Repetitive liquefactions in angular and subangular gravels from an alluvial fan, in the case of two earthquakes with accelerations lower than that of a former which had caused liquefaction some months before, are described. The liquefaction took place from the surface, down to a depth of approximately 10 m. Water laden with sediments spouted out for some tens of minutes after the strong motion ceased. Knowledge of the grain size distribution of the sediments inside the body of the alluvial fan roughly defines the areas of the fan prone to future liquefaction. Non-repetitive liquefaction in overconsolidated fine fluvio-lacustrine sand of glacial origin at the unusual depth of 14 m to 16 m is also described. From the observation of sand lifted up for 10 m inside a large diameter well, and of that which spouted out from several microvents, it was estimated that extra-pore pressure was close to lithostatic conditions. Nevertheless, modeling of intrinsic pore pressure buildup on the DESRA2 programme gives lower values than the experimental one. Geotechnical characteristics of the 12 m-thick sandy stratum indicate that the upper part is unusually soft, either due to water circulation or past repetitive liquefactions which prevented reconsolidation. It is suggested that excess pore pressure generated by the earthquake was also due to redistribution of pressure from adjacent sediments.

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Circuit techniques to enhance the linearity of input-voltage-to-current (V/I) conversion and to increase the output impedance of a current source by compensating for the low intrinsic gain of a transistor were introduced to realize a high-frequency operational transconductance amplifier (OTA) for a low supply voltage using sub-100-nm CMOS processes. Applying these techniques, a MOS th-order Gm- linear-phase low-pass filter (LPF) was realized using a 65nm CMOS process. A simplified biquad LPF that can serve as a component of a th-order LPF was newly developed by replacing OTAs with resistors. As a result, the -3dB frequency bandwidth, group delay ripple, 3rd-order distortion, and 3rd-order input intercept point (IIP3) were 200MHz, 2.2%, ≤ -55dB with a 100MHz input, and +10.3dBm, respectively, all with a ±0.1Vp-p input signal at each input terminal in the pseudodifferential configuration. The LPF including an output buffer dissipated 60mW in the case of a 1.2V supply. Wide spurious-free dynamic range (SFDR) characteristics were confirmed up to high frequencies.

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A full account is given of the chemical behavior observed for , -dialkyladeninium salts (16). On treatment with boiling 1N aqueous NaOH for 60min, 16a, b, , (X=I), 16 (X=Br), and 16 (X=ClO₄) rearranged to isomeric , -dialkyladenines (21a-) in 50-% yields. Treatment of the salts with 0.N aqueous Na₂CO₃ at room temperature for 30-min or with Amberlite CG-400 (OH^-) in H₂O at room temperature gave the ring-opened derivatives a- (in the trans-formamide form) in 56-83% yields, and rate constants for the ring-opening reactions of 16a, b, -g (X=ClO₄) and 16 (X=Br) leading to a-g were determined in H₂O at pH .84 and ionic strength 0.50 at 25°. Cyclization of a with NaH in AcNMe₂ at room temperature or with boiling 1N aqueous NaOH produced 21a in 84% or 72% yield, respectively.In solution, the trans-formamides seemed to transform slowly into the cis-formamides 23, attaining equilibria. The existence of such an equilibrium in or Me₂SO- at 25° or in H₂O at pH .84 and ionic strength 0.50 at 25° was kinetically confirmed in the case of a, and the mechanism of the rearrangement of 16 to 21 through is discussed on the basis of the above kinetic results and Deslongchamps' theory of stereoelectronic control. On treatment with NaBH₄ in MeOH at room temperature, 16a (X=I) furnished the , -dihydro derivative 28 (84% yield), which slowly decomposed in H₂O at 60° to give a in 49% yield.The , -dialkyladeninium salts (16) were found to be obtainable from N'-alkoxy-1-alkyl--formamidoimidazole-4-carboxamidines () through an alternative synthetic route : Alkylations of with alkyl halides in HCONMe₂ in the absence of base, followed by hydrogenolysis of the N'-alkoxy group and cyclizatio (or vice versa) produced 16 in acceptable yields. In order to interpret the proton nuclear magnetic resonance spectrum of a, the 2-deuterated species 26 was also synthesized from 24 via 25 and 27.

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Incoherent scatter spectra for a plasma with a negative ion component are calculated successively by the kinetic and hydrodynamic approaches. It is shown that mesospheric negative ions enhance significantly the scattered power and the width of the ion component of the incoherent scatter spectrum. A simplified method is proposed for determining the mesospheric parameters from the measured incoherent scatter spectrum.

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Ten furostanol saponins were isolated as five pairs of 25R and 25S epimers from the fresh rhizomes of Polygonatum kingianum. Seven of them were identified as new compounds, (25S)-kingianoside (2), (25S)-kingiano-side (4), (25R,)-hydroxylwattinoside (), kingianoside (), (25S)-kingianoside (), kingianoside () and (25S)-kingianoside (10), together with three known saponins, kingianoside (1), kingianoside (3), and -hydroxylwattinoside (). The structures of the new saponins were determinded by detailed analysis of their 1 and 2 NMR spectra, and by comparison of the spectral data with those reported.

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The activities of tobramycin derivatives acetylated and ethylated on the '-N, 2'-N and 3-N positions were examined. The MICs of these derivatives against tobramycin sensitive strains indicated that 2'-N-ethylated and '-N-ethylated derivatives have a fairly good activity, and confirmed that the 3-N position is the most important one for antibiotic activity since 3-N derivatives were less active. The MICs of these derivatives against tobramycin resistant strains, and their inactivation by tobramycin modifying enzymes were examined. These results showed that 2'-N or '-N ethylation protects the drug against inactivation by AAC(2') or AAC('), respectively, and 2'-N-ethyltobramycin and '-N-ethyltobramycin were active against strains containing these modifying enzymes. On the other hand, 3-N ethylation protects the drug against inactivation by AAC(3) but 3-N-ethyl tobramycin does not inhibit strains containing this enzyme.

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(³H) Tobramycin was used as a probe to determine the relationship between the structure of aminoglycoside antibiotics and their ability to remove this drug from its higher affinity binding site on the ribosome. The dissacharide moieties (neamine, tobramine, gentamine) appeared to have a common binding site, whereas the kanosamine, garosamine and ribose moieties determined the specificity of this binding. Amikacin and butikacin behaved in an anomalous manner in spite of their close structural relationship to tobramycin.

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カンキツ主要12種を用いて染色体のクロモマイシン A₃(CMA) 染色を行った．染色体は CMA(+) バンドの有無および位置から 種類に区分できた．すなわち，CMA(+) を A: 両端および動原体近傍に有する，B: 一方の端部と動原体近傍に有する，: 両端に有する，: 一方の端部に有する，: CMA(+) がない，: 動原体近傍に有する，Dst: 付随染色体を有する 型，である．各種はこれらのうち 2～ 種類の染色体を有し，独自の CMA バンドパターンを示した．

C

. medica では 2B + + ，

C

. limon では 1B + 1 + + ，

C

. aurantifolia では 2B + + ，

C

. aurantium では 1A + 1B + 1 + + ，

C

. sinensis では 2B+ 2 + + ，

C

. maxima では 3A + 3 + 4 + ，

C

. paradisi では 2A + 3 + + ，

C

. ichangensis では 2B + 2 + 12 + 2，

C

. latipes では 2A + + + 3，

C

. micrantha では 1B + 11 + 4 + 2Dst，

C

. macroptera では 2B + 1 + 11 + 3 + 1，

C

. hystrix では 3B + 1 + + 3 + 2 + 1Dst であった．

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Electric charges, surface concentrations, and the dynamic behaviours of Cs, Re, and O on self-supported disk surface of Cs and Re-doped silver powder during the operation of O₂-Jet under UHV were examined using XPS. Pile-up and creep-in of doped elements, in analogy with O, were observed with heating and cooling of the sample, respectively. A drastic shift of Re 4 /2 spectrum of 46. (+) to 40. V (Re⁰) took place when the sample was heated at 110 to 210°, while Cs 3 /2 only lay in the range of 724.∼725.2 V. Conspicuous transient responses to O₂-Jet were exhibited by the sample heated at 210°; with increasing exposure time, the binding energy of Re 4 /2 rapidly shifted from 40. (Re⁰) to 45.3 eV (+), Cs 3 /2 did so from 725.2 to 724. V, and O 1s gradually became a twin peak of 530. and 528. V, of which composition of five core spectra obtained by deconvolution was varied vigorously. The O 1s core spectrum of 528. eV assigned to oxydic oxygen and CS₂O was found only during the operation of O₂-Jet at 210°.

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Thirty-six patients (19 males, 17 females: atypical schizophrenia; 3, typical schizophrenia; , depression; 11, neurosis and other psychiatric disorders; ) were operated on according to orbitoventromedial undercutting by Hirose. In all cases, the Rorschach test was carried out and daily behaviors were studied. Thirty-one scales of the test were subjected to multivariate analysis whereas the behaviors were evaluated according to the following criteria, i.., A: recovered or symptom free, B: markedly improved, : moderately improved, : slightly improved and : not improved. The following results were obtained.
1) The evaluation of behaviors is as follows. A: 12 cases, B: , : , : , : none.
2) It was found that scores of +106% and R+106% scales were significantly higher after the operation than before; that correlation coefficients between the scores before and after the operation were considerably high.
3) Factor analysis followed by varimax rotation was carried out. Six factors were extracted, i.., (1) sensitivity to emotional stimuli, (2) ego-strength, (3) obsessional rigidity, (4) reaction time, () anxiety and tension and () empathy. It was revealed that 2 was high in atypical schizophrenia, depression and neurosis, and that 2 and were significantly different in terms of the factor scores among the four groups A, B, and ; 2 was highest in A, and lowest in regardless of whether it was before or after the operation. showed high scores in both A and , and low in .
4) Multiple discriminant analysis was applied to the data of the Rorschach test before the operation, by classifying 36 subjects into the four groups A, B, and . As a result, high rates of correct diagnosis were obtained, i.., 100% for A, 78% for B, 56% for and 100% for . When the groups and were combined into one group (+) the highest percentage (100%) was seen in A, followed by B (%) and + group (87%). When the groups A and B were combined into one group (A+B), the percentages of correct diagnosis were 81% for A+B, and 93% for +.
In conclusion, it can be said that scales of the Rorschach test have been proved to be valid for predicting mental and physical states after the orbito-ventromedial undercutting.

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The advantages and disadvantages of using a back analysis of slope failures to evaluate soil shear strength are discussed. A methodology is presented herein that allows the implied level of reliability associated with soil shear strength parameters back calculated from slope failures to be estimated. A reliability approach is also used to estimate the probability of failure for a given limit equilibrium slope stability method, design factor of safety, and combination of back calculated Mohr-Coulomb shear strength parameters, ' and φ'. The methodology is illustrated using 39 landslides in the Orinda Formation in the San Francisco Bay area. The impact of additional case histories in the same geologic setting, i.., a larger data set, on the required design factor of safety for a given probability of failure is also investigated.

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