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  • 岩永 大気
    関西フランス語フランス文学
    2023年 29 巻 61-72
    発行日: 2023/03/31
    公開日: 2023/11/10
    ジャーナル フリー

     Conçue comme une négativité infinie et absolue, l’ironie déclenche une déstructuration sémantique et diégétique. Dans En attendant Godot de Beckett, la fonction de chaque discours et de chaque action est systématiquement réduite à une méta-action négative, par quoi on peut définir la notion d’attente. Cette perturbation qui détraque les discours et les actions opère à tous les niveaux de la pièce.C’est la méthode de(dé)construction fondamentale chez Beckett,qui consiste à injecter en permanence de l’ironie pour subvertir l’ordre des choses. La même démarche ironique avait été adoptée par les préromantiques pour surmonter une difficulté soulevée par la philosophie idéaliste,à savoir la division entre les phénomènes et les choses en soi.Marqué par l’influence profonde de la pensée de Schopenhauer,Beckett se place dans le sillage idéaliste des préromantiques,et leur emprunte leur méthode d’évocation de l’inexprimable par le recours à l’ironie.

  • CONSTANTINE A. STAMATOPOULOS, ELENI G. VELGAKI, SARADA K. SARMA
    地盤工学会論文報告集
    2000年 40 巻 6 号 61-75
    発行日: 2000/12/15
    公開日: 2008/02/29
    ジャーナル フリー
    The objective of this article is to propose and evaluate a sliding-block model to deal with very large displacements of slopes when a horizontal earthquake is applied. The slip surface consists of two inclinations on which full shear resistance is mobilized. Internal shearing exists along a sub-plane that intersects the angle between the two sub-planes that form the external slip surface. The ratio of the distance moved along the two external sub-planes depends on the inclination of the internal sub-plane. If there is a water table line, undrained conditions are assumed during motion and total stress analysis is performed. The governing equations of motion are formulated, analytical solutions are obtained for some cases, and back-analysis of four well-documented slides is performed.
  • HOE I. LING, DOV LESHCHINSKY
    土質工学会論文報告集
    1995年 35 巻 2 号 85-94
    発行日: 1995/06/15
    公開日: 2008/02/29
    ジャーナル フリー
    This paper is concerned with an extension of a rotational limit equilibrium method for determining the permanent displacements of slopes under seismic excitation. In the proposed procedure, the sliding mass is treated as a rigid rotating body defined by a log spiral trace. Permanent displacements are obtained by double-integration of the equation of motion in a manner similar to Newmark's translational sliding block method. The seismic slope stability analysis is based on the rotational (variational) limit equilibrium approach. This stability analysis was verified with dynamic experimental results obtained from centrifuge model testing. A series of parametric studies was conducted on"unstable"slopes, investigating the effects of soil properties and characteristics of excitation on the magnitude of permanent displacements. The higher the frictional angle, the smaller the permanent displacement of the slope is. Low excitation frequency yields larger slope displacement if the excitation is extended for the same time period of time. The effect of frequency becomes less distinct when a larger value of yield seismic coefficient is used. The proposed procedures produce a rational criterion to evaluate the seismic performance of simple slopes. This criterion is based on permanent displacement limit rather than factor of safety alone.
  • 汪 発武, 佐々 恭二, 福岡 浩
    地盤工学会論文報告集
    2000年 40 巻 1 号 35-46
    発行日: 2000/02/15
    公開日: 2008/02/29
    ジャーナル フリー
    By employing an undrained cyclic loading ring-shear apparatus, a series of tests to reproduce the dynamic behavior of the Nikawa landslide induced by the January 17, 1995 Hyogoken-Nambu earthquake, is conducted. The test sample is Osaka-group coarse sandy soil taken from the landslide. The initial stress condition acting on a soil element in the sliding surface is applied to the sample. Based on the seismic records monitored at the JR Takarazuka Station, the input seismic wave is synthesized to reproduce the seismic stress acting on the sliding surface. The test results show that the soil failed due to the dynamic loading of the earthquake. The most important results are the excess pore water pressure generation and the acceleration of shear displacement continuing after the main shock. Combined with the grain crushing at the shear zone and the volume reduction in the drained constant-speed ring-shear test, the mechanism of this landslide is interpreted as, shear displacement causing grain crushing in the shear zone and volume reduction, and then resulting in a localized liquefaction phenomenon, "sliding-surface liquefaction". This geotechnical simulation test provides a reasonable interpretation of this highly mobile landslide.
  • 齋藤 仁弘, 金子 和幸, 堀江 康夫, 小泉 寛恭, 大谷 一紀, 五十嵐 孝義, 塩田 陽二, 吉橋 和江, 廣瀬 英晴, 西山 實
    歯科材料・器械
    2001年 20 巻 2 号 124-130
    発行日: 2001/03/25
    公開日: 2018/08/06
    ジャーナル フリー
    フィラー含有量の多い歯冠用硬質レジン(高フィラー型硬質レジン)の4製品, エステニア(EE, ED), アートグラス(AE,
    AD
    ), ベルグラスHP(BE,
    BD
    ), グラディア(GE, GD)のそれぞれ2種類(エナメル用, デンチン用)について, それらの曲げ強さ, 曲げ弾性率, ヌープ硬さ, 吸水量および溶解量を測定した. 試験体の作製は, 製造者指示に従い, 測定結果はt-検定(危険率5%)で統計処理を行った. 曲げ強さは
    96
    .2〜210.
    6
    MPaを示し, エナメル用ではEE>BE>AE>GE, デンチン用では,
    BD
    ,ED>
    AD
    >GDの順に大きな値であった. 曲げ弾性率は
    6
    ,
    8
    〜24.
    6
    GPaを示し, エナメル用ではEE>AE, BE>GE, デンチン用では
    BD
    >ED>
    AD
    >GDの順に大きな値であった. ヌープ硬さは42.7〜163.
    8
    を示し, エナメル用ではEE>BE>AE, GE, デンチン用では
    BD
    >ED>
    AD
    , GDの順に大きな値であった. 吸水量は9.7〜28.1μg/mm3を示し, エナメル用ではGE>AE, BE>EE, デンチン用ではGD>
    AD
    >
    BD
    >EDの順に大きな値であった. 溶解量は0.2〜0.
    6
    μg/mm^3を示し, エナメル用およびデンチン用の両者で有意差は認められなかった. 以上の結果から, 高フィラー型硬質レジンは製品ごとの性質を理解した上で, 適切な症例や応用部位に用いるべきであることが示唆された.
  • Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE
    Agricultural and Biological Chemistry
    1988年 52 巻 12 号 3217-3218
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • 尾形 強, 佐藤 治代, 吉田 弘, 猪川 三郎
    日本化学会誌(化学と工業化学)
    1974年 1974 巻 2 号 382-385
    発行日: 1974/02/10
    公開日: 2011/05/30
    ジャーナル フリー
    The Beckmann rearrangement of aliphatic ketone oximes, R(CHs)C=NOH (R=Et (1); n-Pr (2); iso-Pr (3); iso-Bu (4)), with polyphosphoric acid (PPA), polyphosphate ester (PPE), and ester of phosphoric acid (2 P-5 R) was carried out and migratory ratios ((a)/(b) in eq. (1)) were determined, The results are shown in Fig.1, 2, and 3, respectively.
    In Fig.1 and 2, the migratory ratios decrease with reaction time and nearly approach to the ratios of anti-alkyl form/syn-alkylform in benzene(A1) or DMSO(A2)except for (3) (See Table 1). From this fact, it has been found that PPA and PPE are inactive for isomerization of the oximes andanti-alkyl oximes rearrange faster than syn-alkyl ones. ln the case of (3), migratery ratios are smaller than Ai or A2. As acetonitrile is detected by GLC, it is presumed that fission has been occurred simultaneously with rearrangement in anti-alkyl oxime (eq. (3)). In the case of 2 P-5 R, all modes of the reaction arethe same as in above, except that the rate of fission is tnuch faster than that in PPA and PPE.
    The reaction of anti-alkyl ketone oximes having a bulky grouphas been greatly influenced by the use of sterically demanding catalysts such asPPA, PPE, and 2 P-5 R.
  • 藤井 弘章, 国政 華菜, 難波 明代, 横溝 隆之, 西村 伸一, 島田 清, 堀 俊男, 西山 竜朗
    地盤工学会論文報告集
    2000年 40 巻 6 号 117-131
    発行日: 2000/12/15
    公開日: 2008/02/29
    ジャーナル フリー
    This study was performed to clarify which factors affected damage to tame-ike (small embankment dams for irrigation) in Hokudan Town as a result of the January 17, 1995 Hyogoken-Nambu earthquake. Factors were assumed to be : Location (
    e
    .g., Distance to Epicenter, etc.), Structure (
    e
    .g., Angle to Nearest Fault, Embankment Volume, etc.), Soil Properties of Embankment, Geology of Dam Site and History (Era of Construction, Repaired, etc.). Multivariate statistical analyses were performed for documentary data (damaged : 181, undamaged : 328). Ordinary statistical analyses were conducted for the data investigated in situ for soil properties of the embankment. The results show that the factors causing damage to dam are : (1) Nearest Fault (Nojima, Mizukoshi and D2), (2) Distance to Nearest Fault (less than 500 m), (3) Distance to Epicenter (approximately
    8
    to 14 km, which almost agrees with the location of seismic intensity 7 JMA), (4) Elevation of Dam Site (higher than 100 m), (5) Embankment Volume (the greater the volume the more damage was caused), (
    6
    ) Direction of Dam Axis (normal or diagonal to the epicenter or to nearest the fault), (7) Plan View of Dam Axis (3 or 4 axes), (
    8
    ) Surface Geology of Dam Site (non-cohesive soil type ground), (9) Era of Construction (prior to 1891) and (10) Soil Properties of Embankment (sand, not silty sand or gravel, penetration resistance that is 10% smaller than the undamaged dams).
  • 西村 聡, 東畑 郁生, 本多 剛
    地盤工学会論文報告集
    2002年 42 巻 4 号 89-98
    発行日: 2002/08/15
    公開日: 2008/02/29
    ジャーナル フリー
    The rate dependent nature of liquefied sand was investigated by laboratory shear tests. Since previous experience has revealed the many difficulties inherent in maintaining the state of liquefaction of a sandy specimen, new measures were attempted. The test results indicate that the measured shear stress consists of frictional and rate dependent components, and a viscosity coefficient was assessed from the latter component. The measured viscosity varies with the rate of strain as well as the magnitude of strain itself. A similar test on a dry specimen revealed less viscosity and implied that a major part of rate dependency comes from the behavior of pore liquid in the case of water-saturated sand. It was interesting, moreover, that sand with fines was of less viscosity. Finally, a numerical analysis was conducted on a real liquefaction-induced ground deformation and the results were consistent with the observation.
  • 松本 裕子, 森 政樹, 大月 哲也, 室井 一男, 畠 清彦, 小松 則夫, 小澤 敬也
    臨床血液
    2001年 42 巻 1 号 15-22
    発行日: 2001年
    公開日: 2009/07/28
    ジャーナル 認証あり
    急性骨髄性白血病(AML)の寛解導入療法において,海外の基礎および臨床研究では,IDRの有用性が数多く報告され,IDRとシタラビン(Ara-C)の組み合わせが治療戦略の主体となっている。われわれは1995年5月から1998年10月までの当科におけるIDRを寛解導入療法に用いた初発AML41例について,その臨床経過,寛解率,再発率,予後について検討した。その成績は当科での92年から95年に行った,寛解導入にDNRを用いたJALSG-AML92登録26例の成績とほぼ同等であった。なお前者では,従来予後良好因子とされているt(
    8
    ;21)(q
    22
    ;q
    22
    )を有する症例5例が全例再発し,IDRによる寛解導入療法ではこの染色体異常は予後を反映しないことが示唆されたが,CD56陽性など予後不良因子が加味していたことも疑われる。今後長期予後を期待するためには,寛解導入後の地固め療法をより強化することが必要と考えられた。
  • Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE, Kiyomi KOBAYASHI, Suguru TAKATSUTO
    Agricultural and Biological Chemistry
    1988年 52 巻 8 号 2117-2118
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • 西 好一, 金谷 守
    土質工学会論文報告集
    1990年 30 巻 2 号 43-59
    発行日: 1990/06/15
    公開日: 2008/02/29
    ジャーナル フリー
    In this paper, constitutive relations for expressing the inelastic behavior of sandy ground expected at the time of a strong earthquake are proposed. These constitutive relations are formulated by a yield function in terms of effective stress ratio and by a plastic potential function which is derived from the stress ratio-plastic strain incremental ratio defined as a function of accumulated volumetric strain. These constitutive relations employ Sekiguchi and Ohta's stress parameter to take account of the effects of rotation of principal stress axis on the deformation characteristics of sand. The Masing rule is modified in such a way that it can be used in the multi-dimensional stress field, and employed in the hardening function in order to express a hysteretic damping. Material constants contained in the proposed constitutive relations can be easily determined by the mechanical tests which are normally conducted in laboratory. The comparison between predicted behaviors by the constitutive relations and results of undrained cyclic shear tests shows that the dynamic strength-deformation characteristics of sand in a wide range of density can be simulated satisfactorily.
  • Sen-fang Sui, Erich Sackmann
    The Journal of Biochemistry
    1992年 111 巻 1 号 129-138
    発行日: 1992年
    公開日: 2008/11/18
    ジャーナル フリー
    In the first part of the present work the interaction of glycophorin with dimyristoylphosphatidylcholine (DMPC) is studied by freeze fracture electron microscopy, densitometry, calorimetry, and 90° static light scattering. An exothermic lipid/protein interaction energy of WP=190 kJ•mol-1 was found by application of the well known Van Laar relation for the displacement of the freezing point and the Gibbs-Duhem relationship. Secondly, the effects of Ca2+ on the lipid/protein interaction were studied. Following Ca2+ addition a remarkable decoupling of the interaction of the glycophorin head group with the bilayer surface was revealed by densitometry and gold-labeling electron microscopy. It is estimated that about 80% of lipid once disturbed by the adsorption of glycophorin head groups is decoupled after addition of Ca2+. Thirdly, the selective interaction of glycophorin with binary lipid mixtures was studied, including the mixtures of DMPC with dimyristoylphosphatidylserine (DMPS) and dilauroylphosphatidylcholine (DLPC), and the mixture of dipalmitoylphosphatidylcholine (DPPC) with DLPC.
  • 古藤 志保子, 池田 伸夫, 中村 文生, 猪谷 泰史, 古賀 貴美子, 古賀 政貴, 平川 智久, 野田 信之, 杉光 強, 藤田 博, 森信 俊平
    日本物理学会講演概要集
    1998年 53.2.1 巻
    発行日: 1998/09/05
    公開日: 2018/03/04
    会議録・要旨集 フリー
  • Takahito Maki, Masahito Sawahata, Daisuke Uta, Kazuhiro Irie, Toshiaki Kume
    Biological and Pharmaceutical Bulletin
    2023年 46 巻 2 号 359-363
    発行日: 2023/02/01
    公開日: 2023/02/01
    ジャーナル フリー HTML

    Amyloid β (Aβ) plays a key role in the pathology of Alzheimer’s disease (

    AD
    ) and is toxic owing to its ability to aggregate into oligomers and fibrils. Aβ has high aggregative ability and potent toxicity due to the “toxic turn” at positions
    22
    and 23. Furthermore, APP knock-in mice producing
    E
    22
    P-Aβ with the toxic turn exhibited
    AD
    -related phenotypes such as cognitive impairment, Aβ plaque accumulation, and tau hyperphosphorylation. In these mice, it is suggested that the activation of neuroinflammation and dysregulation of hypoxia-inducible factor (HIF) expression in the hippocampus contribute to the pathogenesis of
    AD
    -related phenotype. However, it remains unclear which cells are responsible for the dysregulation of HIF expression and the neuroinflammation which was induced by
    E
    22
    P-Aβ with the toxic turn. Here, we investigated the effects of chronic treatment with
    E
    22
    P-Aβ42 and lipopolysaccharides (LPS) on the inflammatory response in BV-2 microglia. Chronic treatment with
    E
    22
    P-Aβ42 and LPS increased nitric oxide production and the expression of interleukin-
    6
    (IL-
    6
    ), whereas it reduced the expression of HIF-1α and HIF-3α in BV-2 microglia. The reduction of HIF-1α caused by
    E
    22
    P-Aβ42 and LPS was milder than that caused by LPS. Furthermore, chronic treatment with
    E
    22
    P-Aβ42 and LPS increased the nuclear translocation of nuclear factor-kappaB (NF-κB).
    E
    22
    P-Aβ42 could enhance the inflammatory response of microglia with abnormal HIF signaling and contribute to the progression of
    AD
    pathology.

  • FRANÇOIS LE GOFFIC, MARIE-LOUISE CAPMAU, ERÉDÉRIC TANGY, ELIANE CAMINADE
    The Journal of Antibiotics
    1980年 33 巻 8 号 895-899
    発行日: 1980年
    公開日: 2006/04/12
    ジャーナル フリー
    (3H) Tobramycin was used as a probe to determine the relationship between the structure of aminoglycoside antibiotics and their ability to remove this drug from its higher affinity binding site on the ribosome. The dissacharide moieties (neamine, tobramine, gentamine) appeared to have a common binding site, whereas the kanosamine, garosamine and ribose moieties determined the specificity of this binding. Amikacin and butikacin behaved in an anomalous manner in spite of their close structural relationship to tobramycin.
  • *藤本 健資
    日本鉱物学会年会講演要旨集
    2005年 2005 巻 K7-P46
    発行日: 2005年
    公開日: 2006/09/08
    会議録・要旨集 フリー
     単斜晶Bi
    6
    Sr
    8
    -xCa3+xO
    22
    はBi-SrCa-Cu-O系2112超伝導相と共存することが知られているが、基本的な結晶化学的特性に未解明の点が多い.本研究は,この特性を明らかにすると同時に光触媒としての可能性を検討することを目的とする。 2122相と共存する単結晶Bi
    6
    Sr
    8
    -xCa3+xO
    22
    (P21/c; Z=2, a=1.1150(1)nm, b=0.5972(1)nm, c=1.9894(2)nm, β=101.51(1)゜)の単結晶構造解析をRigaku-RAPIDシステムを用いて行い,信頼度因子4.3%の構造モデルを得た. 現在Bi
    6
    Sr
    8
    -xCa3+xO
    22
    の酸化還元挙動の解明とともに,バンドギャップ測定を進めている.
  • *森元 陽子, 川原 幸一, 菊池 清志, 松山 孝司, 中島 結実子, 小薗(藤崎) 清香, 町頭 三保, 丸山 征郎, 和泉 雄一
    会議録・要旨集 フリー
  • 石原 研而, 安田 進, 吉田 喜忠
    土質工学会論文報告集
    1990年 30 巻 3 号 69-80
    発行日: 1990/09/15
    公開日: 2008/02/29
    ジャーナル フリー
    Failure modes of embankments or slopes consisting of saturated cohesionless soils during earthquakes may be classified into two types, the one involving a limited amount of permanent deformation such as settlements or lateral bulging on the order of tens of centimeter to meters, and the other in which complete slumping or flow of materials takes place through distances of tens of meters. Associated with seismic risk evaluation of embankments, there are many cases where the occurrence of limited deformation is tolerated but the flow type of failure is never permissible. In such a case, a methodology becomes necessary for evaluating the safety of embankments against the flow type of failure, once it occurs. Post-earthquake stability analysis in which the conventional analysis is made by employing residual strength or steady-state strength of soils is used for this purpose. However, accurate evaluation of in-situ residual strength is a difficult task particularly for cohesionless soils. Thus, it would appear useful if estimates of the residual strength can be made based on the back analysis of several embankments that have suffered the flow type failure during past earthquakes. In the present study, slope stability analyses were made for several earthquake-damaged embankments and tailings dams composed of silty sands or sandy silts to back-calculate the value of residual strength. The ground conditions at the failure sites were investigated by means of the Dutch cone penetration test or by the Swedish cone test. By comparing the values of the back-calculated residual strength with those of the cone resistance, empirical correlations between them are obtained which may be used in turn for the evaluation of residual strength of similar soils on other sites.
  • Nusret Acikgoz, Yelda Karincaoglu, Necip Ermis, Jülide Yagmur, Halil Atas, Ertugrul Kurtoglu, Mehmet Cansel, Irfan Barutcu, Hasan Pekdemir, Ramazan Özdemir
    The Tohoku Journal of Experimental Medicine
    2010年 221 巻 2 号 119-123
    発行日: 2010年
    公開日: 2010/05/18
    ジャーナル フリー
    The relationship between Behçet's disease (
    BD
    ) and platelet aggregation has not sufficiently been investigated yet. Mean platelet volume (MPV) is a marker of platelet function, and the increase in MPV has been identified as an independent risk factor of recurrent vascular events.
    BD
    is characterized by a relapsing vasculitis of the venous as well as arterial thrombosis. However, the precise pathogenic mechanisms underlying thrombotic tendency in
    BD
    are not known. We hypothesized that there might be an association between thrombotic complication and MPV in these patients. Therefore, we investigated activation of platelets in patients with
    BD
    using a simple marker, MPV, the most accurate measure of platelet size. A total of 60 patients with
    BD
    and 40 age- and gender-matched controls were included. The
    BD
    patients were divided into subgroups based on the presence (n =
    22
    ) or absence of thrombosis (n = 38) and clinically active (n = 30) or inactive (n = 30) state. MPV was higher in patients with
    BD
    than controls (
    8
    .14 ± 0.
    8
    vs. 7.48 ± 0.3 fl, p = 0.001). Among
    BD
    patients, MPV was larger in patients with thrombosis than those without thrombosis (
    8
    .45 ± 1.0 vs. 7.
    96
    ± 0.7 fl, p = 0.038). However, there was no significant difference in MPV between
    BD
    patients with active and inactive states. The increase in MPV is independent of the disease activity, and the presence of thrombosis is associated with higher MPV in
    BD
    patients. Therefore, antiplatelet therapy may be useful to prevent thrombotic complications in
    BD
    patients.
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