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  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in 95 (
    22
    .2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-2 (
    22
    ), blaCTX-M-3 (16), blaCTX-M-1 (15), blaOXA-1 (
    9
    ) and blaSHV-12 (3) alone or in combination. The most frequently encountered phylogenetic group was group A1 (35.
    8
    %), followed by group D2 (
    22
    .1%),
    B
    1 (15.
    8
    %), D1 (
    9
    .
    5
    %),
    A0
    (
    7
    .4%),
    B22
    (
    5
    .3%) and
    B23
    (4.2%), respectively. PMQR genes, aac(6’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.3, 10.
    5
    and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.
    0
    % for tobramycin to 56.
    8
    % for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE,
    f17a
    -A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

  • Joey
    B
    . Tanney, Leonard J. Hutchison
    Mycoscience
    2012年 53 巻 1 号 31-35
    発行日: 2012年
    公開日: 2023/03/31
    ジャーナル オープンアクセス

    The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

  • I.
    F
    . Davies
    Journal of Light & Visual Environment
    1984年 8 巻 1 号 1_9-1_20
    発行日: 1984年
    公開日: 2011/05/20
    ジャーナル フリー
  • 小林 優, 家坂 貴子, 中野 江身子, 平山 耕一郎
    天然有機化合物討論会講演要旨集
    1989年 31 巻 71/P2-1
    発行日: 1989/09/17
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Six new cembranoids sarcophytol P (3), R (4), S (
    5
    ), K (
    8
    ),
    F
    (11), and T (13) were isolated from the soft coral Sarcophyton glaucum. Sarcophytol P (3) was shown to be the 20-hydroxy derivative of the major component sarcophytol A (1), and afforded the cyclization product 6 in CHCl_3 at room temperature, in a same way as in 1. Sarcophytols R (4) and S (
    5
    ) were correlated to 1, by conversion of its
    7
    R,
    8
    R and
    7
    S,
    8
    S epoxide derivatives. Sarcophytol K(
    8
    ) was a 13, 14-dihydroxycembranoid having a 1
    E
    ,3Z-diene moiety. The absolute configuration of
    8
    and its 1Z,3
    E
    - and 1Z,3Z-isomers sarcophytol
    B
    (2) and J (10) were determined by circular dichroism study of their bis-p-dimethylaminobenzoate derivatives. Sarcophytols
    F
    (11) and T (13) were 1
    E
    - and 1
    E
    ,3Z-isomers of 1. Compound 11 showed characteristic broadening of the ^1H-NMR chemical shifts, due to the restricted conformational interconversion. Using the three cembranoids sarcophytols
    F
    (11, 1
    E
    ,3
    E
    ), N (15, 1Z,3Z) and T (13,1
    E
    ,3Z), spontaneous autoxidation-cyclization, in CHCl_3,was examined, in order to compare the stereochemical course of the reaction with that of 1 (1Z,3
    E
    ), which affords trans-fused bicyclo[
    9
    .3.
    0
    ]tetradecene systems. The 1
    E
    ,3Z-isomer 13 gave the same cyclization product 18, as in the reaction of 1, even though it is isomeric at C-1,3. The 1Z,3Z isomer 15 gave 19, in consequence of the reversed geometry at C-3 of 15. The 1
    E
    ,3
    E
    -isomer (11) gave the bicyclic product
    22
    , having an antipodal fusion as compared with 19. This was confirmed by PCC oxidation of 19 and
    22
    , giving enantiomeric ketones 23 and 24 respectively. The 1(14)-epoxide 26 was shown to be the immediate precursor of
    22
    , and acounted for the inversion of the geometry at C-1 of the cyclization product. Compound 26 is isomeric with the epoxide 17 derived from 1. The epoxide 17 is the postulated precursor in the conversion of 13 to 18. It is noteworthy that the mode of antipodal fusion of the cyclopentane rings, in 18 and
    22
    , was controlled by the chirality of the epoxy rings. The C-14 hydroxyl group participates in the transannular cyclization, but was found not to be the requisite functional group for the reaction. Similar treatment of cembrene C (30), the parent hydrocarbon of 1, also reacted in CHCl_3 giving the bicyclic product 32.
  • 泌尿器科領域における臨床分離株と環境分離株に関する疫学的検討
    鎌田 日出男
    日本泌尿器科學會雑誌
    1979年 70 巻 10 号 1142-1158
    発行日: 1979/10/20
    公開日: 2010/07/23
    ジャーナル フリー
    1) P. aeruginosa has been consistently isolated from 26.
    5
    to 42.4% of the patients with urinary tract infections in the urological ward of Okayama University Hospital for the past
    7
    years. 232 (
    22
    .3%) out of 1042 hospitalized patients were with urinary tract infections with P. aeruginosa for past 4 years. Of these, 149 (64.2%) were thought to be the catheter induced urinary tract infections. The mode of spreading of this organism was epidemiologically investigated.
    2) The following three laboratory assays were used for identification of P. aeruginosa isolated from clinical and environmental strains; serological typing, antibiotic sensitivity and protease and elastase production. Serological typing with 13 immunodiagnostic sera (Toshiba Chemical Industry) was performed by slide agglutination method. Protease and elastase production were detected by the method described by Goto et al.
    In combination with serological typing and antibiograms, protease and elastase production offers the finest means of differentiating the strains of P. aeruginosa.
    3) Of 136 clinical strains of P. aeruginosa, 89.
    7
    % were serotypable strains. Serotype K was the most prevalent (36.
    0
    %), followed by serotype
    E
    (28.
    7
    %),
    F
    (10.3%) and A (
    7
    .4%). Most of serotype
    F
    and
    B
    which were concurrently isolated from patients in 1976 had the same patterns of antibiogram and production of protease and elastase. It was strongly suggested that these patients were nosocomially cross-infected with the P. aeruginosa from the catheterization or through instrumentation.
    4) Of 354 environmental specimens, 78 P. aeruginosa (
    22
    .
    8
    %) were isolated, which were frequently isolated from floor mops and sink-drains. Of these strains, 87.2% were serotypable strains. Serotype
    E
    was the most prevalent (42.3%), followed by serotype K (24.4%) and
    B
    (12.
    8
    %). The same strains were seldom detected at the same sources successively, but different types of P. aeruginosa were usually detected. Among the serotypes
    E
    ,
    F
    and K, 18 strains (23.1%) were identical with the clinical strains. All of these were found during or after the clinical outbreaks of P. aeruginosa infections. There was no environmental strains that caused clinical infections. The other 60 strains (76.
    9
    %) were different from the clinical strains, and present only transiently in the hospital environments.
    5
    ) Both clinical and environmental strains similary produced protease and elastase at 70 to
    80
    %, hemolysin at 100%. Only 10 out of 37 environmental strains (27.
    0
    %) were found to produced exotoxin.
  • Jae-Sun Uhm, Boyoung Joung, Hye Jin Hwang, Jong-Youn Kim, Moon-Hyoung Lee, Hui-Nam Pak
    Journal of Arrhythmia
    2011年 27 巻 Supplement 号 OP58_2
    発行日: 2011年
    公開日: 2012/03/27
    ジャーナル フリー
    Backgrounds: We evaluated that electrophysiological characteristics and clinical outcomes of atrial fibrillation (
    AF
    ) with sinus node dysfunction (SND) after radiofrequency catheter ablation (RFCA). Methods: Among 428 patients (male, 77.3%; 56.
    0
    ±11.
    0
    years old; paroxysmal
    AF
    , 69.4%) who underwent RFCA for
    AF
    , 50 patients (11.
    7
    %) who had ECG documented symptomatic SND (28 Tachybrady (T-Bs) and
    22
    sick sinus syndrome; SSS) were compared with 378 patients without SND. Results: 1. The patients with SND were older (60.3±61617;
    9
    .
    7
    vs. 55.4±61617; 11.1 years, p=
    0
    .003) and had higher
    E
    /
    E
    ′ (12.4±61617;
    5
    .1 vs.
    9
    .
    9
    ±61617; 4.1, p=
    0
    .002) than those without SND. 2. Effective refractory period (ERP) at high right atrium (RA) was longer (ERP; 244.1±61617; 26.1 vs. 232.2±61617; 28.2 ms, p=
    0
    .033) and endocardial voltage at posterior left atrium (LA) was higher (1.2±61617;
    0
    .
    8
    vs.
    0
    .
    9
    ±61617;
    0
    .
    8
    mV, p=
    0
    .041) in patients with SND than those without it. 3. The recurrence rate was not different significantly between groups (28.
    0
    % vs. 20.
    0
    %, p=
    0
    .623) during 12.
    7
    ±
    5
    .
    9
    months. A patient with SSS (4.
    5
    %) and a patient with T-Bs (3.6%) were implanted pacemaker because of recurrent symptomatic bradycardia after RFCA. Conclusion:
    AF
    is associated with SND more often in patients with old age, diastolic dysfunction, and high RA ERP. RFCA results in comparable clinical outcome in those patients, but 4% of them required pacemaker implantation due to
    AF
    recurrence and symptomatic bradycardia.
  • 香山 滉一郎, 森下 政夫, 張 国鋒
    粉体および粉末冶金
    2006年 53 巻 5 号 419-429
    発行日: 2006年
    公開日: 2006/12/19
    ジャーナル オープンアクセス
    The phase diagrams of the Ni-Mo-
    B
    and Ni-W-
    B
    ternary systems in the region of less than 50mol%
    B
    were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
    E1
    :L (1365K, 71.
    5
    mol%Ni-6.
    0
    mol%Mo-
    22
    .
    5
    mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiMo2B2

    E2
    :L (1355K, 62.
    5
    mol%Ni-2.
    5
    mol%Mo-30.
    5
    mol%
    B
    )=
    Ni3B
    +
    Ni2B
    +
    NiMo2B2

    E3
    :L (1445K, 42.
    0
    mol%Ni-30.6mol%Mo-10.3mol%
    B
    )=(Ni)+NiMo+
    NiMo2B2

    P1:L (1812K, 34.
    9
    mol%Ni-42.3mol%Mo-
    22
    .
    8
    mol%
    B
    )+MoB=
    Mo2B
    +
    NiMo2B2

    P2:L (1633K, 42.3mol%Ni-40.4mol%Mo-17.3mol%
    B
    )+Mo=
    Mo2B
    +
    NiMo2B2

    P3:L (1812K, 53.
    5
    mol%Ni-33.
    7
    mol%Mo-12.
    8
    mol%
    B
    )+Mo=NiMo+
    NiMo2B2

    E1
    :L (1622K, 51.
    0
    mol%Ni-31.6mol%W-17.4mol%
    B
    )=(Ni)+W+
    NiW2B2

    E2
    :L (1260K, 71.
    0
    mol%Ni-
    7
    .
    0
    mol%W-
    22
    .
    0
    mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiW2B2

    E3
    :L (1291K, 65.4mol%Ni-4.
    8
    mol%W-29.
    8
    mol%
    B
    )=
    Ni2B
    +
    Ni3B
    +
    NiW2B2

    P1:L (2115K, 23.
    8
    mol%Ni-43.1mol%W-33.1mol%
    B
    )+WB=
    W2B
    +
    NiW2B2

    P2:L (1657K, 48.
    9
    mol%Ni-33.1mol%W-18.
    0
    mol%
    B
    )+
    W2B
    =W+
    NiW2B2

    The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
  • Sook Kyoung Kim, Kyoung-Jin Shin, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
    Journal of Arrhythmia
    2011年 27 巻 Supplement 号 OP42_4
    発行日: 2011年
    公開日: 2012/03/14
    ジャーナル フリー
    Backgrounds: It has been reported that somatic mutations of mitochondrial DNA (mtDNA) is related with aging, or development of cardiovascular disease. We hypothesized that mtDNA4977 deletion mutation (4977-) detected from human blood contributes to atrial dysfunction in patients with
    AF
    . Methods: We studied for mtDNA4977- in 183 patients with non-valvular
    AF
    , (127 PAF, 56 PeAF) and 69 patients with healthy control. The detection of mtDNA4977- was determined by Gene Scan. Results: 1. The mtDNA4977- in
    AF
    patients were older than those without mutation (61.4±
    9
    .2 vs. 51.
    8
    ±
    9
    .
    9
    , p<
    0
    .0001). 2. Frequency of mtDNA4977- mutation in patients with
    AF
    ≤45 years old was not different to age matched control (
    7
    .3% vs. 11.6%, p=
    0
    .2371). 3. The mtDNA4977- had higher
    E
    /
    E
    , (11.3±4.
    8
    vs.
    9
    .1±3.1, p=
    0
    .0005), plasma levels of TIMP-1 (1.51±
    0
    .77 vs. 1.28±
    0
    .57 ng/mL, p=
    0
    .0210) and ANP (3.11±2.67 vs. 1.91±2.01 nmole/L, p=
    0
    .0010), and were more frequently taking statin (27.2% vs.
    22
    .4%, p=
    0
    .0055) than those without mutation. 4. 82.3% with mtDNA4977- and 85.
    5
    % without mtDNA4977- remain in sinus rhythm 12.
    7
    ±
    5
    .
    9
    months after RFCA (p=
    0
    .3008). Conclusion: mtDNA4977- was related with aging, diastolic dysfunction, serologic markers related with atrial remodeling or pressure overloading. Its frequency was not different to age matched patients with control, and did not affect the clinical outcome after RFCA.
  • 小田切 孝人, 田代 眞人
    ウイルス
    2013年 63 巻 2 号 233-240
    発行日: 2013/12/25
    公開日: 2014/10/31
    ジャーナル フリー
  • Yasuyuki Gono, Manabu Fujioka, Tamotsu Toriyama
    Journal of the Physical Society of Japan
    1970年 29 巻 2 号 255-258
    発行日: 1970/08/05
    公開日: 2007/06/01
    ジャーナル 認証あり
    The gamma-ray spectrum and the conversion-electron spectrum are measured in the decay of the Tb152 activity. The L-subshell electron lines of the 586.
    7
    keV
    22
    +→21+ transition are separated by the ion-free beta-ray spectrometer. The M1-
    E
    2 mixing ratio, δ2, and the dimensionless ratio X of
    E
    0
    -
    E
    2 mixing of the 586.
    7
    keV transition are obtained to be δ2
    0
    .16 and
    0
    .034≤X
    0
    .038, respectively. The
    E
    2 branching ratio
    B
    (
    E
    2;
    22
    +→
    0g
    +):
    B
    (
    E
    2;
    22
    +→21+):
    B
    (
    E
    2;
    22
    +→01+) is determined to be
    0
    .023 : 1.
    0
    :
    5
    .6.
  • Yukichi Yamaguchi, Jian-zhi Runan(Gen), Teruaki Nagahara
    Journal of the Physical Society of Japan
    1975年 38 巻 4 号 911-916
    発行日: 1975/04/15
    公開日: 2007/06/01
    ジャーナル 認証あり
    The gamma-ray spectrum and the conversion-electron spectrum are measured in the decay of the 116mIn activity. Directional correlations are also measured for 818–1293 and 1097–1293 keV cascades. The M1-
    E
    2 mixing ratio δ, and the
    E
    0
    -
    E
    2 mixing ratio μk are obtained for 818.
    7
    keV
    22
    +→21+ transition to be δ=1.52
    0.22
    +
    0.26
    , and μk≤6.1×10−4 respectively. The
    E
    2 branching ratio
    B
    (
    E
    2;
    22
    +→
    0g
    +):
    B
    (
    E
    2;
    22
    +→21+):
    B
    (
    E
    2;
    22
    +→01+) is determined to be
    0
    .0158:1.
    0
    :
    5
    .86.
  • Mitsunobu Ono, Masanobu Shindoh, Masanobu Kobayashi, Fumihiro Higashino, Takao Kohgo, Koichi Yoshida, Yasunori Totsuka
    Oral Medicine & Pathology
    2004年 9 巻 1 号 19-24
    発行日: 2004/03/25
    公開日: 2008/04/01
    ジャーナル フリー
    E
    1
    AF
    , an ets-oncogene family transcription factor, has been shown to upregulate transcription from matrix metalloproteinase (MMP) genes, which confers the invasive phenotype on cancer cells. On the other hand, we have demonstrated by luciferase assay that
    E
    1
    AF
    positively regulates transcription from the p21waf1/cip1 promoter. Ca
    9
    .
    22
    cells were transfected with a metallothionein-inducible
    E
    1
    AF
    expression vector (Ca
    9
    .
    22
    MTF) to investigate the relationship between invasive ability and cell cycle modulation caused by
    E
    1
    AF
    . MMP-
    9
    and p21waf1/cip1 protein were synergistically increased in the ZnCl2 stimulated CA
    9
    .
    22
    MTF cells, and both proteins were identified in the same cells when
    E
    1
    AF
    was induced. These results imply that invasive growth of tumor cells occurs in the static state of the cell cycle and that
    E
    1
    AF
    plays a key role in this phenomenon.
  • Takaaki ISHIZUKA, Yasunori YAOITA, Masao KIKUCHI
    Chemical and Pharmaceutical Bulletin
    1997年 45 巻 11 号 1756-1760
    発行日: 1997/11/15
    公開日: 2008/03/31
    ジャーナル フリー
    Four new sterols,
    , 6α-epoxy-(
    22
    E
    , 24R)-ergosta-
    8
    (14),
    22
    -diene-3β,
    -diol (1), (
    22
    E
    , 24R)-ergosta-
    8
    ,
    22
    -diene-3β,
    , 6β,
    -tetrol (2), (
    22
    E
    , 24R)-ergosta-
    7
    ,
    9
    (11),
    22
    -triene-3β,
    , 6β-triol (3) and 3β,
    , 6β-trihydroxy-(
    22
    E
    , 24R)-ergost-
    22
    -en-
    7
    -one (4), have been isolated from the fruit bodies of Grifola frondosa (FR.) S.
    F
    . GRAY (Polyporaceae)together with fourteen known ones (
    5
    -18), of which two (
    5
    and 6) are reported for the first time from a natural source. The structures of these compounds were elucidated on the basis of spectral data.
  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with
    7
    kinds of factors, as follows ; A^^〜=
    B
    +C+D+K+aE+bF+cG. A^^〜=estimated values of the readership score. 1)
    B
    , C, D, K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into
    7
    categories. C=pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories. D=kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2)
    E
    ,
    F
    , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into 6 kinds of area (2.
    5
    , 3.
    5
    ,
    5
    ,
    7
    , 10, 15) and 15 column means a whole page, about 2,000cm^2.
    E
    ,
    F
    are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement.
    F
    =the marks obtained on the whole effect of the design. 3) a,
    b
    , c : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+bF=A-(
    B
    +C+D+K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was 3,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is
    0
    .951. The table 2^* shows the contribution indexes of each factor by 3 kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, (3) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of
    E
    ,
    F
    .
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _1+
    E
    _2+
    E
    _3+
    E
    _4. design elements [table]
    E
    _1,
    E
    _2,
    E
    _3,
    E
    _4, these values have the
    5
    grades, as
    0
    , 1, 2, 3, 4 and
    0
    is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of
    0
    to
    9
    grades as the sum of them. The values of
    F
    have also
    5
    grades,
    0
    to 4. The principles to determine the values of
    E
    ,
    F
    are as follows : a) The marks obtained of
    E
    ,
    F
    must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. c) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    ,
    F
    values, as the table
    5
    -4, and
    5
    -
    5
    in the thesis in Japanese.
  • 大石 勉, 木村 規
    高分子論文集
    1976年 33 巻 11 号 685-691
    発行日: 1976/11/25
    公開日: 2010/02/26
    ジャーナル フリー
    N-n-ヘキシル-マレイミド (I), N-シクロヘキシル-マレイミド (II), N-ベンジル-マレイミド (III) の単独重合, 共重合をアゾビスイソブチロニトリル (IV) を開始剤としてテトラヒドロフラン中, 60℃で行った. 単独重合の初速度 (Rp) はRp=k [I]
    2.5
    [IV]
    0.80
    , Rp=>k [II]
    2.8
    [IV]
    0.80
    , Rp=>k [III]
    2.7
    [IV]
    0.54
    となった. kは速度定数である. 全重合の活性化エネルギー (
    E
    ), 頻度係数 (A) は
    E
    =
    22
    .
    8
    kcal/mol (I),
    22
    .2kcal/mol (II), 24.1kcal/mol (III), A=
    9
    .
    5
    ×1011 (I), 6.4×1011 (II), 6.6×1012 (III) となった. またN-置換マレイミドとメタクリル酸メチル (V) との共重合におけるモノマー反応性比r1, r2およびQ,
    e
    値を次のように決定した. I (M1) -V (M2) 系でr1=
    0
    .17, r2=2.02, Q1=
    0
    .56,
    e1
    =1.43, II (M1) -V (M2) 系でr1=
    0
    .13, r2=2.29, Q1=
    0
    .50,
    e1
    =1.50, III (M1) -V (M2) 系でr1=
    0
    .14, r2=1.54, Q1=
    0
    .79,
    e1
    =1.63となった.
  • Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE
    Agricultural and Biological Chemistry
    1988年 52 巻 12 号 3217-3218
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • Tariq
    F
    . Alghazzawi
    Journal of Prosthodontic Research
    2017年 61 巻 3 号 305-314
    発行日: 2017年
    公開日: 2017/09/12
    ジャーナル オープンアクセス

    Purpose: The purpose of this study was to determine if the optical properties of zirconia and glass–ceramic (

    e
    .max) were affected by low-temperature degradation (aging).

    Methods: Experiment samples were fabricated with seven zirconia brands (n=10): Zenostar, Zirlux, Katana, Bruxzir, DD-BioZX2, DD-cubeX2, NexxZr; and

    e
    .max were used as a control. This resulted in a total of
    80
    samples in the experiment. The L*, a* and
    b
    * were measured for each sample, and then the optical properties including translucency parameter (TP), contrast ratio (CR), and opalescence parameter (OP) were calculated. The samples were aged (20, 40, 60,
    80
    , 100h), and the optical properties were calculated after each interval.

    Results: Most zirconia brands had lower L*, higher a*, higher

    b
    * with increased aging, which visually corresponds to darker, redder, and more yellow. Aging also increased CR, lowered TP, and lowered OP.
    e
    .max was also affected by aging but still had the highest TP (23.
    9
    ±2.
    8
    ), L* (81.
    7
    ±3.4), and lowest CR (
    0
    .41±
    0
    .05) compared to any zirconia. The Zenostar had the closest TP (24.1±
    0
    .4), and L* (90.2±
    0
    .
    5
    ) values to
    e
    .max before aging. However, after 100h of aging, the DD-cubeX2 was least effected and had the highest TP (
    22
    .2±
    0
    .6) and lowest CR (
    0
    .43±
    0
    .01) compared with other zirconia samples and highest OP (11.3±
    0
    .2) of all ceramic samples.

    Conclusions: The optical properties of zirconia and

    e
    .max materials were affected by aging with the effects increasing with time. The magnitude of change was affected by seven brands of dental zirconia.

  • Keishi Hata, Fuyuki Sugawara, Naganori Ohisa, Saori Takahashi, Kazuyuki Hori
    Biological and Pharmaceutical Bulletin
    2002年 25 巻 8 号 1040-1044
    発行日: 2002年
    公開日: 2002/08/01
    ジャーナル フリー
    We screened the differentiation-inducing activities of 39 mushroom extracts from Akita prefecture, Japan, on the mouse osteoblastic cell line, MC3T3-
    E
    1. Sixteen phosphate buffered saline (PBS),
    8
    boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MC3T3-
    E
    1 cell differentiation. The enzyme activities were markedly induced by extracts of Tricholoma auratum, and we isolated the active compound from methanol extracts of this mushroom. Physical data for the isolated active compound were identical to those for (
    22E
    ,24R)-ergosta-
    7
    ,
    22
    -diene-3β,
    ,6β-triol (1). 1 induced ALP activities of MC3T3-
    E
    1 cells and promoted cell proliferation. To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MC3T3-
    E
    1 cells by 1, ergosterol (2), ergocalciferol (3), cholesta-3β,
    ,6β-triol (4),
    7
    -dehydrocholesterol (
    5
    ) and cholecalciferol (6) were tested. The enzyme activities of MC3T3-
    E
    1 cells were increased 3.
    0
    -fold by 10 μM 1 and 2.4-fold by 10 μM 4. However, 2, 3,
    5
    and 6 did not induce MC3T3-
    E
    1 cell ALP activity at
    0
    .1—10 μM. These results suggested that the OH groups at C-
    5
    and/or C-6 of 1 and 4 played an important role in their differentiation-inducing activities on MC3T3-
    E
    1 cells. Furthermore, 1 suppressed induction of MC3T3-
    E
    1 cell apoptosis by serum starvation.
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