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  • FRANÇOIS LE GOFFIC, FRÉDÉRIC TANGY, BERNARD MOREAU
    The Journal of Antibiotics
    1979年 32 巻 12 号 1288-1292
    発行日: 1979年
    公開日: 2006/04/12
    ジャーナル フリー
    A sample of [
    3H
    ] tobrarnycin (5, 000 Ci/Mole) has been synthetized and incubated with
    the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
    two types of binding sites. The primary one is probably responsible for the inhibition of
    protein synthesis whereas the secondary one is probably related to the misreading and reading
    tiirough of the messenger RNA.
  • FRANÇOIS LE GOFFIC, MARIE-LOUISE CAPMAU, ERÉDÉRIC TANGY, ELIANE CAMINADE
    The Journal of Antibiotics
    1980年 33 巻 8 号 895-899
    発行日: 1980年
    公開日: 2006/04/12
    ジャーナル フリー
    (
    3H
    ) Tobramycin was used as a probe to determine the relationship between the structure of aminoglycoside antibiotics and their ability to remove this drug from its higher affinity binding site on the ribosome. The dissacharide moieties (neamine, tobramine, gentamine) appeared to have a common binding site, whereas the kanosamine, garosamine and ribose moieties determined the specificity of this binding. Amikacin and butikacin behaved in an anomalous manner in spite of their close structural relationship to tobramycin.
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • S. SICSIC, J. F. LE BIGOT,
    C
    . VINCENT,
    C
    . CERCEAU, F. LE GOFFIC
    The Journal of Antibiotics
    1982年 35 巻 5 号 574-579
    発行日: 1982年
    公開日: 2006/04/12
    ジャーナル フリー
    The activities of tobramycin derivatives acetylated and ethylated on the
    6
    '-N,
    2
    '-N and
    3
    -N positions were examined. The MICs of these derivatives against tobramycin sensitive strains indicated that
    2
    '-N-ethylated and
    6
    '-N-ethylated derivatives have a fairly good activity, and confirmed that the
    3
    -N position is the most important one for antibiotic activity since
    3
    -N derivatives were less active. The MICs of these derivatives against tobramycin resistant strains, and their inactivation by tobramycin modifying enzymes were examined. These results showed that
    2
    '-N or
    6
    '-N ethylation protects the drug against inactivation by AAC(
    2
    ') or AAC(
    6
    '), respectively, and
    2
    '-N-ethyltobramycin and
    6
    '-N-ethyltobramycin were active against strains containing these modifying enzymes. On the other hand,
    3
    -N ethylation protects the drug against inactivation by AAC(
    3
    ) but
    3
    -N-ethyl tobramycin does not inhibit strains containing this enzyme.
  • Mohd Suhail, Mohd Faizul Suhail, Hina Khan
    Journal of Clinical Biochemistry and Nutrition
    2008年 43 巻 3 号 210-220
    発行日: 2008年
    公開日: 2008/10/31
    ジャーナル フリー
    We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group
    B
    which comprised preeclamptics who were supplemented their diets with vitamins
    C
    and
    E
    . MDA increased from
    6
    .
    22
     ± 
    2
    .
    8
    (placebo) to
    8
    .48 ± 1.
    2
    (A) and
    8
    .02 ± 1.
    8
     nmol/gHb (
    B
    ). NO concentrations were enhanced from 19.
    3
     ± 4.
    2
    (P) to 23.
    8
     ± 
    6
    .4 (A) and 24.1 ± 5.4 μmol/L (
    B
    ). GSH contents were decreased from 10.42 ± 
    2
    .
    81
    (P) to
    8
    .02 ± 
    2
    .92 (A) and
    9
    .39 ± 1.02 μmol/g Hb (
    B
    ), whereas GSSG concentrations increased from 0.98 ± 0.28 (P) to 1.24 ± 0.29 (A) and 1.08 ± 0.12 μmol/g Hb (
    B
    ). SOD activity decreased 23% in A and 14% in
    B
    ; GRx decreased 27% in A and 5.5% in
    B
    ; GPx decreased 12% in A and
    9
    .
    6
    % in
    B
    . Catalase activity, however, increased 27% in A and 29% in
    B
    as compared to control. Thus, we conclude that the use of vitamins
    C
    and
    E
    should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.
  • Misaki Kojima, Takeya Morozumi
    Journal of Health Science
    2004年 50 巻 5 号 518-529
    発行日: 2004年
    公開日: 2004/10/01
    ジャーナル フリー
    Six full-length cDNAs encoding pig cytochrome P450 (CYP) enzymes, CYP1A1, CYP
    2
    A19, CYP
    2
    B
    22
    , CYP
    2
    C
    33v4, CYP
    2
    C
    49, and CYP
    2
    E
    1, were isolated and sequenced. The cDNA sequences of pig CYP1A1, CYP
    2
    A19, CYP
    2
    B
    22
    , CYP
    2
    C
    49, and CYP
    2
    E
    1 showed high similarity to human CYP1A1 (85.4%),
    CYP2A13
    (
    88
    .
    6
    %),
    CYP2B6
    (
    81
    .1%),
    CYP2C18
    (85.
    3
    %), and
    CYP2E1
    (82.5%), respectively, and pig
    CYP2C33v4
    cDNA showed high similarity to rat
    CYP2C23
    (79.
    2
    %). Reverse transcription-polymerase chain reaction (RT-PCR) assays revealed hepatic gene expression of all these pig CYP enzymes: the order of expression was
    CYP2C33v4
    and
    CYP2E1
    >
    CYP2C49
    > CYP1A1 and
    CYP2A19
    >
    CYP2B22
    . In the kidney, the
    CYP2C33v4
    gene was expressed at the same level as in the liver, but the CYP1A1,
    CYP2A19
    , and
    CYP2B22
    genes were expressed at lower levels than in the liver. Little renal gene expression of CYP
    2
    C
    49 and CYP
    2
    E
    1 was observed. We revealed for the first time the full-length cDNA sequences encoding pig CYP1A1 and five CYP enzymes belonging to the
    CYP2
    gene family, thus making it possible to examine the gene expression levels of these CYP enzymes in pig tissues by RT-PCR.
  • MARIE LAVAULT, ALAIN FOURNET, HELENE GUINAUDEAU, JEAN BRUNETON
    Chemical and Pharmaceutical Bulletin
    1986年 34 巻 3 号 1148-1152
    発行日: 1986/03/25
    公開日: 2008/03/31
    ジャーナル フリー
    Nine isoquinoline alkaloids belonging to the protoberberine, proaporphine and bisbenzyl-isoquinoline series were isolated from Caryomene olivascens (Menispermaceae). Four compounds are new : (-)-
    2
    -norlimacine (4), (-)-caryolivine (
    6
    ), (+)-1,
    2
    -dehydro-
    2
    -norlimacusine (
    9
    ) and N-formylstepharine (
    3
    ). The last one is the first N-formyl derivative to be reported in the proaporphine group. Its biogenetic origin is discussed. Structures were established on the basis of 360 MHz (FT) nuclear magnetic resonance measurements and also by chemical correlation in the case of
    3
    .
  • 加藤 行男, 松本 智, 潮田 弘, 谷川 力, 高木 敬彦, 光崎 研一, 金内 長司
    日本獣医師会雑誌
    1996年 49 巻 6 号 408-410
    発行日: 1996/06/20
    公開日: 2011/06/17
    ジャーナル フリー
    魚市場およびと畜場のドブネズミにおけるStaphylococcus auresの保有率はそれぞれ74.
    6
    % (44/59), 34.
    6
    % (
    9
    /26) であった. 魚市場のネズミ由来S. aureus104株の生物型は
    C
    81
    株 (77.
    9
    %),
    B
    型16株 (15.4%), A型
    6
    株 (5.
    8
    %), 型別不能1株 (1%) で, と畜場由来
    9
    株はG型
    8
    株 (
    88
    .
    9
    %),
    B
    型1株 (11.1%) であった. 魚市場のネズミ由来株のコアグラーゼ型は, VIII型 (26.
    9
    %), 1型 (
    22
    .1%), VII型 (13.5%), IV型 (
    8
    .7%), II型 (5.
    8
    %), III型 (
    2
    .
    9
    %), V型 (
    2
    .
    9
    %), VI型 (
    2
    .
    9
    %), 同定不能 (14.4%) で, と畜場由来株は, VIII型 (44.4%), V型 (
    22
    .
    2
    %), VI [型 (
    22
    .
    2
    %), 同定不能 (11.1%) であった.魚市場のネズミ
    9
    匹由来の12株からはエンテロトキシンA (11株) および
    B
    (1株) が産生された.
  • M. L. GHOSH
    Journal of Physics of the Earth
    1972年 20 巻 2 号 165-186
    発行日: 1972年
    公開日: 2009/04/30
    ジャーナル フリー
    The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.
  • I. F. Davies
    Journal of Light & Visual Environment
    1984年 8 巻 1 号 1_9-1_20
    発行日: 1984年
    公開日: 2011/05/20
    ジャーナル フリー
  • 黒川 美貴雄, 吉田 耕治, 永井 保嵩, 宇野 準
    Chemical and Pharmaceutical Bulletin
    1983年 31 巻 12 号 4312-4318
    発行日: 1983/12/25
    公開日: 2008/03/31
    ジャーナル フリー
    Two new partially saturated tricyclic ring systems,
    6
    ,
    6
    a, 7,
    8
    ,
    9
    , 10, 10a, 11-octahydro-11-oxodibenz [
    b
    ,
    e
    ] oxepins (
    3
    a and
    3
    b
    ), and -thiepins (4a and 4
    b
    ) were synthesized. Compounds 4a and 4
    b
    were desulfurized to give a pair of isomeric
    2
    -methylbenzoylcyclohexanes (10a and 10
    b
    ). Deuterated 4a and 4
    b
    (11a and 11
    b
    ) were prepared starting from butadiene-
    d6
    (12). The stereochemical features of
    3
    a (trans),
    3
    b
    (cis), 4a (trans) and 4
    b
    (cis) are compared with those of 10a, 10
    b
    , 11a and 11
    b
    on the basis of proton nuclear magnetic resonance data.
  • 張 曼濤
    印度學佛教學研究
    1967年 15 巻 2 号 650-652
    発行日: 1967/03/31
    公開日: 2010/03/09
    ジャーナル フリー
  • ―特にアポ蛋白Eの変化について―
    本間 康彦, 三神 美和, 佐藤 美智子, 石原 仁一, 吉川 広, 木下 栄治, 田川 隆介, 星合 充基, 古屋 秀夫, 井出 満, 田辺 晃久, 玉地 寛光, 兼本 成斌, 友田 春夫, 中谷 矩章, 五島 雄一郎
    動脈硬化
    1984年 12 巻 3 号 599-603
    発行日: 1984/08/01
    公開日: 2011/09/21
    ジャーナル フリー
    Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for
    2
    weeks. Cholesterol amounts in VLDL, LDL, HDL,
    HDL2
    and
    HDL3
    were estimated on the 0th, 7th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
    B
    ,
    C
    -II,
    E
    levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL,
    HDL2
    and
    HDL3
    were 15.
    9
    ±7.5mg/dl (mean±SD), 150.
    9
    ±58.1mg/dl 43.
    8
    ±
    9
    .
    6
    mg/dl, 16.4±5.
    8
    mg/dl and 24.
    9
    ±
    6
    .
    3
    mg/dl respectively. Plasma apoprotein A-I, A-II,
    B
    ,
    C
    -II and
    E
    levels were
    81
    .7±
    22
    .0 mg/dl, 15.1±5.4mg/dl, 93.7±36.0mg/dl,
    3
    .83±1.00mg/dl and 4.29±1.36mg/dl respectively. After
    2
    weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-
    C
    (r=0.348),
    HDL2
    -
    C
    (r=0.612) and
    HDL3
    (r=0.569). Apoprotein
    B
    correlated with total cholesterol (TC) (r=0.610), VLDL-
    C
    (r=0.341), LDL-
    C
    (r=0.726), HDL-
    C
    (r=0.432) and
    HDL2
    -
    C
    (r=0.465). Apoprotein
    C
    -II correlated with TC (r=0.765), TG (r=0.679), VLDL-
    C
    (r=0.651), LDL-
    C
    (r=0.461) and
    HDL2
    -
    C
    (r=0.326). Apoprotein
    E
    correlated with TC (r=0.580), TG (r=0.575) and VLDL-
    C
    (r=0.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=0.468). Apoprotein
    B
    correlated with apoprotein
    C
    -II (r=0.393). Apoprotein
    C
    -II correlated with apoprotein
    B
    (r=0.393) and
    E
    (r=0.549). Apoprotein
    E
    only correlated with apoprotein
    C
    -II (r=0.549).
  • 香山 滉一郎, 森下 政夫, 張 国鋒
    粉体および粉末冶金
    2006年 53 巻 5 号 419-429
    発行日: 2006年
    公開日: 2006/12/19
    ジャーナル オープンアクセス
    The phase diagrams of the Ni-Mo-
    B
    and Ni-W-
    B
    ternary systems in the region of less than 50mol%
    B
    were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
    E1
    :L (1365K, 71.5mol%Ni-
    6
    .0mol%Mo-
    22
    .5mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiMo2B2

    E2
    :L (1355K, 62.5mol%Ni-
    2
    .5mol%Mo-30.5mol%
    B
    )=
    Ni3B
    +
    Ni2B
    +
    NiMo2B2

    E3
    :L (1445K, 42.0mol%Ni-30.
    6
    mol%Mo-10.
    3
    mol%
    B
    )=(Ni)+NiMo+
    NiMo2B2

    P1:L (1812K, 34.
    9
    mol%Ni-42.
    3
    mol%Mo-
    22
    .
    8
    mol%
    B
    )+MoB=
    Mo2B
    +
    NiMo2B2

    P2
    :L (1633K, 42.
    3
    mol%Ni-40.4mol%Mo-17.
    3
    mol%
    B
    )+Mo=
    Mo2B
    +
    NiMo2B2

    P3
    :L (1812K, 53.5mol%Ni-33.7mol%Mo-12.
    8
    mol%
    B
    )+Mo=NiMo+
    NiMo2B2

    E1
    :L (1622K, 51.0mol%Ni-31.
    6
    mol%W-17.4mol%
    B
    )=(Ni)+W+
    NiW2B2

    E2
    :L (1260K, 71.0mol%Ni-7.0mol%W-
    22
    .0mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiW2B2

    E3
    :L (1291K, 65.4mol%Ni-4.
    8
    mol%W-29.
    8
    mol%
    B
    )=
    Ni2B
    +
    Ni3B
    +
    NiW2B2

    P1:L (2115K, 23.
    8
    mol%Ni-43.1mol%W-33.1mol%
    B
    )+WB=
    W2B
    +
    NiW2B2

    P2
    :L (1657K, 48.
    9
    mol%Ni-33.1mol%W-18.0mol%
    B
    )+
    W2B
    =W+
    NiW2B2

    The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
  • Tsuji Kunihiko, Yoshida Haruyoshi, Kang John-Hong, Sakurai Yasuo, Katanuma Akio, Miyoshi Shigeki, Osanai Manabu, Yanagawa Nobuyuki, Izumi Shinichi, Itoh Hideto, Watanabe Seiji, Takahashi Kuniyuki, Nomura Masahumi, Maguchi Hiroyuki, Yoshida Junichi, Maekubo Hiroshi
    Journal of Microwave Surgery
    1999年 17 巻 79-83
    発行日: 1999年
    公開日: 2008/09/24
    ジャーナル フリー
    Background : Usefulness of endoscopic microwave coagulation therapy (
    E
    -MCT) was examined in 27 patients with hepatocellular carcinoma (HCC).
    Material and Methods : HCC was found in
    8
    patients with type
    B
    liver cirrhosis (LC), 16 patients with type
    C
    LC, and
    3
    patients with non
    B
    non
    C
    LC. Median tumor size was 23 mm (solitary lesion
    22
    , multiple 5). Laparoscopic MCT was performed for
    S2
    -
    6
    lesion and thoracoscopic MCT for
    S8
    lesion under general anesthesia. Linear type ultrasonography was used in every case for monitoring lesion ant therapeutic effect.
    Results : Complete tumor necrosis was obtained in 24 cases (
    81
    %) and local recurrence was found in 5 cases after the observation period of maximum 34 months. Pleural abscess, hemorrhage and hepatic infarction were found in
    3
    cases without serious outcome.
    Conclusions : We conclude that
    E
    -MCT is quite promising therapy for surface type HCC in term of minimally invasive and curative procedure a time. It is important that sufficient marginal coagulation should be obtained.
  • 澁谷 啓, 三田地 利之, 黄 聖春
    地盤工学会論文報告集
    2000年 40 巻 3 号 87-100
    発行日: 2000/06/15
    公開日: 2008/02/29
    ジャーナル フリー
    Natural sedimentary clays exhibit ageing effects on their behaviour when subjected to both consolidation and shearing. Attempts to characterising the in-situ 'structure'of soft marine clays have been made in case studies performed in Ariake (Japan) and in Bangkok (Thailand), each showing a typical profile of aged clay-structure with depth reflecting its site-specific geological consolidation history. In each site, profiles of Atterberg limits, natural water content, overconsolidation ratio (OCR), quasi-elastic shear modulus Gmax and the undrained shear strength cu with depth were attained from various laboratory tests, together with the a comparable profile of quasi-elastic shear modulus from insitu seismic survey Gf. Quantitative assessment of the aged clay-structure was made by using two different measures, metastability index MI (G) and the soil constant reflecting structure S (Jamiolkowski et al., 1994). The profiles of MI (G) and the S-value with depth were both determined based on the corresponding Gmax behaviour of the reconstituted sample. "Disturbance"of laboratory samples retrieved by using two different samplers (i.
    e
    ., Laval and Japanese thin-walled samplers) with two different sampling techniques (i.
    e
    ., pre-boring and displacement methods) was discussed. A new approach to estimate cu"in the ground", termed by the authors the MILK (Metastability Index coupled with Laboratory Ko test) method, is proposed. A trial of the MILK-method is demonstrated in soft Bangkok clay, the texture of which is similar to "soft cheese".
  • 福元 葵, K. Sumfleth
    紙パ技協誌
    2002年 56 巻 11 号 1598-1601
    発行日: 2002/11/01
    公開日: 2009/11/19
    ジャーナル フリー
    Since 135 years
    E.C
    .H.Will Hamburg is one of the leading manufacturers of converting machinery for the paper industry.The company has gained worldwide acknowledgement when introducing cut size sheeters for copy paper. These machines are used worldwide by all well-known paper makers and also in the meantime by smaller paper converting companies.
    With regard to folio size sheeter
    E.C
    .H.Will was and is reknown for special solutions instead. Based on and with the knowhow of hundreds of cut size sheeters and some hundred folio size sheeters having been delivered, the concept of the Will “global folio size sheeter” type GFS has been developed.
    The great technical experience in cutting and transporting paper as well as introducing innovative ideas, new materials and, last but not least, the influence of various customers' requests, which are known to
    E.C
    .H.Will from numerous special projects, were the base for development of the GFS folio sheeter.
  • 増大する資源
    E
    . F. Boswell
    紙パ技協誌
    1998年 52 巻 7 号 885-889
    発行日: 1998/07/01
    公開日: 2009/11/19
    ジャーナル フリー
    The world is in the midst of a huge fundamental shift in fibre supply, demand balances, and policy changes. Governments around the world are introducing policy changes which influence the supply demand balance as the politicians' thoughts are uttered. Government agencies and their bureaucrats are imposing changes on industry even before the legislation is passed by the government in question.
    This ad hoc change process will continue for a time to come until the countries in question show a tough-mindedness with regard to their land use policies. Policies affecting forest areas such as protection areas, Native land claims, the protection of biodiversity and a true goal of sustainable development ; which addresses the combined issues of cultural, environmental, social and economic matters.
    Eventually all of these difficult issues will reach essential closure. Then there will be great new opportunities for investment to meet the growing demand for forest products ; leading to a strengthening competitive position in the more traditional producing areas such as Canada.
  • Tariq F. Alghazzawi
    Journal of Prosthodontic Research
    2017年 61 巻 3 号 305-314
    発行日: 2017年
    公開日: 2017/09/12
    ジャーナル オープンアクセス

    Purpose: The purpose of this study was to determine if the optical properties of zirconia and glass–ceramic (

    e
    .max) were affected by low-temperature degradation (aging).

    Methods: Experiment samples were fabricated with seven zirconia brands (n=10): Zenostar, Zirlux, Katana, Bruxzir, DD-

    BioZX2
    , DD-
    cubeX2
    , NexxZr; and
    e
    .max were used as a control. This resulted in a total of 80 samples in the experiment. The L*, a* and
    b
    * were measured for each sample, and then the optical properties including translucency parameter (TP), contrast ratio (CR), and opalescence parameter (OP) were calculated. The samples were aged (20, 40, 60, 80, 100h), and the optical properties were calculated after each interval.

    Results: Most zirconia brands had lower L*, higher a*, higher

    b
    * with increased aging, which visually corresponds to darker, redder, and more yellow. Aging also increased CR, lowered TP, and lowered OP.
    e
    .max was also affected by aging but still had the highest TP (23.
    9
    ±
    2
    .
    8
    ), L* (
    81
    .7±
    3
    .4), and lowest CR (0.41±0.05) compared to any zirconia. The Zenostar had the closest TP (24.1±0.4), and L* (
    90
    .
    2
    ±0.5) values to
    e
    .max before aging. However, after 100h of aging, the DD-
    cubeX2
    was least effected and had the highest TP (
    22
    .
    2
    ±0.
    6
    ) and lowest CR (0.43±0.01) compared with other zirconia samples and highest OP (11.
    3
    ±0.
    2
    ) of all ceramic samples.

    Conclusions: The optical properties of zirconia and

    e
    .max materials were affected by aging with the effects increasing with time. The magnitude of change was affected by seven brands of dental zirconia.

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