Urinary estrogens (
E
) were determined by means of fluorimetric method described previously in normal young adults and normal aged adults of both sex as well as in patients with pituitary-adrenocortical disorders, gonadal disease and chronic liver disease, totalling
80
subjects. Each fraction of estrone (EO), estradiol (ED) and estriol (ET)was measured in every subjects. In a part of them, in where ACTH-test with daily injections of 20 units ACTH-Z for
3
days, suppression test with Dexamethasone and Gonadotropin test were performed, change of urinary excretion on estrogens was also studied. The results obtained from thus measured 222 times totally are summerized as follows.
1
) In
8
subjects of normal young adult males(20-28 years old), the mean of daily excretion of urinary total estrogens (
E
) and its standard deviation (SD) were found to be 16.35×5.03μg(EO:
3
.03×
1.69μg
, ED:
2
.63×
1.73μg
and ET: 10.58×
2.96μg
). The mean and its SD of daily excretion per
1
m
2
of body surface area, measured in
6
out of
8
sublects, was 7.32×
3.82μg
. The means and their SD of total
E
in 7normal young menstruating femals (20~34 years old) during follicular phase and luteal phase were 23.07×
12.2μg
(EO: 5.97×
3.10μg
, ED:
4
.31×
2.08μg
and ET: 13.21×
4.39μg
)and 41.55×14.40μg(EO: 12.73×
2.50μg
, ED: 7.89×
3.40μg
and ET: 21.00×5.45μg)respectively. The mean and the SD in
8
normal aged males(70-
84
years old)was
9
.
88
×
4.73μg
for total
E
(EO:
1
.51×
0.80μg
, ED:
1
.77×
1.35μg
and ET:
6
.60×
3.47μg
)with a conversion value per
1
m2
of body surface area as 7.32×
3.82μg
which was calculated in 5 out of
8
subjects. The means and their SD in
8
normal aged feamles(69-
84
years old)was
8
.45×
3.12μg
for total
E
(EO:
1
.56×
1.34μg
, ED:
1
.90×
1.52μg
and ET: 5.00×
2.73μg
)and 7.18×
3.26μg
for
E
excretion per
1
m2
of body surface area calculated in 5 out of
8
subjects.
2
) A change of total
E
excretion was observed on ACTH-test in
2
normal young males, which illustrated that the daily excretions orderly increased by injection of ACTH with the maximum value being on the third day and rapid return to the preinjected value after discontinuation of the injection. The minimum, maximum and average values of the sum of amount of increases on the second and the third days of ACTH injection were
15.1μg
,
116.1μg
and
49.9μg
respectively in normal adult males,
31.4μg
,
96.6μg
and 50.0μg espectively in 5 normal menstruating females,
8.3μg
37.5μg and
24.6μg
respectively in 5 normal aged males and
6.4μg
,
4.97μg
and
19.1μg
respectively in
4
normal aged females.
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