The stability of
Δ9
‒tetrahydrocannabinol acetate (
Δ9
‒THC‒OAc) and
Δ8
‒tetrahydrocannabinol acetate (
Δ8
‒THC‒OAc) in
e
-liquid during storage was investigated.
Δ9
‒THC‒OAc liquids in cartridges were stored at 80℃ or 30℃ for 28 days. The relative concentrations of cannabinoids in the liquids were measured by gas chromatography with flame ionization detection.
Δ9
‒THC‒OAc decreased during storage at either temperature.
Δ9
‒THC, a minor impurity, also decreased.
Δ8
‒THC‒OAc liquid in a cartridge was stored at 80℃ for 57 days. The concentration of
Δ8
‒THC‒OAc and
Δ8
‒THC, a minor impurity, did not change during that time. Cannabinol acetate increased in all liquids, and unknown products were also detected by gas chromatography/mass spectrometry (GC/MS). The
Δ9
‒THC‒OAc and
Δ8
‒THC‒OAc liquids were subjected to GC/MS to detect representative diluents, glycerol, propylene glycol, and polyethylene glycol 400, but none of these were detected.
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