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中国でヒトに感染した鳥インフルエンザA(H
7
N
9
) ウイルスの性状，検査系の開発およびワクチン開発とその問題点

小田切孝人, 田代眞人

ウイルス
2013年 63 巻 2 号 233-240
発行日: 2013/12/25
公開日: 2014/10/31

DOI https://doi.org/10.2222/jsv.63.233

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Syntheses of
6
,
6
a,
7
,
8
,
9
, 10, 10a, 11-Octahydro-11-oxodibenz [
b
,
e
] oxepins and
6
,
6
a,
7
,
8
,
9
, 10, 10a, 11-Octahydro-11-oxodibenzo [
b
,
e
] thiepins

黒川美貴雄, 吉田耕治, 永井保嵩, 宇野準

Chemical and Pharmaceutical Bulletin
1983年 31 巻 12 号 4312-4318
発行日: 1983/12/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.31.4312

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Two new partially saturated tricyclic ring systems,
6
,
6
a,
7
,
8
,
9
, 10, 10a, 11-octahydro-11-oxodibenz [
b
,
e
] oxepins (3a and 3
b
), and -thiepins (
4
a and
4
b
) were synthesized. Compounds
4
a and
4
b
were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10
b
). Deuterated
4
a and
4
b
(11a and 11
b
) were prepared starting from butadiene-
d₆
(12). The stereochemical features of 3a (trans), 3
b
(cis),
4
a (trans) and
4
b
(cis) are compared with those of 10a, 10
b
, 11a and 11
b
on the basis of proton nuclear magnetic resonance data.
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Sythesis and Stereochemistry of 11-Amino-
6
,
6
a,
7
,
8
,
9
, 10, 10a, 11-octahydrodibenzo[
b
,
e
]thiepines and-oxepines

黒川美貴雄, 糸川彰, 松本純一, 福本吉久, 月原冨武

Chemical and Pharmaceutical Bulletin
1992年 40 巻 9 号 2270-2274
発行日: 1992/09/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.40.2270

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11-Amino-
6
,
6
a,
7
,
8
,
9
, 10, 10a, 11-octahydrodibebenzo[
b
,
e
]thiepines (
6
a-d) and -oxepines (
7
a-d) were synthesized by the Leuckart reaction of
6
,
6
a,
7
,
8
,
9
, 10, 10a, 11-octahydro-11-oxodibenzo[
b
,
e
]thiepines (1a,
b
)and -oxepines (2a,
b
) followed by hydrolysis of the reaction products
4
a-d and
5
a-d, respectively. The four diastereomers, cis(
6
a-H, 10a-H)-cis(10a-H, 11-H)
6
a and
7
a, cis(
6
a-H, 10a-H)-trans(10a-H, 11-H)
6
b
and
7
b
, trans(
6
a-H, 10a-H)-trans(10a-H, 11a-H)
6
c
and
7
c
, and trans(
6
a-H, 10a-H)-cis(10a-H, 11-H)
6
d and
7
d, were isolated and their configurations and conformations were elucidated by chemical methods together with ¹H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.
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英国における過去半世紀 (1922～1972) 間の冶金用コークスの研究

George W. Lee

燃料協会誌
1973年 52 巻 3 号 171-177
発行日: 1973/03/20
公開日: 2010/06/28

DOI https://doi.org/10.3775/jie.52.171

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REPETITIVE LIQUEFACTION AT A GRAVELLY SITE AND LIQUEFACTION IN OVERCONSOLIDATED SANDS

LIVIO SIROVICH

地盤工学会論文報告集
1996年 36 巻 4 号 23-34
発行日: 1996/12/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf.36.4_23

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Repetitive liquefactions in angular and subangular gravels from an alluvial fan, in the case of two earthquakes with accelerations lower than that of a former which had caused liquefaction some months before, are described. The liquefaction took place from the surface, down to a depth of approximately 10 m. Water laden with sediments spouted out for some tens of minutes after the strong motion ceased. Knowledge of the grain size distribution of the sediments inside the body of the alluvial fan roughly defines the areas of the fan prone to future liquefaction. Non-repetitive liquefaction in overconsolidated fine fluvio-lacustrine sand of glacial origin at the unusual depth of 14 m to 16 m is also described. From the observation of sand lifted up for 10 m inside a large diameter well, and of that which spouted out from several microvents, it was estimated that extra-pore pressure was close to lithostatic conditions. Nevertheless, modeling of intrinsic pore pressure buildup on the DESRA2 programme gives lower values than the experimental one. Geotechnical characteristics of the 12 m-thick sandy stratum indicate that the upper part is unusually soft, either due to water circulation or past repetitive liquefactions which prevented reconsolidation. It is suggested that excess pore pressure generated by the earthquake was also due to redistribution of pressure from adjacent sediments.
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The Japan Connection

Nicholas ISYUMOV, Eric HO, Peter KING, David SURRY, Barry VICKERY

日本風工学会誌
2010年 35 巻 4 号 265-271
発行日: 2010/10/31
公開日: 2011/04/01

DOI https://doi.org/10.5359/jawe.35.265

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STEREOSELECTIVE ALDOL REACTION OF A LITHIUM α-VINYL ENOLATE TO α-ALKOXY ALDEHYDES

井原正隆, 千尋正利, 福本圭一郎, 亀谷哲治

Chemical and Pharmaceutical Bulletin
1984年 32 巻 1 号 373-376
発行日: 1984/01/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.32.373

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Stereoselective synthesis of the
4
,
5
-syn,
5
,
6
-anti adducts (14 and 16) on the aldol condensation of the Z (O)-lithium enolate, derived from the
E
-enone (2), to α-alkoxy aldehydes (12 and 13) was proved via the successive intramolecular Diels-Alder reaction.
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Synthesis of Pyridazine Derivatives with Sulfur-Containing Substituent. II. A Novel Cyclization Furnishing the Concurrent Formation of 2,
7
-Dibenzyldipyridazo-[
4
,
5
-
b
:
4
',
5
'-
e
]-1,
4
-dithiin-1,
6
(2H,
7
H)-dione and 2,
8
-Dibenzyldipyridazo [
4
,
5
-
b
:
4
',
5
'-
e
]-1,
4
-dithiin-1,
9
(2H,
8
H)-dione. (1)

鍛治健司, 葛谷昌之 /, RAYMONDN. CASTLE

Chemical and Pharmaceutical Bulletin
1970年 18 巻 1 号 147-156
発行日: 1970/01/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.18.147

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2-Benzyl-
4
-chloro-
5
-mercapto-3 (2H)-pyridazinone (1) was heated in ethanol under reflux for 10 hours to form concurrently 2,
7
-dibenzyldipyridazo [
4
,
5
-
b
:
4
',
5
'-
e
]-1,
4
-dithiin-1,
6
(2H,
7
H)-dione (Ia) (57% in yield) and 2,
8
-dibenzyldipyridazo [
4
,
5
-
b
:
4
',
5
'-
e
]-1,
4
-dithiin-1,
9
(2H,
8
H)-dione (IIa) (14% in yield). Assignment of the two products to the corresponding structures is established by their physico-chemical constants and chemical behaviors. The concurrent formation of the dipyridazo [
4
,
5
-
b
:
4
',
5
'-
e
]-1,
4
-dithiin-1,
6
(2H,
7
H)-dione and the -1,
9
(2H,
8
H)-dione were observed in, not only heating
4
-chloro-
5
-mercapto-3 (2H)-pyridazinones (1-3) in polar solvent, but warming
4
-mercapto-
5
-chloro-3 (2H)-pyridazinones (
4
-
6
) in the presence of potassium carbonate in DMF. For the interpretation of the reaction, keto-thioketo carbenes as active intermediate species and a reversible interconversion among them are suggested on the basis of the fact that there was nonexistence of an equilibrium between the two compounds, such as Ia and IIa, under the reaction condition and a trapping keto-thioketo carbene species as 2-phenylimino-
5
-benzylpyridazo [
4
,
5
-d]-1, 3-dithiol-
4
(
5
H)-one (IVa) (14% in yield) along with the major products, (Ia) and (IIa), was furnished by warming 1 with phenylisothiocyanate in the presence of triethylamine in dry benzene. On the contrary, participation of a reversible interconversion between Ia and IIa, to a considerable extent, with the concurrent formation of them in the case of benzylation of either Ib or IIb, by warming with benzylchloride in the presence of potassium carbonate in DMF at 80°, might not be neglected, because an attempted approach to an equilibrium between Ia and IIa in a similar reaction condition except the use of benzylchloride realized, whereas non-existence of an equilibrium between Ib and IIb in the similar reaction condition was observed.
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FINITE ELEMENT ANALYSIS OF THE COUPLED HEAT FLOW AND CONSOLIDATION AROUND HOT BURIED OBJECTS

A.M. BRITTO,
C
. SAVVIDOU, M.J. GUNN, J.R. BOOKER

土質工学会論文報告集
1992年 32 巻 1 号 13-25
発行日: 1992/03/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf1972.32.13

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One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.
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BINDING OF TOBRAMYCIN TO ESCHERICHIA COLI RIBOSOMES: CHARACTERISTICS AND EQUILIBRIUM OF THE REACTION

FRANÇOIS LE GOFFIC, FRÉDÉRIC TANGY, BERNARD MOREAU

The Journal of Antibiotics
1979年 32 巻 12 号 1288-1292
発行日: 1979年
公開日: 2006/04/12

DOI https://doi.org/10.7164/antibiotics.32.1288

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A sample of [³H] tobrarnycin (
5
, 000 Ci/Mole) has been synthetized and incubated with
the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
two types of binding sites. The primary one is probably responsible for the inhibition of
protein synthesis whereas the secondary one is probably related to the misreading and reading
tiirough of the messenger RNA.
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The production of nematode-immobilizing secretory cells by Climacodon septentrionalis

Joey
B
. Tanney, Leonard J. Hutchison

Mycoscience
2012年 53 巻 1 号 31-35
発行日: 2012年
公開日: 2023/03/31

DOI https://doi.org/10.1007/s10267-011-0128-1

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The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

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熱力学諸量の測定とその結果を用いた化学熱力学計算によるNi-Mo-
B
およびNi-W-
B
3成分系状態図の決定

香山滉一郎, 森下政夫, 張国鋒

粉体および粉末冶金
2006年 53 巻 5 号 419-429
発行日: 2006年
公開日: 2006/12/19

DOI https://doi.org/10.2497/jjspm.53.419

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The phase diagrams of the Ni-Mo-
B
and Ni-W-
B
ternary systems in the region of less than 50mol%
B
were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
E₁
:L (1365K, 71.
5
mol%Ni-
6
.0mol%Mo-
22
.
5
mol%
B
)=(Ni)+
Ni₃B
+
NiMo₂B₂

E₂
:L (1355K, 62.
5
mol%Ni-2.
5
mol%Mo-30.
5
mol%
B
)=
Ni₃B
+
Ni₂B
+
NiMo₂B₂

E₃
:L (1445K, 42.0mol%Ni-30.
6
mol%Mo-10.3mol%
B
)=(Ni)+NiMo+
NiMo₂B₂

P₁:L (1812K, 34.
9
mol%Ni-42.3mol%Mo-
22
.
8
mol%
B
)+MoB=
Mo₂B
+
NiMo₂B₂

P₂:L (1633K, 42.3mol%Ni-40.
4
mol%Mo-17.3mol%
B
)+Mo=
Mo₂B
+
NiMo₂B₂

P₃:L (1812K, 53.
5
mol%Ni-33.
7
mol%Mo-12.
8
mol%
B
)+Mo=NiMo+
NiMo₂B₂

E₁
:L (1622K, 51.0mol%Ni-31.
6
mol%W-17.
4
mol%
B
)=(Ni)+W+
NiW₂B₂

E₂
:L (1260K, 71.0mol%Ni-
7
.0mol%W-
22
.0mol%
B
)=(Ni)+
Ni₃B
+
NiW₂B₂

E₃
:L (1291K, 65.
4
mol%Ni-
4
.
8
mol%W-29.
8
mol%
B
)=
Ni₂B
+
Ni₃B
+
NiW₂B₂

P₁:L (2115K, 23.
8
mol%Ni-43.1mol%W-33.1mol%
B
)+WB=
W₂B
+
NiW₂B₂

P₂:L (1657K, 48.
9
mol%Ni-33.1mol%W-18.0mol%
B
)+
W₂B
=W+
NiW₂B₂

The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
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より実用的な飛行機への探求

Grover Loening

日本航空学会誌
1963年 11 巻 119 号 373-380
発行日: 1963年
公開日: 2009/05/25

DOI https://doi.org/10.2322/jjsass1953.11.373

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CONTINUOUS SHIFTWORKING IN PROCESS INDUSTRIES: DOES FIRM EFFICIENCY IMPLY HIGH HUMAN COSTS?

Cbesseredes HORTS

Journal of Human Ergology
1982年 11 巻 Supplement 号 429-440
発行日: 1982/12/15
公開日: 2011/02/23

DOI https://doi.org/10.11183/jhe1972.11.Supplement_429

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地盤数値情報データベースを用いた熊本県中部域斜面災害の解析

田尻要, 中山洋, 今泉繁良

土質工学会論文報告集
1992年 32 巻 2 号 159-168
発行日: 1992/06/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf1972.32.2_159

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エキヌリンおよび関連化合物の合成研究(第
5
報) : Aspergillus amstelodamiから得られるエキヌリン, ネオエキヌリン型天然物の抽出, 構造および合成

井上昭二, 村田順子, 高松昇, 永納秀男, 岸義人

YAKUGAKU ZASSHI
1977年 97 巻 5 号 576-581
発行日: 1977/05/25
公開日: 2008/05/30

DOI https://doi.org/10.1248/yakushi1947.97.5_576

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Six natural products, named
E
-
6
,
E
-
7
,
E
-
8
,
E
-
9
,
E
-10, and
E
-11, were isolated from ether and methylene chloride extracts of freeze-dried mycelium of Aspergillus amstelodami IFO-6667.
E
-
9
and
E
-11 were found to be identical with neoechinulin (2) and echinulin (1), respectively, from spectroscopic and melting point data. Alkaline hydrolysis of
E
-
7
,
E
-
8
, and
E
-10 gave indole-3-carbaldehydes (
4
a,
4
b
and
4
c
), respectively. Analysis of the spectroscopic data revealed the presence of a methylenediketopiperazine moiety in
E
-
7
,
E
-
8
, and
E
-10. Based on these informations, the structures 3a, 3
b
, and 3
c
were assigned to
E
-
7
,
E
-
8
, and
E
-10, respectively. These three alkaloids were synthesized by condensation of indole-3-carbaldehydes (
4
a,
4
b
, and
4
c
) with methylenediketopiperazine (
5
). The stereochemistry of
E
-
7
,
E
-
8
, and
E
-10 were determined as shown in the structures. A possible rationalization to explain the isopentenylation in the echinulin-neoechinulin alkaloid biosyntheses was presented.
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わが国における主要中晩生および香酸カンキツ染色体のCMA染色

山本雅史, 久保達也, 冨永茂人

園芸学会雑誌
2005年 74 巻 6 号 476-478
発行日: 2005年
公開日: 2006/02/24

DOI https://doi.org/10.2503/jjshs.74.476

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わが国における主要中晩生および香酸カンキツ染色体のクロモマイシンA₃ (CMA) 染色を行った. 染色体はCMA(+) バンドの有無および位置から
5
種類に区分できた. すなわち, CMA(+) をA: 両端および動原体近傍に有する,
B
: 一方の端部と動原体近傍に有する,
C
: 両端に有する, D: 一方の端部に有する,
E
: CMA(+) がない, である. 各種はこれらのうち
4
,
5
種類の染色体を有し, 独自のCMAバンドパターンを示した. ハッサクでは1A+1
C
+
8
D+
8
E
, ヒュウガナツでは2A+2
C
+
5
D+
9
E
, ‘川野なつだいだい’では1A+2
C
+
7
D+
8
E
, ‘宮内伊予柑’では1A+1
B
+1
C
+
8
D+
7
E
, タンカン‘垂水1号’では1A+1
B
+1
C
+
8
D+
7
E
, カボスでは3
B
+2
C
+
5
D+
8
E
, スダチでは1
B
+2
C
+
9
D+
6
E
およびユズ‘山根’では2
B
+1
C
+11D+
4
E
であった. 以上の結果, 本研究においても近縁の種間では似通ったCMAバンドパターンが観察された.
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虚血性心臟病におけるコレステロール負荷時の血清リポ蛋白変動(第2報)

―特にアポ蛋白Eの変化について―

本間康彦, 三神美和, 佐藤美智子, 石原仁一, 吉川広, 木下栄治, 田川隆介, 星合充基, 古屋秀夫, 井出満, 田辺晃久, 玉地寛光, 兼本成斌, 友田春夫, 中谷矩章, 五島雄一郎

動脈硬化
1984年 12 巻 3 号 599-603
発行日: 1984/08/01
公開日: 2011/09/21

DOI https://doi.org/10.5551/jat1973.12.3_599

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Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL₂ and HDL₃ were estimated on the 0th,
7
th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
B
,
C
-II,
E
levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL₂ and HDL₃ were 15.
9
±
7
.
5
mg/dl (mean±SD), 150.
9
±58.1mg/dl 43.
8
±
9
.
6
mg/dl, 16.
4
±
5
.
8
mg/dl and 24.
9
±
6
.3mg/dl respectively. Plasma apoprotein A-I, A-II,
B
,
C
-II and
E
levels were 81.
7
±
22
.0 mg/dl, 15.1±
5
.
4
mg/dl, 93.
7
±36.0mg/dl, 3.83±1.00mg/dl and
4
.29±1.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-
C
(r=0.348), HDL₂-
C
(r=0.612) and HDL₃ (r=0.569). Apoprotein
B
correlated with total cholesterol (TC) (r=0.610), VLDL-
C
(r=0.341), LDL-
C
(r=0.726), HDL-
C
(r=0.432) and HDL₂-
C
(r=0.465). Apoprotein
C
-II correlated with TC (r=0.765), TG (r=0.679), VLDL-
C
(r=0.651), LDL-
C
(r=0.461) and HDL₂-
C
(r=0.326). Apoprotein
E
correlated with TC (r=0.580), TG (r=0.575) and VLDL-
C
(r=0.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=0.468). Apoprotein
B
correlated with apoprotein
C
-II (r=0.393). Apoprotein
C
-II correlated with apoprotein
B
(r=0.393) and
E
(r=0.549). Apoprotein
E
only correlated with apoprotein
C
-II (r=0.549).
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Role of Vitamins
C
and
E
in Regulating Antioxidant and Pro-Oxidant Markers in Preeclampsia

Mohd Suhail, Mohd Faizul Suhail, Hina Khan

Journal of Clinical Biochemistry and Nutrition
2008年 43 巻 3 号 210-220
発行日: 2008年
公開日: 2008/10/31

DOI https://doi.org/10.3164/jcbn.2008067

ジャーナルフリー

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We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group
B
which comprised preeclamptics who were supplemented their diets with vitamins
C
and
E
. MDA increased from
6
.
22
± 2.
8
(placebo) to
8
.48 ± 1.2 (A) and
8
.02 ± 1.
8
nmol/gHb (
B
). NO concentrations were enhanced from 19.3 ±
4
.2 (P) to 23.
8
±
6
.
4
(A) and 24.1 ±
5
.
4
μmol/L (
B
). GSH contents were decreased from 10.42 ± 2.81 (P) to
8
.02 ± 2.92 (A) and
9
.39 ± 1.02 μmol/g Hb (
B
), whereas GSSG concentrations increased from 0.98 ± 0.28 (P) to 1.24 ± 0.29 (A) and 1.08 ± 0.12 μmol/g Hb (
B
). SOD activity decreased 23% in A and 14% in
B
; GRx decreased 27% in A and
5
.
5
% in
B
; GPx decreased 12% in A and
9
.
6
% in
B
. Catalase activity, however, increased 27% in A and 29% in
B
as compared to control. Thus, we conclude that the use of vitamins
C
and
E
should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.

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Syntheses of Apogalanthamine Analogs as α-Adrenergic Blocking Agents. VIII. Syntheses of
4
- and
9
-Bromo-
5
,
6
,
7
,
8
-tetrahydrodibenz [
c
,
e
] azocines and Their Methylenedioxy Derivatives

木原勝, 三宅美行, 飯富守夫, 小林茂

Chemical and Pharmaceutical Bulletin
1985年 33 巻 3 号 1260-1265
発行日: 1985/03/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.33.1260

ジャーナルフリー

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The apogalanthamine analogs
4
- and
9
-bromo-
5
,
6
,
7
,
8
-tetrahydrodibenz [
c
,
e
] azocines (
5
a and
6
a) and their methylenedioxy derivatives (
5
b
and
6
b
) were prepared by photolysis of the hydrochlorides of the respective N-benzyl-β-phenethylamines (
8
a,
b
and
9
a,
b
) substituted with both iodine and bromine atoms. The dibenz [
c
,
e
] azocines
6
a and
6
b
were also obtained by thermal syntheses from the biphenyl compounds 17a and 17
b
, respectively.
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