A sample of [³H] tobrarnycin (, 000 Ci/Mole) has been synthetized and incubated with
the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
two types of binding sites. The primary one is probably responsible for the inhibition of
protein synthesis whereas the secondary one is probably related to the misreading and reading
tiirough of the messenger RNA.

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(³H) Tobramycin was used as a probe to determine the relationship between the structure of aminoglycoside antibiotics and their ability to remove this drug from its higher affinity binding site on the ribosome. The dissacharide moieties (neamine, tobramine, gentamine) appeared to have a common binding site, whereas the kanosamine, garosamine and ribose moieties determined the specificity of this binding. Amikacin and butikacin behaved in an anomalous manner in spite of their close structural relationship to tobramycin.

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The activities of tobramycin derivatives acetylated and ethylated on the 6'-N, '-N and 3-N positions were examined. The MICs of these derivatives against tobramycin sensitive strains indicated that '-N-ethylated and 6'-N-ethylated derivatives have a fairly good activity, and confirmed that the 3-N position is the most important one for antibiotic activity since 3-N derivatives were less active. The MICs of these derivatives against tobramycin resistant strains, and their inactivation by tobramycin modifying enzymes were examined. These results showed that '-N or 6'-N ethylation protects the drug against inactivation by AAC(') or AAC(6'), respectively, and '-N-ethyltobramycin and 6'-N-ethyltobramycin were active against strains containing these modifying enzymes. On the other hand, 3-N ethylation protects the drug against inactivation by AAC(3) but 3-N-ethyl tobramycin does not inhibit strains containing this enzyme.

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Repetitive liquefactions in angular and subangular gravels from an alluvial fan, in the case of two earthquakes with accelerations lower than that of a former which had caused liquefaction some months before, are described. The liquefaction took place from the surface, down to a depth of approximately 10 m. Water laden with sediments spouted out for some tens of minutes after the strong motion ceased. Knowledge of the grain size distribution of the sediments inside the body of the alluvial fan roughly defines the areas of the fan prone to future liquefaction. Non-repetitive liquefaction in overconsolidated fine fluvio-lacustrine sand of glacial origin at the unusual depth of 14 m to 16 m is also described. From the observation of sand lifted up for 10 m inside a large diameter well, and of that which spouted out from several microvents, it was estimated that extra-pore pressure was close to lithostatic conditions. Nevertheless, modeling of intrinsic pore pressure buildup on the DESRA programme gives lower values than the experimental one. Geotechnical characteristics of the 12 m-thick sandy stratum indicate that the upper part is unusually soft, either due to water circulation or past repetitive liquefactions which prevented reconsolidation. It is suggested that excess pore pressure generated by the earthquake was also due to redistribution of pressure from adjacent sediments.

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The syntheses of (S)-13-hydroxy-(, , )-tetradecatrienoic acid (1) and (, , Z-tetradecatrienoic acid () were carried out by using the Wittig reaction as the key step. The asymmetric center at -13 and the double bond between - and - for natural compound 1 were reconfirmed as being of (S) configuration and , respectively. The relationship between the structure of the unsaturated hydroxy fatty acids and their inhibitory effect on the growth of lettuce was investigated.

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A comparative study of the static and dynamic response of a slope is carried out, using the large deformation theory of the updated Lagrangian formulation and the conventional infinitesimal theory. In the static analysis, a strength reduction method proposed by one of the authors is used to evaluate the safety factor of the slope. It is found that by the large deformation theory, the safety factor is larger than that calculated by the infinitesimal theory, and this difference becomes large along with the reduction of elastic modulus. In the dynamic analysis, it is observed that the large deformation theory gives smaller sliding displacement and larger response acceleration than the infinitesimal approach. It is concluded that in many cases the large deformation approach gives more adequate solutions.

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The Gujarat earthquake in India occurred in January, 2001, and caused significant damage in the province of Gujarat. The Japanese Geotechnical Society sent a small reconnaissance team to the damaged region after the quake. The present text presents the report from this activity. The major attention of the team was focused on geotechnical aspects of the damage which were related to earthfill dams and harbor land fills. It was found that a significant portion of damage was concentrated in fills resting on soft natural soils. Swedish weight soundings which were conducted at two places demonstrated the existence of such a soft subsoil. From this, it was concluded that amplification of earthquake shaking as well as the permanent deformation in the soft foundation soil induced such kinds of damage as subsidence, cracking, and lateral spreading in overlying artificial fills. For the better seismic resistance of those affected fills during future earthquakes, the improvement of soft subsoil seems essential.

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The boundary element method expanded in frequency domains is presented to analyze the dynamic interaction between an embedded flexible rectangular foundation and soil with consideration of the obliquely incident waves. Numerical results describing the influence of the flexibility of the foundation on the dynamic responses of the foundation due to obliquely incident waves indicate that the flexibility of actual foundations can diminish the reduction of translation responses and increase the rotational responses in the high frequency range. These phenomena are more conspicuous as the embedment ratio is larger and the value of the wave velocity ratio of the soil and the foundation approaches to unity. When the high frequency components of the input ground motion are important and the basement has higher flexibility (for example

2v_s

/₁v_s >0.

4

), the analysis method which considers the basement as a rigid foundation may lead to unsafety estimations and the estimation of the flexibility of the foundation is necessary as analysing the effective input motion with consideration of the incident waves.

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The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.

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Nine isoquinoline alkaloids belonging to the protoberberine, proaporphine and bisbenzyl-isoquinoline series were isolated from Caryomene olivascens (Menispermaceae). Four compounds are new : (-)--norlimacine (), (-)-caryolivine (6), (+)-1, -dehydro--norlimacusine () and N-formylstepharine (3). The last one is the first N-formyl derivative to be reported in the proaporphine group. Its biogenetic origin is discussed. Structures were established on the basis of 360 MHz (FT) nuclear magnetic resonance measurements and also by chemical correlation in the case of 3.

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 The stability of

‒tetrahydrocannabinol acetate (‒THC‒OAc) and ‒tetrahydrocannabinol acetate (‒THC‒OAc) in -liquid during storage was investigated. ‒THC‒OAc liquids in cartridges were stored at 80℃ or 30℃ for 28 days. The relative concentrations of cannabinoids in the liquids were measured by gas chromatography with flame ionization detection. ‒THC‒OAc decreased during storage at either temperature. ‒THC, a minor impurity, also decreased. ‒THC‒OAc liquid in a cartridge was stored at 80℃ for 57 days. The concentration of ‒THC‒OAc and ‒THC, a minor impurity, did not change during that time. Cannabinol acetate increased in all liquids, and unknown products were also detected by gas chromatography/mass spectrometry (GC/MS). The ‒THC‒OAc and ‒THC‒OAc liquids were subjected to GC/MS to detect representative diluents, glycerol, propylene glycol, and polyethylene glycol 400, but none of these were detected.

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Based on the concept "intermediate soil wedge" which is dependent on mobilized frictional resistance, a new theory has been developed for evaluating the seismic earth pressures against retaining walls under any condition between the active and passive states. For this theory, the seismic earth pressure is separated into four components according to their formation. New equations are proposed to determine the distribution, resultant and point of application for each component. An equivalent seismic coefficient is introduced to take into account non-uniform seismic acceleration distribution with depth. The equations place special emphasis on dependence of the seismic earth pressure on mode and level of wall movement. The equations can be reduced to the Mononobe-Okabe equation for the limiting conditions. Their applicability was confirmed by comparing the predictions with a number of previous model test results.

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A finite element model capable of taking into account nonlinear hysteretic soil behavior is presented to study earthquake induced retaining wall movement. The model also accounts for increase in lateral stresses and settlement associated with grain slip caused by cyclic loads. The predictive capability of the proposed method is verified by comparing responses given by the model with those computed by another existing finite element model and also with responses recorded at the Cambridge centrifuge facility. The study reveals that the wall displacement can be substantially affected, among other factors, by the increase in lateral stresses due to grain slip and wall-soil friction. Care should be taken when selecting a constant value of wall-soil friction angle for the entire duration of excitation since structural changes can occur in the soil adjacent to the wall.

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All the birds examined were also associated with bone dysplasia (art alczaormal develop-ment of bone tissue) in the diaphyseal cortex of the leg bones, especially of bones affectedwith dyschondroplasia. This result is very significant in order to clarifyz tlais disease entity.1970:J14, k -1 } 7 ) 7, M77 ) i? ht /, ( K ) 7 ( # L", MB @ (7) t, If!TB& U ", Jff Dyschondroplasia (1*t%7fi!dW) ().g:#[!:.fLlt! K?3o, [1: (7)M;tC, rff.?U/:cD, =1lC#li6*H(DX15RI!!D& t, r, ccl)Efff7flr.#.??t"ut:.?T<3.1.?l??/?t:>"A??1!? > >?TMOll?, lI]%G (-srRM) -ts;;.*BI) *M[t fL 54 t:.;*.{1*I[l?(), t@Yllll*fJ?H@(7) %?Jfipj@ (Dyschondroplasia) p, }, (, 1lTi{-X, WIKIM itt{= t D"tl%tff{tO 1111IH(-UP!z U-ii) >ES- -)%Wi*fd?1J*[lEj: >11"i6ifI".*"H*Tl*&Z") #)/?-"k l - vich ) J&it(Vh3iO"= >If-ffi"!1lYl*I")Ji/l![40111!>D*!)<Y14M)?A"!>CL(Il], k7.ClT"ltTt*flB1? & $U [-" U" L % w, Zl1*.IlBl tI1J, FA(y L-x") LVfAK t: >3llltPJIiI " } ) t- ! Al j: >kP11liR6, &ffl(NWi Z 3lk(#L" Ct ?!M"- fL#, -()%.IWMd1.XI1*I1EPW(tit ff1lR)

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