Non specific cellular immune responses in bladder cancer patients (
BC
), other malignant tumor patients (OMT) and benign disease patients (
BD
) were studied for PHA-induced blastoid formation and PPD skin reaction.
1) PHA-induced lymphocyte blastoid formation was indicated by the difference of
3H-Tdr incorporation (dpm) between PHA-stimulated tubes and non stimulated, and were studied in 16 patients with
BC
, 17 patients with OMT and 26 patients with
BD
.
The following results were obtained: The mean incorporation±SE from 7 patients with low grade
BC
was 2285±511.3dpm that from,
9
patients with high grade
BC
1199±487.
6
dpm that from, OMT 781±281.
6
dpm and that from,
BD
3712±587.3dpm. PHA-induced lymphocyte blastoid formation was reduced in high grade
BC
in progressed and malignant patients.
2) Delayed skin hypersensitivity reactions with purified protein derivative (PPD) were observed at 48hrs. The mean reaction with SE from 8 patients with grade I of
BC
was 18.0±2.44mm, that from 29 patients with grade II of
BC
19.
6
±2.53mm that from, 19 patients with grade III of
BC
15.3±3.56mm that from, 21 patients with grade IV of
BC
10.
5
±1.70mm, and that from 47 patients with
BD
19.2±1.
95
mm. The mean reaction from 18 patints with stage O, A of
BC
16.
9
±3.45mm, that from
5
patients with stage
B1
of
BC
16.
9
±7.44 that from, 12 patients with stage
B2
, C of
BC
9
.8±1.92mm, and that from 14 patients with stage D of
BC
14.
4
±
4
.01mm. PPD reaction was reduced as grade or stage of the bladder cancer progressed and in malignant patients group.
3) Some followed up cases of bladder cancer were discussed with the course although the non specific cellular immune responces of the patients with bladder cancer were generally reduced.
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