The association between apolipoprotein
E
(Apo-
E
) polymorphism and the response of plasma cholesterol to dietary therapy (cholesterol intake of less than 300mg/day) was investigated for about
8
weeks in 208 nonfamilial hypercholesterolemia patients (
E
3
/
3
161,
E
4
/
3
47). The baseline lipoprotein concentration and the intake of energy and lipids were not significantly different between subjects with
E
3
/
3
and those with
E
4
/
3
phenotypes. After the dietary therapy plasma total cholesterol and low density lipoprotein cholesterol were significantly decreased in both phenotype groups (p<0.05). The patients with
E
4
/
3
had significantly smaller reductions of LDL-C than the patients with
E
3
/
3
. The changes of LDL-C showed a significant difference between the patients with
E
3
/
3
and
E
4
/
3
by the Kruskal Wallis test (p=0.041). The presence of
E
4
/
3
predicted the degree of cholesterol reduction following dietary therapy.
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