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  • 小田切 孝人, 田代 眞人
    ウイルス
    2013年 63 巻 2 号 233-240
    発行日: 2013/12/25
    公開日: 2014/10/31
    ジャーナル フリー
  • A.M. BRITTO, C. SAVVIDOU, M.J. GUNN, J.R. BOOKER
    土質工学会論文報告集
    1992年 32 巻 1 号 13-25
    発行日: 1992/03/15
    公開日: 2008/02/29
    ジャーナル フリー
    One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.
  • Joey
    B
    . Tanney, Leonard J. Hutchison
    Mycoscience
    2012年 53 巻 1 号 31-35
    発行日: 2012年
    公開日: 2023/03/31
    ジャーナル オープンアクセス

    The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

  • 村上 孝夫, 木村 毅, 和田 浩志, 田中 信寿, 斎木 保久, 陳 秋明
    Chemical and Pharmaceutical Bulletin
    1981年 29 巻 3 号 866-868
    発行日: 1981/03/25
    公開日: 2008/03/31
    ジャーナル フリー
    From the fronds of Polystichum tripteron (KUNZE) PR. a new norcarotenoid glycoside was isolated and shown to be (6R,
    7
    E
    ,
    9
    R)-
    9
    -hydroxy-megastigma-4,
    7
    -dien-
    3
    -one-
    9
    -O-β-
    D
    -glucoside. The fronds of Dennstaedtia wilfordii (MOORE) CHRIST. contain the same glucoside.
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in 95 (
    22
    .2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-2 (
    22
    ), blaCTX-M-
    3
    (16), blaCTX-M-1 (15), blaOXA-1 (
    9
    ) and blaSHV-12 (
    3
    ) alone or in combination. The most frequently encountered phylogenetic group was group A1 (35.8%), followed by group
    D2
    (
    22
    .1%),
    B
    1 (15.8%),
    D1
    (
    9
    .
    5
    %), A0 (
    7
    .4%),
    B22
    (
    5
    .
    3
    %) and
    B23
    (4.2%), respectively. PMQR genes, aac(6’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.
    3
    , 10.
    5
    and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.8% for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE,
    f17a
    -A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • 長谷川 親太郎
    The Keio Journal of Medicine
    1992年 41 巻 3 号 146-153
    発行日: 1992年
    公開日: 2009/03/27
    ジャーナル フリー
    Tumor-infiltrating lymphocytes (TIL) were tested for cytotoxicity against autologous tumor cells in a study utilizing a chemically induced cancer ofthe bladder (transitional cell carcinoma),
    BC
    -47, in inbred ACI/N rats. From tumors grown after subcutaneous implantation of
    BC
    -47 in the rats TIL were separated by density gradient centrifugation and incubated in plastic dishes for separation of non-adherent from adherent cells. The non-adherent cells were further fractionated into T and
    B
    cells by the panning method using anti-rat
    F
    (ab')2 antibody. The cell fractions were each added to
    BC
    -47 in culture to be assessed for antitumor effect by the crystal violet dye exclusion method and
    3
    H-thymidine incorporation inhibition assay. Peripheral blood mononuclear cells (PBMC) were also tested as described above. TIL expressed significantly higher cytotoxicity against
    BC
    -47 with the mean % cytotoxicity of 56.6±
    5
    .6% and 87.
    5
    ±
    7
    .1% at
    E
    /T ratios of 10:1 and 20:1, respectively, as compared to PBMC(
    9
    .
    9
    ±
    5
    .0% at
    E
    /T 10:1) (P<0.001). The adherent cells,
    B
    and T cell fractions showed respective % cytotoxicity of 92.4±2.8%, 57.
    9
    ±10.6% and
    9
    .
    9
    ±
    7
    .8% at an
    E
    /T ratio of 10:1. TIL pretreated with IFN or rIL-2 for 24or 48 hours did not exhibit any noticeably enhanced antitumor activity at an
    E
    /T ratio of
    5
    :1. Prevention of direct contact of
    BC
    -47 cells and TIL by an interposed Millipore membrane (0.45μm) resulted in an unequivocal reduction of antitumor effect. This finding clearly indicates that the direct contact with
    BC
    -47cells and TIL is necessary for TIL to manifest their cytotoxicity against the autologous tumor cells, suggesting that TIL exhibit autologous tumor killing activity through cell-mediated cytotoxicity.
  • 黒川 美貴雄, 吉田 耕治, 永井 保嵩, 宇野 準
    Chemical and Pharmaceutical Bulletin
    1983年 31 巻 12 号 4312-4318
    発行日: 1983/12/25
    公開日: 2008/03/31
    ジャーナル フリー
    Two new partially saturated tricyclic ring systems, 6, 6a,
    7
    , 8,
    9
    , 10, 10a, 11-octahydro-11-oxodibenz [
    b
    ,
    e
    ] oxepins (
    3
    a and
    3
    b
    ), and -thiepins (4a and 4
    b
    ) were synthesized. Compounds 4a and 4
    b
    were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10
    b
    ). Deuterated 4a and 4
    b
    (11a and 11
    b
    ) were prepared starting from butadiene-
    d6
    (12). The stereochemical features of
    3
    a (trans),
    3
    b
    (cis), 4a (trans) and 4
    b
    (cis) are compared with those of 10a, 10
    b
    , 11a and 11
    b
    on the basis of proton nuclear magnetic resonance data.
  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with
    7
    kinds of factors, as follows ; A^^〜=
    B
    +C+
    D
    +K+aE+bF+cG. A^^〜=estimated values of the readership score. 1)
    B
    , C,
    D
    , K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into
    7
    categories. C=pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories.
    D
    =kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2)
    E
    ,
    F
    , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into 6 kinds of area (2.
    5
    ,
    3
    .
    5
    ,
    5
    ,
    7
    , 10, 15) and 15 column means a whole page, about 2,000cm^2.
    E
    ,
    F
    are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement.
    F
    =the marks obtained on the whole effect of the design.
    3
    ) a,
    b
    , c : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+bF=A-(
    B
    +C+
    D
    +K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was
    3
    ,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table 2^* shows the contribution indexes of each factor by
    3
    kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, (
    3
    ) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of
    E
    ,
    F
    .
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _1+
    E
    _2+
    E
    _
    3
    +
    E
    _4. design elements [table]
    E
    _1,
    E
    _2,
    E
    _
    3
    ,
    E
    _4, these values have the
    5
    grades, as 0, 1, 2,
    3
    , 4 and 0 is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of 0 to
    9
    grades as the sum of them. The values of
    F
    have also
    5
    grades, 0 to 4. The principles to determine the values of
    E
    ,
    F
    are as follows : a) The marks obtained of
    E
    ,
    F
    must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. c) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    ,
    F
    values, as the table
    5
    -4, and
    5
    -
    5
    in the thesis in Japanese.
  • 山本 雅史, Abkenar Asad Asadi, 松本 亮司, 根角 博久, 吉田 俊雄, 國賀 武, 久保 達也, 冨永 茂人
    園芸学会雑誌
    2007年 76 巻 1 号 36-40
    発行日: 2007年
    公開日: 2007/03/06
    ジャーナル フリー
    カンキツ主要12種を用いて染色体のクロモマイシン
    A3
    (CMA) 染色を行った.染色体は CMA(+) バンドの有無および位置から
    7
    種類に区分できた.すなわち,CMA(+) を A: 両端および動原体近傍に有する,
    B
    : 一方の端部と動原体近傍に有する,C: 両端に有する,
    D
    : 一方の端部に有する,
    E
    : CMA(+) がない,
    F
    : 動原体近傍に有する,Dst: 付随染色体を有する
    D
    型,である.各種はこれらのうち 2~6 種類の染色体を有し,独自の CMA バンドパターンを示した.C. medica では 2
    B
    + 8
    D
    + 8
    E
    C. limon では 1
    B
    + 1C + 8
    D
    + 8
    E
    C. aurantifolia では 2
    B
    +
    9
    D
    +
    7
    E
    C. aurantium では 1A + 1
    B
    + 1C +
    7
    D
    + 8
    E
    C. sinensis では 2
    B
    + 2C +
    7
    D
    +
    7
    E
    C. maxima では
    3
    A +
    3
    C + 4
    D
    + 8
    E
    C. paradisi では 2A +
    3
    C + 6
    D
    +
    7
    E
    C. ichangensis では 2
    B
    + 2C + 12
    D
    + 2
    E
    C. latipes では 2A +
    5
    C + 8
    D
    +
    3
    E
    C. micrantha では 1
    B
    + 11
    D
    + 4
    E
    + 2Dst,C. macroptera では 2
    B
    + 1C + 11
    D
    +
    3
    E
    + 1
    F
    C. hystrix では
    3
    B
    + 1C + 8
    D
    +
    3
    E
    + 2
    F
    + 1Dst であった.
  • 和田 昭盛, 平石 佐栄子, 伊藤 允好
    Chemical and Pharmaceutical Bulletin
    1994年 42 巻 3 号 757-759
    発行日: 1994/03/15
    公開日: 2008/03/31
    ジャーナル フリー
    Stereoselective synthesis of
    7
    E
    ,
    9
    E
    - and
    7
    E
    ,
    9
    Z-β-ionylideneacetaldehydes was accomplished from the β-ionone tricarbonyl iron complex, and the latter was converted to
    9
    Z-retinoic acid.
  • Takeshi ITABASHI, Nobuko OGASAWARA, Koohei NOZAWA, Ken-ichi KAWAI
    Chemical and Pharmaceutical Bulletin
    1996年 44 巻 12 号 2213-2217
    発行日: 1996/12/15
    公開日: 2008/03/31
    ジャーナル フリー
    Three new azaphilone derivatives designated falconensins
    E
    5
    (
    5
    ),
    F
    (6), and G (
    7
    ) were isolated from the mycelium o Emericella falconensis, along with falconensins A (1),
    B
    (2), C (
    3
    ),
    D
    (4), and H (8), and three hopane-type triterpenes, zeorin (
    9
    ), hepane-
    ,
    22
    -diol (10), and hopane-6α,
    ,
    22
    -triol (11). The structures of
    5
    -
    7
    were confirmed by spectroscopic investigation and chemical correlations. The absolute stereochemistry of falconensins A (1) to G(
    7
    ) was also established.
  • 小林 優, 神田 扶由子, S. M.
    D
    . Kumar, Ch. V. Lakshmana Rao,
    D
    . Srinivasa Rao,
    D
    . Venkata Rao, C. Bheemasankara Rao
    天然有機化合物討論会講演要旨集
    1990年 32 巻 20
    発行日: 1990/09/25
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Melithasterols A-
    D
    (1-4), isolated from a gorgoinan coral Melithaea ocracea of Okinawa, were shown to be cholestane-, 24-methyl-
    22
    -dehydrocholestane-,
    22
    -dehydrocholestane-, and 24-methylenecholestane-derivatives. respectively, having a common
    3
    β,
    7
    α -dihydroxy-
    5
    α, 6α-epoxy-Δ^8 steroid nucleus. This was confirmed by direct comparison with the authentic sample prepared by lead tetra-acetate oxydation of cholest-6-ene-
    3
    β,
    5
    α, 8α-triol
    3
    -monoacetate. Twelve new polyhydroxysterols were isolated from an Alcyonium sp. (
    7
    ,8,
    9
    ), and Sclerophytum sp. (14,16,19
    b
    ,20,21,
    22
    a,23,26,28) soft corals collected off the coasts of the Andaman and Nicobar Islands in the Indian Ocean. All the Sclerophytum sp. soft corals contained 17a or its 25-deacetyl derivative. Compounds
    7
    to
    9
    were identified as 24-methylenecholest-
    5
    -ene-
    3
    β, 16β-diol-
    3
    -0-α-L fucoside (
    7
    ) and its
    7
    β-(8) and
    7
    α-hydroxy (
    9
    ) derivatives. Compound 14 was shown to be 24S-24-methylcholest-
    5
    -ene-
    3
    β,25ξ,26-triol and was correlated to the known compound 15 by
    5
    α, 6β-glycolation. Compound 16 was shown to be
    5
    β, 6α-isomer of 17
    b
    , correlating to 17
    b
    by PCC oxidation followed by dehydration. Compound 19
    b
    was identified with 25-deacetyl derivative of the known compound lobosterol (19a) by hydrolysis of authentic lobosterol. Compounds 20 and 21 were shown to be
    7
    -dehydro-(20) and
    22
    E
    -dehydro-(21) derivative of 17a and 17
    b
    , respectively, by comparisons of their spectral data with reference compounds. Compounds
    22
    a and 23 were 24S-methylcholestane-
    3
    β,
    5
    α 25-triol-6-one 25-monoacetate (
    22
    a) and its 25-deacetoxyl derivative (23). Partial PCC oxidation of 17a afforded
    22
    a. Compounds 26 (andamansterol) and 28 (nicobarsterol) were shown to be gorgost-
    5
    -ene-
    3
    β,
    9
    α. 11α, 21-tetrol and novel secosteroid, 11,21-cyclo-
    B
    -homo-11-oxa-
    9
    , 11-secoergostane-
    3
    β, 6α, 12ξ-triol-
    9
    -one, respectively, by spectral analyses (H-HCOSY, HMQC, HMBC).
  • 林 雄二, 松本 武
    天然有機化合物討論会講演要旨集
    1981年 24 巻 42
    発行日: 1981/09/10
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Reactions of nor-diterpenoid dilactones isolated from Podocarpus plants have been investigated. The
    7
    : 8,
    9
    : 11-dienolide type [C] dilactones, the least available but biologically the most active members, are mainly derived from naturally abundant dilactone components of α-pyrone type [A] and
    7
    : 8-epoxy-
    9
    : 11-enolide type [
    B
    ] for total-synthetic and biological purposes. From nagilactone
    E
    (
    5
    ), for example, a combined sequence of hydrogenolysis of
    7
    : 8-epoxide group and dehydration gives nagilactone
    F
    (
    7
    ),
    3
    β-hydroxynagilactone
    F
    (8) and 2:
    3
    -dehydronagilactone
    F
    (19), which have been found from natural sources. From nagilactone A (1), photo-hydration and concomitant double bond migration of its acetate results in a lactol (
    22
    ), which is reduced to 1β-hydroxynagilactone
    F
    (
    9
    ), another natural type [C] dilactone. Derivation of the type [A] or [
    B
    ] from others is not successful. Some attempts for conversion of the ring A functional groups have also been studied.
  • Zhe Fang, Su Yang Jeong, Hyun Ah Jung, Jae Sue Choi, Byung Sun Min, Mi Hee Woo
    Chemical and Pharmaceutical Bulletin
    2010年 58 巻 9 号 1236-1239
    発行日: 2010/09/01
    公開日: 2010/09/01
    ジャーナル フリー
    Activity-directed isolation of the ethyl acetate, methylene chloride and n-hexane fractions of Gloiopeltis furcata resulted in the isolation of 18 compounds. Their structures were elucidated as 2-(
    3
    -hydroxy-
    5
    -oxotetrahydrofuran-
    3
    -yl)acetic acid (1), glutaric acid (2), succinic acid (
    3
    ), nicotinic acid (4), (
    E
    )-4-hydroxyhex-2-enoic acid (
    5
    ), cholesterol (6),
    7
    -hydroxycholesterol (
    7
    ), uridine (8), glycerol (
    9
    ),
    5
    -(hydroxymethyl)-2-methoxybenzene-1,
    3
    -diol (10), (
    5E
    ,
    7E
    )-
    9
    -oxodeca-
    5
    ,
    7
    -dienoic acid (11), (Z)-
    3
    -ethylidene-4-methylpyrrolidine-2,
    5
    -dione (12), dehydrovomifoliol (13), loliolide (14), cholesteryl stearate (15), palmitic acid (16), cis-
    5
    ,8,11,14,17-eicosapentaenoic acid (17) and α-linolenic acid (18) on the basis of spectroscopic and chemical evidences. Their anticholinesterase and antioxidant activities were evaluated via inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) as well as scavenging activities on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and peroxynitrite (ONOO). All isolated compounds (118) exhibited moderate AChE inhibitory activities with IC50 values ranging from 1.14—12.50 μg/ml, whereas 1,
    7
    ,
    9
    , 17, and 18 showed mild BChE inhibitory activities with IC50 values ranging from
    5
    .57—15.89 μg/ml. Although most of the compounds isolated were lacking the scavenging activity on DPPH radical and ONOO,
    5
    and 10 showed good DPPH radical scavenging activity, and
    5
    , 10, and 16 showed potent ONOO scavenging activity.
  • 橋口 英俊
    日本医科大学雑誌
    1983年 50 巻 4 号 563-585
    発行日: 1983/08/15
    公開日: 2009/12/04
    ジャーナル フリー
    Thirty-six patients (19 males, 17 females: atypical schizophrenia;
    3
    , typical schizophrenia;
    9
    , depression; 11, neurosis and other psychiatric disorders; 8) were operated on according to orbitoventromedial undercutting by Hirose. In all cases, the Rorschach test was carried out and daily behaviors were studied. Thirty-one scales of the test were subjected to multivariate analysis whereas the behaviors were evaluated according to the following criteria, i.
    e
    ., A: recovered or symptom free,
    B
    : markedly improved, C: moderately improved,
    D
    : slightly improved and
    E
    : not improved. The following results were obtained.
    1) The evaluation of behaviors is as follows. A: 12 cases,
    B
    :
    9
    , C:
    9
    ,
    D
    : 6,
    E
    : none.
    2) It was found that scores of
    F
    +106% and R+106% scales were significantly higher after the operation than before; that correlation coefficients between the scores before and after the operation were considerably high.
    3
    ) Factor analysis followed by varimax rotation was carried out. Six factors were extracted, i.
    e
    ., (
    F
    1) sensitivity to emotional stimuli, (
    F
    2) ego-strength, (
    F
    3
    ) obsessional rigidity, (
    F
    4) reaction time, (
    F
    5
    ) anxiety and tension and (
    F
    6) empathy. It was revealed that
    F
    2 was high in atypical schizophrenia, depression and neurosis, and that
    F
    2 and
    F
    6 were significantly different in terms of the factor scores among the four groups A,
    B
    , C and
    D
    ;
    F
    2 was highest in A, and lowest in
    D
    regardless of whether it was before or after the operation.
    F
    6 showed high scores in both A and C, and low in
    D
    .
    4) Multiple discriminant analysis was applied to the data of the Rorschach test before the operation, by classifying 36 subjects into the four groups A,
    B
    , C and
    D
    . As a result, high rates of correct diagnosis were obtained, i.
    e
    ., 100% for A, 78% for
    B
    , 56% for C and 100% for
    D
    . When the groups C and
    D
    were combined into one group (C+
    D
    ) the highest percentage (100%) was seen in A, followed by
    B
    (89%) and C+
    D
    group (87%). When the groups A and
    B
    were combined into one group (A+
    B
    ), the percentages of correct diagnosis were
    81
    % for A+
    B
    , and 93% for C+
    D
    .
    In conclusion, it can be said that scales of the Rorschach test have been proved to be valid for predicting mental and physical states after the orbito-ventromedial undercutting.
  • 矢原 正治, 西依 健, 江田 昭英, 野原 稔弘, 西岡 五夫
    Chemical and Pharmaceutical Bulletin
    1991年 39 巻 8 号 2024-2036
    発行日: 1991/08/25
    公開日: 2008/03/31
    ジャーナル フリー
    A chemical examination of Magnoliae Cortex produced in China (Magnolia officinalis REHD. et WIL S., Magnoliaceae) has led to the isolation of eighteen new lignans and related compounds [four monoterpenyl-lignans : piperitylmagnolol (
    3
    ), dipiperitylmagnolol (4), piperitylhonokiol (
    5
    ) and bornylmagnolol (6); seven lignans : magnaldehydes
    B
    (8), C(
    9
    ), magnolignans A(10),
    B
    (11), C(12),
    D
    (13) and
    E
    (14); three norlignans : magnatriol
    B
    (16), magnaldehydes
    D
    (17) and
    E
    (18); and four dilignans : magnolignans
    F
    (19), G(20), H(21) and I(
    22
    )], together with randainal (
    7
    ), randaiol (15), sinapic aldehyde, syringaresinol, syringaresinol 4'-O-β-
    D
    -glucopyranoside and 6'-O-methylhonokiol. Their structures were determined by the chemical and spectral methods.
  • 黒川 美貴雄, 糸川 彰, 松本 純一, 福本 吉久, 月原 冨武
    Chemical and Pharmaceutical Bulletin
    1992年 40 巻 9 号 2270-2274
    発行日: 1992/09/25
    公開日: 2008/03/31
    ジャーナル フリー
    11-Amino-6, 6a,
    7
    , 8,
    9
    , 10, 10a, 11-octahydrodibebenzo[
    b
    ,
    e
    ]thiepines (6a-
    d
    ) and -oxepines (
    7
    a-
    d
    ) were synthesized by the Leuckart reaction of 6, 6a,
    7
    , 8,
    9
    , 10, 10a, 11-octahydro-11-oxodibenzo[
    b
    ,
    e
    ]thiepines (1a,
    b
    )and -oxepines (2a,
    b
    ) followed by hydrolysis of the reaction products 4a-
    d
    and
    5
    a-
    d
    , respectively. The four diastereomers, cis(6a-H, 10a-H)-cis(10a-H, 11-H) 6a and
    7
    a, cis(6a-H, 10a-H)-trans(10a-H, 11-H) 6
    b
    and
    7
    b
    , trans(6a-H, 10a-H)-trans(10a-H, 11a-H)6c and
    7
    c, and trans(6a-H, 10a-H)-cis(10a-H, 11-H) 6
    d
    and
    7
    d
    , were isolated and their configurations and conformations were elucidated by chemical methods together with 1H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.
  • I.
    F
    . Davies
    Journal of Light & Visual Environment
    1984年 8 巻 1 号 1_9-1_20
    発行日: 1984年
    公開日: 2011/05/20
    ジャーナル フリー
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