The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.

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The effect of composition and controlled thermomechanical process parameters on the mechanical properties of HSLA steels is modelled using the Widrow-Hoff's concept of training a neural net with feed-forward topology by applying Rumelhart's back propagation type algorithm for supervised learning, using a Petri like net structure. The data used are from laboratory experiments as well as from the published literature. The results from the neural network are found to be consistent and in good agreement with the experimented results.

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A sample of [

3H

] tobrarnycin (

5

, 000 Ci/Mole) has been synthetized and incubated with
the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
two types of binding sites. The primary one is probably responsible for the inhibition of
protein synthesis whereas the secondary one is probably related to the misreading and reading
tiirough of the messenger RNA.

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An unsupervised learning technique and an associative memory have been used for encoding weights by a special type of Petri network named Petri neural net for modelling the influence of alloying elements on the final property of the high strength low alloy steel. The combined effects of alloying elements for different strengthening mechanisms is predicted when weights and threshold values are chosen on the basis of metallurgical understanding. The technique is found to be effective to create an associative memory of input-output relations in unknown data sets so that the same can be subsequently be used as a predictive tool.

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Primarily from the point of view of improvement of yield strength due to additions of niobium, titanium and boron in HSLA steels, the experimental steels are divided into five classes. The data are then supplied for learning a Self Organising Map (Kohonen network). It is found that the network with six neurons possesses better capacity of prediction with unknown data. Another effort of clustering the steels according to its major strength contributing mechanisms is also made. But the capacity of the network to cluster unknown data is found to be rather poor and has failed to follow from the metallurgical principles. To avoid this limitation, Learning Vector Quantisation method is adopted to impart a certain amount of supervision in the learning process and it is found that the training pattern of the network attains a good convergence thereby leading to a good predictive ability.

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A boron treated copper bearing HSLA steel containing austenite formers like manganese and nickel, somewhat lower in amount than that in HSLA 100 variety of steel is chosen for the study. The role of thermomechanical processing on the microstructure and mechanical properties of the above steel has been investigated. Differential scanning calorimetric study is carried out for understanding the precipitation behaviour of copper in HSLA steel under the influence of boron. The microstructure of the experimental steel is found to consist of laths of martensites and bainite. MA constituents of ribbon like morphology are observed at the lath boundaries. Higher strength properties of the steel are attributed to the presence of finely distributed precipitates of copper and microalloy carbides.

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Horizontal plate anchors are widely used in civil engineering constructions to resist vertical pulling loads. The available theoretical model suggested by Vesic to estimate the breakout resistance of plate anchors is in significant error, particularly for dense sandy soils. A theoretical model assuming a curved surface of failure through the surrounding soil, to evaluate the ultimate breakout resistance of horizontal plate anchors, has been proposed. It successfully brings out the concept of characteristics relative depth beyond which the breakout factor reaches a constant final value. It is capable of predicting breakout factors for wide range of values of angle of shearing resistance of sand.

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Simultaneous measurements of the total geomagnetic field intensity by the same type of the proton precession magnetometers at two stations in NW Turkey have been taken cooperatively by a research group since December 1970. Up to the end of July 1971 mainly three probable local magnetic changes were observed. It was seen that after a decrease in the local field at a magnetic station (Erdek) a few earthquakes occured at either nearly N or S of that station, and after an increase in the local field an earthquake took place nearly W of the same station. In this paper the data and some results of the first part of observations are given.

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Nine isoquinoline alkaloids belonging to the protoberberine, proaporphine and bisbenzyl-isoquinoline series were isolated from Caryomene olivascens (Menispermaceae). Four compounds are new : (-)--norlimacine (4), (-)-caryolivine (), (+)-1, -dehydro--norlimacusine (9) and N-formylstepharine (). The last one is the first N-formyl derivative to be reported in the proaporphine group. Its biogenetic origin is discussed. Structures were established on the basis of 360 MHz (FT) nuclear magnetic resonance measurements and also by chemical correlation in the case of .

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An investigation was undertaken to evaluate the integrity of a geogrid-reinforced steep slope subjected to significant differential settlements and seismic loading. The reinforced soil structure under investigation was constructed in 1987 in order to enhance the stability of steep landfill slopes at the Operating Industries, Inc. (OII) Superfund site, a hazardous waste site in southern California. The site is in an area of high seismicity. The 4.60 m high, 460 m long geogrid-reinforced structure was founded, along most of its length, on concrete piers located towards the front of the structure. However, as the back of the reinforced slope was founded on waste, the structure experienced more than 600 mm of differential settlements ten years after its construction. A geogrid experimental testing program was implemented to evaluate the performance of the reinforcements when loaded rapidly after a period of constant load. A finite element numerical simulation was performed to assess the integrity of the geogrid reinforcements when subjected to 30 years of additional differential settlements followed by the design earthquake. The maximum geogrid strains predicted for a sequence of expected static and extreme seismic loadings were found to be well below the geogrid allowable strain values, indicating that the integrity of the structure should be maintained even when subjected to large differential settlements and severe earthquake loads. The numerical results show that the critical reinforced zone (i.., the reinforcement layers that are strained the most) that corresponds to different loading mechanisms (construction, differential settlement, seismic loading) occurs at different elevations within the reinforced soil structure.

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We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group which comprised preeclamptics who were supplemented their diets with vitamins C and . MDA increased from . ± . (placebo) to .48 ± 1. (A) and .02 ± 1. nmol/gHb (). NO concentrations were enhanced from 19. ± 4. (P) to 23. ± .4 (A) and 24.1 ± .4 μmol/L (). GSH contents were decreased from 10.42 ± . (P) to .02 ± .92 (A) and 9.39 ± 1.02 μmol/g Hb (), whereas GSSG concentrations increased from 0.98 ± 0.28 (P) to 1.24 ± 0.29 (A) and 1.08 ± 0.12 μmol/g Hb (). SOD activity decreased 23% in A and 14% in ; GRx decreased 27% in A and .% in ; GPx decreased 12% in A and 9.% in . Catalase activity, however, increased 27% in A and 29% in as compared to control. Thus, we conclude that the use of vitamins C and should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.

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Six full-length cDNAs encoding pig cytochrome P450 (CYP) enzymes, CYP1A1, CYPA19, CYP, CYPC33v4, CYPC49, and CYP1, were isolated and sequenced. The cDNA sequences of pig CYP1A1, CYPA19, CYP, CYPC49, and CYP1 showed high similarity to human CYP1A1 (85.4%), (88.%), (.1%), (85.%), and (.%), respectively, and pig cDNA showed high similarity to rat (79.%). Reverse transcription-polymerase chain reaction (RT-PCR) assays revealed hepatic gene expression of all these pig CYP enzymes: the order of expression was and > > CYP1A1 and > . In the kidney, the gene was expressed at the same level as in the liver, but the CYP1A1, , and genes were expressed at lower levels than in the liver. Little renal gene expression of CYPC49 and CYP1 was observed. We revealed for the first time the full-length cDNA sequences encoding pig CYP1A1 and five CYP enzymes belonging to the gene family, thus making it possible to examine the gene expression levels of these CYP enzymes in pig tissues by RT-PCR.

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Background : Usefulness of endoscopic microwave coagulation therapy (-MCT) was examined in 27 patients with hepatocellular carcinoma (HCC).
Material and Methods : HCC was found in patients with type liver cirrhosis (LC), 16 patients with type C LC, and patients with non non C LC. Median tumor size was 23 mm (solitary lesion , multiple ). Laparoscopic MCT was performed for - lesion and thoracoscopic MCT for lesion under general anesthesia. Linear type ultrasonography was used in every case for monitoring lesion ant therapeutic effect.
Results : Complete tumor necrosis was obtained in 24 cases (%) and local recurrence was found in cases after the observation period of maximum 34 months. Pleural abscess, hemorrhage and hepatic infarction were found in cases without serious outcome.
Conclusions : We conclude that -MCT is quite promising therapy for surface type HCC in term of minimally invasive and curative procedure a time. It is important that sufficient marginal coagulation should be obtained.

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