Two new partially saturated tricyclic ring systems, , a, , , , 10, 10a, 11-octahydro-11-oxodibenz [, ] oxepins (a and ), and -thiepins (a and ) were synthesized. Compounds a and were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10). Deuterated a and (11a and 11) were prepared starting from butadiene- (12). The stereochemical features of a (trans), (cis), a (trans) and (cis) are compared with those of 10a, 10, 11a and 11 on the basis of proton nuclear magnetic resonance data.

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11-Amino-, a, , , , 10, 10a, 11-octahydrodibebenzo[, ]thiepines (a-) and -oxepines (a-) were synthesized by the Leuckart reaction of , a, , , , 10, 10a, 11-octahydro-11-oxodibenzo[, ]thiepines (1a, )and -oxepines (2a, ) followed by hydrolysis of the reaction products a- and a-, respectively. The four diastereomers, cis(a-H, 10a-H)-cis(10a-H, 11-H) a and a, cis(a-H, 10a-H)-trans(10a-H, 11-H) and , trans(a-H, 10a-H)-trans(10a-H, 11a-H)c and c, and trans(a-H, 10a-H)-cis(10a-H, 11-H) and , were isolated and their configurations and conformations were elucidated by chemical methods together with ¹H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.

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Nアルキル,:,10-ペリレンテトラカルボン酸モノアンヒドリド=モノイミド[a～]と芳香族アミン(アニリン,p-トルイジン,p-アニシジン,,-キシリジン,-アミノナゾベンゼン,およびo-フェニレンジアミン)を縮合して非対称型,:,10-ペリレンビス(ジカルボキシミド)誘導体-N-アルキル-N'-アリール-,:,10-ペリレンビス(ジカルボキシミド)(〔a～〕,〔a～〕,〔a～〕,〔a～〕,〔a～〕,および〔10a～〕)を合成した. これらの各誘導体はすべて赤色系の色相を示し, 顔料試験の結果N-ブチル-N'-アリール-,:,10-ペリレンビス(ジカルボキシミド)(たとえば〔〕や〔〕)がとくにすぐれた耐光性を示した.

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The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.

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One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.

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From the fronds of Polystichum tripteron (KUNZE) P_R. a new norcarotenoid glycoside was isolated and shown to be (R, , R)--hydroxy-megastigma-, -dien--one--O-β--glucoside. The fronds of Dennstaedtia wilfordii (MOORE) CHRIST. contain the same glucoside.

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A boron treated copper bearing HSLA steel containing austenite formers like manganese and nickel, somewhat lower in amount than that in HSLA 100 variety of steel is chosen for the study. The role of thermomechanical processing on the microstructure and mechanical properties of the above steel has been investigated. Differential scanning calorimetric study is carried out for understanding the precipitation behaviour of copper in HSLA steel under the influence of boron. The microstructure of the experimental steel is found to consist of laths of martensites and bainite. MA constituents of ribbon like morphology are observed at the lath boundaries. Higher strength properties of the steel are attributed to the presence of finely distributed precipitates of copper and microalloy carbides.

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In order to elucidate the typhoid and paratyphoid phage type distributions in Japan, during the period of 1956-1965, a total of 1, 808 typhoid cases from 1, 002 foci and 114 paratyphoid cases from foci were submitted for phage typing of their infected organisms, and the following results were obtained.
1. The typhoid strains tested fell into at least 30 Vi-phage types. The sequence of frequency as counted by foci was as follows : types 2 (20%), M1 (13%), 1 (12%), A (.%), N+1 (.%), 1 (2.%), (2.%), 2 (2.%), 39 (1.%), H (1.1%), J1 and 46 (0.80%) ; C, L1 and 41 (0.50%) ; 1, , C, , 10, 2, , , L2, T, 28, 29, 36, 38 and 47 (less than 0.50%) . Distri-bution of typhoid Vi-phage types in Japan was characteristic of preponderance of types 2 and M1.
2. Of the foci studied, .% could not be assigned that their causative organisms belonged to any hitherto recognized Vi-phage type.
. The prevalent typhoid Vi-phage types, 2, M1, 1, A and N+1 were evenly encountered throughout the last ten years and distributed among almost throughout the country.
. Some of the rearly recognized typhoid Vi-phage types were indigenous to the relatively limited areas.
. Three new Vi-phage types, 39, 41 and 47 were identified.
. Paratyphoid phage types encountered were as follows: Types a (49%), 1 (33%), (.%), Dundee (2.%), aI (1.1%) and Beccles (1.1%) . The remainders could not he assigned to any known type.

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The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

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Two new polyacetylene compounds (, , 12)-1-acetoxy--isovaleryloxytetradeca-, , 12-trien-, 10-diyn-14-ol (), and (, , 12)-1-acetoxy--(2-methylbutyryloxy)tetradeca-, , 12-trien-, 10-diyn-14-ol (C) have been isolated along with (, , 12)-1-acetoxy--senecioyloxytetradeca-, , 12-trien-, 10-diyn-14-ol (A) from Atractylodes Rhizome (Karabyakujutu). The structures of these compounds were determined on the basis of their spectral data.

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2-Benzyl--chloro--mercapto- (2H)-pyridazinone (1) was heated in ethanol under reflux for 10 hours to form concurrently 2, -dibenzyldipyridazo [, - : ', '-]-1, -dithiin-1, (2H, H)-dione (Ia) (57% in yield) and 2, -dibenzyldipyridazo [, - : ', '-]-1, -dithiin-1, (2H, H)-dione (IIa) (14% in yield). Assignment of the two products to the corresponding structures is established by their physico-chemical constants and chemical behaviors. The concurrent formation of the dipyridazo [, - : ', '-]-1, -dithiin-1, (2H, H)-dione and the -1, (2H, H)-dione were observed in, not only heating -chloro--mercapto- (2H)-pyridazinones (1-) in polar solvent, but warming -mercapto--chloro- (2H)-pyridazinones (-) in the presence of potassium carbonate in DMF. For the interpretation of the reaction, keto-thioketo carbenes as active intermediate species and a reversible interconversion among them are suggested on the basis of the fact that there was nonexistence of an equilibrium between the two compounds, such as Ia and IIa, under the reaction condition and a trapping keto-thioketo carbene species as 2-phenylimino--benzylpyridazo [, -]-1, -dithiol- (H)-one (IVa) (14% in yield) along with the major products, (Ia) and (IIa), was furnished by warming 1 with phenylisothiocyanate in the presence of triethylamine in dry benzene. On the contrary, participation of a reversible interconversion between Ia and IIa, to a considerable extent, with the concurrent formation of them in the case of benzylation of either Ib or IIb, by warming with benzylchloride in the presence of potassium carbonate in DMF at 80°, might not be neglected, because an attempted approach to an equilibrium between Ia and IIa in a similar reaction condition except the use of benzylchloride realized, whereas non-existence of an equilibrium between Ib and IIb in the similar reaction condition was observed.

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This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

. coli isolates were detected in (.2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: bla_CTX-M-15 (62), blaTEM-

1b

(42), bla_CMY-2 (

22

), blaCTX-M-

3

(16), bla_CTX-M-1 (15), bla_OXA-1 (

9

) and bla_SHV-12 (

3

) alone or in combination. The most frequently encountered phylogenetic group was group A₁ (35.

8

%), followed by group

D₂

(

22

.1%),

B

1 (15.

8

%),

D₁

(

9

.

5

%), A₀ (

7

.

4

%),

B2₂

(

5

.

3

%) and

B2₃

(

4

.2%), respectively. PMQR genes, aac(

6

’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.

3

, 10.

5

and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.

8

% for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE, f17a-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing

E

. coli clone O25

b

:ST131/

B

2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing

E

. coli isolates among dogs in Turkey.

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Natural sedimentary clays exhibit ageing effects on their behaviour when subjected to both consolidation and shearing. Attempts to characterising the in-situ 'structure'of soft marine clays have been made in case studies performed in Ariake (Japan) and in Bangkok (Thailand), each showing a typical profile of aged clay-structure with depth reflecting its site-specific geological consolidation history. In each site, profiles of Atterberg limits, natural water content, overconsolidation ratio (OCR), quasi-elastic shear modulus G_max and the undrained shear strength c_u with depth were attained from various laboratory tests, together with the a comparable profile of quasi-elastic shear modulus from insitu seismic survey G_f. Quantitative assessment of the aged clay-structure was made by using two different measures, metastability index MI (G) and the soil constant reflecting structure S (Jamiolkowski et al., 1994). The profiles of MI (G) and the S-value with depth were both determined based on the corresponding G_max behaviour of the reconstituted sample. "Disturbance"of laboratory samples retrieved by using two different samplers (i.., Laval and Japanese thin-walled samplers) with two different sampling techniques (i.., pre-boring and displacement methods) was discussed. A new approach to estimate c_u"in the ground", termed by the authors the MILK (Metastability Index coupled with Laboratory K_o test) method, is proposed. A trial of the MILK-method is demonstrated in soft Bangkok clay, the texture of which is similar to "soft cheese".

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Thirty-six patients (19 males, 17 females: atypical schizophrenia; , typical schizophrenia; , depression; 11, neurosis and other psychiatric disorders; ) were operated on according to orbitoventromedial undercutting by Hirose. In all cases, the Rorschach test was carried out and daily behaviors were studied. Thirty-one scales of the test were subjected to multivariate analysis whereas the behaviors were evaluated according to the following criteria, i.., A: recovered or symptom free, : markedly improved, C: moderately improved, : slightly improved and : not improved. The following results were obtained.
1) The evaluation of behaviors is as follows. A: 12 cases, : , C: , : , : none.
2) It was found that scores of F+106% and R+106% scales were significantly higher after the operation than before; that correlation coefficients between the scores before and after the operation were considerably high.
) Factor analysis followed by varimax rotation was carried out. Six factors were extracted, i.., (F1) sensitivity to emotional stimuli, (F2) ego-strength, (F) obsessional rigidity, (F) reaction time, (F) anxiety and tension and (F) empathy. It was revealed that F2 was high in atypical schizophrenia, depression and neurosis, and that F2 and F were significantly different in terms of the factor scores among the four groups A, , C and ; F2 was highest in A, and lowest in regardless of whether it was before or after the operation. F showed high scores in both A and C, and low in .
) Multiple discriminant analysis was applied to the data of the Rorschach test before the operation, by classifying 36 subjects into the four groups A, , C and . As a result, high rates of correct diagnosis were obtained, i.., 100% for A, 78% for , 56% for C and 100% for . When the groups C and were combined into one group (C+) the highest percentage (100%) was seen in A, followed by (89%) and C+ group (%). When the groups A and were combined into one group (A+), the percentages of correct diagnosis were % for A+, and 93% for C+.
In conclusion, it can be said that scales of the Rorschach test have been proved to be valid for predicting mental and physical states after the orbito-ventromedial undercutting.

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The phase diagrams of the Ni-Mo- and Ni-W- ternary systems in the region of less than 50mol% were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
:L (1365K, 71.mol%Ni-.0mol%Mo-.mol%)=(Ni)++
:L (1355K, 62.mol%Ni-2.mol%Mo-30.mol%)=++
:L (1445K, 42.0mol%Ni-30.mol%Mo-10.mol%)=(Ni)+NiMo+
P₁:L (1812K, 34.mol%Ni-42.mol%Mo-.mol%)+MoB=+
P₂:L (1633K, 42.mol%Ni-40.mol%Mo-17.mol%)+Mo=+
:L (1812K, 53.mol%Ni-33.mol%Mo-12.mol%)+Mo=NiMo+
:L (1622K, 51.0mol%Ni-31.mol%W-17.mol%)=(Ni)+W+
:L (1260K, 71.0mol%Ni-.0mol%W-.0mol%)=(Ni)++
:L (1291K, 65.mol%Ni-.mol%W-29.mol%)=++
P₁:L (2115K, 23.mol%Ni-43.1mol%W-33.1mol%)+WB=+
P₂:L (1657K, 48.mol%Ni-33.1mol%W-18.0mol%)+=W+
The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.

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放牧牛において,prostaglandin F_2α(PGF_2α)とestradiol benzoate()の同時筋肉注射による発情同期化効果及び同期化された発情期における受胎性にっいて検討し,次の成績を得た。
1.放牧牛31頭(ホルスタイン種未経産牛)において,黄体期にPGF_2α15mgを筋肉注射(A群15頭)あるいはこれと同時に.mgを筋肉注射(群16頭)した結果,処置後31~96時間に発情が発現したものはA群では13頭(86.%),群では15頭(93.%)であり,両群の間には大差がなかった。しかし,発情はA群では処置後37~84時間に13頭 (86.%),群では31~60時間に14頭(.%)に集中して発現し,の併用によって発情発現までの時間は短縮した。
2.排卵は,A群では処置後73~120時間に13頭(86.%),群では61~96時間に14頭(.%)に起こり,の併用によって排卵の時期は処置後早期に,かつ短い時間帯に集中した。
.同期化された発情期に授精したA群の13頭中頭(53.%),群の16頭中頭(56.%)がそれぞれ受胎し,受胎率において両群の間に差異はなかった。
.以上の成績から,PGF_2αとを同時に併用筋肉注射することは,発情及び排卵の同期化に効果的であることを認めたが,この処置によって同期化された発情期の受胎性については,さらに多数例について検討する必要がある。

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