To determine the position of the anteriorly displaced articular disc, we examined temporomandibular joints by magnetic resonance imaging (MRI) in 54 patients with unilateral temporomandibular joint dysfunction. MRI was done before conservative therapy in the occlusal and maximal open-mouth position. We drew a straight line connecting the lowest point of the articular eminence (point A) and the highest point of the external acoustic pore (point ) by tracing the sagittal view on MRI. On the standard A- line, points ', ', and D' were sought by dropping perpendicular lines from the deepest point of the glenoid fossa (point ), the highest point of the condylar head (point ), and the most posterior point of the articular disc (point D). We then determined the sagittal position of the articular disc in the glenoid fossa by measuring the distances ' and 'D' and sought the correlation between these distances and clinical findings. The results were as follows. 1. The distance ' in 33 patients with MRI-defined irreversible displacement of the disc was shorter than that in 10 patients with reversible displacement (3.±1.mm vs 6.±2.mm, p<.0001). In contrast, the distance 'D' in the former was longer than that in the latter (6.±1.mm vs 3.4±1.mm, P<.0001). Of 29 discs displaced anteriorly less than mm in distance 'D', 19 (66%) had reversible or no displacement. However, 23 (92%) of 25 discs displaced more than mm in distance 'D' had irreversible displacement. 2. Disc deformity and abnormal signal intensity bands in the condylar head closely correlated with distances ' and 'D'. In 17 patients without disc deformity, mean ' and 'D' distances were .± 2.mm and .2± 2.mm, respectively. In 19 and 18 patients with mild to moderate and severe deformity, the mean '('D') distances were .4±1.mm (4.±1.6mm) and 2.±1.mm (6.±1.mm), respectively. 3. Although distance ' and 'D' did not correlate with clinical symptoms, the degree of anterior disc displacement correlated with the therapeutic effect of conservative therapy. The mean ' distance (.3±3.mm) in 15 patients with a complete response to conservative therapy was longer than that (3.4±1.4mm) in patients with no improvement. These results indicate that the sagittal position of the articular disc can be determined by MRI and that successful conservative therapy is unlikely if anterior disc displacement extends beyond mm from the top of the condylar head, often resulting in irreversible displacement.

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Coronary arteries of 215 autopsied hearts with myocardial infarction (MI), were macroscopically examined by multiple cross sections, for sclerotic narrowing and thrombotic occlusion. Grade of the narrowing was estimated by scores i. . 1 for minimal, 2 for 25%, 3 for 50%, 4 for 75% and for complete occlusion. Entire epicardial course of the coronary arteries consisted of right coronary artery (R), left stem (LS), anterior descending artery () and circumflex branch (), was divided into 17 segments with equal length, and stenotic score was given to the maximal lesion for each segment proximal or distal to thrombosis as well as at just thrombotic site.
Fourty-six fresh thrombi were analysed for detection of the relationship between pre-existed sclerotic narrowing and thrombus formation. In general, the thrombosis occurred at just mildly stenotic site (.), sandwiched by modrate stenosis (2.) from both proximal and distal side. In male, the stenotic score at each branch proximal to thrombosis was (3.)> (3.6)>R (2.)>LS () and that distal to thrombosis was (3.3)> (3.2)>LS (2.)>R (2.1). In female, the stenotic score proximal to thrombosis was R (3.)> (3.2)> (1.), and that distal to thrombosis was R (4.1)> (3.)> (1.). The stenotic score was increasing with age in female, but not in male. Incidence of marked (4 or more in score), moderate (3), and mild (2 or less) pre-existed Stenosis related to thrombosis was 46%, %, and 32% respectively, in general. In male, marked stenosis was frequently seen in and , and in famale, marked one was in R.
The results indicated possibility that even mild atherosclerotic narrowing could provoke thrombosis in 1/3 cases with MI. Male predominancy for and LS lesion and female predominancy for R lesion could cause a quite sex difference on the types of MI and coronary thrombosis.

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Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL₂ and HDL₃ were estimated on the th, th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II, , -II, levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL₂ and HDL₃ were 15.±.mg/dl (mean±SD), 150.±58.1mg/dl 43.±.6mg/dl, 16.4±.mg/dl and 24.±6.3mg/dl respectively. Plasma apoprotein A-I, A-II, , -II and levels were 81.±. mg/dl, 15.1±.4mg/dl, 93.±36.mg/dl, 3.83±1.00mg/dl and 4.29±1.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL- (r=.348), HDL₂- (r=.612) and HDL₃ (r=.569). Apoprotein correlated with total cholesterol (TC) (r=.610), VLDL- (r=.341), LDL- (r=.726), HDL- (r=.432) and HDL₂- (r=.465). Apoprotein -II correlated with TC (r=.765), TG (r=.679), VLDL- (r=.651), LDL- (r=.461) and HDL₂- (r=.326). Apoprotein correlated with TC (r=.580), TG (r=.575) and VLDL- (r=.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=.468). Apoprotein correlated with apoprotein -II (r=.393). Apoprotein -II correlated with apoprotein (r=.393) and (r=.549). Apoprotein only correlated with apoprotein -II (r=.549).

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