[1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with 7 kinds of factors, as follows ; A^^〜=++D+K+++cG. A^^〜=estimated values of the readership score. 1) , , D, K : these four factors are given as category values (so we call them); each factor is classified into several categories. =week day, classified into 7 categories. =pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into categories. D=kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2) , F, G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into 6 kinds of area (2., ., , 7, 10, 15) and 15 column means a whole page, about 2,000cm^2. , F are the marks obtained in the design of advertizements. =sum of the marks obtained in each design element on the advertizement. F=the marks obtained on the whole effect of the design. ) a, , : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: +=A-(++D+K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was ,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table 2^* shows the contribution indexes of each factor by kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, () Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of , F. is the sum of the marks obtained in each design element, classified into four kinds : =_1+_2+_+_4. design elements [table] _1, _2, _, _4, these values have the grades, as 0, 1, 2, , 4 and 0 is given to the design that has no attractive effect or no applicable element. And obtain the marks of 0 to grades as the sum of them. The values of F have also grades, 0 to 4. The principles to determine the values of , F are as follows : a) The marks obtained of , F must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained. ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. ) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of , F values, as the table -4, and - in the thesis in Japanese.

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We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group which comprised preeclamptics who were supplemented their diets with vitamins and . MDA increased from 6. ± 2.8 (placebo) to 8.48 ± 1.2 (A) and 8.02 ± 1.8 nmol/gHb (). NO concentrations were enhanced from 19. ± 4.2 (P) to 23.8 ± 6.4 (A) and 24.1 ± .4 μmol/L (). GSH contents were decreased from 10.42 ± 2. (P) to 8.02 ± 2. (A) and .39 ± 1.02 μmol/g Hb (), whereas GSSG concentrations increased from 0.98 ± 0.28 (P) to 1.24 ± 0.29 (A) and 1.08 ± 0.12 μmol/g Hb (). SOD activity decreased 23% in A and 14% in ; GRx decreased 27% in A and .% in ; GPx decreased 12% in A and .6% in . Catalase activity, however, increased 27% in A and 29% in as compared to control. Thus, we conclude that the use of vitamins and should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.

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Repetitive liquefactions in angular and subangular gravels from an alluvial fan, in the case of two earthquakes with accelerations lower than that of a former which had caused liquefaction some months before, are described. The liquefaction took place from the surface, down to a depth of approximately 10 m. Water laden with sediments spouted out for some tens of minutes after the strong motion ceased. Knowledge of the grain size distribution of the sediments inside the body of the alluvial fan roughly defines the areas of the fan prone to future liquefaction. Non-repetitive liquefaction in overconsolidated fine fluvio-lacustrine sand of glacial origin at the unusual depth of 14 m to 16 m is also described. From the observation of sand lifted up for 10 m inside a large diameter well, and of that which spouted out from several microvents, it was estimated that extra-pore pressure was close to lithostatic conditions. Nevertheless, modeling of intrinsic pore pressure buildup on the DESRA2 programme gives lower values than the experimental one. Geotechnical characteristics of the 12 m-thick sandy stratum indicate that the upper part is unusually soft, either due to water circulation or past repetitive liquefactions which prevented reconsolidation. It is suggested that excess pore pressure generated by the earthquake was also due to redistribution of pressure from adjacent sediments.

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One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.

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The small strain stiffness and anisotropic nature of two sands with different geological origin have been determined via laboratory seismic tests performed in a triaxial cell. Dry triaxial reconstituted specimens of Ticino river silica sand (TS) and of Kenya carbonatic sand (KS) were subjected to isotropic and anisotropic states of effective stress ; then both shear and constrained compression waves were propagated in vertical, horizontal and oblique directions by means of five couples of piezoelectric transducers especially arranged in the specimens. The propagated compression and shear waves allow the assessment of the constrained M₀ and shear G₀ moduli respectively, at very small strains where, as a first approximation many soils can be assumed, from an engineering point of view, to behave as an elastic cross-anisotropic medium with a vertical axis of symmetry. This paper, after a brief description of the novel measuring technique adopted and of the tested materials, summarises the test results and their interpretation in order to separate the effects of the fabric anisotropy from those produced by the state of effective stresses on soil stiffness. The stiffness and anisotropic response of the two tested sands are compared. Finally the results enable us to establish five independent constants of the cross-anisotropic elasticity model, which appears to be appropriate to reproduce the behaviour at small strain of the two sands.

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Piled bridge abutments on soft clay may be loaded laterally from horizontal soil movements generated by the approach embankment. A limited number of field trials have been described in the literature, although the data are generally limited in extent, complicated by variations in geometry or soil conditions, or of relatively poor quality. This paper presents the results of a series of centrifuge model tests aimed at clarifying the behaviour of piled bridge abutments on soft clay. The centrifuge modelling techniques and equipment used are initially described. Attention is focused on the induced pile bending moments and deflections, and the response is shown to be critically dependent on the factor of safety of the embankment against failure. The effects of variations in pile rake, embankment geometry and abutment wall loading are described. The response of pile groups with time after embankment construction is outlined and the causes of time dependent behaviour identified.

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As a fundamental study on dibenzothiepins, reaction of 11-phenyl-6, 11-dihydrodibenzo [, ] thiepin-11-ol (10) or 11-chloro-11-phenyl-6, 11-dihydrodibenzo [, ] thiepin (14) with triphenylmethyl cation or was examined under various conditions. 11-Phenyl-6, 11-dihydrodibenzo [, ] thiepin-11-ylium salt (8) was isolated as a black powder (perchlorate) and a green powder (hexachloroantimonate), but salt was obtained only as a solution. Treatment of the hexachloroantimonate with excess of was found to result in a novel dehydrocyclization reaction to give selectively , 13-dihydrofluoreno [1, a, -, d] [2]-benzothiepin-13-ylium hexachloroantimonate (19). Some discussions were made on the mechanism of the formation of 19.

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　The stability of

-tetrahydrocannabinol acetate (-THC-OAc) in the presence of diluents or during vaping was investigated. Laboratory-made pure -THC-OAc and glycerol, propylene glycol (PG), or polyethylene glycol 400 (PEG400) were dissolved in ethanol and subjected to the quantification method for -tetrahydrocannabinol (-THC) recommended by UNODC. The pure -THC-OAc diluted by glycerol, PG, or PEG400 was stored at 40° for 27 days. A retail liquid product of -THC-OAc containing -THC as an impurity was stored at 80° for 28 days in the presence of glycerol, PG, or PEG400. A cartridge containing the -THC-OAc liquid was installed in an -cigarette device, which was heated and vaporized using a syringe connected to the cartridge through a silicone tube. The -THC-OAc liquid was put into a test tube and heated at 200 or 400° for  min. The relative concentrations of cannabinoids in the test solution before and after each operation were measured by liquid chromatography with photodiode array detection or by gas chromatography with flame ionization detection. -THC was not detected in any cases of pure -THC-OAc, and it decreased or disappeared in all cases of -THC-OAc liquid. The present result showed that -THC-OAc does not decompose into -THC during each process.

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Circuit techniques to enhance the linearity of input-voltage-to-current (V/I) conversion and to increase the output impedance of a current source by compensating for the low intrinsic gain of a transistor were introduced to realize a high-frequency operational transconductance amplifier (OTA) for a low supply voltage using sub-100-nm CMOS processes. Applying these techniques, a MOS 7th-order Gm- linear-phase low-pass filter (LPF) was realized using a 65nm CMOS process. A simplified biquad LPF that can serve as a component of a 7th-order LPF was newly developed by replacing OTAs with resistors. As a result, the -dB frequency bandwidth, group delay ripple, rd-order distortion, and rd-order input intercept point (IIP) were 200MHz, 2.2%, ≤ -55dB with a 100MHz input, and +10.dBm, respectively, all with a ±0.1Vp-p input signal at each input terminal in the pseudodifferential configuration. The LPF including an output buffer dissipated 60mW in the case of a 1.2V supply. Wide spurious-free dynamic range (SFDR) characteristics were confirmed up to high frequencies.

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Walking rehabilitation machines have drawn great attentions with more and more people suffering from walking disabilities in an aging society. However, most of the developed walking rehabilitation machines aim at enhancing muscle strength, neglecting the recovery of the neural system. 58% of walking disabilities are caused by problems in the neural system. Therefore, we propose a rehabilitation system which includes both muscle strength enhancement by a walking rehabilitation machine and neurological rehabilitation by imaginary walking. In this paper we compared the activation in motor area of the brain during real walking and imaginary walking by means of fNIRS (functional Near-InfraRed Spectroscopy). Two subjects participated in the experiment. During imaginary walking, the subjects were instructed to imagine that they were walking with the same pace to a person in the video being shown to the subjects. As a result, the concentration of oxygenated hemoglobin in motor area during imaginary walking was higher than that during real walking in both of the subjects. This was because that it was not necessary to pay attention to the movements of the legs and feet during normal walking on the plain road without any obstacles, while movement planning was required when the subjects imagined their walking in the same way to another person. The experiment result indicated that it is possible to quicken walking rehabilitation by imaginary walking.

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