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  • 小田切 孝人, 田代 眞人
    ウイルス
    2013年 63 巻 2 号 233-240
    発行日: 2013/12/25
    公開日: 2014/10/31
    ジャーナル フリー
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE
    Agricultural and Biological Chemistry
    1988年 52 巻 12 号 3217-3218
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • Mohd Suhail, Mohd Faizul Suhail, Hina Khan
    Journal of Clinical Biochemistry and Nutrition
    2008年 43 巻 3 号 210-220
    発行日: 2008年
    公開日: 2008/10/31
    ジャーナル フリー
    We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group
    B
    which comprised preeclamptics who were supplemented their diets with vitamins C and
    E
    . MDA increased from
    6
    .
    22
     ± 
    2
    .
    8
    (placebo) to
    8
    .48 ± 1.
    2
    (A) and
    8
    .02 ± 1.
    8
     nmol/gHb (
    B
    ). NO concentrations were enhanced from 19.
    3
     ± 
    4
    .
    2
    (P) to 23.
    8
     ± 
    6
    .
    4
    (A) and 24.1 ± 
    5
    .
    4
     μmol/L (
    B
    ). GSH contents were decreased from 10.42 ± 
    2
    .
    81
    (P) to
    8
    .02 ± 
    2
    .92 (A) and
    9
    .39 ± 1.02 μmol/g Hb (
    B
    ), whereas GSSG concentrations increased from 0.98 ± 0.28 (P) to 1.24 ± 0.29 (A) and 1.08 ± 0.12 μmol/g Hb (
    B
    ). SOD activity decreased 23% in A and 14% in
    B
    ; GRx decreased 27% in A and
    5
    .
    5
    % in
    B
    ; GPx decreased 12% in A and
    9
    .
    6
    % in
    B
    . Catalase activity, however, increased 27% in A and 29% in
    B
    as compared to control. Thus, we conclude that the use of vitamins C and
    E
    should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.
  • 香山 滉一郎, 森下 政夫, 張 国鋒
    粉体および粉末冶金
    2006年 53 巻 5 号 419-429
    発行日: 2006年
    公開日: 2006/12/19
    ジャーナル オープンアクセス
    The phase diagrams of the Ni-Mo-
    B
    and Ni-W-
    B
    ternary systems in the region of less than 50mol%
    B
    were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
    E1
    :L (1365K, 71.
    5
    mol%Ni-
    6
    .0mol%Mo-
    22
    .
    5
    mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiMo2B2

    E2
    :L (1355K, 62.
    5
    mol%Ni-
    2
    .
    5
    mol%Mo-30.
    5
    mol%
    B
    )=
    Ni3B
    +
    Ni2B
    +
    NiMo2B2

    E3
    :L (1445K, 42.0mol%Ni-30.
    6
    mol%Mo-10.
    3
    mol%
    B
    )=(Ni)+NiMo+
    NiMo2B2

    P1:L (1812K, 34.
    9
    mol%Ni-42.
    3
    mol%Mo-
    22
    .
    8
    mol%
    B
    )+MoB=
    Mo2B
    +
    NiMo2B2

    P2
    :L (1633K, 42.
    3
    mol%Ni-40.
    4
    mol%Mo-17.
    3
    mol%
    B
    )+Mo=
    Mo2B
    +
    NiMo2B2

    P3
    :L (1812K, 53.
    5
    mol%Ni-33.7mol%Mo-12.
    8
    mol%
    B
    )+Mo=NiMo+
    NiMo2B2

    E1
    :L (1622K, 51.0mol%Ni-31.
    6
    mol%W-17.
    4
    mol%
    B
    )=(Ni)+W+
    NiW2B2

    E2
    :L (1260K, 71.0mol%Ni-7.0mol%W-
    22
    .0mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiW2B2

    E3
    :L (1291K, 65.
    4
    mol%Ni-
    4
    .
    8
    mol%W-29.
    8
    mol%
    B
    )=
    Ni2B
    +
    Ni3B
    +
    NiW2B2

    P1:L (2115K, 23.
    8
    mol%Ni-43.1mol%W-33.1mol%
    B
    )+WB=
    W2B
    +
    NiW2B2

    P2
    :L (1657K, 48.
    9
    mol%Ni-33.1mol%W-18.0mol%
    B
    )+
    W2B
    =W+
    NiW2B2

    The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
  • M. L. GHOSH
    Journal of Physics of the Earth
    1972年 20 巻 2 号 165-186
    発行日: 1972年
    公開日: 2009/04/30
    ジャーナル フリー
    The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.
  • Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE, Kiyomi KOBAYASHI, Suguru TAKATSUTO
    Agricultural and Biological Chemistry
    1988年 52 巻 8 号 2117-2118
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • Joey
    B
    . Tanney, Leonard J. Hutchison
    Mycoscience
    2012年 53 巻 1 号 31-35
    発行日: 2012年
    公開日: 2023/03/31
    ジャーナル オープンアクセス

    The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On

    2
    % modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in 95 (
    22
    .
    2
    %) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-
    2
    (
    22
    ), blaCTX-M-
    3
    (16), blaCTX-M-1 (15), blaOXA-1 (
    9
    ) and blaSHV-12 (
    3
    ) alone or in combination. The most frequently encountered phylogenetic group was group A1 (35.
    8
    %), followed by group
    D2
    (
    22
    .1%),
    B
    1 (15.
    8
    %), D1 (
    9
    .
    5
    %), A0 (7.
    4
    %),
    B22
    (
    5
    .
    3
    %) and
    B23
    (
    4
    .
    2
    %), respectively. PMQR genes, aac(
    6
    ’)-Ib-cr, qnr
    S1 and qnrB10 were detected in 25.
    3
    , 10.
    5
    and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.
    8
    % for tetracycline. The virulence genes were only detected in 34 (36.
    2
    %) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE, f17a-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2
    . To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

  • 増大する資源
    E
    . F. Boswell
    紙パ技協誌
    1998年 52 巻 7 号 885-889
    発行日: 1998/07/01
    公開日: 2009/11/19
    ジャーナル フリー
    The world is in the midst of a huge fundamental shift in fibre supply, demand balances, and policy changes. Governments around the world are introducing policy changes which influence the supply demand balance as the politicians' thoughts are uttered. Government agencies and their bureaucrats are imposing changes on industry even before the legislation is passed by the government in question.
    This ad hoc change process will continue for a time to come until the countries in question show a tough-mindedness with regard to their land use policies. Policies affecting forest areas such as protection areas, Native land claims, the protection of biodiversity and a true goal of sustainable development ; which addresses the combined issues of cultural, environmental, social and economic matters.
    Eventually all of these difficult issues will reach essential closure. Then there will be great new opportunities for investment to meet the growing demand for forest products ; leading to a strengthening competitive position in the more traditional producing areas such as Canada.
  • Misaki Kojima, Takeya Morozumi
    Journal of Health Science
    2004年 50 巻 5 号 518-529
    発行日: 2004年
    公開日: 2004/10/01
    ジャーナル フリー
    Six full-length cDNAs encoding pig cytochrome P450 (CYP) enzymes, CYP1A1, CYP
    2
    A19, CYP
    2
    B
    22
    , CYP
    2
    C33v
    4
    , CYP
    2
    C49, and CYP
    2
    E
    1, were isolated and sequenced. The cDNA sequences of pig CYP1A1, CYP
    2
    A19, CYP
    2
    B
    22
    , CYP
    2
    C49, and CYP
    2
    E
    1 showed high similarity to human CYP1A1 (85.
    4
    %),
    CYP2A13
    (
    88
    .
    6
    %),
    CYP2B6
    (
    81
    .1%),
    CYP2C18
    (85.
    3
    %), and
    CYP2E1
    (82.
    5
    %), respectively, and pig
    CYP2C33v4
    cDNA showed high similarity to rat
    CYP2C23
    (79.
    2
    %). Reverse transcription-polymerase chain reaction (RT-PCR) assays revealed hepatic gene expression of all these pig CYP enzymes: the order of expression was
    CYP2C33v4
    and
    CYP2E1
    >
    CYP2C49
    > CYP1A1 and
    CYP2A19
    >
    CYP2B22
    . In the kidney, the
    CYP2C33v4
    gene was expressed at the same level as in the liver, but the CYP1A1,
    CYP2A19
    , and
    CYP2B22
    genes were expressed at lower levels than in the liver. Little renal gene expression of CYP
    2
    C49 and CYP
    2
    E
    1 was observed. We revealed for the first time the full-length cDNA sequences encoding pig CYP1A1 and five CYP enzymes belonging to the
    CYP2
    gene family, thus making it possible to examine the gene expression levels of these CYP enzymes in pig tissues by RT-PCR.
  • 鍛治 健司, 葛谷 昌之 /, RAYMONDN. CASTLE
    Chemical and Pharmaceutical Bulletin
    1970年 18 巻 1 号 147-156
    発行日: 1970/01/25
    公開日: 2008/03/31
    ジャーナル フリー
    2
    -Benzyl-
    4
    -chloro-
    5
    -mercapto-
    3
    (
    2
    H)-pyridazinone (1) was heated in ethanol under reflux for 10 hours to form concurrently
    2
    , 7-dibenzyldipyridazo [
    4
    ,
    5
    -
    b
    :
    4
    ',
    5
    '-
    e
    ]-1,
    4
    -dithiin-1,
    6
    (
    2
    H, 7H)-dione (Ia) (57% in yield) and
    2
    ,
    8
    -dibenzyldipyridazo [
    4
    ,
    5
    -
    b
    :
    4
    ',
    5
    '-
    e
    ]-1,
    4
    -dithiin-1,
    9
    (
    2
    H,
    8
    H)-dione (IIa) (14% in yield). Assignment of the two products to the corresponding structures is established by their physico-chemical constants and chemical behaviors. The concurrent formation of the dipyridazo [
    4
    ,
    5
    -
    b
    :
    4
    ',
    5
    '-
    e
    ]-1,
    4
    -dithiin-1,
    6
    (
    2
    H, 7H)-dione and the -1,
    9
    (
    2
    H,
    8
    H)-dione were observed in, not only heating
    4
    -chloro-
    5
    -mercapto-
    3
    (
    2
    H)-pyridazinones (1-
    3
    ) in polar solvent, but warming
    4
    -mercapto-
    5
    -chloro-
    3
    (
    2
    H)-pyridazinones (
    4
    -
    6
    ) in the presence of potassium carbonate in DMF. For the interpretation of the reaction, keto-thioketo carbenes as active intermediate species and a reversible interconversion among them are suggested on the basis of the fact that there was nonexistence of an equilibrium between the two compounds, such as Ia and IIa, under the reaction condition and a trapping keto-thioketo carbene species as
    2
    -phenylimino-
    5
    -benzylpyridazo [
    4
    ,
    5
    -d]-1,
    3
    -dithiol-
    4
    (
    5
    H)-one (IVa) (14% in yield) along with the major products, (Ia) and (IIa), was furnished by warming 1 with phenylisothiocyanate in the presence of triethylamine in dry benzene. On the contrary, participation of a reversible interconversion between Ia and IIa, to a considerable extent, with the concurrent formation of them in the case of benzylation of either Ib or IIb, by warming with benzylchloride in the presence of potassium carbonate in DMF at 80°, might not be neglected, because an attempted approach to an equilibrium between Ia and IIa in a similar reaction condition except the use of benzylchloride realized, whereas non-existence of an equilibrium between Ib and IIb in the similar reaction condition was observed.
  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with 7 kinds of factors, as follows ; A^^〜=
    B
    +C+D+K+
    aE
    +bF+cG. A^^〜=estimated values of the readership score. 1)
    B
    , C, D, K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into 7 categories. C=pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories. D=kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys.
    2
    )
    E
    , F, G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into
    6
    kinds of area (
    2
    .
    5
    ,
    3
    .
    5
    ,
    5
    , 7, 10, 15) and 15 column means a whole page, about
    2
    ,000cm^
    2
    .
    E
    , F are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement. F=the marks obtained on the whole effect of the design.
    3
    ) a,
    b
    , c : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score:
    aE
    +bF=A-(
    B
    +C+D+K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was
    3
    ,541,
    2
    ,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table
    2
    ^* shows the contribution indexes of each factor by
    3
    kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (
    2
    ) Standard deviations of the category values, (
    3
    ) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table
    2
    in the thesis in Japanese. [
    2
    ] The important point was in the determination of the values of
    E
    , F.
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _1+
    E
    _
    2
    +
    E
    _
    3
    +
    E
    _
    4
    . design elements [table]
    E
    _1,
    E
    _
    2
    ,
    E
    _
    3
    ,
    E
    _
    4
    , these values have the
    5
    grades, as 0, 1,
    2
    ,
    3
    ,
    4
    and 0 is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of 0 to
    9
    grades as the sum of them. The values of F have also
    5
    grades, 0 to
    4
    . The principles to determine the values of
    E
    , F are as follows : a) The marks obtained of
    E
    , F must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. c) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    , F values, as the table
    5
    -
    4
    , and
    5
    -
    5
    in the thesis in Japanese.
  • Nicholas ISYUMOV, Eric HO, Peter KING, David SURRY, Barry VICKERY
    日本風工学会誌
    2010年 35 巻 4 号 265-271
    発行日: 2010/10/31
    公開日: 2011/04/01
    ジャーナル フリー
  • 高津戸 秀, 池川 信夫
    Chemical and Pharmaceutical Bulletin
    1984年 32 巻 5 号 2001-2004
    発行日: 1984/05/25
    公開日: 2008/03/31
    ジャーナル フリー
    Brassinolide analogues, (
    22
    R, 23R, 24R)-
    ,
    ,
    22
    , 23-tetrahydroxy-
    B
    -homo-7-oxa-
    -ergostan-
    6
    -one (24-epibrassinolide) (10) and (
    22
    S, 23S, 24R)-
    ,
    ,
    22
    , 23-tetrahydroxy-
    B
    -homo-7-oxa-
    -ergostan-
    6
    -one (
    9
    ), were synthesized from brassicasterol (
    3
    a) in five steps and with ca. 20% overall yield. The key steps are the direct formation of (
    22
    E
    , 24R)-
    ,
    5
    -cyclo-
    -ergost-
    22
    -en-
    6
    -one (
    4
    ) from brassicasterol mesylate (
    3
    b
    ), the acid-catalyzed rearrangement of
    4
    to (
    22
    E
    , 24R)-
    -ergosta-
    2
    ,
    22
    -dien-
    6
    -one (
    6
    ), and the Baeyer-Villiger oxidation of the tetrahydroxy
    -ergostan-
    6
    -ones 7 and
    8
    .
  • ―特にアポ蛋白Eの変化について―
    本間 康彦, 三神 美和, 佐藤 美智子, 石原 仁一, 吉川 広, 木下 栄治, 田川 隆介, 星合 充基, 古屋 秀夫, 井出 満, 田辺 晃久, 玉地 寛光, 兼本 成斌, 友田 春夫, 中谷 矩章, 五島 雄一郎
    動脈硬化
    1984年 12 巻 3 号 599-603
    発行日: 1984/08/01
    公開日: 2011/09/21
    ジャーナル フリー
    Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for
    2
    weeks. Cholesterol amounts in VLDL, LDL, HDL,
    HDL2
    and
    HDL3
    were estimated on the 0th, 7th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
    B
    , C-II,
    E
    levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL,
    HDL2
    and
    HDL3
    were 15.
    9
    ±7.
    5
    mg/dl (mean±SD), 150.
    9
    ±58.1mg/dl 43.
    8
    ±
    9
    .
    6
    mg/dl, 16.
    4
    ±
    5
    .
    8
    mg/dl and 24.
    9
    ±
    6
    .
    3
    mg/dl respectively. Plasma apoprotein A-I, A-II,
    B
    , C-II and
    E
    levels were
    81
    .7±
    22
    .0 mg/dl, 15.1±
    5
    .
    4
    mg/dl, 93.7±36.0mg/dl,
    3
    .83±1.00mg/dl and
    4
    .29±1.36mg/dl respectively. After
    2
    weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-C (r=0.348),
    HDL2
    -C (r=0.612) and
    HDL3
    (r=0.569). Apoprotein
    B
    correlated with total cholesterol (TC) (r=0.610), VLDL-C (r=0.341), LDL-C (r=0.726), HDL-C (r=0.432) and
    HDL2
    -C (r=0.465). Apoprotein C-II correlated with TC (r=0.765), TG (r=0.679), VLDL-C (r=0.651), LDL-C (r=0.461) and
    HDL2
    -C (r=0.326). Apoprotein
    E
    correlated with TC (r=0.580), TG (r=0.575) and VLDL-C (r=0.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=0.468). Apoprotein
    B
    correlated with apoprotein C-II (r=0.393). Apoprotein C-II correlated with apoprotein
    B
    (r=0.393) and
    E
    (r=0.549). Apoprotein
    E
    only correlated with apoprotein C-II (r=0.549).
  • 加藤 行男, 松本 智, 潮田 弘, 谷川 力, 高木 敬彦, 光崎 研一, 金内 長司
    日本獣医師会雑誌
    1996年 49 巻 6 号 408-410
    発行日: 1996/06/20
    公開日: 2011/06/17
    ジャーナル フリー
    魚市場およびと畜場のドブネズミにおけるStaphylococcus auresの保有率はそれぞれ74.
    6
    % (44/59), 34.
    6
    % (
    9
    /26) であった. 魚市場のネズミ由来S. aureus104株の生物型はC型
    81
    株 (77.
    9
    %),
    B
    型16株 (15.
    4
    %), A型
    6
    株 (
    5
    .
    8
    %), 型別不能1株 (1%) で, と畜場由来
    9
    株はG型
    8
    株 (
    88
    .
    9
    %),
    B
    型1株 (11.1%) であった. 魚市場のネズミ由来株のコアグラーゼ型は, VIII型 (26.
    9
    %), 1型 (
    22
    .1%), VII型 (13.
    5
    %), IV型 (
    8
    .7%), II型 (
    5
    .
    8
    %), III型 (
    2
    .
    9
    %), V型 (
    2
    .
    9
    %), VI型 (
    2
    .
    9
    %), 同定不能 (14.
    4
    %) で, と畜場由来株は, VIII型 (44.
    4
    %), V型 (
    22
    .
    2
    %), VI [型 (
    22
    .
    2
    %), 同定不能 (11.1%) であった.魚市場のネズミ
    9
    匹由来の12株からはエンテロトキシンA (11株) および
    B
    (1株) が産生された.
  • 黒川 美貴雄, 吉田 耕治, 永井 保嵩, 宇野 準
    Chemical and Pharmaceutical Bulletin
    1983年 31 巻 12 号 4312-4318
    発行日: 1983/12/25
    公開日: 2008/03/31
    ジャーナル フリー
    Two new partially saturated tricyclic ring systems,
    6
    ,
    6
    a, 7,
    8
    ,
    9
    , 10, 10a, 11-octahydro-11-oxodibenz [
    b
    ,
    e
    ] oxepins (
    3
    a and
    3
    b
    ), and -thiepins (
    4
    a and
    4
    b
    ) were synthesized. Compounds
    4
    a and
    4
    b
    were desulfurized to give a pair of isomeric
    2
    -methylbenzoylcyclohexanes (10a and 10
    b
    ). Deuterated
    4
    a and
    4
    b
    (11a and 11
    b
    ) were prepared starting from butadiene-
    d6
    (12). The stereochemical features of
    3
    a (trans),
    3
    b
    (cis),
    4
    a (trans) and
    4
    b
    (cis) are compared with those of 10a, 10
    b
    , 11a and 11
    b
    on the basis of proton nuclear magnetic resonance data.
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • 伊東 常男, 富井 保雄, 内藤 貴之, 山村 美奈子, 石川 一郎, 川原 徳夫, 水野 義久, 小倉 治夫
    Chemical and Pharmaceutical Bulletin
    1989年 37 巻 8 号 2197-2199
    発行日: 1989/08/25
    公開日: 2008/03/31
    ジャーナル フリー
    5
    -Amino-
    6
    -mercapto-1,
    3
    -dimethyluracil (
    2
    ) was prepared by the treatment of
    5
    ,
    6
    -diamino-1,
    3
    -dimethyluracil (1) with liquid
    H2S
    and pyridine in a sealed steel tube at 60°C for 20 h. Thiazolo[
    5
    ,
    4
    -d]pyrimidinediones
    3
    a,
    b
    were obtained from
    2
    by cyclization with
    HCO2H
    and AcOH.Under stringent conditions, however, 1 was converted into the
    5
    ,
    9
    -dihydrodipyrimido[
    4
    ,
    5
    -
    b
    :
    5
    ',
    4
    '-
    e
    ][1,
    4
    ]thiazine derivtive
    4
    a.The structure of
    4
    a was confirmed by spectral (nuclear magnetic resonance and mass spectra) data and by comparison with a sample which was prepared from
    2
    and
    5
    -hydroxy-1,
    3
    -dimethyluracil.Benzylation of
    4
    a gave 1,
    3
    , 7,
    9
    -tetramethyl-
    5
    -benzyl (or p-bromobenzyl)-
    5
    ,
    9
    -dihydrodipyrimido[
    4
    ,
    5
    -
    b
    :
    5
    ',
    4
    '-
    e
    ][1,
    4
    ]thiazine-
    2
    ,
    4
    ,
    6
    ,
    8
    -(1H,
    3
    H, 7H)-tetrone (
    4
    b
    , c) and 1,
    3
    , 7,
    9
    -tetramethyl-
    5
    -benzyl (or p-bromobenzyl)-
    5
    ,
    9
    -dihydropyrrolo[
    3
    ,
    2
    -d :
    4
    ,
    5
    -d']dipyrimidine-
    2
    ,
    4
    ,
    6
    ,
    8
    -(1H,
    3
    H, 7H)-tetrone (
    6
    a,
    b
    ).
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