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BINDING OF TOBRAMYCIN TO ESCHERICHIA COLI RIBOSOMES: CHARACTERISTICS AND EQUILIBRIUM OF THE REACTION

FRANÇOIS LE GOFFIC, FRÉDÉRIC TANGY, BERNARD MOREAU

The Journal of Antibiotics
1979年 32 巻 12 号 1288-1292
発行日: 1979年
公開日: 2006/04/12

DOI https://doi.org/10.7164/antibiotics.32.1288

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A sample of [³H] tobrarnycin (
5
, 000 Ci/Mole) has been synthetized and incubated with
the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
two types of binding sites. The primary one is probably responsible for the inhibition of
protein synthesis whereas the secondary one is probably related to the misreading and reading
tiirough of the messenger RNA.
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中国でヒトに感染した鳥インフルエンザA(H
7
N
9
) ウイルスの性状，検査系の開発およびワクチン開発とその問題点

小田切孝人, 田代眞人

ウイルス
2013年 63 巻 2 号 233-240
発行日: 2013/12/25
公開日: 2014/10/31

DOI https://doi.org/10.2222/jsv.63.233

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Syntheses of
6
,
6
a,
7
,
8
,
9
, 10, 10a, 11-Octahydro-11-oxodibenz [
b
,
e
] oxepins and
6
,
6
a,
7
,
8
,
9
, 10, 10a, 11-Octahydro-11-oxodibenzo [
b
,
e
] thiepins

黒川美貴雄, 吉田耕治, 永井保嵩, 宇野準

Chemical and Pharmaceutical Bulletin
1983年 31 巻 12 号 4312-4318
発行日: 1983/12/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.31.4312

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Two new partially saturated tricyclic ring systems,
6
,
6
a,
7
,
8
,
9
, 10, 10a, 11-octahydro-11-oxodibenz [
b
,
e
] oxepins (3a and 3
b
), and -thiepins (4a and 4
b
) were synthesized. Compounds 4a and 4
b
were desulfurized to give a pair of isomeric
2
-methylbenzoylcyclohexanes (10a and 10
b
). Deuterated 4a and 4
b
(11a and 11
b
) were prepared starting from butadiene-
d₆
(12). The stereochemical features of 3a (trans), 3
b
(cis), 4a (trans) and 4
b
(cis) are compared with those of 10a, 10
b
, 11a and 11
b
on the basis of proton nuclear magnetic resonance data.
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MICROSEISM BARRIERS

M. L. GHOSH

Journal of Physics of the Earth
1972年 20 巻 2 号 165-186
発行日: 1972年
公開日: 2009/04/30

DOI https://doi.org/10.4294/jpe1952.20.165

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The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.
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Sythesis and Stereochemistry of 11-Amino-
6
,
6
a,
7
,
8
,
9
, 10, 10a, 11-octahydrodibenzo[
b
,
e
]thiepines and-oxepines

黒川美貴雄, 糸川彰, 松本純一, 福本吉久, 月原冨武

Chemical and Pharmaceutical Bulletin
1992年 40 巻 9 号 2270-2274
発行日: 1992/09/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.40.2270

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11-Amino-
6
,
6
a,
7
,
8
,
9
, 10, 10a, 11-octahydrodibebenzo[
b
,
e
]thiepines (
6
a-d) and -oxepines (
7
a-d) were synthesized by the Leuckart reaction of
6
,
6
a,
7
,
8
,
9
, 10, 10a, 11-octahydro-11-oxodibenzo[
b
,
e
]thiepines (1a,
b
)and -oxepines (
2
a,
b
) followed by hydrolysis of the reaction products 4a-d and
5
a-d, respectively. The four diastereomers, cis(
6
a-H, 10a-H)-cis(10a-H, 11-H)
6
a and
7
a, cis(
6
a-H, 10a-H)-trans(10a-H, 11-H)
6
b
and
7
b
, trans(
6
a-H, 10a-H)-trans(10a-H, 11a-H)
6
c and
7
c, and trans(
6
a-H, 10a-H)-cis(10a-H, 11-H)
6
d and
7
d, were isolated and their configurations and conformations were elucidated by chemical methods together with ¹H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.
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カナダにおける製紙原料供給の現状

増大する資源

E
. F. Boswell

紙パ技協誌
1998年 52 巻 7 号 885-889
発行日: 1998/07/01
公開日: 2009/11/19

DOI https://doi.org/10.2524/jtappij.52.885

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The world is in the midst of a huge fundamental shift in fibre supply, demand balances, and policy changes. Governments around the world are introducing policy changes which influence the supply demand balance as the politicians' thoughts are uttered. Government agencies and their bureaucrats are imposing changes on industry even before the legislation is passed by the government in question.
This ad hoc change process will continue for a time to come until the countries in question show a tough-mindedness with regard to their land use policies. Policies affecting forest areas such as protection areas, Native land claims, the protection of biodiversity and a true goal of sustainable development ; which addresses the combined issues of cultural, environmental, social and economic matters.
Eventually all of these difficult issues will reach essential closure. Then there will be great new opportunities for investment to meet the growing demand for forest products ; leading to a strengthening competitive position in the more traditional producing areas such as Canada.
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熱力学諸量の測定とその結果を用いた化学熱力学計算によるNi-Mo-
B
およびNi-W-
B
3成分系状態図の決定

香山滉一郎, 森下政夫, 張国鋒

粉体および粉末冶金
2006年 53 巻 5 号 419-429
発行日: 2006年
公開日: 2006/12/19

DOI https://doi.org/10.2497/jjspm.53.419

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The phase diagrams of the Ni-Mo-
B
and Ni-W-
B
ternary systems in the region of less than 50mol%
B
were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
E₁
:L (1365K, 71.
5
mol%Ni-
6
.
0
mol%Mo-
22
.
5
mol%
B
)=(Ni)+
Ni₃B
+
NiMo₂B₂

E₂
:L (1355K, 62.
5
mol%Ni-
2
.
5
mol%Mo-30.
5
mol%
B
)=
Ni₃B
+
Ni₂B
+
NiMo₂B₂

E₃
:L (1445K, 42.
0
mol%Ni-30.
6
mol%Mo-10.3mol%
B
)=(Ni)+NiMo+
NiMo₂B₂

P₁:L (1812K, 34.
9
mol%Ni-42.3mol%Mo-
22
.
8
mol%
B
)+MoB=
Mo₂B
+
NiMo₂B₂

P₂
:L (1633K, 42.3mol%Ni-40.4mol%Mo-17.3mol%
B
)+Mo=
Mo₂B
+
NiMo₂B₂

P₃:L (1812K, 53.
5
mol%Ni-33.
7
mol%Mo-12.
8
mol%
B
)+Mo=NiMo+
NiMo₂B₂

E₁
:L (1622K, 51.
0
mol%Ni-31.
6
mol%W-17.4mol%
B
)=(Ni)+W+
NiW₂B₂

E₂
:L (1260K, 71.
0
mol%Ni-
7
.
0
mol%W-
22
.
0
mol%
B
)=(Ni)+
Ni₃B
+
NiW₂B₂

E₃
:L (1291K, 65.4mol%Ni-4.
8
mol%W-29.
8
mol%
B
)=
Ni₂B
+
Ni₃B
+
NiW₂B₂

P₁:L (2115K, 23.
8
mol%Ni-43.1mol%W-33.1mol%
B
)+WB=
W₂B
+
NiW₂B₂

P₂
:L (1657K, 48.
9
mol%Ni-33.1mol%W-18.
0
mol%
B
)+
W₂B
=W+
NiW₂B₂

The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
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虚血性心臟病におけるコレステロール負荷時の血清リポ蛋白変動(第
2
報)

―特にアポ蛋白Eの変化について―

本間康彦, 三神美和, 佐藤美智子, 石原仁一, 吉川広, 木下栄治, 田川隆介, 星合充基, 古屋秀夫, 井出満, 田辺晃久, 玉地寛光, 兼本成斌, 友田春夫, 中谷矩章, 五島雄一郎

動脈硬化
1984年 12 巻 3 号 599-603
発行日: 1984/08/01
公開日: 2011/09/21

DOI https://doi.org/10.5551/jat1973.12.3_599

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Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for
2
weeks. Cholesterol amounts in VLDL, LDL, HDL,
HDL₂
and HDL₃ were estimated on the
0
th,
7
th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
B
, C-II,
E
levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL,
HDL₂
and HDL₃ were 15.
9
±
7
.
5
mg/dl (mean±SD), 150.
9
±58.1mg/dl 43.
8
±
9
.
6
mg/dl, 16.4±
5
.
8
mg/dl and 24.
9
±
6
.3mg/dl respectively. Plasma apoprotein A-I, A-II,
B
, C-II and
E
levels were
81
.
7
±
22
.
0
mg/dl, 15.1±
5
.4mg/dl,
93
.
7
±36.
0
mg/dl, 3.83±1.00mg/dl and 4.29±1.36mg/dl respectively. After
2
weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-C (r=
0
.348),
HDL₂
-C (r=
0
.612) and HDL₃ (r=
0
.569). Apoprotein
B
correlated with total cholesterol (TC) (r=
0
.610), VLDL-C (r=
0
.341), LDL-C (r=
0
.726), HDL-C (r=
0
.432) and
HDL₂
-C (r=
0
.465). Apoprotein C-II correlated with TC (r=
0
.765), TG (r=
0
.679), VLDL-C (r=
0
.651), LDL-C (r=
0
.461) and
HDL₂
-C (r=
0
.326). Apoprotein
E
correlated with TC (r=
0
.580), TG (r=
0
.575) and VLDL-C (r=
0
.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=
0
.468). Apoprotein
B
correlated with apoprotein C-II (r=
0
.393). Apoprotein C-II correlated with apoprotein
B
(r=
0
.393) and
E
(r=
0
.549). Apoprotein
E
only correlated with apoprotein C-II (r=
0
.549).
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The production of nematode-immobilizing secretory cells by Climacodon septentrionalis

Joey
B
. Tanney, Leonard J. Hutchison

Mycoscience
2012年 53 巻 1 号 31-35
発行日: 2012年
公開日: 2023/03/31

DOI https://doi.org/10.1007/s10267-011-0128-1

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The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On
2
% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

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Role of Vitamins C and
E
in Regulating Antioxidant and Pro-Oxidant Markers in Preeclampsia

Mohd Suhail, Mohd Faizul Suhail, Hina Khan

Journal of Clinical Biochemistry and Nutrition
2008年 43 巻 3 号 210-220
発行日: 2008年
公開日: 2008/10/31

DOI https://doi.org/10.3164/jcbn.2008067

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We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group
B
which comprised preeclamptics who were supplemented their diets with vitamins C and
E
. MDA increased from
6
.
22
±
2
.
8
(placebo) to
8
.48 ± 1.
2
(A) and
8
.02 ± 1.
8
nmol/gHb (
B
). NO concentrations were enhanced from 19.3 ± 4.
2
(P) to 23.
8
±
6
.4 (A) and 24.1 ±
5
.4 μmol/L (
B
). GSH contents were decreased from 10.42 ±
2
.
81
(P) to
8
.02 ±
2
.92 (A) and
9
.39 ± 1.02 μmol/g Hb (
B
), whereas GSSG concentrations increased from
0
.98 ±
0
.28 (P) to 1.24 ±
0
.29 (A) and 1.08 ±
0
.12 μmol/g Hb (
B
). SOD activity decreased 23% in A and 14% in
B
; GRx decreased 27% in A and
5
.
5
% in
B
; GPx decreased 12% in A and
9
.
6
% in
B
. Catalase activity, however, increased 27% in A and 29% in
B
as compared to control. Thus, we conclude that the use of vitamins C and
E
should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.

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Petri Neural Network Model for the Effect of Controlled Thermomechanical Process Parameters on the Mechanical Properties of HSLA Steels

S. Datta, J. Sil, M. K. Banerjee

ISIJ International
1999年 39 巻 10 号 986-990
発行日: 1999/10/15
公開日: 2007/05/31

DOI https://doi.org/10.2355/isijinternational.39.986

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The effect of composition and controlled thermomechanical process parameters on the mechanical properties of HSLA steels is modelled using the Widrow-Hoff's concept of training a neural net with feed-forward topology by applying Rumelhart's back propagation type algorithm for supervised learning, using a Petri like net structure. The data used are from laboratory experiments as well as from the published literature. The results from the neural network are found to be consistent and in good agreement with the experimented results.
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より実用的な飛行機への探求

Grover Loening

日本航空学会誌
1963年 11 巻 119 号 373-380
発行日: 1963年
公開日: 2009/05/25

DOI https://doi.org/10.2322/jjsass1953.11.373

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Certainty Factor Estimation Using Petri Neural Net for HSLA Steel

S. DATTA, M. K. BANERJEE

ISIJ International
2005年 45 巻 1 号 121-126
発行日: 2005年
公開日: 2006/01/27

DOI https://doi.org/10.2355/isijinternational.45.121

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An unsupervised learning technique and an associative memory have been used for encoding weights by a special type of Petri network named Petri neural net for modelling the influence of alloying elements on the final property of the high strength low alloy steel. The combined effects of alloying elements for different strengthening mechanisms is predicted when weights and threshold values are chosen on the basis of metallurgical understanding. The technique is found to be effective to create an associative memory of input-output relations in unknown data sets so that the same can be subsequently be used as a predictive tool.
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Kohonen Network Modelling for the Strength of Thermomechanically Processed HSLA Steel

S. Datta, M. K. Banerjee

ISIJ International
2004年 44 巻 5 号 846-851
発行日: 2004/05/15
公開日: 2007/05/31

DOI https://doi.org/10.2355/isijinternational.44.846

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Primarily from the point of view of improvement of yield strength due to additions of niobium, titanium and boron in HSLA steels, the experimental steels are divided into five classes. The data are then supplied for learning a Self Organising Map (Kohonen network). It is found that the network with six neurons possesses better capacity of prediction with unknown data. Another effort of clustering the steels according to its major strength contributing mechanisms is also made. But the capacity of the network to cluster unknown data is found to be rather poor and has failed to follow from the metallurgical principles. To avoid this limitation, Learning Vector Quantisation method is adopted to impart a certain amount of supervision in the learning process and it is found that the training pattern of the network attains a good convergence thereby leading to a good predictive ability.
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Effect of Thermomechanical Processing on the Microstructure and Properties of a Low Carbon Copper Bearing Steel

M. K. Banerjee, P. S. Banerjee, S. Datta

ISIJ International
2001年 41 巻 3 号 257-261
発行日: 2001/03/15
公開日: 2007/05/31

DOI https://doi.org/10.2355/isijinternational.41.257

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A boron treated copper bearing HSLA steel containing austenite formers like manganese and nickel, somewhat lower in amount than that in HSLA 100 variety of steel is chosen for the study. The role of thermomechanical processing on the microstructure and mechanical properties of the above steel has been investigated. Differential scanning calorimetric study is carried out for understanding the precipitation behaviour of copper in HSLA steel under the influence of boron. The microstructure of the experimental steel is found to consist of laths of martensites and bainite. MA constituents of ribbon like morphology are observed at the lath boundaries. Higher strength properties of the steel are attributed to the presence of finely distributed precipitates of copper and microalloy carbides.
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Prevalence and molecular characterization of extended-spectrum β-lactamase (ESBL) and plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli in dogs

Özkan ASLANTAŞ, Ebru Şebnem YILMAZ

Journal of Veterinary Medical Science
2017年 79 巻 6 号 1024-1030
発行日: 2017年
公開日: 2017/06/16
[早期公開] 公開日: 2017/04/27

DOI https://doi.org/10.1292/jvms.16-0432

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This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant
E
. coli isolates were detected in 95 (
22
.
2
%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: bla_CTX-M-15 (62), bla_{TEM-1b
(42), bla_{CMY-2
(22
), bla_CTX-M-3 (16), bla_CTX-M-1 (15), bla_OXA-1 (9
) and bla_SHV-12 (3) alone or in combination. The most frequently encountered phylogenetic group was group A₁ (35.8
%), followed by group D₂
(22
.1%), B
1 (15.8
%), D₁ (9
.5
%), A₀
(7
.4%), B2₂
(5
.3%) and B2₃
(4.2
%), respectively. PMQR genes, aac(6
’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.3, 10.5
and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0
% for tobramycin to 56.8
% for tetracycline. The virulence genes were only detected in 34 (36.2
%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE, f17a-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing E
. coli clone O25b
:ST131/B
2
. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing E
. coli isolates among dogs in Turkey.
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BREAKOUT RESISTANCE OF HORIZONTAL ANCHORS IN SAND

B
.C. CHATTOPADHYAY, P.J. PISE

土質工学会論文報告集
1986年 26 巻 4 号 16-22
発行日: 1986/12/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf1972.26.4_16

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Horizontal plate anchors are widely used in civil engineering constructions to resist vertical pulling loads. The available theoretical model suggested by Vesic to estimate the breakout resistance of plate anchors is in significant error, particularly for dense sandy soils. A theoretical model assuming a curved surface of failure through the surrounding soil, to evaluate the ultimate breakout resistance of horizontal plate anchors, has been proposed. It successfully brings out the concept of characteristics relative depth beyond which the breakout factor reaches a constant final value. It is capable of predicting breakout factors for wide range of values of angle of shearing resistance of sand.
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英国における過去半世紀 (1922～1972) 間の冶金用コークスの研究

George W. Lee

燃料協会誌
1973年 52 巻 3 号 171-177
発行日: 1973/03/20
公開日: 2010/06/28

DOI https://doi.org/10.3775/jie.52.171

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CASE STUDIES OF IN-SITU STRUCTURE OF NATURAL SEDIMENTARY CLAYS

澁谷啓, 三田地利之, 黄聖春

地盤工学会論文報告集
2000年 40 巻 3 号 87-100
発行日: 2000/06/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf.40.3_87

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Natural sedimentary clays exhibit ageing effects on their behaviour when subjected to both consolidation and shearing. Attempts to characterising the in-situ 'structure'of soft marine clays have been made in case studies performed in Ariake (Japan) and in Bangkok (Thailand), each showing a typical profile of aged clay-structure with depth reflecting its site-specific geological consolidation history. In each site, profiles of Atterberg limits, natural water content, overconsolidation ratio (OCR), quasi-elastic shear modulus G_max and the undrained shear strength c_u with depth were attained from various laboratory tests, together with the a comparable profile of quasi-elastic shear modulus from insitu seismic survey G_f. Quantitative assessment of the aged clay-structure was made by using two different measures, metastability index MI (G) and the soil constant reflecting structure S (Jamiolkowski et al., 1994). The profiles of MI (G) and the S-value with depth were both determined based on the corresponding G_max behaviour of the reconstituted sample. "Disturbance"of laboratory samples retrieved by using two different samplers (i.
e
., Laval and Japanese thin-walled samplers) with two different sampling techniques (i.
e
., pre-boring and displacement methods) was discussed. A new approach to estimate c_u"in the ground", termed by the authors the MILK (Metastability Index coupled with Laboratory K_o test) method, is proposed. A trial of the MILK-method is demonstrated in soft Bangkok clay, the texture of which is similar to "soft cheese".
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GEOTECHNICAL RECONNAISSANCE STUDY ON DAMAGE CAUSED BY 2001 GUJARAT EARTHQUAKE, INDIA

東畑郁生, PRASAD S.K., 本多剛, CHANDRADHARA G.P.

地盤工学会論文報告集
2002年 42 巻 4 号 77-88
発行日: 2002/08/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf.42.4_77

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The Gujarat earthquake in India occurred in January, 2001, and caused significant damage in the province of Gujarat. The Japanese Geotechnical Society sent a small reconnaissance team to the damaged region after the quake. The present text presents the report from this activity. The major attention of the team was focused on geotechnical aspects of the damage which were related to earthfill dams and harbor land fills. It was found that a significant portion of damage was concentrated in fills resting on soft natural soils. Swedish weight soundings which were conducted at two places demonstrated the existence of such a soft subsoil. From this, it was concluded that amplification of earthquake shaking as well as the permanent deformation in the soft foundation soil induced such kinds of damage as subsidence, cracking, and lateral spreading in overlying artificial fills. For the better seismic resistance of those affected fills during future earthquakes, the improvement of soft subsoil seems essential.
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