A methanol extract of the flowers of Mammea siamensis (Calophyllaceae) was found to inhibit enzymatic activity against aromatase (IC₅₀=16. µg/mL). From the extract, two new geranylated coumarins, mammeasins C (1) and D (2), were isolated together with seven coumarins: -hydroxy--methyl--(3,-dimethyl-octa-2,-dienyl)-9-(2-methyl-1-oxobutyl)-4,-dihydropyrano[4,3,2-de]chromen-2-one (9), -hydroxy--methyl--(3,-dimethyl-octa-2,-dienyl)-9-(3-methyl-1-oxobutyl)-4,-dihydropyrano[4,3,2-de]chromen-2-one (10), mammeas A/AA (14), A/ (15), A/AA cyclo D (18), / (23), and /BC cyclo D (25). The structures of 1 and 2 were elucidated on the basis of spectroscopic evidence. Among the isolates including 17 previously reported coumarins, 1 (IC₅₀=2. µM), 2 (3. µM), and mammea / cyclo D (21, 3.1 µM) showed relatively strong inhibitory activities comparable to the activity of the synthetic nonsteroidal aromatase inhibitor aminoglutethimide (2.0 µM).

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The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

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The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.

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Three objects are A, and C. The ship's positon is P. This is the instrument by which the ship's course will be recorded on the chart, if one on board is moving index mirror so that image A may be on through telescope on sextant and the other is moving another sextant so that image C may be on A. Figure 1 shows the principle of this instrument except sextant, where D is the point which ^2=AC・AD. Take Q and such that ^2=AP・AQ, =AE. then follows ∠ABQ=∠APB, ∠ADQ=∠APC. Fig.2 shows the outline of this instrument put on paper except sextant. Fig.3, 4, , are in detail of fig.2. Fig. shows the sextant with synchromotor, (12) shows the cover of syncromotor. Fig., 9 shows the part of instrument which must be reformed next time.

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Two new partially saturated tricyclic ring systems, , a, , , 9, 10, 10a, 11-octahydro-11-oxodibenz [, ] oxepins (3a and 3), and -thiepins (4a and 4) were synthesized. Compounds 4a and 4 were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10). Deuterated 4a and 4 (11a and 11) were prepared starting from butadiene- (12). The stereochemical features of 3a (trans), 3 (cis), 4a (trans) and 4 (cis) are compared with those of 10a, 10, 11a and 11 on the basis of proton nuclear magnetic resonance data.

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A sample of [³H] tobrarnycin (, 000 Ci/Mole) has been synthetized and incubated with
the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
two types of binding sites. The primary one is probably responsible for the inhibition of
protein synthesis whereas the secondary one is probably related to the misreading and reading
tiirough of the messenger RNA.

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The calculation for the articulation index in the case of binaural hearing has been made possible by means of a new function, namely, the loudness parameter, as follows; In the case of the monoaural hearing, the articulation index A_m and loudness N_m are given by the equation (1) and (2). A_m=1/p⎰^∞_0W_m{(α, f)}D(f)df=A_m(α, f) (1) N_m=⎰^∞_0N_f{Z(α, f)}F(f)df=N_m(α, f) (2) And in the case of binaural hearing, the loudness N_ is given as follows N_=2⎰^∞_0N_f{Z(α, f)}F(f)df=2N_m(α, f). (3) Assuming that the articulation index in binaural hearing is expressed by following equation =(α, f). (4) Elimination α in equation (1) and (2), we can express A_m in terms of N_m with a new function G_m, that is A_m(f)=G_m{N_m(f)}. () Similarly, =G_{N_(f)}=G_{2N_m(f)}. () Assuming G_m=G_=G, () we find that become (f)=G{2N_m(f)}=G{N_(f)}. () Therefore, can be calculated with A_m, N_m and new function G. This G is named by us as "loudness parameter". And with the experiments, it was proved that the assumption G_m=G_=G is held at any case.

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Aim: Antiphospholipid syndrome (APS) is characterized by recurrent thrombosis and/or gestational morbidity in patients with antiphospholipid autoantibodies (aPL). Over recent years, IgA anti-beta2-glycoprotein I (

2GPI) antibodies (IgA 2GPI) have reached similar clinical relevance as IgG or IgM isotypes. We recently described the presence of immune complexes of IgA bounded to 2GPI (2A-CIC) in the blood of patients with antecedents of APS symptomalology. However, 2A-CIC's clinical associations with thrombotic events (TEV) have not been described yet.

Methods: A total of 145 individuals who were isolate positive for IgA

2GPI were studied: 50 controls without any APS antecedent, patients with recent TEV (Group-1), and 73 patients with antecedents of old TEV (Group-2).

Results: Mean

2A-CIC levels and prevalence in Group-1 were 29.±4.1 AU and .%, respectively, and were significantly higher than those of Group-2 and controls (p＜0.001). In a multivariable analysis, positivity of 2A-CIC was an independent variable for acute thrombosis with a . odd ratio (confidence interval .1–101., 95%, p＜0.001). Levels of 2A-CIC dropped significantly two months after the TEV. 2A-CIC positive patients had lower platelet levels than 2A-CIC-negative patients (p＜0.001) and more prevalence of thrombocytopenia (p＜0.019). Group-1 had no significant differences in C3 and C4 levels compared with other groups.

Conclusion:

2A-CIC is strongly associated with acute TEV. Patients who did not develop thrombosis and were 2A-CIC positive had lower platelet levels, which suggest a hypercoagulable state. This mechanism is unrelated to complement-fixing aPL. 2A-CIC could potentially select IgA 2GPI-positive patients at risk of developing a thrombotic event.

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On blood group ABO, A antigen is converted from O antigen (H-substance) with A-transferase, whereas antigen from the same substrate with -transferease. Yamamoto et al (Nature, 345: 229-233, 1990) recently elucidated cDNA sequence of ABO genes, and showed the differences among A, , and O allelic cDNAs. Therefore, the determination of ABO-genotype can be analysed by means of PCR of genomic DNAs and digestion of the PCR-products with restriction enzymes at the different points of nucleotides. We collected blood samples from a total of 52 Japanese healthy volunteers (30 female and male), which include 16 A-type, 14 -type, 10 O-type, and 12 -type, and defined the ABO genotype utilizing PCR and restriction enzymes. The results are followings; 3 AA (18.%) and 13 AO (.2%) in phenotype A, BB (35.%) and 9 BO (64.3%) in phenotype . No conflict results were observed in individuals with phenotypes and O.

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Serotonin 2C receptor (-HT2CR) mRNA receives editing at nucleotide positions (sites A – ) located in the sequence encoding the second intracellular loop of -HT2CR. -HT2CR mRNA without editing and with editing at sites , ABD, ABC, ABCD, and C are translated to isoforms of -HT2CR: INI(non-edited), VNI(), VNV(ABD), VSI(ABC), VSV(ABCD), and ISI(C), respectively. In this study, we investigated electrophysiologically the ability of these isoforms to couple with the G protein / phospholipase C (PLC) system using Xenopus oocytes injected with edited -HT2CR RNAs and muscarinic M₁ receptor (M1R) RNA. The efficacy with which -HT stimulated each isoform was calculated by comparing -HT–induced current with 100 μM acetylcholine–induced M1R current. Stimulation with -HT of INI(non-edited), VNI(), VNV(ABD), VSI(ABC), VSV(ABCD), and ISI(C) expressed in Xenopus oocytes showed concentration-dependent responses with EC₅₀ values of ., 17.2, 76,, .0, 91.2, and 20.3 nM, respectively. No significant difference in the ability of -HT to induce currents among the oocytes expressing these isoforms was detected, but in the oocytes expressing VSI(ABC) or VSV(ABCD), -HT had a significantly reduced ability to induce currents. These results suggest that editing at site C together with sites A and and/or D markedly reduces -HT2CR function by generating isoforms with reduced ability to activate PLC.

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The phase diagrams of the Ni-Mo- and Ni-W- ternary systems in the region of less than 50mol% were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
:L (1365K, 71.mol%Ni-.0mol%Mo-.mol%)=(Ni)++
:L (1355K, 62.mol%Ni-2.mol%Mo-30.mol%)=++
:L (1445K, 42.0mol%Ni-30.mol%Mo-10.3mol%)=(Ni)+NiMo+
P₁:L (1812K, 34.9mol%Ni-42.3mol%Mo-.mol%)+MoB=+
P₂:L (1633K, 42.3mol%Ni-40.4mol%Mo-17.3mol%)+Mo=+
P₃:L (1812K, 53.mol%Ni-33.mol%Mo-12.mol%)+Mo=NiMo+
:L (1622K, 51.0mol%Ni-31.mol%W-17.4mol%)=(Ni)+W+
:L (1260K, 71.0mol%Ni-.0mol%W-.0mol%)=(Ni)++
:L (1291K, 65.4mol%Ni-4.mol%W-29.mol%)=++
P₁:L (2115K, 23.mol%Ni-43.1mol%W-33.1mol%)+WB=+
P₂:L (1657K, 48.9mol%Ni-33.1mol%W-18.0mol%)+=W+
The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.

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Diese Untersuchung behandelt sich darum, das Phaenomen der Anschauungsbilder () experimentell nachzuprüfen, das zwar auch in Japan schon bekannt, aber noch nicht geprüft worden ist.
Unsere Versuchsmethode ist im drei Stufen geteilt,
1) an den an sich (ersteU ntersuchung)
2) an den Komponenten der im gewöhnlichen Wahrnehmung (zweite Untersuchung), und
3) an den spontanen (dritteU ntersuchung)
Die erste Untersuchung ist nach den Methoden von . R. Jaensch, W. Jaensch und O. Kroh geordnet.
A. Die nachbildliche Komponente bei Fixation
I. Untersuchung des gewöhnlichen Nachbildes
a) rotes Quadrat (12cm×12cm oder 10cm×10cm)
) längere Fixation (20sek)
c) auf homogenen grauen Hintergrund.
d) massen Untersuchung
II. Untersuchung des nachbildlichen Falls.
a) mit einfachen und komplizierten Silhouettedarstellungsbildern.
) Fixation (15 sek)
c) auf dasselben Hintergrund
d) Untersuchung des Einzelnen
. Die vorstellungsnahe Komponente bei ungezwungener Betrachtung
III. Untersuchung des vorstellungsnahen Nachbildes
a) rotes Quadrat
) bei ungezwungener Betrachtung (10-15 sek)
c) auf dasselben Hintergrund
d) Untersuchung des Einzelnen
IV. Untersuchung des Anschauungsbildes
a) mit einfachem Tierbilde und kompliziertem Silhouettedarstellungsbilde
) bei ungezwungener Betrachtung (solange, dass das Kind es verlangt)
c) auf dasselben Hintergrund
d) Untersuchung des Einzelnen (Herr Yamashita hat geordnet)
Dutch die Untersuchung dieser vier Stufen finden wir einige ausgepraägte Eidetiker, die uns lange Dauer zeigen und mehr einzelne sehen konnten.
Z. . H. Y. 840 sek
S. M. 720,,
K. K. 180,,
T. M. 180,,
Selektionstendenz oder Tendenz zur Vollständigung und Weiterbildung befinden sich bei ihnen.
Kurz, unser Ergebnis entspricht der Auffassung der Marburger Schule. Der engere Zuzammenhang der eidetischen Aniage mit dem. Unterricht ist auch in diesen Untersuchungen gefunden, denn wir haben mehr stärkere Eidetiker in der Erlebnis-Schule als andere gefunden. (mit Herrn T. Yamashita untersucht)
Die zweite Untersuchung enthalt drei Verfahren am Aufbaue der Wahrnehmungswelt.
a) das konvarianten-Phaenomen,
) die scheinbare Sehgrösse, und
c) die scheinbare Gestalt.
Diese drei Untersuchungen konnten die Komponenten der im gewöhnlichen Sehen nachweisen . Im konvarianten Phaenomen ist der Paralellismus zwischen und WB, und in der Untersuchung der scheinbaren Sehgrösse die Abweichung vom Emmert'schen Gesetze gezeigt.
Z. . 50cm→100cm (Abstand des Hintergrund)
T. S. 1. .0cm-.cm
2. 4.9,,-.,,
3. .3,,-.3,,
O. U. 1. .1,,-.9,,
2. .0,,-.,,
3. .1,,-.3,,
H. Y. 1. .4,,→.,,←.3
2..4cm→9.cm←.1
Ausgeprägtes Beispiel ist,
T.M. 50cm→35cm
1.4.,,-4.,,
2..,,-.4,,
3..9,,-.1,,
4.4.4,,-.3,,
Und die beiden Eidetiker zeigen die Labilität and Plastizität in der scheinbaren Gestalt.
Die dritte Untersuchung an den spontanen ist folgend;
a) die Protokolle der Erlebnisse an den spontanen zu sammeln and zu beschreiben,
) die spontanen im bestimmten Zustande hervorzubringen, und
c) an den Werken und Biographien der Künstler zu versuchen.
Wir finden dass manche gesunde Kinder in den interessanten und traurigen Erzählungen die spontanen haben und die ausgeprägte Eidetiker diese freilich erzeugen.
Durch diese drei Untersuchungen sind unsere Ergebnisse im Stande die Eidetik nachzuweisen.
Am Schluss danke ich Herrn T. Yamaqshita.

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1, 3-Dialkoxy-4-bromo-2-cyano-1, 2, 3, 4-tetrahydroisoquinolines (2, to 11) are obtained quantitatively by the addition of cyanogen bromide to isoquinoline (1) dissolved in the corresponding alcohol, followed by application of bromine and saturated sodium carbonate solution. These products are a mixture of stereoisomers with the hydrogen atoms in 3- and 4-positions in cis (main) and trans configuration. Dehydrobromination of the cis-type compounds with potassium cyanide easily gives 3-alkoxyisoquinolines (, 12-15). Hydrolysis of with conc. hydrochloric acid affords 4-bromoisoquinoline (a) from cis-type compounds and 4-chloroisoquinoline () from trans-type compounds. It had been difficult to obtain compounds and 12 to 15. 4-Bromo--nitroisoquinoline (21) was obtained from -nitroisoquinoline (18) by the application of the above reaction but 3-methoxy--nitroisoquinoline () could not be obtained. Application of this reaction to 1, -naphthyridine easily gave -bromo-1, -naphthyridine (27) and -methoxy-1, -naphthyridine (28), compounds in which a substituent had been introduced into the - and -positions that had never been attempted so far.

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The tragus of the ear varies in its form and shape, hence its role as a posterior reference for alatragal plane and tragus canthus line is very subjective. Further, the various tragal references recommended in the literature are not always recognisable nor definable.

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11-Amino-, a, , , 9, 10, 10a, 11-octahydrodibebenzo[, ]thiepines (a-d) and -oxepines (a-d) were synthesized by the Leuckart reaction of , a, , , 9, 10, 10a, 11-octahydro-11-oxodibenzo[, ]thiepines (1a, )and -oxepines (2a, ) followed by hydrolysis of the reaction products 4a-d and a-d, respectively. The four diastereomers, cis(a-H, 10a-H)-cis(10a-H, 11-H) a and a, cis(a-H, 10a-H)-trans(10a-H, 11-H) and , trans(a-H, 10a-H)-trans(10a-H, 11a-H)c and c, and trans(a-H, 10a-H)-cis(10a-H, 11-H) d and d, were isolated and their configurations and conformations were elucidated by chemical methods together with ¹H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.

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Assuming is expressed in term of a new function W_, the articulation index in the case of binaural hearing must be able to be calculated as in the case of monoaural hearing, as follows; =1/p⎰^∞_0W_{(α, f)}D(f)df (1) where W_ stands for the component of articulation index of binaural hearing as W_m in the case of monoaural hearing. With the loudness parameter G described in preceding report(1), the function W_ can be estimated; Assuming that the frequency response of transmission system is flat, is estimated by means of the method of loudness parameter; (f)=G{2N_m(f)} (2) and on the other hand, the mean effective sensational level (α) of this system is estimated by; ∸(α)=⎰^∞_0(α, f)D(f)df. (3) Plotting the of equation (2) with ∸, W_ is expressed in similar manner as W_m. And this theoretical result proves that it does not contradict the result of experiment.

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We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group which comprised preeclamptics who were supplemented their diets with vitamins C and . MDA increased from . ± 2. (placebo) to .48 ± 1.2 (A) and .02 ± 1. nmol/gHb (). NO concentrations were enhanced from 19.3 ± 4.2 (P) to 23. ± .4 (A) and 24.1 ± .4 μmol/L (). GSH contents were decreased from 10.42 ± 2. (P) to .02 ± 2.92 (A) and 9.39 ± 1.02 μmol/g Hb (), whereas GSSG concentrations increased from 0.98 ± 0.28 (P) to 1.24 ± 0.29 (A) and 1.08 ± 0.12 μmol/g Hb (). SOD activity decreased 23% in A and 14% in ; GRx decreased 27% in A and .% in ; GPx decreased 12% in A and 9.% in . Catalase activity, however, increased 27% in A and 29% in as compared to control. Thus, we conclude that the use of vitamins C and should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.

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