One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.

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The gamma-ray spectrum and the conversion-electron spectrum are measured in the decay of the ^116mIn activity. Directional correlations are also measured for 818–1293 and 1097–1293 keV cascades. The M1-2 mixing ratio δ, and the 0-2 mixing ratio μ_k are obtained for 818. keV +→2₁⁺ transition to be δ=1.52−

0.22

+0.26, and μ_k≤6.1×10⁻⁴ respectively. The

E

2 branching ratio

B

(

E

2;

2₂

+→0_g⁺):

B

(

E

2;

2₂

+→2₁⁺):

B

(

E

2;

2₂

+→0₁⁺) is determined to be 0.0158:1.0:5.

86

.

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The group velocities of surface waves in the period range - s were measured to retrieve the anisotropy pattern of the surface wave velocities in the Eastern Pacific Ocean. WWSSN long period records at KIP, Hawaii, from ridge events in the Gulf of California, the East Pacific rise, and the Easter Island Cordillera were used to cover propagation directions N60°-N140°. These station and epicenters are in very favorable positions to minimize the effects of the lateral heterogeneity owing to ocean floor ages. The fast direction of the Rayleigh wave group velocity is normal to ridge, showing 3-5% azimuthal anisotropy. The Love wave group velocity shows little azimuthal anisotropy. A model of a possible type of preferred orientation of constituent olivine beneath the Pacific Ocean is proposed, based on the elastic constants and the petrofabrics of dunite from Hidaka, Hokkaido, Japan, and that of olivine nodules in the ophiolite complex from the Bay of Islands and Oman. In this model, a-axis is concentrated along a particular direction and - and c-axes form a girdle. Elastic constants of the model are C₁₁=2.44, =C₃₃=2.05, C₁₂=C₁₃=0.72, C₂₃=0.67, C₄₄=0.69, and C₅₅= =0.75 (10¹² dyn·cm), where X₁-axis, or the direction of the a-axis concentration, is normal to ridge and X₃-axis is vertical. If we assume that the type of the preferred orientation is an age-independent property of suboceanic lithosphere, this model can explain the overall features of the large-scale anisotropy in the Pacific Ocean: the azimuthal anisotropy of surface wave velocities as described above; the SH-SV anisotropy of surface waves of about 0.15 km/s; the P_n, anisotropy of . km/s to 8.6 km/s; the high S_m, velocity of about 4.8 km/s; and the ScS polarization anisotropy

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Stereoselective synthesis of , - and , Z-β-ionylideneacetaldehydes was accomplished from the β-ionone tricarbonyl iron complex, and the latter was converted to Z-retinoic acid.

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A monoclonal antibody, 6 established from mice injected with dolphin peripheral blood lymphocytes (PBLs) was characterized. In addition to its reactivity against .4% of dolphin PBLs, 6 reacted with 33.1% of bovine PBLs of which % were CD5 ⁺, 11.1% were CD5^-. 6 recognized a 34 kD protein on the surface of dolphin and bovine PBLs. Analysis of the protein's N-terminal amino acid sequence indicated that 6 recognizes bovine major histocompatibility complex (MHC) class II antigens. These results suggested that 6 recognized MHC class II antigens on bovine PBLs. As we have already produced an anti-dolphin MHC class I monoclonal antibody, analysis of immune system using these monoclonal antibodies will advance our understanding of the evolution of the mammalian immune system.

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Chemical properties of ergosta-4, 6, 8(14), -tetraen-3-one (1) were investigated. Though 1 is rather stable to acids or bases, it reacts easily with two moleculres of oxygen on irradiation with UV light to give 6α, -epidioxy-14α-hydroperoxyergosta-4, , -trien-3-one (2), which is transformed successively to 6α, ;8α, -diepoxy-14α-hydroperoxyergosta-4, -dien-3-one (3) and 14α-hydroperoxy--hydroxyergosta-4, , -triene-3, 6-dione (4) under these reaction conditions.

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Two new partially saturated tricyclic ring systems, 6, 6a, , 8, , 10, 10a, 11-octahydro-11-oxodibenz [, ] oxepins (3a and 3), and -thiepins (4a and 4) were synthesized. Compounds 4a and 4 were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10). Deuterated 4a and 4 (11a and 11) were prepared starting from butadiene-d₆ (12). The stereochemical features of 3a (trans), 3 (cis), 4a (trans) and 4 (cis) are compared with those of 10a, 10, 11a and 11 on the basis of proton nuclear magnetic resonance data.

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From the fronds of Polystichum tripteron (KUNZE) P_R. a new norcarotenoid glycoside was isolated and shown to be (6R, , R)--hydroxy-megastigma-4, -dien-3-one--O-β-D-glucoside. The fronds of Dennstaedtia wilfordii (MOORE) CHRIST. contain the same glucoside.

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症例は75歳，女性。1997年月に甲状腺原発非ホジキンリンパ腫の診断を受け，CHOP類似治療を5回受けたが完全寛解が得られず，甲状腺摘出術とetoposideの投与が行われた（1998年2月∼2000年5月，総量16775mg）。2000年6月汎血球減少のため当科に紹介，典型的な骨髄像より治療関連急性前骨髄球性白血病(t-APL)と診断した。染色体分析では20細胞すべてがt(15:17)をもち，さらに4細胞はt(;)を伴っていた。All-trans retinoic acidを中心とした治療により完全寛解が得られ，染色体異常も消失した。10ヵ月後再発したが，染色体異常はt(15:17)のみであった。遺伝子検査をおこなっておらず，t(;)の病状への関与については充分に検討し得ないが，これまでにt(15:17)とt(;)を同時に持つt-APLクローンの報告例はなく，きわめてまれな症例である。

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Brassinolide analogues, (R, 23R, 24R)-2α, 3α, , 23-tetrahydroxy--homo--oxa-5α-ergostan-6-one (24-epibrassinolide) (10) and (S, 23S, 24R)-2α, 3α, , 23-tetrahydroxy--homo--oxa-5α-ergostan-6-one (), were synthesized from brassicasterol (3a) in five steps and with ca. 20% overall yield. The key steps are the direct formation of (, 24R)-3α, 5-cyclo-5α-ergost--en-6-one (4) from brassicasterol mesylate (3), the acid-catalyzed rearrangement of 4 to (, 24R)-5α-ergosta-2, -dien-6-one (6), and the Baeyer-Villiger oxidation of the tetrahydroxy 5α-ergostan-6-ones and 8.

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Laparoscopic multiple punch resections were applied on the surface of the ovaries in 38 infertile patients who did not have spontaneous ovulation, and the effects on the clinical aspects of ovulation and gestation, and endocrinological state were examined. The patients were categorized into three groups to determine the indication of this treatment as follows. Group A (n=): ovulated under administration of 100mg/day clomiphene. Group (n=): ovulated under administration of 200mg/day clomiphene, failed to ovulate under administration of 100mg/day. Group C (n=): failed to ovulate even under administration of 200mg/day. The dose of clomiphene to induce ovulation was reduced in 8 (%) in group A, 19 (%) in Group and 6 (%) patients in group C. Although no patients became pregnant in group A, 17 (77%) in Group and 5 (71%) in Group C became pregnant after this treatment. Irrespective of the good clinical outcome, no endocrinological improvements was found in the results of LH-RH test and serum testosterone levels. These findings suggest that this treatment is effective on the patients with severe anovulation, and that this effect is not based on the endocrinological improvement but on the local mechanical factors.

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Eight new sterols, 5α, 8α-epidioxy-(, 24R)-23-methylergosta-6, -dien-3β-ol (1), 3β, 5α, -trihydroxy-(, 24R)-23-methylergosta-, -dien-6-one (2), 3β, 5α, -trihydroxy-(24S)-ergost--en-6-one (3), 3β, 5α, , 14α-tetrahydroxy-(, 24R)-ergosta-, -dien-6-one (4), (, 24R)-ergosta-, -diene-3β, 5α, 6α, -tetrol (5), 5α, -epidioxy-3β-hydroxy-(, 24R)-ergosta-, -dien-6-one (6), 5α, -epidioxy-3β-hydroxy-(24S)-ergost--en-6-one () and 5α, 6α-epoxy-(, 24R)-ergosta-8, -diene-3β, , 14α-triol (8), have been isolated from five edible mushrooms, Lentinus edodes, Flammulina velutipes, Hypsizigus marmoreus, Pleurotus ostreatus and Pholiota nameko together with fifteen known ones (-23), of which two (16 and 17) are reported for the first time from a fungal source. The structures of these new compounds were elucidated on the basis of their spectral data.

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Melithasterols A-D (1-4), isolated from a gorgoinan coral Melithaea ocracea of Okinawa, were shown to be cholestane-, 24-methyl--dehydrocholestane-, -dehydrocholestane-, and 24-methylenecholestane-derivatives. respectively, having a common 3β, α -dihydroxy-5α, 6α-epoxy-Δ^8 steroid nucleus. This was confirmed by direct comparison with the authentic sample prepared by lead tetra-acetate oxydation of cholest-6-ene- 3β, 5α, 8α-triol 3-monoacetate. Twelve new polyhydroxysterols were isolated from an Alcyonium sp. (,8,), and Sclerophytum sp. (14,16,19,20,21,a,23,26,28) soft corals collected off the coasts of the Andaman and Nicobar Islands in the Indian Ocean. All the Sclerophytum sp. soft corals contained 17a or its 25-deacetyl derivative. Compounds to were identified as 24-methylenecholest-5-ene- 3β, 16β-diol-3-0-α-L fucoside () and its β-(8) and α-hydroxy () derivatives. Compound 14 was shown to be 24S-24-methylcholest-5-ene-3β,25ξ,26-triol and was correlated to the known compound 15 by 5α, 6β-glycolation. Compound 16 was shown to be 5β, 6α-isomer of 17, correlating to 17 by PCC oxidation followed by dehydration. Compound 19 was identified with 25-deacetyl derivative of the known compound lobosterol (19a) by hydrolysis of authentic lobosterol. Compounds 20 and 21 were shown to be -dehydro-(20) and -dehydro-(21) derivative of 17a and 17, respectively, by comparisons of their spectral data with reference compounds. Compounds a and 23 were 24S-methylcholestane-3β, 5α 25-triol-6-one 25-monoacetate (a) and its 25-deacetoxyl derivative (23). Partial PCC oxidation of 17a afforded a. Compounds 26 (andamansterol) and 28 (nicobarsterol) were shown to be gorgost-5-ene-3β, α. 11α, 21-tetrol and novel secosteroid, 11,21-cyclo--homo-11-oxa-, 11-secoergostane-3β, 6α, 12ξ-triol--one, respectively, by spectral analyses (H-HCOSY, HMQC, HMBC).

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