11-Amino-, a, , , , 10, 10a, 11-octahydrodibebenzo[, ]thiepines (a-) and -oxepines (a-) were synthesized by the Leuckart reaction of , a, , , , 10, 10a, 11-octahydro-11-oxodibenzo[, ]thiepines (1a, )and -oxepines (2a, ) followed by hydrolysis of the reaction products 4a- and a-, respectively. The four diastereomers, cis(a-H, 10a-H)-cis(10a-H, 11-H) a and a, cis(a-H, 10a-H)-trans(10a-H, 11-H) and , trans(a-H, 10a-H)-trans(10a-H, 11a-H) and , and trans(a-H, 10a-H)-cis(10a-H, 11-H) and , were isolated and their configurations and conformations were elucidated by chemical methods together with ¹H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.

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Two new partially saturated tricyclic ring systems, , a, , , , 10, 10a, 11-octahydro-11-oxodibenz [, ] oxepins (3a and 3), and -thiepins (4a and 4) were synthesized. Compounds 4a and 4 were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10). Deuterated 4a and 4 (11a and 11) were prepared starting from butadiene- (12). The stereochemical features of 3a (trans), 3 (cis), 4a (trans) and 4 (cis) are compared with those of 10a, 10, 11a and 11 on the basis of proton nuclear magnetic resonance data.

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カンキツ主要12種を用いて染色体のクロモマイシン A₃(CMA) 染色を行った．染色体は CMA(+) バンドの有無および位置から 種類に区分できた．すなわち，CMA(+) を A: 両端および動原体近傍に有する，: 一方の端部と動原体近傍に有する，: 両端に有する，: 一方の端部に有する，: CMA(+) がない，: 動原体近傍に有する，Dst: 付随染色体を有する 型，である．各種はこれらのうち 2～ 種類の染色体を有し，独自の CMA バンドパターンを示した．

C

. medica では 2 + + ，

C

. limon では 1 + 1 + + ，

C

. aurantifolia では 2 + + ，

C

. aurantium では 1A + 1 + 1 + + ，

C

. sinensis では 2+ 2 + + ，

C

. maxima では 3A + 3 + 4 + ，

C

. paradisi では 2A + 3 + + ，

C

. ichangensis では 2 + 2 + 12 + 2，

C

. latipes では 2A + + + 3，

C

. micrantha では 1 + 11 + 4 + 2Dst，

C

. macroptera では 2 + 1 + 11 + 3 + 1，

C

. hystrix では 3 + 1 + + 3 + 2 + 1Dst であった．

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Stereoselective synthesis of the 4, -syn, , -anti adducts (14 and 16) on the aldol condensation of the Z (O)-lithium enolate, derived from the -enone (2), to α-alkoxy aldehydes (12 and 13) was proved via the successive intramolecular Diels-Alder reaction.

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In order to study the effects of residual stenosis on myocardial salvage, we created % coronary stenosis with or without contrast washout delay at reperfusion in six groups of dogs. In Group A (n=), the artery was occluded for 1h before being fully reperfused. In Group (n=), the artery was occluded for 1h, then subjected to h of % stenosis without contrast washout delay. In Group (n=), the artery was occluded for 1h, followed by 1 week of % stenosis without contrast washout delay. In Group (n=10). again the artery was occluded for 1h, then subjected to h of % stenosis with contrast washout delay. In Group (n=). the artery was occluded for h, then fully reperfused for 1 week. Finally, in Group (n=). the occlusion lasted for a full week. All dogs were sacrificed 1 week after occlusion. In Group A, myocardial creatine phosphokinase activity (CK) in the inner layer was 43.±12.% that of non-infarcted myocardium. Myocardial CK in Group (46.±.4%) was little different but in Group it dropped to 26.±.4%, suggesting that % residual stenosis is not deleterious if it is continued for h or less but that it will result in considerable depletion of myocardial CK, if it is sustained for 1 week. In Group , myocardial CK dropped markedly to 11.3±3.%, little different from that for either Group (13.3±2.%) or Group (.3±3.3%). This suggests that contrast washout de-lay following % stenosis is not beneficial to myocardial salvage. Infarct size, as determined using triphenyl tetrazolium chloride as a stain was smallest for Group A (.±3.%) and largest for Group (62.±.%). Group showed smaller infarct size (13.2±3.%) than did either Group (27.0±.%) or Group (25.3±.3%). From this. we came to the conclusion that % residual stenosis without contrast washout delay is not deleterious provided it is sustained for h or less.

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One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.

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All the birds examined were also associated with bone dysplasia (art alczaormal develop-ment of bone tissue) in the diaphyseal cortex of the leg bones, especially of bones affectedwith dyschondroplasia. This result is very significant in order to clarifyz tlais disease entity.1970:J14, k -1 } ) , M77 ) i? ht /, ( K ) ( # L", MB @ () t, If!TB& U ", Jff Dyschondroplasia (1*t%fi!dW) ().g:#[!:.fLlt! K?3o, [1: ()M;tC, rff.?U/:cD, bb=1lC#li*H(DX15RI!!& t, r, ccl)Efffflr.#.??t"ut:2.?T<3.1.?l??/?t:>"A??1!? > >?TMOll?, lI]%G (-srRM) -ts;;.*BI) *M[t fL 54 t:.;*.{1*I[l?(), t@Yllll*fJ?H@() %?Jfipj@ (Dyschondroplasia) p, }, (, 1lTi{-X, WIKIM itt{= t "tl%tff{tO 1111IH(-UP!z U-ii) >ES- -)%Wi*fd?1J*[lEj: >11"iifI".*"H*Tl*&Z") #)/2?-"k l - vich ) J&it(Vh3iO"= >If-ffi"!1lYl*I4")Ji/l![40111!>*!)<Y14M)?A"!>CL(Il], k.ClT"ltTt*flB1? & $4U [-" U" L % w, Zl1*.IlBl tI1J, FA(y L-x") LVfAK t: >3llltPJ4IiI " } ) t- ! Al j: >kP11liR, &ffl(NWi Z 3lk(#L" Ct ?!4M2"- fL#, -()%.IWMd1.XI1*I1EPW(tit ff1lR)

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Reactions of nor-diterpenoid dilactones isolated from Podocarpus plants have been investigated. The : ,: 11-dienolide type [] dilactones, the least available but biologically the most active members, are mainly derived from naturally abundant dilactone components of α-pyrone type [A] and : -epoxy-: 11-enolide type [] for total-synthetic and biological purposes. From nagilactone (), for example, a combined sequence of hydrogenolysis of : -epoxide group and dehydration gives nagilactone (), 3β-hydroxynagilactone () and 2: 3-dehydronagilactone (19), which have been found from natural sources. From nagilactone A (1), photo-hydration and concomitant double bond migration of its acetate results in a lactol (), which is reduced to 1β-hydroxynagilactone (), another natural type [] dilactone. Derivation of the type [A] or [] from others is not successful. Some attempts for conversion of the ring A functional groups have also been studied.

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Repetitive liquefactions in angular and subangular gravels from an alluvial fan, in the case of two earthquakes with accelerations lower than that of a former which had caused liquefaction some months before, are described. The liquefaction took place from the surface, down to a depth of approximately 10 m. Water laden with sediments spouted out for some tens of minutes after the strong motion ceased. Knowledge of the grain size distribution of the sediments inside the body of the alluvial fan roughly defines the areas of the fan prone to future liquefaction. Non-repetitive liquefaction in overconsolidated fine fluvio-lacustrine sand of glacial origin at the unusual depth of 14 m to 16 m is also described. From the observation of sand lifted up for 10 m inside a large diameter well, and of that which spouted out from several microvents, it was estimated that extra-pore pressure was close to lithostatic conditions. Nevertheless, modeling of intrinsic pore pressure buildup on the DESRA2 programme gives lower values than the experimental one. Geotechnical characteristics of the 12 m-thick sandy stratum indicate that the upper part is unusually soft, either due to water circulation or past repetitive liquefactions which prevented reconsolidation. It is suggested that excess pore pressure generated by the earthquake was also due to redistribution of pressure from adjacent sediments.

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Three new azaphilone derivatives designated falconensins (), (), and G () were isolated from the mycelium o Emericella falconensis, along with falconensins A (1), (2), (3), (4), and H (), and three hopane-type triterpenes, zeorin (), hepane-, -diol (10), and hopane-, , -triol (11). The structures of - were confirmed by spectroscopic investigation and chemical correlations. The absolute stereochemistry of falconensins A (1) to G() was also established.

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This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

. coli isolates were detected in 95 (.2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: bla_CTX-M-15 (62), blaTEM-

1b

(42), bla_CMY-2 (

22

), bla_CTX-M-3 (16), bla_CTX-M-1 (15), bla_OXA-1 (

9

) and bla_SHV-12 (3) alone or in combination. The most frequently encountered phylogenetic group was group A₁ (35.

8

%), followed by group

D₂

(

22

.1%),

B

1 (15.

8

%),

D₁

(

9

.

5

%), A₀ (

7

.4%),

B2₂

(

5

.3%) and

B2₃

(4.2%), respectively. PMQR genes, aac(

6

’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.3, 10.

5

and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.

8

% for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE,

f17a

-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing

E

. coli clone O25

b

:ST131/

B

2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing

E

. coli isolates among dogs in Turkey.

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-Hydroxy-, , , -tetrahydrodibenz[, ]azocines 4, and their methoxy and methylenedioxy derivatives a- and a- were prepared by cyclization of O-protected 1-phenyl-2-aminoethanols , , a- and 10a- with zerovalent nickel, followed by hydrolysis of the resulting O-protected azocines 4, , - and -, respectively. The half-tub conformation of the tetrahydroazocine ring of these -hydroxydibenz[, ]azocines and the quasi-equatorial configuration of the -hydroxy group were supported by the proton nuclear magnetic resonance spectra.

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A chemical examination of Magnoliae Cortex produced in China (Magnolia officinalis REHD. et WIL S., Magnoliaceae) has led to the isolation of eighteen new lignans and related compounds [four monoterpenyl-lignans : piperitylmagnolol (3), dipiperitylmagnolol (4), piperitylhonokiol () and bornylmagnolol (); seven lignans : magnaldehydes (), (), magnolignans A(10), (11), (12), (13) and (14); three norlignans : magnatriol (16), magnaldehydes (17) and (18); and four dilignans : magnolignans (19), G(20), H(21) and I()], together with randainal (), randaiol (15), sinapic aldehyde, syringaresinol, syringaresinol 4'-O-β--glucopyranoside and '-O-methylhonokiol. Their structures were determined by the chemical and spectral methods.

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Thirty-six patients (19 males, 17 females: atypical schizophrenia; 3, typical schizophrenia; , depression; 11, neurosis and other psychiatric disorders; ) were operated on according to orbitoventromedial undercutting by Hirose. In all cases, the Rorschach test was carried out and daily behaviors were studied. Thirty-one scales of the test were subjected to multivariate analysis whereas the behaviors were evaluated according to the following criteria, i.., A: recovered or symptom free, : markedly improved, : moderately improved, : slightly improved and : not improved. The following results were obtained.
1) The evaluation of behaviors is as follows. A: 12 cases, : , : , : , : none.
2) It was found that scores of +106% and R+106% scales were significantly higher after the operation than before; that correlation coefficients between the scores before and after the operation were considerably high.
3) Factor analysis followed by varimax rotation was carried out. Six factors were extracted, i.., (1) sensitivity to emotional stimuli, (2) ego-strength, (3) obsessional rigidity, (4) reaction time, () anxiety and tension and () empathy. It was revealed that 2 was high in atypical schizophrenia, depression and neurosis, and that 2 and were significantly different in terms of the factor scores among the four groups A, , and ; 2 was highest in A, and lowest in regardless of whether it was before or after the operation. showed high scores in both A and , and low in .
4) Multiple discriminant analysis was applied to the data of the Rorschach test before the operation, by classifying 36 subjects into the four groups A, , and . As a result, high rates of correct diagnosis were obtained, i.., 100% for A, 78% for , 56% for and 100% for . When the groups and were combined into one group (+) the highest percentage (100%) was seen in A, followed by (89%) and + group (87%). When the groups A and were combined into one group (A+), the percentages of correct diagnosis were 81% for A+, and 93% for +.
In conclusion, it can be said that scales of the Rorschach test have been proved to be valid for predicting mental and physical states after the orbito-ventromedial undercutting.

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From the fronds of Polystichum tripteron (KUNZE) P_R. a new norcarotenoid glycoside was isolated and shown to be (R, , R)--hydroxy-megastigma-4, -dien-3-one--O-β--glucoside. The fronds of Dennstaedtia wilfordii (MOORE) CHRIST. contain the same glucoside.

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