詳細検索結果
以下の条件での結果を表示する: 検索条件を変更
クエリ検索: %22%E5%A3%AB%E6%97%8F%E5%8F%8D%E4%B9%B1%22
5,158,066件中 1-20の結果を表示しています
  • 小田切 孝人, 田代 眞人
    ウイルス
    2013年 63 巻 2 号 233-240
    発行日: 2013/12/25
    公開日: 2014/10/31
    ジャーナル フリー
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • 山本 雅史, Abkenar Asad Asadi, 松本 亮司, 根角 博久, 吉田 俊雄, 國賀 武, 久保 達也, 冨永 茂人
    園芸学会雑誌
    2007年 76 巻 1 号 36-40
    発行日: 2007年
    公開日: 2007/03/06
    ジャーナル フリー
    カンキツ主要12種を用いて染色体のクロモマイシン
    A3
    (CMA) 染色を行った.染色体は CMA(+) バンドの有無および位置から 7 種類に区分できた.すなわち,CMA(+) を A: 両端および動原体近傍に有する,
    B
    : 一方の端部と動原体近傍に有する,C: 両端に有する,
    D
    : 一方の端部に有する,
    E
    : CMA(+) がない,
    F
    : 動原体近傍に有する,Dst: 付随染色体を有する
    D
    型,である.各種はこれらのうち 2~
    6
    種類の染色体を有し,独自の CMA バンドパターンを示した.C. medica では 2
    B
    +
    8
    D
    +
    8
    E
    C. limon では
    1
    B
    +
    1
    C +
    8
    D
    +
    8
    E
    C. aurantifolia では 2
    B
    +
    9
    D
    + 7
    E
    C. aurantium では
    1
    A +
    1
    B
    +
    1
    C + 7
    D
    +
    8
    E
    C. sinensis では 2
    B
    + 2C + 7
    D
    + 7
    E
    C. maxima では
    3
    A +
    3
    C +
    4
    D
    +
    8
    E
    C. paradisi では 2A +
    3
    C +
    6
    D
    + 7
    E
    C. ichangensis では 2
    B
    + 2C + 12
    D
    + 2
    E
    C. latipes では 2A +
    5
    C +
    8
    D
    +
    3
    E
    C. micrantha では
    1
    B
    + 11
    D
    +
    4
    E
    + 2Dst,C. macroptera では 2
    B
    +
    1
    C + 11
    D
    +
    3
    E
    +
    1
    F
    C. hystrix では
    3
    B
    +
    1
    C +
    8
    D
    +
    3
    E
    + 2
    F
    +
    1
    Dst であった.
  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in 95 (
    22
    .2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-2 (
    22
    ), blaCTX-M-
    3
    (16), blaCTX-M-
    1
    (15), blaOXA-
    1
    (
    9
    ) and blaSHV-12 (
    3
    ) alone or in combination. The most frequently encountered phylogenetic group was group
    A1
    (35.
    8
    %), followed by group
    D2
    (
    22
    .
    1
    %),
    B
    1
    (15.
    8
    %),
    D1
    (
    9
    .
    5
    %), A0 (7.
    4
    %),
    B22
    (
    5
    .
    3
    %) and
    B23
    (
    4
    .2%), respectively. PMQR genes, aac(
    6
    ’)-Ib-cr,
    qnrS1
    and qnrB10 were detected in 25.
    3
    , 10.
    5
    and
    1
    .
    1
    % of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.
    8
    % for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE,
    f17a
    -A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

  • I.
    F
    . Davies
    Journal of Light & Visual Environment
    1984年 8 巻 1 号 1_9-1_20
    発行日: 1984年
    公開日: 2011/05/20
    ジャーナル フリー
  • Yanchun Peng, Zitong Yu, Shahidul Islam, Yujuan Zhang, Xiaolong Wang, Zhensheng Lei, Kan Yu, Dongfa Sun, Wujun Ma
    Breeding Science
    2016年 66 巻 4 号 646-652
    発行日: 2016年
    公開日: 2016/09/30
    [早期公開] 公開日: 2016/08/11
    ジャーナル フリー HTML
    電子付録

    Low molecular weight glutenin subunits are important components of wheat storage proteins, which play an important role in determining end-use quality of common wheat. A newly established matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) procedure was used to analyze 478 landraces of bread wheat collected from the Yangtze-River region in China. Results indicated that 17 alleles at three loci: Glu-

    A3
    , Glu-
    B3
    and Glu-
    D3
    were identified, resulting in 87 different allele combinations. Of the 17 alleles detected at all the Glu-
    3
    loci, five belonged to Glu-
    A3
    , seven to Glu-
    B3
    and five to Glu-
    D3
    locus. MALDI-TOF-MS indicated Glu-A
    3
    a/c
    was present in 72.
    8
    %, Glu-
    A3b
    in
    8
    .
    4
    %, Glu-
    A3d
    in
    8
    .
    4
    %, Glu-
    A3f
    in
    5
    .2% and Glu-
    A3e
    in
    3
    .
    6
    % lines. Seven types of alleles were identified at the Glu-
    B3
    locus: Glu-
    B
    3
    d
    /i
    (25.
    5
    %), Glu-
    B3b
    (21.
    3
    %), Glu-
    B3c
    (16.
    9
    %), Glu-
    B3h
    (13.
    8
    %), Glu-
    B3f
    (
    8
    .
    4
    %), Glu-
    B3a
    (
    8
    .2%), and Glu-
    B3g
    (
    5
    .2%). Five types of Glu-
    D3
    alleles were detected: Glu-
    D3a
    (58.
    4
    %), Glu-
    D3c
    (
    22
    .
    6
    %), Glu-
    D3d
    (15.
    5
    %), Glu-
    D3b
    (
    3
    .
    3
    %) and Glu-
    D3f
    (0.2%). Four new alleles that showed abnormal MALDI-TOF spectrum patterns were identified at the Glu-
    A3
    and Glu-
    B3
    loci. A detailed study is needed to further characterize these alleles and their potential usage for wheat improvement.

  • 板倉 智敏, 五藤 精知, 藤原 義昭
    日本獸醫學雜誌(The Japanese Journal of Veterinary Science)
    1973年 35 巻 4 号 289-297_5
    発行日: 1973/08/25
    公開日: 2008/02/13
    ジャーナル フリー
    All the birds examined were also associated with bone dysplasia (art alczaormal develop-ment of bone tissue) in the diaphyseal cortex of the leg bones, especially of bones affectedwith dyschondroplasia. This result is very significant in order to clarifyz tlais disease entity.1970:J14, k -
    1
    } 7 ) 7, M77 ) i? ht /, ( K ) 7 (C # L"C, MB @ (7) t, If!TB& U "C, Jff Dyschondroplasia (
    1
    *t%7fi!dW) ().g:#
    f
    [!:.fLlt! K?
    3
    o, [
    1
    : (7)M;tC, rff.?U/:cD
    8
    , bb=
    1
    lC#li
    6
    *H(DX15RI!!
    D
    & t, r, ccl)Efff7flr.#.??t"ut:2.?T<
    3
    .
    1
    .?l?
    F
    ?/?t:>"A??
    1
    !? >
    E
    >?TMOll?, lI]%G (
    f
    -srRM) -ts;
    5
    ;
    e
    .*BI) *M[t fL 54
    5
    t:.;*.{
    1
    *I[l?(), t@Yllll*fJ?H@(7) %?Jfipj@ (Dyschondroplasia) p, }, (,
    1
    lTi{-X, WIKIM itt{
    b
    =
    b
    t
    D
    "tl%tff{tO 1111IH(-UP!z
    8
    U-ii) >ES- -)%Wi*fd?
    1
    J*[lEj: >11"i
    6
    ifI".*"H*Tl*&Z") #)/2?-"k l
    E
    B
    - vich ) J&it(Vh
    3
    iO"= >If-ffi"!
    1
    lYl*I
    4
    ")Ji/l![40111!>
    D
    9
    *
    F
    !)<Y14M)?A"!>CL(Il], k7.Cl
    8
    T"ltTt*flB
    1
    ? & $
    4
    U [-" C U" L % w, Zl
    1
    *.IlBl tI
    1
    J, FA(y L-x") LVfAK t: >
    3
    llltPJ
    4
    IiI " } ) t- ! Al j: >kP11liR
    6
    , &ffl(C
    5
    NWi Z
    3
    lk(C#L" Ct ?
    f
    !
    4
    M2"C- fL#, -()%
    E
    .IWMd
    1
    .XI
    1
    *I
    1
    EPW(tit ff
    1
    lR)
  • 小林 優, 家坂 貴子, 中野 江身子, 平山 耕一郎
    天然有機化合物討論会講演要旨集
    1989年 31 巻 71/P2-1
    発行日: 1989/09/17
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Six new cembranoids sarcophytol P (
    3
    ), R (
    4
    ), S (
    5
    ), K (
    8
    ),
    F
    (11), and T (13) were isolated from the soft coral Sarcophyton glaucum. Sarcophytol P (
    3
    ) was shown to be the 20-hydroxy derivative of the major component sarcophytol A (
    1
    ), and afforded the cyclization product
    6
    in CHCl_
    3
    at room temperature, in a same way as in
    1
    . Sarcophytols R (
    4
    ) and S (
    5
    ) were correlated to
    1
    , by conversion of its 7R,
    8
    R and 7S,
    8
    S epoxide derivatives. Sarcophytol K(
    8
    ) was a 13, 14-dihydroxycembranoid having a
    1
    E
    ,
    3
    Z-diene moiety. The absolute configuration of
    8
    and its
    1
    Z,
    3
    E
    - and
    1
    Z,
    3
    Z-isomers sarcophytol
    B
    (2) and J (10) were determined by circular dichroism study of their bis-p-dimethylaminobenzoate derivatives. Sarcophytols
    F
    (11) and T (13) were
    1
    E
    - and
    1
    E
    ,
    3
    Z-isomers of
    1
    . Compound 11 showed characteristic broadening of the ^
    1
    H-NMR chemical shifts, due to the restricted conformational interconversion. Using the three cembranoids sarcophytols
    F
    (11,
    1
    E
    ,
    3
    E
    ), N (15,
    1
    Z,
    3
    Z) and T (13,
    1
    E
    ,
    3
    Z), spontaneous autoxidation-cyclization, in CHCl_
    3
    ,was examined, in order to compare the stereochemical course of the reaction with that of
    1
    (
    1
    Z,
    3
    E
    ), which affords trans-fused bicyclo[
    9
    .
    3
    .0]tetradecene systems. The
    1
    E
    ,
    3
    Z-isomer 13 gave the same cyclization product 18, as in the reaction of
    1
    , even though it is isomeric at C-
    1
    ,
    3
    . The
    1
    Z,
    3
    Z isomer 15 gave 19, in consequence of the reversed geometry at C-
    3
    of 15. The
    1
    E
    ,
    3
    E
    -isomer (11) gave the bicyclic product
    22
    , having an antipodal fusion as compared with 19. This was confirmed by PCC oxidation of 19 and
    22
    , giving enantiomeric ketones 23 and 24 respectively. The
    1
    (14)-epoxide 26 was shown to be the immediate precursor of
    22
    , and acounted for the inversion of the geometry at C-
    1
    of the cyclization product. Compound 26 is isomeric with the epoxide 17 derived from
    1
    . The epoxide 17 is the postulated precursor in the conversion of 13 to 18. It is noteworthy that the mode of antipodal fusion of the cyclopentane rings, in 18 and
    22
    , was controlled by the chirality of the epoxy rings. The C-14 hydroxyl group participates in the transannular cyclization, but was found not to be the requisite functional group for the reaction. Similar treatment of cembrene C (30), the parent hydrocarbon of
    1
    , also reacted in CHCl_
    3
    giving the bicyclic product 32.
  • 西海枝 東雄, 北川 徳治郎, 佐々木 秀明 /, ALBERT M.VAN LEUSEN
    Chemical and Pharmaceutical Bulletin
    1982年 30 巻 11 号 4199-4204
    発行日: 1982/11/25
    公開日: 2008/03/31
    ジャーナル フリー
    Tosylmethyl isocyanide (
    4
    ) reacted readily with azole carbaldehydes, i.
    e
    ., indole-2-carbaldehyde (
    8
    a), pyrazole-
    3
    (
    5
    )-carbaldehyde (
    8
    b
    ),
    3
    (
    5
    )-methylpyrazole-
    5
    (
    3
    )-carbaldehyde (
    8
    c),
    3
    (
    5
    )-(2-furyl) pyrazole-
    5
    (
    3
    )-carbaldehyde (
    8
    d
    ),
    1
    , 2,
    4
    -triazole-
    3
    (
    5
    )-carbaldehyde (
    8
    e
    ), and tetrazole-
    5
    -carbaldehyde (
    8
    f
    ), in the presence of an equimolar amount of potassium carbonate in refluxing methanol to yield the corresponding
    5
    -substituted oxazoles (10 and 15
    b
    -
    f
    ) as the final products. In the case of the reaction of
    4
    with imidazole-2-carbaldehyde (
    8
    g), however, N-(
    1
    -tosyl-
    1
    -alkenyl) formamide of type 18g,
    1
    -amino-
    1
    -tosyl-2-alkene of type 19g, and
    3
    -tosylimidazo [
    1
    , 2-c] pyrimidine (
    22
    g) were obtained, depending on the reaction conditions.
  • 橋口 英俊
    日本医科大学雑誌
    1983年 50 巻 4 号 563-585
    発行日: 1983/08/15
    公開日: 2009/12/04
    ジャーナル フリー
    Thirty-six patients (19 males, 17 females: atypical schizophrenia;
    3
    , typical schizophrenia;
    9
    , depression; 11, neurosis and other psychiatric disorders;
    8
    ) were operated on according to orbitoventromedial undercutting by Hirose. In all cases, the Rorschach test was carried out and daily behaviors were studied. Thirty-one scales of the test were subjected to multivariate analysis whereas the behaviors were evaluated according to the following criteria, i.
    e
    ., A: recovered or symptom free,
    B
    : markedly improved, C: moderately improved,
    D
    : slightly improved and
    E
    : not improved. The following results were obtained.
    1
    ) The evaluation of behaviors is as follows. A: 12 cases,
    B
    :
    9
    , C:
    9
    ,
    D
    :
    6
    ,
    E
    : none.
    2) It was found that scores of
    F
    +106% and R+106% scales were significantly higher after the operation than before; that correlation coefficients between the scores before and after the operation were considerably high.
    3
    ) Factor analysis followed by varimax rotation was carried out. Six factors were extracted, i.
    e
    ., (
    F
    1
    ) sensitivity to emotional stimuli, (
    F
    2) ego-strength, (
    F
    3
    ) obsessional rigidity, (
    F
    4
    ) reaction time, (
    F
    5
    ) anxiety and tension and (
    F
    6
    ) empathy. It was revealed that
    F
    2 was high in atypical schizophrenia, depression and neurosis, and that
    F
    2 and
    F
    6
    were significantly different in terms of the factor scores among the four groups A,
    B
    , C and
    D
    ;
    F
    2 was highest in A, and lowest in
    D
    regardless of whether it was before or after the operation.
    F
    6
    showed high scores in both A and C, and low in
    D
    .
    4
    ) Multiple discriminant analysis was applied to the data of the Rorschach test before the operation, by classifying 36 subjects into the four groups A,
    B
    , C and
    D
    . As a result, high rates of correct diagnosis were obtained, i.
    e
    ., 100% for A, 78% for
    B
    , 56% for C and 100% for
    D
    . When the groups C and
    D
    were combined into one group (C+
    D
    ) the highest percentage (100%) was seen in A, followed by
    B
    (89%) and C+
    D
    group (87%). When the groups A and
    B
    were combined into one group (A+
    B
    ), the percentages of correct diagnosis were 81% for A+
    B
    , and 93% for C+
    D
    .
    In conclusion, it can be said that scales of the Rorschach test have been proved to be valid for predicting mental and physical states after the orbito-ventromedial undercutting.
  • 特にfibronectin-およびlaminin-receptorについて
    尾形 隆, 山川 光徳, 山田 和彦, 大類 広, 柘植 通, 新野 恵司, 鈴木 明彦, 角田 卓哉, 湯田 文朗, 今井 大, 市毛 明彦
    日本網内系学会会誌
    1995年 35 巻 6 号 319-331
    発行日: 1995年
    公開日: 2009/06/04
    ジャーナル フリー
    The expression of adhesion molecules on human tonsillar follicular dendritic cells (FDCs) in vivo on cryostat sections and in vitro on isolated FDCs on cytospin preparations was studied. Isolation of FDCs was performed using a magnetic cell sorter (MACS). Immunochemically, FDCs were positive for Mac-
    1
    (CD11
    b
    ), sialyl-Lex (CD15s), CD
    22
    , integrin
    β1
    (CD29), CD40, VLA-
    α3
    (CD49c), VLA-
    α5
    (CD49
    e
    ), VLA-
    α6
    (CD49
    f
    ), ICAM-
    3
    (CD50), ICAM-
    1
    (CD54),
    B
    7 (CD80), and VCAM-
    1
    (CD106). These adhesion molecules, except ICAM-
    3
    (CD50) which was weakly positive only in the light zone (LZ), were positive with a lacy pattern in all zones of secondary lymphoid follicle, especially strong in the LZ. ICAM-
    3
    (CD50) was positive on more than half of isolated FDCs, but other molecules were positive on almost all isolated FDCs. Concerning the ligands on
    B
    cells for these adhesion molecules, the Mac-
    1
    (CD11
    b
    )-ICAM-
    1
    (CD54), the ICAM-
    3
    (CD50)-LFA-
    1
    (CD11a/18), and the VCAM-
    1
    (CD106)-VLA-
    4
    (CD29/49
    d
    ) interactions in the LZ, the sialy-Lex (CD15s)-L-selectin (CD62L) and the VCAM-
    1
    (CD106)-VLA-
    4
    (CD29/49
    d
    ) interactions in the mantle zone, and the ICAM-
    1
    (CD54)-LFA-
    1
    (CD11a/18) interaction in the entire lymphoid follicle may participate in FDC-
    B
    cell adhesion. Furthermore, above mentioned immunohistochemical evidence that FDCs were positive for fibronectin-receptor (CD29/CD49
    e
    ) and laminin-receptor (CD29/CD49
    f
    ), was confirmed with a frozen-section binding assay, using isolated FDCs and cryostat sections of tonsils. The numbers of FDCs binding to germinal centers (GCs) were reduced remarkably by pretreatment with monoclonal antibodies for CD29 (32.
    8
    ±
    4
    .
    1
    % of the control), CD49
    e
    (29.7±2.
    5
    %), and CD49
    f
    (18.
    8
    ±0.
    8
    %). These data clearly indicated that FDCs bind to the reticulin or laminin fiber in GCs via either receptor.
  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [
    1
    ] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with 7 kinds of factors, as follows ; A^^〜=
    B
    +C+
    D
    +K+aE+bF+cG. A^^〜=estimated values of the readership score.
    1
    )
    B
    , C,
    D
    , K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into 7 categories. C=pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories.
    D
    =kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2)
    E
    ,
    F
    , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into
    6
    kinds of area (2.
    5
    ,
    3
    .
    5
    ,
    5
    , 7, 10, 15) and 15 column means a whole page, about 2,000cm^2.
    E
    ,
    F
    are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement.
    F
    =the marks obtained on the whole effect of the design.
    3
    ) a,
    b
    , c : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+bF=A-(
    B
    +C+
    D
    +K+cG). In this research, I used
    1
    ,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was
    3
    ,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table 2^* shows the contribution indexes of each factor by
    3
    kinds of expression-(
    1
    ) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, (
    3
    ) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of
    E
    ,
    F
    .
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _
    1
    +
    E
    _2+
    E
    _
    3
    +
    E
    _
    4
    . design elements [table]
    E
    _
    1
    ,
    E
    _2,
    E
    _
    3
    ,
    E
    _
    4
    , these values have the
    5
    grades, as 0,
    1
    , 2,
    3
    ,
    4
    and 0 is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of 0 to
    9
    grades as the sum of them. The values of
    F
    have also
    5
    grades, 0 to
    4
    . The principles to determine the values of
    E
    ,
    F
    are as follows : a) The marks obtained of
    E
    ,
    F
    must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. c) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    ,
    F
    values, as the table
    5
    -
    4
    , and
    5
    -
    5
    in the thesis in Japanese.
  • 菊池 志津子, 御領 政信, 石井 映子, 岡田 幸助
    日本獣医師会雑誌
    1998年 51 巻 2 号 65-69
    発行日: 1998/02/20
    公開日: 2011/06/17
    ジャーナル フリー
    伝染性ファブリキウス嚢病ウイルス (IBDV) による免疫抑制下で, トリレオウイルス (ARV) と大腸菌 (
    E
    . coli
    ) の混合感染による頭部腫脹症候群の再現を試みた. 各群
    8
    9
    羽の
    1
    週齢SPF鶏にIBDV993株を経口接種し,
    3
    週齢でARVMJ3810株を点眼接種後
    1
    ,
    4
    あるいは7日に大腸菌を点眼接種し, 接種後20日に剖検したところ, 頭部の腫脹はみられなかったが, それぞれ2/
    9
    羽,
    4
    /
    9
    羽,
    1
    /
    8
    羽に頭蓋骨air spaceおよび中耳内に炎症性病変および肉芽腫がみられた. ついで, 別の
    8
    群 (A~H; 各群13~14羽) にはそれぞれ次の組合せで接種を行い, 大腸菌接種後
    4
    ~20日に剖検した: A (無処置),
    B
    (
    E
    . coli
    ), C (ARV),
    D
    (ARV+
    E
    . coli
    ),
    E
    (IBDV),
    F
    (IBDV+
    E
    . coli
    ), G (IBDV+ARV), H (IBDV+ARV+
    E
    . coli
    ) では,
    B
    群の2羽, H群の
    3
    羽には軽度の眼瞼腫脹がみられ, 軽度の炎症性病変を含めると, 組織学的には
    B
    群の
    3
    羽,
    D
    群の2羽,
    F
    群の
    1
    羽, G群の2羽, H群の
    5
    羽に頭部の病変がみられたが, 頭部皮下織炎は
    B
    群の2羽, H群の
    4
    羽のみに認められた.
  • 吉田 登美男, 岩崎 俊一, 永井 健三
    日本音響学会誌
    1961年 17 巻 1 号 18-26
    発行日: 1961/03/30
    公開日: 2017/06/02
    ジャーナル フリー
    The calculation for the articulation index in the case of binaural hearing has been made possible by means of a new function, namely, the loudness parameter, as follows; In the case of the monoaural hearing, the articulation index A_m and loudness N_m are given by the equation (
    1
    ) and (2). A_m=
    1
    /p&lmoust;^∞_0W_m{
    E
    (α,
    f
    )}
    D
    (
    f
    )df=A_m(α,
    f
    ) (
    1
    ) N_m=&lmoust;^∞_0N_
    f
    {Z(α,
    f
    )}
    F
    (
    f
    )df=N_m(α,
    f
    ) (2) And in the case of binaural hearing, the loudness N_
    b
    is given as follows N_
    b
    =2&lmoust;^∞_0N_
    f
    {Z(α,
    f
    )}
    F
    (
    f
    )df=2N_m(α,
    f
    ). (
    3
    ) Assuming that the articulation index
    A_b
    in binaural hearing is expressed by following equation
    A_b
    =
    A_b
    (α,
    f
    ). (
    4
    ) Elimination α in equation (
    1
    ) and (2), we can express A_m in terms of N_m with a new function G_m, that is A_m(
    f
    )=G_m{N_m(
    f
    )}. (
    5
    ) Similarly,
    A_b
    =G_
    b
    {N_
    b
    (
    f
    )}=G_
    b
    {2N_m(
    f
    )}. (
    6
    ) Assuming G_m=G_
    b
    =G, (7) we find that
    A_b
    become
    A_b
    (
    f
    )=G{2N_m(
    f
    )}=G{N_
    b
    (
    f
    )}. (
    8
    ) Therefore,
    A_b
    can be calculated with A_m, N_m and new function G. This G is named by us as "loudness parameter". And with the experiments, it was proved that the assumption G_m=G_
    b
    =G is held at any case.
  • Takeshi ITABASHI, Nobuko OGASAWARA, Koohei NOZAWA, Ken-ichi KAWAI
    Chemical and Pharmaceutical Bulletin
    1996年 44 巻 12 号 2213-2217
    発行日: 1996/12/15
    公開日: 2008/03/31
    ジャーナル フリー
    Three new azaphilone derivatives designated falconensins
    E
    5
    (
    5
    ),
    F
    (
    6
    ), and G (7) were isolated from the mycelium o Emericella falconensis, along with falconensins A (
    1
    ),
    B
    (2), C (
    3
    ),
    D
    (
    4
    ), and H (
    8
    ), and three hopane-type triterpenes, zeorin (
    9
    ), hepane-7β,
    22
    -diol (10), and hopane-
    , 7β,
    22
    -triol (11). The structures of
    5
    -7 were confirmed by spectroscopic investigation and chemical correlations. The absolute stereochemistry of falconensins A (
    1
    ) to G(7) was also established.
  • 藤井 澄三, 斎藤 徹, 木津 京子, 林原 央美, 熊澤 幸成, 中嶋 悟視, 藤澤 哲則
    Chemical and Pharmaceutical Bulletin
    1991年 39 巻 2 号 301-308
    発行日: 1991/02/25
    公開日: 2008/03/31
    ジャーナル フリー
    A detailed account is given of the syntheses of
    9
    -alkyl-2-deuterioadenines (
    5
    b
    -
    d
    ), adenosine-2-
    d
    (
    5
    e
    ), and 2'-deoxyadenosine-2-
    d
    (
    5
    f
    ) from the
    9
    -substituted adenines
    1
    b
    -
    f
    through cyclization of the aminoimidazolecarbox-amidine salts
    9
    or the corresponding free bases
    8
    with formic-
    d
    acid-
    d
    or
    1
    -(formyl-
    d
    )-2(
    1
    H)-pyridone. Glycosidic hydrolysis of
    5
    e
    with boiling 0.
    5
    N aqueous HCl afforded adenine-2-
    d
    (
    5
    a) in 77% yield. Peracid oxidation of
    5
    a-
    e
    produced the corresponding
    1
    -N-oxides (12a-
    e
    ) in fair yields. Methylation of
    9
    -methyl- (12
    b
    ) and
    9
    -benzyladenine-2-
    d
    1
    -oxide (12
    d
    ) and adenosine-2-
    d
    1
    -oxide (12
    e
    ) with MeI in AcNMe2 gave the corresponding
    1
    -methoxy derivatives (13
    b
    ,
    d
    ,
    e
    ) in good yields. Dimroth rearrangements of 13
    b
    , 13
    d
    , and 13
    e
    via the free bases 14
    b
    , 14
    d
    , and 14
    e
    furnished the
    N6
    -methoxy isomers 15
    b
    , 15
    d
    , and 15
    e
    , but their isotopic purities were unsatisfactory. Unambiguous assignments of the purine-ring proton signals in the proton nuclear magnetic resonance spectra of the unlabeled adenines (
    1
    a-
    f
    , 2a-
    e
    ,
    3
    b
    ,
    d
    , and 10
    e
    ) have been made by comparison with those of the labeled species (
    5
    a-
    f
    , 12a-
    e
    , 13
    b
    ,
    d
    , and 14
    e
    ).
  • 財満 鎮雄, 竹内 洋一郎, 入交 裕
    軽金属
    1975年 25 巻 8 号 310-313
    発行日: 1975/08/30
    公開日: 2008/07/23
    ジャーナル フリー
    The modulns of longitudinal elasticity and their temperature dependence in commercial aluminum cast alloys were measured in the temperature range from room temperature (20°C) to 250°C by the resonant frequency method. The results obtained are as follows:
    The modulus of longitudinal elasticity tended to decrease weakly and linearly (the tangent of its decrease, m = (-2.
    4
    --
    3
    .
    3
    ) × 102kg/cm2/°C) with the rise of temperature. Within the range of the experiments, aluminum cast alloys were divided into
    3
    groups, the lst group materials having large moduli of elasticity
    E0
    at room temperature (i.
    e
    .,
    E0
    = (7.15-7.25) × 105kg/cm2) were AC2A-T
    6
    , AC
    3
    A-
    F
    , AC
    4
    A-
    F
    , AC
    4
    A-T
    4
    , AC
    4
    B
    -
    F
    , AC
    4
    B
    -T
    4
    , AC
    8
    A-
    F
    , AC
    8
    A-T
    4
    , etc., the 2nd group materials having intermediate moduli (i.
    e
    .,
    E0
    = (
    6
    .85-
    6
    .98) × 105kg/cm2) were AC
    4
    C-
    F
    , AC
    4
    C-T
    5
    , AC
    4
    C-T
    6
    , AC
    4
    D
    -
    F
    , AC
    4
    D
    -T
    6
    , AC7A-
    F
    , etc. and the
    3
    rd group materials showing considerably smaller moduli (i.
    e
    .,
    E0
    = (
    6
    .58-
    6
    .65) × 105kg/cm2) were AC
    1
    A-
    F
    , AC
    1
    A-T
    6
    , AC2A-
    F
    , etc. However, there were some differences between the moduli in this experiments and the moduli in the other data books, and these were considered due to the difference of the measurement principles and of hypotheses or assumptions involved in these principles, so it is suggested that the moduli of elasticity should be reported with indication of the measuring method.
  • 矢原 正治, 西依 健, 江田 昭英, 野原 稔弘, 西岡 五夫
    Chemical and Pharmaceutical Bulletin
    1991年 39 巻 8 号 2024-2036
    発行日: 1991/08/25
    公開日: 2008/03/31
    ジャーナル フリー
    A chemical examination of Magnoliae Cortex produced in China (Magnolia officinalis REHD. et WIL S., Magnoliaceae) has led to the isolation of eighteen new lignans and related compounds [four monoterpenyl-lignans : piperitylmagnolol (
    3
    ), dipiperitylmagnolol (
    4
    ), piperitylhonokiol (
    5
    ) and bornylmagnolol (
    6
    ); seven lignans : magnaldehydes
    B
    (
    8
    ), C(
    9
    ), magnolignans A(10),
    B
    (11), C(12),
    D
    (13) and
    E
    (14); three norlignans : magnatriol
    B
    (16), magnaldehydes
    D
    (17) and
    E
    (18); and four dilignans : magnolignans
    F
    (19), G(20), H(21) and I(
    22
    )], together with randainal (7), randaiol (15), sinapic aldehyde, syringaresinol, syringaresinol
    4
    '-O-β-
    D
    -glucopyranoside and
    6
    '-O-methylhonokiol. Their structures were determined by the chemical and spectral methods.
  • 張 恵平, 五味 和枝, 釜野 徳明, 繁森 英幸, 石橋 正己, 小林 淳一, 小坂 俊幸, 木津 治久, 糸川 秀治, George R. Pettit, Cherry L. Herald
    天然有機化合物討論会講演要旨集
    1994年 36 巻 9
    発行日: 1994/09/20
    公開日: 2017/08/18
    会議録・要旨集 フリー
    During our search for new bioactive substances from marine organisms, we have examined extracts of the Floridian bryozoan Amathia convoluta and obtained the six new alkaloids, convolutamides A (
    1
    a),
    B
    (
    1
    b
    ), C (2a),
    D
    (2
    b
    ),
    E
    (
    3
    a), and
    F
    (
    3
    b
    ), possessing an N-acyl-γ-lactam moiety with a dibromophenol group. Also, from the same extracts, the five new β-phenylethylamine alkaloids, convolutamines A (
    4
    ),
    B
    (
    5
    ), C (
    6
    ),
    D
    (7), and
    E
    (
    8
    ) were obtained. The structures have been elucidated on the basis of extensive spectroscopic data such as ^
    1
    H-^
    1
    H COSY, HMQC, HMBC, NOESY, HMQC-HOHAHA, INADEQUATE experiments. The structures of convolutamides A〜
    F
    were shown in Fig.
    1
    . The NMR data of convolutamides A (
    1
    a) and
    B
    (
    1
    b
    ) were shown in Table
    1
    . The partial structure of the γ-lactam moiety was deduced from the COSY correlations as well as the HMBC cross-peaks, in addition to FAB MS/MS spectral data (Table 2). In Fig. 2, the daughter ions observed in the negative FAB MS/MS for the acyl part of
    1
    b
    and 2
    b
    were illustrated. On the other hand, the structures of convolutamines A〜
    E
    were shown in Fig.
    3
    . The ^
    1
    H and ^<13>C NMR data were indicated in Table
    3
    and
    4
    . The relative stereochemistry of the morpholine ring in the structure of convolutamine
    E
    (
    8
    ) was illustrated in Fig.
    4
    . To our knowledge, compounds with oxazolidine as convolutamine
    D
    (7) are rare in nature. While, convolutamides A〜
    F
    (
    1
    a〜
    3
    b
    ) may belong to an unprecedented class of natural product possessing a unique γ-lactam and dibromophenol ring system. Convolutamides A (
    1
    a) and
    B
    (
    1
    b
    ) exhibited against L1210 and KB cells with IC50 values of
    4
    .
    8
    and 2.
    8
    μg/ml, respectively. Also, convolutamines A (
    1
    ),
    B
    (2), and
    D
    (
    4
    ) exhibited against P388 cell with IC50 values of 10.
    6
    ,
    4
    .
    8
    , and
    8
    .
    6
    μg/ml, respectively.
feedback
Top