We reported a case of basal cell nevus syndrome (BCNS) . A 12-year old boy visited us for the examination of numerous skin pits on the palms. He showed hypertelorism, mandibular cyst, calcification of the falx, and mental retardation. Clinical diagnosis of BCNS was made by these findings. Examination of other family members did not reveal palmar pits or any other signs of BCNS. Skin biopsy from the palmar pits showed reduced thickness of the stratum corneum and the presence of basal cell carcinoma in the dermis.
Chromosome-analysis of peripheral leukocytes revealed the deletion of q21.3-.. His parents did not show any abnormalities in chromosome-analysis. Very few cases of BCNS have been reported that have basal cell carcinoma on the palms. [Skin Cancer (Japan) 2000; 15: 27-30]

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As a fundamental study on dibenzothiepins, reaction of 11-phenyl-6, 11-dihydrodibenzo [, ] thiepin-11-ol (10) or 11-chloro-11-phenyl-6, 11-dihydrodibenzo [, ] thiepin (14) with triphenylmethyl cation or was examined under various conditions. 11-Phenyl-6, 11-dihydrodibenzo [, ] thiepin-11-ylium salt (8) was isolated as a black powder (perchlorate) and a green powder (hexachloroantimonate), but BF₄ salt was obtained only as a solution. Treatment of the hexachloroantimonate with excess of was found to result in a novel dehydrocyclization reaction to give selectively , 13-dihydrofluoreno [, a, -c, d] [2]-benzothiepin-13-ylium hexachloroantimonate (19). Some discussions were made on the mechanism of the formation of 19.

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症例は75歳，女性。1997年7月に甲状腺原発非ホジキンリンパ腫の診断を受け，CHOP類似治療を回受けたが完全寛解が得られず，甲状腺摘出術とetoposideの投与が行われた（1998年2月∼2000年月，総量16775mg）。2000年6月汎血球減少のため当科に紹介，典型的な骨髄像より治療関連急性前骨髄球性白血病(t-APL)と診断した。染色体分析では20細胞すべてがt(15:17)をもち，さらに4細胞はt(;)を伴っていた。All-trans retinoic acidを中心とした治療により完全寛解が得られ，染色体異常も消失した。10ヵ月後再発したが，染色体異常はt(15:17)のみであった。遺伝子検査をおこなっておらず，t(;)の病状への関与については充分に検討し得ないが，これまでにt(15:17)とt(;)を同時に持つt-APLクローンの報告例はなく，きわめてまれな症例である。

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Staphylotrichum boninense, anewhyphomycete classified in the Chaetomiaceae (Ascomycota), was isolated from soils in the Bonin Islands, Japan. It is characterized morphologically by the production of yellow-orange colonies and subglobose holoblastic conidia. Morphologically the species is similar to S. coccosporum, but it is significantly different from S. coccosporum in phylogeny and also differs with respect to its secondary metabolite profile.

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The small strain stiffness and anisotropic nature of two sands with different geological origin have been determined via laboratory seismic tests performed in a triaxial cell. Dry triaxial reconstituted specimens of Ticino river silica sand (TS) and of Kenya carbonatic sand (KS) were subjected to isotropic and anisotropic states of effective stress ; then both shear and constrained compression waves were propagated in vertical, horizontal and oblique directions by means of five couples of piezoelectric transducers especially arranged in the specimens. The propagated compression and shear waves allow the assessment of the constrained M₀ and shear G₀ moduli respectively, at very small strains where, as a first approximation many soils can be assumed, from an engineering point of view, to behave as an elastic cross-anisotropic medium with a vertical axis of symmetry. This paper, after a brief description of the novel measuring technique adopted and of the tested materials, summarises the test results and their interpretation in order to separate the effects of the fabric anisotropy from those produced by the state of effective stresses on soil stiffness. The stiffness and anisotropic response of the two tested sands are compared. Finally the results enable us to establish five independent constants of the cross-anisotropic elasticity model, which appears to be appropriate to reproduce the behaviour at small strain of the two sands.

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One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.

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症例は50歳男性。汎血球減少の精査目的で入院。骨髄検査では芽球38%, 前骨髄球20%, Faggot細胞陽性。染色体検査で46, XY, t(15;17)(q;q12)[]/46, XY, del(6)(q?), t(;)(q34;q11.2)[]/46, XY[10], RT-PCR法でPML-RARA .2×10⁴ copies/μgRNA, minor BCR-ABL 6.×10² copies/μgRNAが検出された。急性前骨髄球性白血病としてall-trans retinoic acidで治療し，51日目に血液学的寛解に到達した。寛解時の染色体は46, XY[20]であり，PML-RARA 2.4×10² copies/μgRNA, minor BCR-ABLは検出感度以下であった。本例のt(15;17)とt(;)は別クローン由来と考えられ，転座に対応するキメラ遺伝子も証明された。同様の報告はこれまでなく，貴重な症例と考える。

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調合組成が(_<0.>Ca_<0.>) (Y_xB'_</2>)O_<(3x+4.)/2> (' = Nb^<+>, Ta^<+>)であるセラミックスの作製とそのマイクロ波誘電性につき研究した。ペロブス力イト相が単一に生成したのはxが0.3の場合で、0.4や0.ではY2O3が共存した。従って、xが0.3で組成が(Ca_</>Y_<3/>Nb_</>)O_3および (Ca_</>Y_<3/>Ta_</>)O_3の新しい化合物が生成する。これらの化合物の比誘電率は(Y_</2>'_</2>)O_3 ('=Nb^<+>,Ta^<+>)のそれより明らかに大きく、Nb系での増大が顕著である。

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