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  • 小田切 孝人, 田代 眞人
    ウイルス
    2013年 63 巻 2 号 233-240
    発行日: 2013/12/25
    公開日: 2014/10/31
    ジャーナル フリー
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in 95 (
    22
    .2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-2 (
    22
    ), blaCTX-M-
    3
    (16), blaCTX-M-
    1
    (15), blaOXA-
    1
    (
    9
    ) and blaSHV-12 (
    3
    ) alone or in combination. The most frequently encountered phylogenetic group was group
    A1
    (35.
    8
    %), followed by group
    D2
    (
    22
    .
    1
    %),
    B
    1
    (15.
    8
    %),
    D1
    (
    9
    .
    5
    %), A0 (
    7
    .
    4
    %),
    B22
    (
    5
    .
    3
    %) and
    B23
    (
    4
    .2%), respectively. PMQR genes, aac(
    6
    ’)-Ib-cr,
    qnrS1
    and qnrB10 were detected in 25.
    3
    , 10.
    5
    and
    1
    .
    1
    % of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.
    8
    % for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE,
    f17a
    -A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

  • Joey
    B
    . Tanney, Leonard J. Hutchison
    Mycoscience
    2012年 53 巻 1 号 31-35
    発行日: 2012年
    公開日: 2023/03/31
    ジャーナル オープンアクセス

    The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–

    1
    ,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

  • 山本 雅史, Abkenar Asad Asadi, 松本 亮司, 根角 博久, 吉田 俊雄, 國賀 武, 久保 達也, 冨永 茂人
    園芸学会雑誌
    2007年 76 巻 1 号 36-40
    発行日: 2007年
    公開日: 2007/03/06
    ジャーナル フリー
    カンキツ主要12種を用いて染色体のクロモマイシン
    A3
    (CMA) 染色を行った.染色体は CMA(+) バンドの有無および位置から
    7
    種類に区分できた.すなわち,CMA(+) を A: 両端および動原体近傍に有する,
    B
    : 一方の端部と動原体近傍に有する,C: 両端に有する,
    D
    : 一方の端部に有する,
    E
    : CMA(+) がない,
    F
    : 動原体近傍に有する,Dst: 付随染色体を有する
    D
    型,である.各種はこれらのうち 2~
    6
    種類の染色体を有し,独自の CMA バンドパターンを示した.C. medica では 2
    B
    +
    8
    D
    +
    8
    E
    C. limon では
    1
    B
    +
    1
    C +
    8
    D
    +
    8
    E
    C. aurantifolia では 2
    B
    +
    9
    D
    +
    7
    E
    C. aurantium では
    1
    A +
    1
    B
    +
    1
    C +
    7
    D
    +
    8
    E
    C. sinensis では 2
    B
    + 2C +
    7
    D
    +
    7
    E
    C. maxima では
    3
    A +
    3
    C +
    4
    D
    +
    8
    E
    C. paradisi では 2A +
    3
    C +
    6
    D
    +
    7
    E
    C. ichangensis では 2
    B
    + 2C + 12
    D
    + 2
    E
    C. latipes では 2A +
    5
    C +
    8
    D
    +
    3
    E
    C. micrantha では
    1
    B
    + 11
    D
    +
    4
    E
    + 2Dst,C. macroptera では 2
    B
    +
    1
    C + 11
    D
    +
    3
    E
    +
    1
    F
    C. hystrix では
    3
    B
    +
    1
    C +
    8
    D
    +
    3
    E
    + 2
    F
    +
    1
    Dst であった.
  • I.
    F
    . Davies
    Journal of Light & Visual Environment
    1984年 8 巻 1 号 1_9-1_20
    発行日: 1984年
    公開日: 2011/05/20
    ジャーナル フリー
  • M. K. Banerjee, P. S. Banerjee, S. Datta
    ISIJ International
    2001年 41 巻 3 号 257-261
    発行日: 2001/03/15
    公開日: 2007/05/31
    ジャーナル フリー
    A boron treated copper bearing HSLA steel containing austenite formers like manganese and nickel, somewhat lower in amount than that in HSLA 100 variety of steel is chosen for the study. The role of thermomechanical processing on the microstructure and mechanical properties of the above steel has been investigated. Differential scanning calorimetric study is carried out for understanding the precipitation behaviour of copper in HSLA steel under the influence of boron. The microstructure of the experimental steel is found to consist of laths of martensites and bainite. MA constituents of ribbon like morphology are observed at the lath boundaries. Higher strength properties of the steel are attributed to the presence of finely distributed precipitates of copper and microalloy carbides.
  • M. L. GHOSH
    Journal of Physics of the Earth
    1972年 20 巻 2 号 165-186
    発行日: 1972年
    公開日: 2009/04/30
    ジャーナル フリー
    The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.
  • 黒川 美貴雄, 吉田 耕治, 永井 保嵩, 宇野 準
    Chemical and Pharmaceutical Bulletin
    1983年 31 巻 12 号 4312-4318
    発行日: 1983/12/25
    公開日: 2008/03/31
    ジャーナル フリー
    Two new partially saturated tricyclic ring systems,
    6
    ,
    6
    a,
    7
    ,
    8
    ,
    9
    , 10, 10a, 11-octahydro-11-oxodibenz [
    b
    ,
    e
    ] oxepins (
    3
    a and
    3
    b
    ), and -thiepins (
    4
    a and
    4
    b
    ) were synthesized. Compounds
    4
    a and
    4
    b
    were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10
    b
    ). Deuterated
    4
    a and
    4
    b
    (11a and 11
    b
    ) were prepared starting from butadiene-
    d6
    (12). The stereochemical features of
    3
    a (trans),
    3
    b
    (cis),
    4
    a (trans) and
    4
    b
    (cis) are compared with those of 10a, 10
    b
    , 11a and 11
    b
    on the basis of proton nuclear magnetic resonance data.
  • 香山 滉一郎, 森下 政夫, 張 国鋒
    粉体および粉末冶金
    2006年 53 巻 5 号 419-429
    発行日: 2006年
    公開日: 2006/12/19
    ジャーナル オープンアクセス
    The phase diagrams of the Ni-Mo-
    B
    and Ni-W-
    B
    ternary systems in the region of less than 50mol%
    B
    were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
    E1
    :L (1365K, 71.
    5
    mol%Ni-
    6
    .0mol%Mo-
    22
    .
    5
    mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiMo2B2

    E2
    :L (1355K, 62.
    5
    mol%Ni-2.
    5
    mol%Mo-30.
    5
    mol%
    B
    )=
    Ni3B
    +
    Ni2B
    +
    NiMo2B2

    E3
    :L (1445K, 42.0mol%Ni-30.
    6
    mol%Mo-10.
    3
    mol%
    B
    )=(Ni)+NiMo+
    NiMo2B2

    P1
    :L (1812K, 34.
    9
    mol%Ni-42.
    3
    mol%Mo-
    22
    .
    8
    mol%
    B
    )+MoB=
    Mo2B
    +
    NiMo2B2

    P2:L (1633K, 42.
    3
    mol%Ni-40.
    4
    mol%Mo-17.
    3
    mol%
    B
    )+Mo=
    Mo2B
    +
    NiMo2B2

    P3
    :L (1812K, 53.
    5
    mol%Ni-33.
    7
    mol%Mo-12.
    8
    mol%
    B
    )+Mo=NiMo+
    NiMo2B2

    E1
    :L (1622K, 51.0mol%Ni-31.
    6
    mol%W-17.
    4
    mol%
    B
    )=(Ni)+W+
    NiW2B2

    E2
    :L (1260K, 71.0mol%Ni-
    7
    .0mol%W-
    22
    .0mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiW2B2

    E3
    :L (1291K, 65.
    4
    mol%Ni-
    4
    .
    8
    mol%W-29.
    8
    mol%
    B
    )=
    Ni2B
    +
    Ni3B
    +
    NiW2B2

    P1
    :L (2115K, 23.
    8
    mol%Ni-43.
    1
    mol%W-33.
    1
    mol%
    B
    )+WB=
    W2B
    +
    NiW2B2

    P2:L (1657K, 48.
    9
    mol%Ni-33.
    1
    mol%W-18.0mol%
    B
    )+
    W2B
    =W+
    NiW2B2

    The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [
    1
    ] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with
    7
    kinds of factors, as follows ; A^^〜=
    B
    +C+
    D
    +K+aE+bF+cG. A^^〜=estimated values of the readership score.
    1
    )
    B
    , C,
    D
    , K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into
    7
    categories. C=pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories.
    D
    =kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2)
    E
    ,
    F
    , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into
    6
    kinds of area (2.
    5
    ,
    3
    .
    5
    ,
    5
    ,
    7
    , 10, 15) and 15 column means a whole page, about 2,000cm^2.
    E
    ,
    F
    are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement.
    F
    =the marks obtained on the whole effect of the design.
    3
    ) a,
    b
    , c : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+bF=A-(
    B
    +C+
    D
    +K+cG). In this research, I used
    1
    ,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was
    3
    ,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table 2^* shows the contribution indexes of each factor by
    3
    kinds of expression-(
    1
    ) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, (
    3
    ) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of
    E
    ,
    F
    .
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _
    1
    +
    E
    _2+
    E
    _
    3
    +
    E
    _
    4
    . design elements [table]
    E
    _
    1
    ,
    E
    _2,
    E
    _
    3
    ,
    E
    _
    4
    , these values have the
    5
    grades, as 0,
    1
    , 2,
    3
    ,
    4
    and 0 is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of 0 to
    9
    grades as the sum of them. The values of
    F
    have also
    5
    grades, 0 to
    4
    . The principles to determine the values of
    E
    ,
    F
    are as follows : a) The marks obtained of
    E
    ,
    F
    must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. c) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    ,
    F
    values, as the table
    5
    -
    4
    , and
    5
    -
    5
    in the thesis in Japanese.
  • 増大する資源
    E
    .
    F
    . Boswell
    紙パ技協誌
    1998年 52 巻 7 号 885-889
    発行日: 1998/07/01
    公開日: 2009/11/19
    ジャーナル フリー
    The world is in the midst of a huge fundamental shift in fibre supply, demand balances, and policy changes. Governments around the world are introducing policy changes which influence the supply demand balance as the politicians' thoughts are uttered. Government agencies and their bureaucrats are imposing changes on industry even before the legislation is passed by the government in question.
    This ad hoc change process will continue for a time to come until the countries in question show a tough-mindedness with regard to their land use policies. Policies affecting forest areas such as protection areas, Native land claims, the protection of biodiversity and a true goal of sustainable development ; which addresses the combined issues of cultural, environmental, social and economic matters.
    Eventually all of these difficult issues will reach essential closure. Then there will be great new opportunities for investment to meet the growing demand for forest products ; leading to a strengthening competitive position in the more traditional producing areas such as Canada.
  • Takeshi ITABASHI, Nobuko OGASAWARA, Koohei NOZAWA, Ken-ichi KAWAI
    Chemical and Pharmaceutical Bulletin
    1996年 44 巻 12 号 2213-2217
    発行日: 1996/12/15
    公開日: 2008/03/31
    ジャーナル フリー
    Three new azaphilone derivatives designated falconensins
    E
    5
    (
    5
    ),
    F
    (
    6
    ), and G (
    7
    ) were isolated from the mycelium o Emericella falconensis, along with falconensins A (
    1
    ),
    B
    (2), C (
    3
    ),
    D
    (
    4
    ), and H (
    8
    ), and three hopane-type triterpenes, zeorin (
    9
    ), hepane-
    ,
    22
    -diol (10), and hopane-
    ,
    ,
    22
    -triol (11). The structures of
    5
    -
    7
    were confirmed by spectroscopic investigation and chemical correlations. The absolute stereochemistry of falconensins A (
    1
    ) to G(
    7
    ) was also established.
  • 小林 優, 神田 扶由子, S. M.
    D
    . Kumar, Ch. V. Lakshmana Rao,
    D
    . Srinivasa Rao,
    D
    . Venkata Rao, C. Bheemasankara Rao
    天然有機化合物討論会講演要旨集
    1990年 32 巻 20
    発行日: 1990/09/25
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Melithasterols A-
    D
    (
    1
    -
    4
    ), isolated from a gorgoinan coral Melithaea ocracea of Okinawa, were shown to be cholestane-, 24-methyl-
    22
    -dehydrocholestane-,
    22
    -dehydrocholestane-, and 24-methylenecholestane-derivatives. respectively, having a common
    3
    β,
    7
    α -dihydroxy-
    5
    α,
    6
    α-epoxy-Δ^
    8
    steroid nucleus. This was confirmed by direct comparison with the authentic sample prepared by lead tetra-acetate oxydation of cholest-
    6
    -ene-
    3
    β,
    5
    α,
    8
    α-triol
    3
    -monoacetate. Twelve new polyhydroxysterols were isolated from an Alcyonium sp. (
    7
    ,
    8
    ,
    9
    ), and Sclerophytum sp. (14,16,19
    b
    ,20,21,
    22
    a,23,26,28) soft corals collected off the coasts of the Andaman and Nicobar Islands in the Indian Ocean. All the Sclerophytum sp. soft corals contained 17a or its 25-deacetyl derivative. Compounds
    7
    to
    9
    were identified as 24-methylenecholest-
    5
    -ene-
    3
    β, 16β-diol-
    3
    -0-α-L fucoside (
    7
    ) and its
    7
    β-(
    8
    ) and
    7
    α-hydroxy (
    9
    ) derivatives. Compound 14 was shown to be 24S-24-methylcholest-
    5
    -ene-
    3
    β,25ξ,26-triol and was correlated to the known compound 15 by
    5
    α,
    6
    β-glycolation. Compound 16 was shown to be
    5
    β,
    6
    α-isomer of 17
    b
    , correlating to 17
    b
    by PCC oxidation followed by dehydration. Compound 19
    b
    was identified with 25-deacetyl derivative of the known compound lobosterol (19a) by hydrolysis of authentic lobosterol. Compounds 20 and 21 were shown to be
    7
    -dehydro-(20) and
    22
    E
    -dehydro-(21) derivative of 17a and 17
    b
    , respectively, by comparisons of their spectral data with reference compounds. Compounds
    22
    a and 23 were 24S-methylcholestane-
    3
    β,
    5
    α 25-triol-
    6
    -one 25-monoacetate (
    22
    a) and its 25-deacetoxyl derivative (23). Partial PCC oxidation of 17a afforded
    22
    a. Compounds 26 (andamansterol) and 28 (nicobarsterol) were shown to be gorgost-
    5
    -ene-
    3
    β,
    9
    α. 11α, 21-tetrol and novel secosteroid, 11,21-cyclo-
    B
    -homo-11-oxa-
    9
    , 11-secoergostane-
    3
    β,
    6
    α, 12ξ-triol-
    9
    -one, respectively, by spectral analyses (H-HCOSY, HMQC, HMBC).
  • Yanchun Peng, Zitong Yu, Shahidul Islam, Yujuan Zhang, Xiaolong Wang, Zhensheng Lei, Kan Yu, Dongfa Sun, Wujun Ma
    Breeding Science
    2016年 66 巻 4 号 646-652
    発行日: 2016年
    公開日: 2016/09/30
    [早期公開] 公開日: 2016/08/11
    ジャーナル フリー HTML
    電子付録

    Low molecular weight glutenin subunits are important components of wheat storage proteins, which play an important role in determining end-use quality of common wheat. A newly established matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) procedure was used to analyze 478 landraces of bread wheat collected from the Yangtze-River region in China. Results indicated that 17 alleles at three loci: Glu-

    A3
    , Glu-
    B3
    and Glu-
    D3
    were identified, resulting in 87 different allele combinations. Of the 17 alleles detected at all the Glu-
    3
    loci, five belonged to Glu-
    A3
    , seven to Glu-
    B3
    and five to Glu-
    D3
    locus. MALDI-TOF-MS indicated Glu-A
    3
    a/c
    was present in 72.
    8
    %, Glu-
    A3b
    in
    8
    .
    4
    %, Glu-
    A3d
    in
    8
    .
    4
    %, Glu-
    A3f
    in
    5
    .2% and Glu-
    A3e
    in
    3
    .
    6
    % lines. Seven types of alleles were identified at the Glu-
    B3
    locus: Glu-
    B
    3
    d
    /i
    (25.
    5
    %), Glu-
    B3b
    (21.
    3
    %), Glu-
    B3c
    (16.
    9
    %), Glu-
    B3h
    (13.
    8
    %), Glu-
    B3f
    (
    8
    .
    4
    %), Glu-
    B3a
    (
    8
    .2%), and Glu-
    B3g
    (
    5
    .2%). Five types of Glu-
    D3
    alleles were detected: Glu-
    D3a
    (58.
    4
    %), Glu-
    D3c
    (
    22
    .
    6
    %), Glu-
    D3d
    (15.
    5
    %), Glu-
    D3b
    (
    3
    .
    3
    %) and Glu-
    D3f
    (0.2%). Four new alleles that showed abnormal MALDI-TOF spectrum patterns were identified at the Glu-
    A3
    and Glu-
    B3
    loci. A detailed study is needed to further characterize these alleles and their potential usage for wheat improvement.

  • 矢原 正治, 西依 健, 江田 昭英, 野原 稔弘, 西岡 五夫
    Chemical and Pharmaceutical Bulletin
    1991年 39 巻 8 号 2024-2036
    発行日: 1991/08/25
    公開日: 2008/03/31
    ジャーナル フリー
    A chemical examination of Magnoliae Cortex produced in China (Magnolia officinalis REHD. et WIL S., Magnoliaceae) has led to the isolation of eighteen new lignans and related compounds [four monoterpenyl-lignans : piperitylmagnolol (
    3
    ), dipiperitylmagnolol (
    4
    ), piperitylhonokiol (
    5
    ) and bornylmagnolol (
    6
    ); seven lignans : magnaldehydes
    B
    (
    8
    ), C(
    9
    ), magnolignans A(10),
    B
    (11), C(12),
    D
    (13) and
    E
    (14); three norlignans : magnatriol
    B
    (16), magnaldehydes
    D
    (17) and
    E
    (18); and four dilignans : magnolignans
    F
    (19), G(20), H(21) and I(
    22
    )], together with randainal (
    7
    ), randaiol (15), sinapic aldehyde, syringaresinol, syringaresinol
    4
    '-O-β-
    D
    -glucopyranoside and
    6
    '-O-methylhonokiol. Their structures were determined by the chemical and spectral methods.
  • 板倉 智敏, 五藤 精知, 藤原 義昭
    日本獸醫學雜誌(The Japanese Journal of Veterinary Science)
    1973年 35 巻 4 号 289-297_5
    発行日: 1973/08/25
    公開日: 2008/02/13
    ジャーナル フリー
    All the birds examined were also associated with bone dysplasia (art alczaormal develop-ment of bone tissue) in the diaphyseal cortex of the leg bones, especially of bones affectedwith dyschondroplasia. This result is very significant in order to clarifyz tlais disease entity.1970:J14, k -
    1
    }
    7
    )
    7
    , M77 ) i? ht /, ( K )
    7
    (C # L"C, MB @ (
    7
    ) t, If!TB& U "C, Jff Dyschondroplasia (
    1
    *t%
    7
    fi!dW) ().g:#
    f
    [!:.fLlt! K?
    3
    o, [
    1
    : (
    7
    )M;tC, rff.?U/:cD
    8
    , bb=
    1
    lC#li
    6
    *H(DX15RI!!
    D
    & t, r, ccl)Efff
    7
    flr.#.??t"ut:2.?T<
    3
    .
    1
    .?l?
    F
    ?/?t:>"A??
    1
    !? >
    E
    >?TMOll?, lI]%G (
    f
    -srRM) -ts;
    5
    ;
    e
    .*BI) *M[t fL 54
    5
    t:.;*.{
    1
    *I[l?(), t@Yllll*fJ?H@(
    7
    ) %?Jfipj@ (Dyschondroplasia) p, }, (,
    1
    lTi{-X, WIKIM itt{
    b
    =
    b
    t
    D
    "tl%tff{tO 1111IH(-UP!z
    8
    U-ii) >ES- -)%Wi*fd?
    1
    J*[lEj: >11"i
    6
    ifI".*"H*Tl*&Z") #)/2?-"k l
    E
    B
    - vich ) J&it(Vh
    3
    iO"= >If-ffi"!
    1
    lYl*I
    4
    ")Ji/l![40111!>
    D
    9
    *
    F
    !)<Y14M)?A"!>CL(Il], k
    7
    .Cl
    8
    T"ltTt*flB
    1
    ? & $
    4
    U [-" C U" L % w, Zl
    1
    *.IlBl tI
    1
    J, FA(y L-x") LVfAK t: >
    3
    llltPJ
    4
    IiI " } ) t- ! Al j: >kP11liR
    6
    , &ffl(C
    5
    NWi Z
    3
    lk(C#L" Ct ?
    f
    !
    4
    M2"C- fL#, -()%
    E
    .IWMd
    1
    .XI
    1
    *I
    1
    EPW(tit ff
    1
    lR)
  • 廣谷 正男, 金子 麻美, 廣谷 聖子, 浅田 善久, 吉川 孝文
    天然有機化合物討論会講演要旨集
    2000年 42 巻 48/P-13
    発行日: 2000/10/01
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Agaricus blazei is an important fungus for producing bioactive compounds. There are some reports of polysaccharides and steroid derivatives from the fruiting bodies of A. blazei. However, the chemical examination of the secondary metabolites of the cultured mycelia of this species has not been reported. Eight compounds, an unprecedented skeleton have been isolated from the cultured mycelia of A. blazei. The structures of the novel compounds each named blazeispirols A (
    1
    ),
    B
    (2), C (
    3
    ),
    D
    (
    4
    ),
    E
    (
    5
    ) X(
    6
    ), Y (
    7
    ) and Z (
    8
    ) were confirmed by extensive
    1
    D
    and 2
    D
    NMR spectral data and X-ray analysis. Blazeispirols A (
    1
    ),
    B
    (2), C (
    3
    ),
    D
    (
    4
    ) and
    E
    (
    5
    ) were des-A-ergostane type compounds having spiroacetal structure as a side chain. Blazeispirols X (
    6
    ) and Y (
    7
    ) were determined to be (20S,
    22
    S, 23R, 24S)-
    1
    (10→
    6
    ) abeo-14β,
    22
    :
    22
    , 25-diepoxyergosta-
    5
    ,
    7
    ,
    9
    ,11-tetraene-
    3
    α,23-diol and (20S,
    22
    S, 23R, 24S)-14β,
    22
    :
    22
    ,25-diepoxy-
    9
    ,23-dihydroxyergosta-
    4
    ,
    7
    ,11-triene-
    3
    ,
    6
    -dione by comparison of extensive
    1
    D
    and 2
    D
    NMR spectral data with that of blazeispirol A. The biosynthesis of blazeispirol A was investigated by feeding ^<13>C-labeled acetates and methionine to the growing cultures of A. blazei. The labeling patterns of
    1
    derived from singly and doubly ^<13>C-labeled acetates were consistent with that of ergosterol reported previously except for the A-ring and then ^<14>C-labeled ergosterol was incorporated into blazeispirol A. Taking the structures of blazeispirols Z and
    D
    into consideration, it can be assumed that blazeispirol A is biosynthesized from ergosterol by the cleavage of C-
    4
    , C-
    5
    and C-
    1
    , C-10 bonds on retro aldol condensation and Michael reaction via such as intermediate A as shown in Fig.
    4
    . A large number of ergostane-type steroids have been isolated from many fungi. However, blazeispirol A is the first example of a naturally occurring des-A-ergostane-type steroid including a spiroacetal structure moiety as a side chain.
  • 橋口 英俊
    日本医科大学雑誌
    1983年 50 巻 4 号 563-585
    発行日: 1983/08/15
    公開日: 2009/12/04
    ジャーナル フリー
    Thirty-six patients (19 males, 17 females: atypical schizophrenia;
    3
    , typical schizophrenia;
    9
    , depression; 11, neurosis and other psychiatric disorders;
    8
    ) were operated on according to orbitoventromedial undercutting by Hirose. In all cases, the Rorschach test was carried out and daily behaviors were studied. Thirty-one scales of the test were subjected to multivariate analysis whereas the behaviors were evaluated according to the following criteria, i.
    e
    ., A: recovered or symptom free,
    B
    : markedly improved, C: moderately improved,
    D
    : slightly improved and
    E
    : not improved. The following results were obtained.
    1
    ) The evaluation of behaviors is as follows. A: 12 cases,
    B
    :
    9
    , C:
    9
    ,
    D
    :
    6
    ,
    E
    : none.
    2) It was found that scores of
    F
    +106% and R+106% scales were significantly higher after the operation than before; that correlation coefficients between the scores before and after the operation were considerably high.
    3
    ) Factor analysis followed by varimax rotation was carried out. Six factors were extracted, i.
    e
    ., (
    F
    1
    ) sensitivity to emotional stimuli, (
    F
    2) ego-strength, (
    F
    3
    ) obsessional rigidity, (
    F
    4
    ) reaction time, (
    F
    5
    ) anxiety and tension and (
    F
    6
    ) empathy. It was revealed that
    F
    2 was high in atypical schizophrenia, depression and neurosis, and that
    F
    2 and
    F
    6
    were significantly different in terms of the factor scores among the four groups A,
    B
    , C and
    D
    ;
    F
    2 was highest in A, and lowest in
    D
    regardless of whether it was before or after the operation.
    F
    6
    showed high scores in both A and C, and low in
    D
    .
    4
    ) Multiple discriminant analysis was applied to the data of the Rorschach test before the operation, by classifying 36 subjects into the four groups A,
    B
    , C and
    D
    . As a result, high rates of correct diagnosis were obtained, i.
    e
    ., 100% for A, 78% for
    B
    , 56% for C and 100% for
    D
    . When the groups C and
    D
    were combined into one group (C+
    D
    ) the highest percentage (100%) was seen in A, followed by
    B
    (89%) and C+
    D
    group (87%). When the groups A and
    B
    were combined into one group (A+
    B
    ), the percentages of correct diagnosis were 81% for A+
    B
    , and 93% for C+
    D
    .
    In conclusion, it can be said that scales of the Rorschach test have been proved to be valid for predicting mental and physical states after the orbito-ventromedial undercutting.
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