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  • Joey
    B
    . Tanney, Leonard J. Hutchison
    Mycoscience
    2012年 53 巻 1 号 31-35
    発行日: 2012年
    公開日: 2023/03/31
    ジャーナル オープンアクセス

    The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

  • 室町 繁雄, 財満 鎮雄, 高辻 雄三
    日本金属学会誌
    1972年 36 巻 9 号 833-840
    発行日: 1972年
    公開日: 2008/04/04
    ジャーナル フリー
    Six sorts of aluminium-silicon JIS commercial cast alloys, i.
    e
    . AC2
    BF
    , AC2BT
    6
    , AC3
    AF
    , AC4
    AF
    , AC4AT
    6
    and AC4
    BF
    , were examined on drill-machinabilities in regard of drilling resistance, accuracy of drilled holes, deposits on the drill face, chip treatment and others. The results obtained were summarized as follows:
    (1) In the case of
    F
    -materials (as-cast), the drilling resistance and time were smaller in copper-containing materials, i.
    e
    . 2
    BF
    and 4
    BF
    , and were larger in 4
    AF
    , especially 3
    AF
    . And the drilling resistance and time of T
    6
    -materials (heat-treated) were larger than those of
    F
    -materials.
    (2) The drilling temperature was lower in 4AT
    6
    than in the other materials, but the temperatures were about 100∼120°C as a whole and posed no serious problem.
    (3) In the case of
    F
    -materials, the accuracies of drilled holes, i.
    e
    . enlargement of the hole diameter, roundness of the hole figure and surface roughness of the drilled hole in 4
    AF
    and 3
    AF
    were inferior to those in 2
    BF
    and 4
    BF
    , and the roundness of the hole figure and the surface roughness of holes in T
    6
    -materials were better than those in
    F
    -materials.
    (4) In the case of
    F
    -materials, the deposits, such as a cohesive large built-up edge, which deteriorate the accuracy of a drilled hole, were observed on the drill face. This phenomenon was more remarkable in 4
    AF
    , especially 3
    AF
    than in 2
    BF
    and 4
    BF
    . And the deposits in T
    6
    -materials were less cohesive and smaller than those in
    F
    -materials.
    (
    5
    ) There were no difficulties in chip formation regardless of the chip treatment.
  • T BAKER, C. RANGACHARYULU
    日本物理学会講演概要集
    1999年 54.2.1 巻 23pSM-6
    発行日: 1999/09/13
    公開日: 2018/03/04
    会議録・要旨集 フリー
  • Shinji Kaneko, Masanori Shinoda, Ryuji Kubota, Taiki Ohashi, Yosuke Tatami, Motoharu Hayashi, Yuki Yokoi, Hitoshi Kanayama
    Journal of Arrhythmia
    2011年 27 巻 Supplement 号 PJ1_016
    発行日: 2011年
    公開日: 2012/02/02
    ジャーナル フリー
    Background: Atrial fibrillation (
    AF
    ) sometimes cause heart failure (HF) even if a patient has preserved left ventricular (LV) systolic function, but there is unclear what factor lead to heart failure. Methods and Results: From 2008 Sep to 2010 Sep, 180 patients with
    AF
    divide decompensate group (DECO, n=33) is led into NYHA III or IV HF and not decompensate group (NOR, n=147) is otherwise. We exclude under ejection fraction (EF) 55%, adaptation of valvular disease. Data are described consecutively DECO and NOR. Age is 75.3±
    9
    .
    5
    , 65.1±12.
    6
    (p<0.0001). Male gender is 45.
    5
    % and 71.4% (p=0.004). Hypertension is 93.
    9
    %, 59.
    9
    % (p=0.0002). Hypertrophic cardiomyopathy is 33.3% and 12.
    9
    % (p=0.0045). Ischemic heart disease is 21.2% and
    6
    .
    8
    % (p=0.01). Chronic kidney disease is 21.2% and
    8
    .2% (p=0.028). Left atrial diameter is 43.3±
    7
    .
    9
    mm and 39.1±
    6
    .0 mm (p=0.0008). The
    e
    ′ is
    5
    .1±1.
    6
    cm/s and
    7
    .2±2.1 cm/s (p<0.0001).
    E
    /
    e
    ′ is 19.0±12.0 and 11.2±4.
    5
    (p<0.0001). Heart rate on attack is 136±20 bpm and 121±37 bpm (p=0.052). Diabetes mellitus, stroke, valvular disease, medications, LV diastolic diameter, LV systolic diameter, EF, and
    E
    /A have no significant difference. Multivariable logistic regression analysis shows that
    E
    /
    e
    ′ and age have relative risks 1.138 (
    95
    %CI, 1.026–1.261) and 1.069 (
    95
    %CI, 1.008–1.133), respectively. Conclusion:
    E
    /
    e
    ′ and age are independent predictors of HF when patient fall into paroxysmal
    AF
    with preserved systolic function.
  • Jae-Sun Uhm, Boyoung Joung, Hye Jin Hwang, Jong-Youn Kim, Moon-Hyoung Lee, Hui-Nam Pak
    Journal of Arrhythmia
    2011年 27 巻 Supplement 号 OP58_2
    発行日: 2011年
    公開日: 2012/03/27
    ジャーナル フリー
    Backgrounds: We evaluated that electrophysiological characteristics and clinical outcomes of atrial fibrillation (
    AF
    ) with sinus node dysfunction (SND) after radiofrequency catheter ablation (RFCA). Methods: Among 428 patients (male, 77.3%; 56.0±11.0 years old; paroxysmal
    AF
    , 69.4%) who underwent RFCA for
    AF
    , 50 patients (11.
    7
    %) who had ECG documented symptomatic SND (28 Tachybrady (T-Bs) and
    22
    sick sinus syndrome; SSS) were compared with 378 patients without SND. Results: 1. The patients with SND were older (60.3±61617;
    9
    .
    7
    vs. 55.4±61617; 11.1 years, p=0.003) and had higher
    E
    /
    E
    ′ (12.4±61617;
    5
    .1 vs.
    9
    .
    9
    ±61617; 4.1, p=0.002) than those without SND. 2. Effective refractory period (ERP) at high right atrium (RA) was longer (ERP; 244.1±61617; 26.1 vs. 232.2±61617; 28.2 ms, p=0.033) and endocardial voltage at posterior left atrium (LA) was higher (1.2±61617; 0.
    8
    vs. 0.
    9
    ±61617; 0.
    8
    mV, p=0.041) in patients with SND than those without it. 3. The recurrence rate was not different significantly between groups (28.0% vs. 20.0%, p=0.623) during 12.
    7
    ±
    5
    .
    9
    months. A patient with SSS (4.
    5
    %) and a patient with T-Bs (3.
    6
    %) were implanted pacemaker because of recurrent symptomatic bradycardia after RFCA. Conclusion:
    AF
    is associated with SND more often in patients with old age, diastolic dysfunction, and high RA ERP. RFCA results in comparable clinical outcome in those patients, but 4% of them required pacemaker implantation due to
    AF
    recurrence and symptomatic bradycardia.
  • Hajime Ikenouchi, Junpei Koge, Tomotaka Tanaka, Eriko Yamaguchi, Shuhei Egashira, Kazuo Washida, Satoshi Nagase, Kengo Kusano, Kazunori Toyoda, Masafumi Ihara, Masatoshi Koga
    Journal of Atherosclerosis and Thrombosis
    2022年 29 巻 7 号 1069-1075
    発行日: 2022/07/01
    公開日: 2022/07/01
    [早期公開] 公開日: 2021/07/22
    ジャーナル オープンアクセス HTML

    Aims: The relationship between left ventricular (LV) function and

    AF
    detection in embolic stroke of undetermined source (ESUS) patients with insertable cardiac monitors (ICMs) remains unclear. We investigated the association between LV function and
    AF
    detection in patients with ESUS after ICMs implantation.

    Methods: We enrolled patients with ESUS who underwent ICMs implantation from September 2016 to September 2020 using a single-center, prospective registry. LV systolic and diastolic functions were assessed on precordial echocardiography by LV fractional shortening (LVFS) and average

    E
    /
    e
    ’, respectively. Associations between characteristics of LV function and detection of
    AF
    by ICMs were analyzed.

    Results: Participants comprised 101 patients (median age, 74 years; male, 62%). During a median follow-up period of 442 days (interquartile range (IQR), 202–770 days),

    AF
    was detected in 24 patients (24%). Median duration from ICMs implantation to
    AF
    detection was 71 days (IQR, 13–150 days). When LVFS and
    E
    /
    e
    ’ were dichotomized by cutoff value, each of low LVFS (<35.
    5
    %; adjusted hazard ratio (HR), 4.77;
    95
    % confidence interval (CI), 1.77–12.
    9
    ) and high
    E
    /
    e
    ’ (≥
    8
    .65; adjusted HR, 4.56;
    95
    %CI, 1.17–17.
    7
    ) were independently associated with
    AF
    detection after adjusting for age and sex. When patients were divided into four groups according to dichotomized LVFS and
    E
    /
    e
    ’, the combination of low LVFS and high
    E
    /
    e
    ’ was independently associated with
    AF
    .

    Conclusions: In patients with ESUS after ICMs implantation, the LV characteristics of low LVFS and high

    E
    /
    e
    ’ were associated with
    AF
    detection.

  • Sook Kyoung Kim, Kyoung-Jin Shin, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
    Journal of Arrhythmia
    2011年 27 巻 Supplement 号 OP42_4
    発行日: 2011年
    公開日: 2012/03/14
    ジャーナル フリー
    Backgrounds: It has been reported that somatic mutations of mitochondrial DNA (mtDNA) is related with aging, or development of cardiovascular disease. We hypothesized that mtDNA4977 deletion mutation (4977-) detected from human blood contributes to atrial dysfunction in patients with
    AF
    . Methods: We studied for mtDNA4977- in 183 patients with non-valvular
    AF
    , (127 PAF, 56 PeAF) and 69 patients with healthy control. The detection of mtDNA4977- was determined by Gene Scan. Results: 1. The mtDNA4977- in
    AF
    patients were older than those without mutation (61.4±
    9
    .2 vs. 51.
    8
    ±
    9
    .
    9
    , p<0.0001). 2. Frequency of mtDNA4977- mutation in patients with
    AF
    ≤45 years old was not different to age matched control (
    7
    .3% vs. 11.
    6
    %, p=0.2371). 3. The mtDNA4977- had higher
    E
    /
    E
    , (11.3±4.
    8
    vs.
    9
    .1±3.1, p=0.0005), plasma levels of TIMP-1 (1.51±0.77 vs. 1.28±0.57 ng/mL, p=0.0210) and ANP (3.11±2.67 vs. 1.91±2.01 nmole/L, p=0.0010), and were more frequently taking statin (27.2% vs.
    22
    .4%, p=0.0055) than those without mutation. 4. 82.3% with mtDNA4977- and 85.
    5
    % without mtDNA4977- remain in sinus rhythm 12.
    7
    ±
    5
    .
    9
    months after RFCA (p=0.3008). Conclusion: mtDNA4977- was related with aging, diastolic dysfunction, serologic markers related with atrial remodeling or pressure overloading. Its frequency was not different to age matched patients with control, and did not affect the clinical outcome after RFCA.
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • Hideharu Okamatsu, Takahiro Ohara, Hideaki Kanzaki, Ikutaro Nakajima, Koji Miyamoto, Hideo Okamura, Takashi Noda, Takeshi Aiba, Kengo Kusano, Shiro Kamakura, Wataru Shimizu, Kazuhiro Satomi
    Circulation Journal
    2015年 79 巻 2 号 419-424
    発行日: 2015/01/23
    公開日: 2015/01/23
    [早期公開] 公開日: 2014/11/28
    ジャーナル フリー HTML
    Background:The relationship between outcome of radiofrequency catheter ablation (RFCA) for atrial fibrillation (
    AF
    ) and the severity of left ventricular (LV) diastolic dysfunction in patients with hypertrophic cardiomyopathy (HCM) remains unknown.Methods and Results:Twenty-two HCM patients (12 female, aged 65±11 years) with paroxysmal (n=
    5
    ; 23%) or persistent (n=17; 77%)
    AF
    were enrolled. LV diastolic function was evaluated according to the ratio of the mitral inflow early filling velocity to the velocity of the early medial mitral annular ascent (
    E
    /
    e
    ’) measured on pulsed wave and tissue Doppler assessments in all patients. Pulmonary vein isolation was performed in all patients. A second procedure was performed in 3 patients. During a follow-up of 21±12 months, sinus rhythm was maintained in 13 of
    22
    patients (59%).
    E
    /
    e
    ’ was significantly higher in the patients with
    AF
    recurrence than in those without (18±
    7
    vs. 11±3; P<0.01). On Kaplan-Meier analysis the prevalence of
    AF
    recurrence was significantly higher in patients with
    E
    /
    e
    ’ ≥15 (n=
    6
    ) than in those with
    E
    /
    e
    ’ <15 (n=16; P<0.01). On multivariate Cox regression analysis the only significant and independent predictor for
    AF
    recurrence was
    E
    /
    e
    ’ (hazard ratio, 1.16;
    95
    % confidence interval: 1.01–1.37, P=0.03).Conclusions:LV diastolic dysfunction evaluated using
    E
    /
    e
    ’ was associated with difficulty of rhythm control after RFCA in patients with HCM and
    AF
    . (Circ J 2015; 79: 419–424)
  • 吉井 一郎
    日本臨床整形外科学会雑誌
    2017年 43 巻 1 号 1-9
    発行日: 2017年
    公開日: 2018/04/05
    ジャーナル 認証あり

    背景と目的:ステロイド性骨粗鬆症は,積極的な治療介入が必要とされる.その第一選択薬はビスホスホネート製剤(以下ビス)であるが,近年,デノスマブ(以下デノス)も注目を浴びている.ステロイド性骨粗鬆症の骨密度に対する両者の効果を比較検討した.

    方法:ステロイド性骨粗鬆症の管理と治療ガイドライン:2014年改訂版の薬物療法開始の基準を満たした患者を対象とした.無治療群(N群)と,治療介入群として当初よりビスで治療したBB群,ビス後デノスに変更したBD群,デノスで治療したDD群,デノス後ビスに変更したDB群を抽出し,ステロイド投与を開始した時,ステロイド性骨粗鬆症に対する治療を開始した時または薬剤変更から

    6
    カ月後の腰椎,大腿骨頚部と大転子部の骨密度を測定し,それらの変化を統計学的に比較検討した.

    結果:149例が抽出され,その内訳は,N群48例,BB群24例,BD群

    22
    例,DD群21例,DB群34例であった.治療開始時または薬剤変更から
    6
    カ月後にBD群を除くすべての治療介入群で腰椎の骨密度が上昇した.大腿骨の骨密度は,BD群において薬剤変更後に上昇に転じた.

    考察:デノスにはビスと同様の骨密度上昇効果があると考えられた.

    結論:デノスは,ステロイド性骨粗鬆症治療の第一選択薬となり得る.

  • Mitsunobu Ono, Masanobu Shindoh, Masanobu Kobayashi, Fumihiro Higashino, Takao Kohgo, Koichi Yoshida, Yasunori Totsuka
    Oral Medicine & Pathology
    2004年 9 巻 1 号 19-24
    発行日: 2004/03/25
    公開日: 2008/04/01
    ジャーナル フリー
    E
    1
    AF
    , an ets-oncogene family transcription factor, has been shown to upregulate transcription from matrix metalloproteinase (MMP) genes, which confers the invasive phenotype on cancer cells. On the other hand, we have demonstrated by luciferase assay that
    E
    1
    AF
    positively regulates transcription from the p21waf1/cip1 promoter. Ca
    9
    .
    22
    cells were transfected with a metallothionein-inducible
    E
    1
    AF
    expression vector (Ca
    9
    .
    22
    MTF) to investigate the relationship between invasive ability and cell cycle modulation caused by
    E
    1
    AF
    . MMP-
    9
    and p21waf1/cip1 protein were synergistically increased in the ZnCl2 stimulated CA
    9
    .
    22
    MTF cells, and both proteins were identified in the same cells when
    E
    1
    AF
    was induced. These results imply that invasive growth of tumor cells occurs in the static state of the cell cycle and that
    E
    1
    AF
    plays a key role in this phenomenon.
  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with
    7
    kinds of factors, as follows ; A^^〜=
    B
    +C+D+K+aE+
    bF
    +cG. A^^〜=estimated values of the readership score. 1)
    B
    , C, D, K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into
    7
    categories. C=pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories. D=kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2)
    E
    ,
    F
    , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into
    6
    kinds of area (2.
    5
    , 3.
    5
    ,
    5
    ,
    7
    , 10, 15) and 15 column means a whole page, about 2,000cm^2.
    E
    ,
    F
    are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement.
    F
    =the marks obtained on the whole effect of the design. 3) a,
    b
    , c : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+
    bF
    =A-(
    B
    +C+D+K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was 3,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table 2^* shows the contribution indexes of each factor by 3 kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, (3) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of
    E
    ,
    F
    .
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _1+
    E
    _2+
    E
    _3+
    E
    _4. design elements [table]
    E
    _1,
    E
    _2,
    E
    _3,
    E
    _4, these values have the
    5
    grades, as 0, 1, 2, 3, 4 and 0 is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of 0 to
    9
    grades as the sum of them. The values of
    F
    have also
    5
    grades, 0 to 4. The principles to determine the values of
    E
    ,
    F
    are as follows : a) The marks obtained of
    E
    ,
    F
    must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. c) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    ,
    F
    values, as the table
    5
    -4, and
    5
    -
    5
    in the thesis in Japanese.
  • Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE
    Agricultural and Biological Chemistry
    1988年 52 巻 12 号 3217-3218
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • 小田切 孝人, 田代 眞人
    ウイルス
    2013年 63 巻 2 号 233-240
    発行日: 2013/12/25
    公開日: 2014/10/31
    ジャーナル フリー
  • Keishi Hata, Fuyuki Sugawara, Naganori Ohisa, Saori Takahashi, Kazuyuki Hori
    Biological and Pharmaceutical Bulletin
    2002年 25 巻 8 号 1040-1044
    発行日: 2002年
    公開日: 2002/08/01
    ジャーナル フリー
    We screened the differentiation-inducing activities of 39 mushroom extracts from Akita prefecture, Japan, on the mouse osteoblastic cell line, MC3T3-
    E
    1. Sixteen phosphate buffered saline (PBS),
    8
    boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MC3T3-
    E
    1 cell differentiation. The enzyme activities were markedly induced by extracts of Tricholoma auratum, and we isolated the active compound from methanol extracts of this mushroom. Physical data for the isolated active compound were identical to those for (
    22E
    ,24R)-ergosta-
    7
    ,
    22
    -diene-3β,
    ,
    -triol (1). 1 induced ALP activities of MC3T3-
    E
    1 cells and promoted cell proliferation. To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MC3T3-
    E
    1 cells by 1, ergosterol (2), ergocalciferol (3), cholesta-3β,
    ,
    -triol (4),
    7
    -dehydrocholesterol (
    5
    ) and cholecalciferol (
    6
    ) were tested. The enzyme activities of MC3T3-
    E
    1 cells were increased 3.0-fold by 10 μM 1 and 2.4-fold by 10 μM 4. However, 2, 3,
    5
    and
    6
    did not induce MC3T3-
    E
    1 cell ALP activity at 0.1—10 μM. These results suggested that the OH groups at C-
    5
    and/or C-
    6
    of 1 and 4 played an important role in their differentiation-inducing activities on MC3T3-
    E
    1 cells. Furthermore, 1 suppressed induction of MC3T3-
    E
    1 cell apoptosis by serum starvation.
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • 黒川 美貴雄, 吉田 耕治, 永井 保嵩, 宇野 準
    Chemical and Pharmaceutical Bulletin
    1983年 31 巻 12 号 4312-4318
    発行日: 1983/12/25
    公開日: 2008/03/31
    ジャーナル フリー
    Two new partially saturated tricyclic ring systems,
    6
    ,
    6
    a,
    7
    ,
    8
    ,
    9
    , 10, 10a, 11-octahydro-11-oxodibenz [
    b
    ,
    e
    ] oxepins (3a and 3
    b
    ), and -thiepins (4a and 4
    b
    ) were synthesized. Compounds 4a and 4
    b
    were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10
    b
    ). Deuterated 4a and 4
    b
    (11a and 11
    b
    ) were prepared starting from butadiene-
    d6
    (12). The stereochemical features of 3a (trans), 3
    b
    (cis), 4a (trans) and 4
    b
    (cis) are compared with those of 10a, 10
    b
    , 11a and 11
    b
    on the basis of proton nuclear magnetic resonance data.
  • Naoyuki Haba, Yasuhiro Shimizu
    素粒子論研究
    2004年 108 巻 6 号 F59-F60
    発行日: 2004/03/20
    公開日: 2017/10/02
    ジャーナル フリー
  • Sung-Ji Park, Sang-Chol Lee, Shin Yi Jang, Sung-A Chang, Jin-Oh Choi, Seung Woo Park, Jae K Oh
    Circulation Journal
    2011年 75 巻 10 号 2350-2356
    発行日: 2011年
    公開日: 2011/09/22
    [早期公開] 公開日: 2011/07/28
    ジャーナル フリー
    Background: The purpose of this study was to investigate the prognostic values of the
    E
    /
    e
    ' ratio and other echocardiographic and clinical parameters in patients with non-valvular atrial fibrillation (
    AF
    ) with preserved left ventricular (LV) systolic function. Methods and Results: A total of 488 patients (322 men, age: 66±11 years) with non-valvular
    AF
    with preserved LV systolic function (LV ejection fraction >50%) were included. The
    E
    and
    e
    ' velocities were measured in
    5
    consecutive heart beats and averaged. Mean follow-up duration after enrollment was 17.
    7
    ±
    5
    .3 months. All-cause deaths occurred in 45 patients (cardiovascular deaths: n=29). There were significant differences in age (65.
    6
    ±11.3 vs. 71.
    5
    ±
    9
    .1, P<0.001) and hemoglobin concentration (13.
    6
    ±2.
    9
    vs. 11.
    5
    ±3.4g/dl, P<0.0001) between the deceased group and the survivors.
    E
    /
    e
    ' ratio in the deceased group was significantly higher than that in the survivors (17.67±3.39 vs. 10.
    8
    ±3.30, P<0.001). Survival analysis showed that a high
    E
    /
    e
    ' ratio (>15.0) represents a poorer prognosis (P<0.001 by Log-Rank test) than an
    E
    /
    e
    ' ratio of 15 and below. Multivariate analysis identified 2 significant variables that were predictive of all-cause deaths: hemoglobin (hazard ratio (HR)=0.806,
    95
    % confidence interval (CI)=0.733-0.886, P<0.0001), and
    E
    /
    e
    '>15 (HR=3.064,
    95
    %CI=1.38-
    6
    .804, P=0.006). Conclusions:
    E
    /
    e
    ' ratio is a useful independent prognostic parameter for predicting mortality in patients with
    AF
    with preserved LV systolic function. (Circ J 2011; 75: 2350-2356)
  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in
    95
    (
    22
    .2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-2 (
    22
    ), blaCTX-M-3 (16), blaCTX-M-1 (15), blaOXA-1 (
    9
    ) and blaSHV-12 (3) alone or in combination. The most frequently encountered phylogenetic group was group A1 (35.
    8
    %), followed by group D2 (
    22
    .1%),
    B
    1 (15.
    8
    %), D1 (
    9
    .
    5
    %), A0 (
    7
    .4%),
    B22
    (
    5
    .3%) and
    B23
    (4.2%), respectively. PMQR genes, aac(
    6
    ’)-Ib-cr, qnr
    S1 and qnrB10 were detected in 25.3, 10.
    5
    and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.
    8
    % for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE,
    f17a
    -A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

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