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  • 黒川 美貴雄, 吉田 耕治, 永井 保嵩, 宇野 準
    Chemical and Pharmaceutical Bulletin
    1983年 31 巻 12 号 4312-4318
    発行日: 1983/12/25
    公開日: 2008/03/31
    ジャーナル フリー
    Two new partially saturated tricyclic ring systems,
    6
    ,
    6
    a,
    7
    ,
    8
    ,
    9
    , 10, 10a, 11-octahydro-11-oxodibenz [
    b
    ,
    e
    ] oxepins (3a and 3
    b
    ), and -thiepins (4a and 4
    b
    ) were synthesized. Compounds 4a and 4
    b
    were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10
    b
    ). Deuterated 4a and 4
    b
    (11a and 11
    b
    ) were prepared starting from butadiene-
    d6
    (12). The stereochemical features of 3a (trans), 3
    b
    (cis), 4a (trans) and 4
    b
    (cis) are compared with those of 10a, 10
    b
    , 11a and 11
    b
    on the basis of proton nuclear magnetic resonance data.
  • A.M. BRITTO, C. SAVVIDOU, M.J. GUNN, J.R. BOOKER
    土質工学会論文報告集
    1992年 32 巻 1 号 13-25
    発行日: 1992/03/15
    公開日: 2008/02/29
    ジャーナル フリー
    One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.
  • Joey
    B
    . Tanney, Leonard J. Hutchison
    Mycoscience
    2012年 53 巻 1 号 31-35
    発行日: 2012年
    公開日: 2023/03/31
    ジャーナル オープンアクセス

    The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–

    1
    ,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

  • 黒川 美貴雄, 糸川 彰, 松本 純一, 福本 吉久, 月原 冨武
    Chemical and Pharmaceutical Bulletin
    1992年 40 巻 9 号 2270-2274
    発行日: 1992/09/25
    公開日: 2008/03/31
    ジャーナル フリー
    11-Amino-
    6
    ,
    6
    a,
    7
    ,
    8
    ,
    9
    , 10, 10a, 11-octahydrodibebenzo[
    b
    ,
    e
    ]thiepines (
    6
    a-d) and -oxepines (
    7
    a-d) were synthesized by the Leuckart reaction of
    6
    ,
    6
    a,
    7
    ,
    8
    ,
    9
    , 10, 10a, 11-octahydro-11-oxodibenzo[
    b
    ,
    e
    ]thiepines (
    1
    a,
    b
    )and -oxepines (2a,
    b
    ) followed by hydrolysis of the reaction products 4a-d and 5a-d, respectively. The four diastereomers, cis(
    6
    a-H, 10a-H)-cis(10a-H, 11-H)
    6
    a and
    7
    a, cis(
    6
    a-H, 10a-H)-trans(10a-H, 11-H)
    6
    b
    and
    7
    b
    , trans(
    6
    a-H, 10a-H)-trans(10a-H, 11a-H)
    6
    c and
    7
    c, and trans(
    6
    a-H, 10a-H)-cis(10a-H, 11-H)
    6
    d and
    7
    d, were isolated and their configurations and conformations were elucidated by chemical methods together with
    1H
    -nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.
  • KENTARO YUGE, MASANOBU CHINAMI, MASAHISA SHINGU
    The Kurume Medical Journal
    1994年 41 巻 4 号 165-169
    発行日: 1994/12/27
    公開日: 2009/08/11
    ジャーナル フリー
    Using two direct introduction methods, DNA synthesis or cell proliferation activities of three purified proteins from
    E
    . coli, namely, human papillomavirus (HPV)
    E
    7
    proteins of type 16, a mutant type 16 (24 C-G) (transformation defective) and type
    6
    b
    , were measured in mouse fibroblast, C127 cells. By a microinjection method, the order of the cell mitotic indexes for the three
    E
    7
    proteins as determined by 5-bromo-2'-deoxy-uridine (BrdU) staining was type 16,
    6
    b
    and 16 (24 C-G). By the osmotic shock method, the 3H-TdR incorporation and coloration by (3-carboxymethoxy phenyl)-2-(4-sulfophenyl)-2H-tetolazorium (MTS) for the three proteins correlated with the pRb binding and focus forming activities previously reported (hunger et al. 1991). These results indicate that the simple osmotic shock method for direct protein introduction may be generally useful for transformation assays of oncoproteins.
  • M. L. GHOSH
    Journal of Physics of the Earth
    1972年 20 巻 2 号 165-186
    発行日: 1972年
    公開日: 2009/04/30
    ジャーナル フリー
    The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.
  • 和田 昭盛, 平石 佐栄子, 伊藤 允好
    Chemical and Pharmaceutical Bulletin
    1994年 42 巻 3 号 757-759
    発行日: 1994/03/15
    公開日: 2008/03/31
    ジャーナル フリー
    Stereoselective synthesis of
    7
    E
    ,
    9
    E
    - and
    7
    E
    ,
    9
    Z-β-ionylideneacetaldehydes was accomplished from the β-ionone tricarbonyl iron complex, and the latter was converted to
    9
    Z-retinoic acid.
  • 善 功企, /, 大山 巧, TAKUMI OHYAMA
    地盤工学会論文報告集
    1998年 38 巻 2 号 37-47
    発行日: 1998/06/15
    公開日: 2008/02/29
    ジャーナル フリー
    The mechanism of wave-induced instability in a permeable seabed have been studied for more than two decades. The distinction between shear failure and liquefaction, however, has not been clearly defined. This paper presents a fundamental study on the differences in two failure modes for a fully saturated seabed of both finite and infinite thickness. The wave-induced effective stresses and pore pressure, obtained from an analytical solution of Biot's pore-elastic consolidation theory, were employed to examine the failure modes under a two-dimensional plane strain condition. A case study is presented to examine the failure modes with respect to several parameters, such as excess pore pressure, seepage flow, seepage force, failure areas and stress path in the seabed. The conclusions obtained from this study were as follows ; (
    1
    ) the thickness of a permeable seabed affects the pore pressure and effective stress response to ocean waves and the failure mode of the seabed, (2) either a liquefaction or shear failure, or both, occur in the seabed, even in the saturated seabed, (3) the Mohr-Coulomb's failure criterion, when combined with elastic stresses, can not be employed to estimate the liquefaction failure in the seabed, (4) the liquefaction can be evaluated by a criterion in terms of the excess pore pressure, (5) The liquefied zone in the seabed is significantly different from the shear failure zone. The shape beneath the seabed surface for the former is almost identical to the contour where the upward seepage flow is concentrated.
  • 増大する資源
    E
    . F. Boswell
    紙パ技協誌
    1998年 52 巻 7 号 885-889
    発行日: 1998/07/01
    公開日: 2009/11/19
    ジャーナル フリー
    The world is in the midst of a huge fundamental shift in fibre supply, demand balances, and policy changes. Governments around the world are introducing policy changes which influence the supply demand balance as the politicians' thoughts are uttered. Government agencies and their bureaucrats are imposing changes on industry even before the legislation is passed by the government in question.
    This ad hoc change process will continue for a time to come until the countries in question show a tough-mindedness with regard to their land use policies. Policies affecting forest areas such as protection areas, Native land claims, the protection of biodiversity and a true goal of sustainable development ; which addresses the combined issues of cultural, environmental, social and economic matters.
    Eventually all of these difficult issues will reach essential closure. Then there will be great new opportunities for investment to meet the growing demand for forest products ; leading to a strengthening competitive position in the more traditional producing areas such as Canada.
  • 井合 進, 森田 年一, 亀岡 知弘, 松永 康男, 安彦 和之
    土質工学会論文報告集
    1995年 35 巻 1 号 115-131
    発行日: 1995/03/15
    公開日: 2008/02/29
    ジャーナル フリー
    In the 1993 Kushiro-oki Earthquake of Richter magnitude
    7
    .
    8
    , simultaneous recording of earthquake motions was successfully made at the ground surface and at a depth of 77 meters in a dense saturated sand deposit. The peak horizontal acceleration was
    0
    .47 g on the ground surface and
    0
    .21 g at a depth of 77 meters. The acceleration record at the ground surface showed a distinctive ground response, which consisted of a cyclic motion having a period of about
    1
    .5 seconds overlain by a spike at each peak of the motion. In order to study the mechanism of this peculiar ground response, effective stress analysis was conducted on the dense saturated sand deposit. The model used for this study was a strain space multiple mechanism model, which takes into account the effect of principal stress axis rotation. The recorded earthquake motion at a depth of 77 meters was used as the input earthquake motion for the analysis. Sampling after in-situ freezing was done in order to evaluate the properties of the sand. The results of the analysis indicated that the observed ground response was due to the effect of dilatancy of sand, which plays a significant role in the response of the dense saturated sand deposits during strong earthquake motions.
  • 香山 滉一郎, 森下 政夫, 張 国鋒
    粉体および粉末冶金
    2006年 53 巻 5 号 419-429
    発行日: 2006年
    公開日: 2006/12/19
    ジャーナル オープンアクセス
    The phase diagrams of the Ni-Mo-
    B
    and Ni-W-
    B
    ternary systems in the region of less than 50mol%
    B
    were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
    E1
    :L (1365K, 71.5mol%Ni-
    6
    .
    0
    mol%Mo-
    22
    .5mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiMo2B2

    E2
    :L (1355K, 62.5mol%Ni-2.5mol%Mo-30.5mol%
    B
    )=
    Ni3B
    +
    Ni2B
    +
    NiMo2B2

    E3
    :L (1445K, 42.
    0
    mol%Ni-30.
    6
    mol%Mo-10.3mol%
    B
    )=(Ni)+NiMo+
    NiMo2B2

    P1
    :L (1812K, 34.
    9
    mol%Ni-42.3mol%Mo-
    22
    .
    8
    mol%
    B
    )+MoB=
    Mo2B
    +
    NiMo2B2

    P2:L (1633K, 42.3mol%Ni-40.4mol%Mo-17.3mol%
    B
    )+Mo=
    Mo2B
    +
    NiMo2B2

    P3:L (1812K, 53.5mol%Ni-33.
    7
    mol%Mo-12.
    8
    mol%
    B
    )+Mo=NiMo+
    NiMo2B2

    E1
    :L (1622K, 51.
    0
    mol%Ni-31.
    6
    mol%W-17.4mol%
    B
    )=(Ni)+W+
    NiW2B2

    E2
    :L (1260K, 71.
    0
    mol%Ni-
    7
    .
    0
    mol%W-
    22
    .
    0
    mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiW2B2

    E3
    :L (1291K, 65.4mol%Ni-4.
    8
    mol%W-29.
    8
    mol%
    B
    )=
    Ni2B
    +
    Ni3B
    +
    NiW2B2

    P1
    :L (2115K, 23.
    8
    mol%Ni-43.
    1
    mol%W-33.
    1
    mol%
    B
    )+WB=
    W2B
    +
    NiW2B2

    P2:L (1657K, 48.
    9
    mol%Ni-33.
    1
    mol%W-18.
    0
    mol%
    B
    )+
    W2B
    =W+
    NiW2B2

    The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
  • 澁谷 啓, 三田地 利之, 黄 聖春
    地盤工学会論文報告集
    2000年 40 巻 3 号 87-100
    発行日: 2000/06/15
    公開日: 2008/02/29
    ジャーナル フリー
    Natural sedimentary clays exhibit ageing effects on their behaviour when subjected to both consolidation and shearing. Attempts to characterising the in-situ 'structure'of soft marine clays have been made in case studies performed in Ariake (Japan) and in Bangkok (Thailand), each showing a typical profile of aged clay-structure with depth reflecting its site-specific geological consolidation history. In each site, profiles of Atterberg limits, natural water content, overconsolidation ratio (OCR), quasi-elastic shear modulus Gmax and the undrained shear strength cu with depth were attained from various laboratory tests, together with the a comparable profile of quasi-elastic shear modulus from insitu seismic survey Gf. Quantitative assessment of the aged clay-structure was made by using two different measures, metastability index MI (G) and the soil constant reflecting structure S (Jamiolkowski et al., 1994). The profiles of MI (G) and the S-value with depth were both determined based on the corresponding Gmax behaviour of the reconstituted sample. "Disturbance"of laboratory samples retrieved by using two different samplers (i.
    e
    ., Laval and Japanese thin-walled samplers) with two different sampling techniques (i.
    e
    ., pre-boring and displacement methods) was discussed. A new approach to estimate cu"in the ground", termed by the authors the MILK (Metastability Index coupled with Laboratory Ko test) method, is proposed. A trial of the MILK-method is demonstrated in soft Bangkok clay, the texture of which is similar to "soft cheese".
  • ―特にアポ蛋白Eの変化について―
    本間 康彦, 三神 美和, 佐藤 美智子, 石原 仁一, 吉川 広, 木下 栄治, 田川 隆介, 星合 充基, 古屋 秀夫, 井出 満, 田辺 晃久, 玉地 寛光, 兼本 成斌, 友田 春夫, 中谷 矩章, 五島 雄一郎
    動脈硬化
    1984年 12 巻 3 号 599-603
    発行日: 1984/08/01
    公開日: 2011/09/21
    ジャーナル フリー
    Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL2 and HDL3 were estimated on the
    0
    th,
    7
    th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
    B
    , C-II,
    E
    levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL2 and HDL3 were 15.
    9
    ±
    7
    .5mg/dl (mean±SD), 150.
    9
    ±58.
    1
    mg/dl 43.
    8
    ±
    9
    .
    6
    mg/dl, 16.4±5.
    8
    mg/dl and 24.
    9
    ±
    6
    .3mg/dl respectively. Plasma apoprotein A-I, A-II,
    B
    , C-II and
    E
    levels were 81.
    7
    ±
    22
    .
    0
    mg/dl, 15.
    1
    ±5.4mg/dl,
    93
    .
    7
    ±36.
    0
    mg/dl, 3.83±
    1
    .00mg/dl and 4.29±
    1
    .36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-C (r=
    0
    .348), HDL2-C (r=
    0
    .612) and HDL3 (r=
    0
    .569). Apoprotein
    B
    correlated with total cholesterol (TC) (r=
    0
    .610), VLDL-C (r=
    0
    .341), LDL-C (r=
    0
    .726), HDL-C (r=
    0
    .432) and HDL2-C (r=
    0
    .465). Apoprotein C-II correlated with TC (r=
    0
    .765), TG (r=
    0
    .679), VLDL-C (r=
    0
    .651), LDL-C (r=
    0
    .461) and HDL2-C (r=
    0
    .326). Apoprotein
    E
    correlated with TC (r=
    0
    .580), TG (r=
    0
    .575) and VLDL-C (r=
    0
    .666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=
    0
    .468). Apoprotein
    B
    correlated with apoprotein C-II (r=
    0
    .393). Apoprotein C-II correlated with apoprotein
    B
    (r=
    0
    .393) and
    E
    (r=
    0
    .549). Apoprotein
    E
    only correlated with apoprotein C-II (r=
    0
    .549).
  • 石原 研而, 長尾 哲
    土質工学会論文報告集
    1983年 23 巻 1 号 19-37
    発行日: 1983/03/15
    公開日: 2008/02/29
    ジャーナル フリー
    Using the so-called pseudo-static method, a stability analysis was made for the mountain slide that took place at Mitake-iriya village at the time of the Izu-Ohshima-Kinkai earthquake of January 14, 1978. Undisturbed samples of volcanic clay were obtained in blocks from the exposed surface of the deposit identified to have been the sliding surface. The partially saturated clay samples were tested under consolidated undrained conditions using the triaxial test equipment. Dynamic axial stresses with irregular time histories were applied to the specimens in combination with statically sustained axial stresses to determine the soil strength under the conditions simulating in-situ states of stress during the earthquake. The results of the tests were expressed in terms of the Mohr-Coulomb type failure criterion which showed that, while the angle of internal friction remained almost unchanged, the cohesion component in irregular loading increased above values obtained in the static loading. Using the strength parameters thus determined, a pseudo-static analysis was made to check the stability of the soil masses that had actually slid during the 1978 earthquake. The maximum horizontal acceleration required to cause the slide was computed. The computed accelerations were shown to cover a range between 400 and 500 gals which is consistent with the range estimated by other investigators on the basis of overturning of tombstones in the vicinity of the slide area.
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • 和田 ちひろ
    日本小児外科学会雑誌
    2008年 44 巻 3 号 337-
    発行日: 2008/05/20
    公開日: 2017/01/01
    ジャーナル フリー
  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in
    95
    (
    22
    .2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-2 (
    22
    ), blaCTX-M-3 (16), blaCTX-M-
    1
    (15), blaOXA-
    1
    (
    9
    ) and blaSHV-12 (3) alone or in combination. The most frequently encountered phylogenetic group was group
    A1
    (35.
    8
    %), followed by group D2 (
    22
    .
    1
    %),
    B
    1
    (15.
    8
    %),
    D1
    (
    9
    .5%),
    A0
    (
    7
    .4%),
    B22
    (5.3%) and
    B23
    (4.2%), respectively. PMQR genes, aac(
    6
    ’)-Ib-cr,
    qnrS1
    and qnrB10 were detected in 25.3, 10.5 and
    1
    .
    1
    % of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.
    0
    % for tobramycin to 56.
    8
    % for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE, f17a-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

  • 村上 孝夫, 木村 毅, 和田 浩志, 田中 信寿, 斎木 保久, 陳 秋明
    Chemical and Pharmaceutical Bulletin
    1981年 29 巻 3 号 866-868
    発行日: 1981/03/25
    公開日: 2008/03/31
    ジャーナル フリー
    From the fronds of Polystichum tripteron (KUNZE) PR. a new norcarotenoid glycoside was isolated and shown to be (
    6
    R,
    7
    E
    ,
    9
    R)-
    9
    -hydroxy-megastigma-4,
    7
    -dien-3-one-
    9
    -O-β-D-glucoside. The fronds of Dennstaedtia wilfordii (MOORE) CHRIST. contain the same glucoside.
  • 金谷 守, 河井 正, 栃木 均
    地盤工学会論文報告集
    2001年 41 巻 6 号 79-96
    発行日: 2001/12/15
    公開日: 2008/02/29
    ジャーナル フリー
    In this paper, centrifuge shaking table tests were conducted in order to understand the performance of seawalls during a seismic event. The model tests showed that the displacement of the caisson was much affected by the seaward shear deformation of the sand seabed beneath it during shaking. It was also confirmed that an armored embankment played an important role in the displacement of the caisson during shaking. Based on these test results, a two-dimensional DEM-FEM coupled analysis method was newly developed to numerically predict the deformation of seawalls covered with armored embankments during earthquakes. The movements of the armor units were calculated by DE analysis and deformations of the caisson, rubble mound, sand seabed and backfill were calculated by FE analysis considering the non-linearity of the soil materials based on the effective stress. Dynamic interaction was taken into account by delivering the nodal displacements of the finite elements or the nodal forces converted from the contact forces through the imaginary distinct elements defined at the boundaries between the DE and FE domain. The applicability of this method to the prediction of the deformation of seawalls was verified through numerical simulations of the centrifuge model test.
  • 本城 勇介, 岩本 悟志, 杉本 三千雄, 鬼丸 貞友, 吉澤 睦博
    地盤工学会論文報告集
    1998年 38 巻 1 号 131-143
    発行日: 1998/03/15
    公開日: 2008/02/29
    ジャーナル フリー
    Seismic records obtained from a seismometer array located in downtown Tokyo Japan for about ten years were inversely analyzed to estimate the dynamic soil parameters. Due to the illposed nature of the problem, the simple and often used "least square method" does not properly estimate the parameters. The Extended Bayesian Method combined with the Akaike Bayesian Information Criterion was introduced to overcome this difficulty. The results obtained were compared with dynamic triaxial test results obtained at the time of the seismometer installation. The shear moduli agree quite well with the estimated results, however the damping ratios estimated are slightly higher than the ones obtained in the laboratory.
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