putative one-oxygen-atom adducts and cannabinol, were detected but deacetylated products (
    Δ9
    -tetrahydrocannabinol and
    Δ8
    -tetrahydrocannabinol) were not detected. All the samples tested were completely dissolved in hexane differently from propylene glycol and glycerol. Propylene glycol and glycerol were not detected from the samples completely dissolved in hexane. This study indicated that deacetylation of
    Δ9
    -THC-OAc and
    Δ8
    -THC-OAc did not proceed when the sample did not contain propylene glycol and glycerol.

  • 黒川 美貴雄, 吉田 耕治, 永井 保嵩, 宇野 準
    Chemical and Pharmaceutical Bulletin
    1983年 31 巻 12 号 4312-4318
    発行日: 1983/12/25
    公開日: 2008/03/31
    ジャーナル フリー
    Two new partially saturated tricyclic ring systems, 6, 6a, 7,
    8
    ,
    9
    , 10, 10a, 11-octahydro-11-oxodibenz [
    b
    ,
    e
    ] oxepins (3a and 3
    b
    ), and -thiepins (
    4
    a and
    4
    b
    ) were synthesized. Compounds
    4
    a and
    4
    b
    were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10
    b
    ). Deuterated
    4
    a and
    4
    b
    (11a and 11
    b
    ) were prepared starting from butadiene-
    d6
    (12). The stereochemical features of 3a (trans), 3
    b
    (cis),
    4
    a (trans) and
    4
    b
    (cis) are compared with those of 10a, 10
    b
    , 11a and 11
    b
    on the basis of proton nuclear magnetic resonance data.
  • ―特にアポ蛋白Eの変化について―
    本間 康彦, 三神 美和, 佐藤 美智子, 石原 仁一, 吉川 広, 木下 栄治, 田川 隆介, 星合 充基, 古屋 秀夫, 井出 満, 田辺 晃久, 玉地 寛光, 兼本 成斌, 友田 春夫, 中谷 矩章, 五島 雄一郎
    動脈硬化
    1984年 12 巻 3 号 599-603
    発行日: 1984/08/01
    公開日: 2011/09/21
    ジャーナル フリー
    Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL2 and HDL3 were estimated on the
    0
    th, 7th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
    B
    ,
    C
    -II,
    E
    levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL2 and HDL3 were 15.
    9
    ±7.
    5
    mg/dl (mean±SD), 150.
    9
    ±58.1mg/dl 43.
    8
    ±
    9
    .6mg/dl, 16.
    4
    ±
    5
    .
    8
    mg/dl and 24.
    9
    ±6.3mg/dl respectively. Plasma apoprotein A-I, A-II,
    B
    ,
    C
    -II and
    E
    levels were 81.7±
    22
    .
    0
    mg/dl, 15.1±
    5
    .
    4
    mg/dl, 93.7±36.
    0
    mg/dl, 3.83±1.00mg/dl and
    4
    .29±1.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-
    C
    (r=
    0
    .348), HDL2-
    C
    (r=
    0
    .612) and HDL3 (r=
    0
    .569). Apoprotein
    B
    correlated with total cholesterol (TC) (r=
    0
    .610), VLDL-
    C
    (r=
    0
    .341), LDL-
    C
    (r=
    0
    .726), HDL-
    C
    (r=
    0
    .432) and HDL2-
    C
    (r=
    0
    .465). Apoprotein
    C
    -II correlated with TC (r=
    0
    .765), TG (r=
    0
    .679), VLDL-
    C
    (r=
    0
    .651), LDL-
    C
    (r=
    0
    .461) and HDL2-
    C
    (r=
    0
    .326). Apoprotein
    E
    correlated with TC (r=
    0
    .580), TG (r=
    0
    .575) and VLDL-
    C
    (r=
    0
    .666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=
    0
    .468). Apoprotein
    B
    correlated with apoprotein
    C
    -II (r=
    0
    .393). Apoprotein
    C
    -II correlated with apoprotein
    B
    (r=
    0
    .393) and
    E
    (r=
    0
    .549). Apoprotein
    E
    only correlated with apoprotein
    C
    -II (r=
    0
    .549).
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