Two new partially saturated tricyclic ring systems, , a, , , , 10, 10a, 11-octahydro-11-oxodibenz [, ] oxepins (3a and 3), and -thiepins (4a and 4) were synthesized. Compounds 4a and 4 were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10). Deuterated 4a and 4 (11a and 11) were prepared starting from butadiene- (12). The stereochemical features of 3a (trans), 3 (cis), 4a (trans) and 4 (cis) are compared with those of 10a, 10, 11a and 11 on the basis of proton nuclear magnetic resonance data.

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11-Amino-, a, , , , 10, 10a, 11-octahydrodibebenzo[, ]thiepines (a-d) and -oxepines (a-d) were synthesized by the Leuckart reaction of , a, , , , 10, 10a, 11-octahydro-11-oxodibenzo[, ]thiepines (1a, )and -oxepines (2a, ) followed by hydrolysis of the reaction products 4a-d and a-d, respectively. The four diastereomers, cis(a-H, 10a-H)-cis(10a-H, 11-H) a and a, cis(a-H, 10a-H)-trans(10a-H, 11-H) and , trans(a-H, 10a-H)-trans(10a-H, 11a-H) and , and trans(a-H, 10a-H)-cis(10a-H, 11-H) d and d, were isolated and their configurations and conformations were elucidated by chemical methods together with ¹H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.

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A sample of [³H] tobrarnycin (, 000 Ci/Mole) has been synthetized and incubated with
the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
two types of binding sites. The primary one is probably responsible for the inhibition of
protein synthesis whereas the secondary one is probably related to the misreading and reading
tiirough of the messenger RNA.

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The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

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The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.

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Stereoselective synthesis of the 4, -syn, , -anti adducts (14 and 16) on the aldol condensation of the Z (O)-lithium enolate, derived from the -enone (2), to α-alkoxy aldehydes (12 and 13) was proved via the successive intramolecular Diels-Alder reaction.

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Thirty-six patients (19 males, 17 females: atypical schizophrenia; 3, typical schizophrenia; , depression; 11, neurosis and other psychiatric disorders; ) were operated on according to orbitoventromedial undercutting by Hirose. In all cases, the Rorschach test was carried out and daily behaviors were studied. Thirty-one scales of the test were subjected to multivariate analysis whereas the behaviors were evaluated according to the following criteria, i.., A: recovered or symptom free, : markedly improved, : moderately improved, D: slightly improved and : not improved. The following results were obtained.
1) The evaluation of behaviors is as follows. A: 12 cases, : , : , D: , : none.
2) It was found that scores of F+106% and R+106% scales were significantly higher after the operation than before; that correlation coefficients between the scores before and after the operation were considerably high.
3) Factor analysis followed by varimax rotation was carried out. Six factors were extracted, i.., (F1) sensitivity to emotional stimuli, (F2) ego-strength, (F3) obsessional rigidity, (F4) reaction time, (F) anxiety and tension and (F) empathy. It was revealed that F2 was high in atypical schizophrenia, depression and neurosis, and that F2 and F were significantly different in terms of the factor scores among the four groups A, , and D; F2 was highest in A, and lowest in D regardless of whether it was before or after the operation. F showed high scores in both A and , and low in D.
4) Multiple discriminant analysis was applied to the data of the Rorschach test before the operation, by classifying 36 subjects into the four groups A, , and D. As a result, high rates of correct diagnosis were obtained, i.., 100% for A, 78% for , 56% for and 100% for D. When the groups and D were combined into one group (+D) the highest percentage (100%) was seen in A, followed by (%) and +D group (%). When the groups A and were combined into one group (A+), the percentages of correct diagnosis were % for A+, and 93% for +D.
In conclusion, it can be said that scales of the Rorschach test have been proved to be valid for predicting mental and physical states after the orbito-ventromedial undercutting.

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Repetitive liquefactions in angular and subangular gravels from an alluvial fan, in the case of two earthquakes with accelerations lower than that of a former which had caused liquefaction some months before, are described. The liquefaction took place from the surface, down to a depth of approximately 10 m. Water laden with sediments spouted out for some tens of minutes after the strong motion ceased. Knowledge of the grain size distribution of the sediments inside the body of the alluvial fan roughly defines the areas of the fan prone to future liquefaction. Non-repetitive liquefaction in overconsolidated fine fluvio-lacustrine sand of glacial origin at the unusual depth of 14 m to 16 m is also described. From the observation of sand lifted up for 10 m inside a large diameter well, and of that which spouted out from several microvents, it was estimated that extra-pore pressure was close to lithostatic conditions. Nevertheless, modeling of intrinsic pore pressure buildup on the DESRA2 programme gives lower values than the experimental one. Geotechnical characteristics of the 12 m-thick sandy stratum indicate that the upper part is unusually soft, either due to water circulation or past repetitive liquefactions which prevented reconsolidation. It is suggested that excess pore pressure generated by the earthquake was also due to redistribution of pressure from adjacent sediments.

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Nine isoquinoline alkaloids belonging to the protoberberine, proaporphine and bisbenzyl-isoquinoline series were isolated from Caryomene olivascens (Menispermaceae). Four compounds are new : (-)-2-norlimacine (4), (-)-caryolivine (), (+)-1, 2-dehydro-2-norlimacusine () and N-formylstepharine (3). The last one is the first N-formyl derivative to be reported in the proaporphine group. Its biogenetic origin is discussed. Structures were established on the basis of 360 MHz (FT) nuclear magnetic resonance measurements and also by chemical correlation in the case of 3.

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We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group which comprised preeclamptics who were supplemented their diets with vitamins and . MDA increased from . ± 2. (placebo) to .48 ± 1.2 (A) and .02 ± 1. nmol/gHb (). NO concentrations were enhanced from 19.3 ± 4.2 (P) to 23. ± .4 (A) and 24.1 ± .4 μmol/L (). GSH contents were decreased from 10.42 ± 2. (P) to .02 ± 2.92 (A) and .39 ± 1.02 μmol/g Hb (), whereas GSSG concentrations increased from 0.98 ± 0.28 (P) to 1.24 ± 0.29 (A) and 1.08 ± 0.12 μmol/g Hb (). SOD activity decreased 23% in A and 14% in ; GRx decreased 27% in A and .% in ; GPx decreased 12% in A and .% in . Catalase activity, however, increased 27% in A and 29% in as compared to control. Thus, we conclude that the use of vitamins and should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.

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2-Benzyl-4-chloro--mercapto-3 (2H)-pyridazinone (1) was heated in ethanol under reflux for 10 hours to form concurrently 2, -dibenzyldipyridazo [4, - : 4', '-]-1, 4-dithiin-1, (2H, H)-dione (Ia) (57% in yield) and 2, -dibenzyldipyridazo [4, - : 4', '-]-1, 4-dithiin-1, (2H, H)-dione (IIa) (14% in yield). Assignment of the two products to the corresponding structures is established by their physico-chemical constants and chemical behaviors. The concurrent formation of the dipyridazo [4, - : 4', '-]-1, 4-dithiin-1, (2H, H)-dione and the -1, (2H, H)-dione were observed in, not only heating 4-chloro--mercapto-3 (2H)-pyridazinones (1-3) in polar solvent, but warming 4-mercapto--chloro-3 (2H)-pyridazinones (4-) in the presence of potassium carbonate in DMF. For the interpretation of the reaction, keto-thioketo carbenes as active intermediate species and a reversible interconversion among them are suggested on the basis of the fact that there was nonexistence of an equilibrium between the two compounds, such as Ia and IIa, under the reaction condition and a trapping keto-thioketo carbene species as 2-phenylimino--benzylpyridazo [4, -d]-1, 3-dithiol-4 (H)-one (IVa) (14% in yield) along with the major products, (Ia) and (IIa), was furnished by warming 1 with phenylisothiocyanate in the presence of triethylamine in dry benzene. On the contrary, participation of a reversible interconversion between Ia and IIa, to a considerable extent, with the concurrent formation of them in the case of benzylation of either Ib or IIb, by warming with benzylchloride in the presence of potassium carbonate in DMF at 80°, might not be neglected, because an attempted approach to an equilibrium between Ia and IIa in a similar reaction condition except the use of benzylchloride realized, whereas non-existence of an equilibrium between Ib and IIb in the similar reaction condition was observed.

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The phase diagrams of the Ni-Mo- and Ni-W- ternary systems in the region of less than 50mol% were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
:L (1365K, 71.mol%Ni-.0mol%Mo-.mol%)=(Ni)++
:L (1355K, 62.mol%Ni-2.mol%Mo-30.mol%)=++
:L (1445K, 42.0mol%Ni-30.mol%Mo-10.3mol%)=(Ni)+NiMo+
P₁:L (1812K, 34.mol%Ni-42.3mol%Mo-.mol%)+MoB=+
P₂:L (1633K, 42.3mol%Ni-40.4mol%Mo-17.3mol%)+Mo=+
P₃:L (1812K, 53.mol%Ni-33.mol%Mo-12.mol%)+Mo=NiMo+
:L (1622K, 51.0mol%Ni-31.mol%W-17.4mol%)=(Ni)+W+
:L (1260K, 71.0mol%Ni-.0mol%W-.0mol%)=(Ni)++
:L (1291K, 65.4mol%Ni-4.mol%W-29.mol%)=++
P₁:L (2115K, 23.mol%Ni-43.1mol%W-33.1mol%)+WB=+
P₂:L (1657K, 48.mol%Ni-33.1mol%W-18.0mol%)+=W+
The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.

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One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.

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