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Syntheses of 6, 6a,
7
,
8
,
9
, 10, 10a, 11-Octahydro-11-oxodibenz [
b
,
e
] oxepins and 6, 6a,
7
,
8
,
9
, 10, 10a, 11-Octahydro-11-oxodibenzo [
b
,
e
] thiepins

黒川美貴雄, 吉田耕治, 永井保嵩, 宇野準

Chemical and Pharmaceutical Bulletin
1983年 31 巻 12 号 4312-4318
発行日: 1983/12/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.31.4312

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Two new partially saturated tricyclic ring systems, 6, 6a,
7
,
8
,
9
, 10, 10a, 11-octahydro-11-oxodibenz [
b
,
e
] oxepins (3a and 3
b
), and -thiepins (4a and 4
b
) were synthesized. Compounds 4a and 4
b
were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10
b
). Deuterated 4a and 4
b
(11a and 11
b
) were prepared starting from butadiene-d₆ (12). The stereochemical features of 3a (trans), 3
b
(cis), 4a (trans) and 4
b
(cis) are compared with those of 10a, 10
b
, 11a and 11
b
on the basis of proton nuclear magnetic resonance data.
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熱力学諸量の測定とその結果を用いた化学熱力学計算によるNi-Mo-
B
およびNi-W-
B
3成分系状態図の決定

香山滉一郎, 森下政夫, 張国鋒

粉体および粉末冶金
2006年 53 巻 5 号 419-429
発行日: 2006年
公開日: 2006/12/19

DOI https://doi.org/10.2497/jjspm.53.419

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The phase diagrams of the Ni-Mo-
B
and Ni-W-
B
ternary systems in the region of less than 50mol%
B
were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
E₁
:L (1365K, 71.5mol%Ni-6.0mol%Mo-
22
.5mol%
B
)=(Ni)+
Ni₃B
+
NiMo₂B₂

E₂
:L (1355K, 62.5mol%Ni-2.5mol%Mo-30.5mol%
B
)=
Ni₃B
+
Ni₂B
+
NiMo₂B₂

E₃
:L (1445K, 42.0mol%Ni-30.6mol%Mo-10.3mol%
B
)=(Ni)+NiMo+
NiMo₂B₂

P₁:L (1812K, 34.
9
mol%Ni-42.3mol%Mo-
22
.
8
mol%
B
)+MoB=
Mo₂B
+
NiMo₂B₂

P₂:L (1633K, 42.3mol%Ni-40.4mol%Mo-17.3mol%
B
)+Mo=
Mo₂B
+
NiMo₂B₂

P₃:L (1812K, 53.5mol%Ni-33.
7
mol%Mo-12.
8
mol%
B
)+Mo=NiMo+
NiMo₂B₂

E₁
:L (1622K, 51.0mol%Ni-31.6mol%W-17.4mol%
B
)=(Ni)+W+
NiW₂B₂

E₂
:L (1260K, 71.0mol%Ni-
7
.0mol%W-
22
.0mol%
B
)=(Ni)+
Ni₃B
+
NiW₂B₂

E₃
:L (1291K, 65.4mol%Ni-4.
8
mol%W-29.
8
mol%
B
)=
Ni₂B
+
Ni₃B
+
NiW₂B₂

P₁:L (2115K, 23.
8
mol%Ni-43.1mol%W-33.1mol%
B
)+WB=
W₂B
+
NiW₂B₂

P₂:L (1657K, 48.
9
mol%Ni-33.1mol%W-18.0mol%
B
)+
W₂B
=W+
NiW₂B₂

The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
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Cell-mediated Cytotoxicity of Tumor Infiltrating Lymphocytes on Rat Bladder Cancer

長谷川親太郎

The Keio Journal of Medicine
1992年 41 巻 3 号 146-153
発行日: 1992年
公開日: 2009/03/27

DOI https://doi.org/10.2302/kjm.41.146

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Tumor-infiltrating lymphocytes (TIL) were tested for cytotoxicity against autologous tumor cells in a study utilizing a chemically induced cancer ofthe bladder (transitional cell carcinoma),
BC
-47, in inbred ACI/N rats. From tumors grown after subcutaneous implantation of
BC
-47 in the rats TIL were separated by density gradient centrifugation and incubated in plastic dishes for separation of non-adherent from adherent cells. The non-adherent cells were further fractionated into T and
B
cells by the panning method using anti-rat F(ab')₂ antibody. The cell fractions were each added to
BC
-47 in culture to be assessed for antitumor effect by the crystal violet dye exclusion method and 3H-thymidine incorporation inhibition assay. Peripheral blood mononuclear cells (PBMC) were also tested as described above. TIL expressed significantly higher cytotoxicity against
BC
-47 with the mean % cytotoxicity of 56.6±5.6% and 87.5±
7
.1% at
E
/T ratios of 10:1 and 20:1, respectively, as compared to PBMC(
9
.
9
±5.0% at
E
/T 10:1) (P<0.001). The adherent cells,
B
and T cell fractions showed respective % cytotoxicity of 92.4±2.
8
%, 57.
9
±10.6% and
9
.
9
±
7
.
8
% at an
E
/T ratio of 10:1. TIL pretreated with IFN or rIL-2 for 24or 48 hours did not exhibit any noticeably enhanced antitumor activity at an
E
/T ratio of 5:1. Prevention of direct contact of
BC
-47 cells and TIL by an interposed Millipore membrane (0.45μm) resulted in an unequivocal reduction of antitumor effect. This finding clearly indicates that the direct contact with
BC
-47cells and TIL is necessary for TIL to manifest their cytotoxicity against the autologous tumor cells, suggesting that TIL exhibit autologous tumor killing activity through cell-mediated cytotoxicity.
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FINITE ELEMENT ANALYSIS OF THE COUPLED HEAT FLOW AND CONSOLIDATION AROUND HOT BURIED OBJECTS

A.M. BRITTO, C. SAVVIDOU, M.J. GUNN, J.R. BOOKER

土質工学会論文報告集
1992年 32 巻 1 号 13-25
発行日: 1992/03/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf1972.32.13

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One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.
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Prevalence and molecular characterization of extended-spectrum β-lactamase (ESBL) and plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli in dogs

Özkan ASLANTAŞ, Ebru Şebnem YILMAZ

Journal of Veterinary Medical Science
2017年 79 巻 6 号 1024-1030
発行日: 2017年
公開日: 2017/06/16
[早期公開] 公開日: 2017/04/27

DOI https://doi.org/10.1292/jvms.16-0432

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This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant
E
. coli isolates were detected in 95 (
22
.2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: bla_CTX-M-15 (62), bla_{TEM-1b
(42), bla_CMY-2 (22
), bla_CTX-M-3 (16), bla_CTX-M-1 (15), bla_OXA-1 (9
) and bla_SHV-12 (3) alone or in combination. The most frequently encountered phylogenetic group was group A₁ (35.8
%), followed by group D₂ (22
.1%), B
1 (15.8
%), D₁ (9
.5%), A₀ (7
.4%), B2₂
(5.3%) and B2₃
(4.2%), respectively. PMQR genes, aac(6’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.3, 10.5 and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.8
% for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE, f17a-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing E
. coli clone O25b
:ST131/B
2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing E
. coli isolates among dogs in Turkey.
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糸魚川-静岡構造線活断層系南部の最近の断層活動

白州断層・下円井断層・市之瀬断層群トレンチ調査

遠田晋次, 三浦大助, 宮腰勝義, 井上大栄

地震　第2輯
2000年 52 巻 4 号 445-468
発行日: 2000/03/25
公開日: 2010/03/11

DOI https://doi.org/10.4294/zisin1948.52.4_445

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The Itoigawa-Shizuoka Tectonic Line (ISTL) in central Japan is a complex 150km-long fault system consisting of north-trending east-dipping reverse, northwest-trending left-lateral strike-slip, and north-trending west-dipping reverse faults. To help to resolve segmentation and to estimate the magnitude of future shocks on the ISTL, we conducted four trench excavations across the Hakushu fault, the Shimotsuburai fault, and the Ichinose fault group in the southern part of the ISTL, where no paleoseismological data for the surface faulting had been available. On the trench walls at the Hakushu fault, we found the evidence for the most recent surface-rupturing event occurring sometime between 6, 650 and
7
, 000cal. y.
B
. P. (
BC
4700-
BC
5050) with approximately one meter of coseismic slip. On the Shimotsuburai fault, we exposed evidence for three events at two trench sites. The low-angle thrust faults and associated sediments record the most recent and the penultimate events occurring between 1, 370 and 2, 500cal. y.
B
. P. (
AD
580-
BC
550), and between
7
, 940 and
8
, 430cal. y.
B
. P. (
BC
5990-
BC
6480), respectively. Vertically offset terrace gravels indicate the dip-slip rate of the Shimotsuburai fault to be about 0.5mm/yr during the past
22
, 000 years. We also found evidence for the most recent two surface-faulting events on the scarp of the frontal fault of the Ichinose fault group. The most recent event, which accompanied a coseismic slip of 1.
8
-2.2m, is inferred to have occurred sometime between 3, 990 and 6, 270cal. y.
B
. P. (
BC
2040-
BC
4320). The penultimate event, which appears to have a coseismic slip of 2.1-3.0m, is constrained to have occurred between
9
, 520cal. y.
B
. P. (
BC
7570) and 10, 930y.
B
. P. The recurrence time and slip rate are roughly estimated as 5, 000 years and 0.5mm/yr, respectively. Regarding the long elapsed time since the most recent events, the Hakushu fault and the Ichinose fault group have accumulated enough strain to produce surface-rupturing earthquakes today. Based on such long recurrence times and lower slip rates on the southern ISTL relative to the central ISTL, we suggest that multiple segment ruptures of the central and southern ISTL are unlikely to have occurred during the past 10, 000years. However, partial synchronization of rupture timings for the central and southern ISTL might have occurred around
7
, 000y.
B
. P. though. To evaluate the fault activity in the southern ISTL more precisely and to consider fault interaction with central ISTL, we still need to investigate other fault strands of the southern ISTL, and to gather more paleoseismic evidence.
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鉄骨鉄筋コンクリート柱はり接合部のせん断耐力

西村泰志, 南宏一, 若林實

日本建築学会構造系論文報告集
1986年 365 巻 87-98
発行日: 1986/07/30
公開日: 2017/12/25

DOI https://doi.org/10.3130/aijsx.365.0_87

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To clarify the failure mechanism, hysteretic characteristics and load carrying capacity of beam-to-column connections in steel reinforced concrete frames, thirty specimens are tested under monotonic and reversed cyclic loading. Experimental variables are the types of connections ; interior (cruciform), exterior (T-shape) and corner (L-shape) connection, and the ratio of the beam width
B_b
to the column width
B_c
;
B_b
/
B_c
= 0, 0.6, 0.
8
, 1.0. Specimens are designed so as to prevent flexural and shear failure of the members, which connection panels are made of pure steel or steel-and-concrete. The following observations are made in the tests. The failure mode changes from the diagonal tension failure to the diagonal compression failure of concrete, as the type of connection changes from L-shape to cruciform shape, or as the value of
B_b
/
B_c
increases. Connections failing in shear show stable hysteresis loops, even though the shear reinforcement is not provided. The strength deterioration is not observed until the shear strain of the connection reaches about 0.02 rad. Diagonal tension cracking strength is not affected by either the type of connection or the value of
B_b
/
B_c
. On the other hand, ultimate strength is strongly affected by either the type of connection or the value of
B_b
/
B_c
. The ratios of the strength of T-shape and L-shape specimen to the strength of the cruciform specimen are 0.64 and 0.52, respectively. In case of T-shape and L-shape specimens, maximum strengths differ in the positive and negative loading. The shear strength of each type of connection increases with the increase of the value of
B_b
/
B_c
. Effective thickness of the concrete panel can be taken equal to (
B_b
+
B_c
)/2. The strength of the concrete panel is well estimated by proposed empirical formula (
7
.4).
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Interaction of Glycophorin with Lipid Bilayer Studied by Calorimetry, Densitometry, Static Light Scattering, and Electron Microscopy

Sen-fang Sui, Erich Sackmann

The Journal of Biochemistry
1992年 111 巻 1 号 129-138
発行日: 1992年
公開日: 2008/11/18

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In the first part of the present work the interaction of glycophorin with dimyristoylphosphatidylcholine (DMPC) is studied by freeze fracture electron microscopy, densitometry, calorimetry, and 90° static light scattering. An exothermic lipid/protein interaction energy of W_P=190 kJ•mol^-1 was found by application of the well known Van Laar relation for the displacement of the freezing point and the Gibbs-Duhem relationship. Secondly, the effects of Ca²⁺ on the lipid/protein interaction were studied. Following Ca²⁺ addition a remarkable decoupling of the interaction of the glycophorin head group with the bilayer surface was revealed by densitometry and gold-labeling electron microscopy. It is estimated that about 80% of lipid once disturbed by the adsorption of glycophorin head groups is decoupled after addition of Ca²⁺. Thirdly, the selective interaction of glycophorin with binary lipid mixtures was studied, including the mixtures of DMPC with dimyristoylphosphatidylserine (DMPS) and dilauroylphosphatidylcholine (DLPC), and the mixture of dipalmitoylphosphatidylcholine (DPPC) with DLPC.
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Short-Step Synthesis of Plant Growth-Promoting Brassinosteroids

高津戸秀, 池川信夫

Chemical and Pharmaceutical Bulletin
1984年 32 巻 5 号 2001-2004
発行日: 1984/05/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.32.2001

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Brassinolide analogues, (
22
R, 23R, 24R)-2α, 3α,
22
, 23-tetrahydroxy-
B
-homo-
7
-oxa-5α-ergostan-6-one (24-epibrassinolide) (10) and (
22
S, 23S, 24R)-2α, 3α,
22
, 23-tetrahydroxy-
B
-homo-
7
-oxa-5α-ergostan-6-one (
9
), were synthesized from brassicasterol (3a) in five steps and with ca. 20% overall yield. The key steps are the direct formation of (
22
E
, 24R)-3α, 5-cyclo-5α-ergost-
22
-en-6-one (4) from brassicasterol mesylate (3
b
), the acid-catalyzed rearrangement of 4 to (
22
E
, 24R)-5α-ergosta-2,
22
-dien-6-one (6), and the Baeyer-Villiger oxidation of the tetrahydroxy 5α-ergostan-6-ones
7
and
8
.
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Archaeomagnetic Intensity in Finland during the Last 6400 Years: Evidence for a Latitude-Dependent Nondipole Field at ∼
AD
500

L. J. Pesonen, M. A. H. Leino, H. Nevanlinna

Journal of geomagnetism and geoelectricity
1995年 47 巻 1 号 19-40
発行日: 1995/01/20
公開日: 2007/04/03

DOI https://doi.org/10.5636/jgg.47.19

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Archaeomagnetic field intensity in Finland (Lat. 61°N, Long.
22
°
E
) has been determined for the past 6400 years with the Thellier technique of bricks, potsherds and baked clays. The normalized archaeointensity curve for Finland, based on 23 mean values, shows an increase from ∼4360
BC
to the maximum at
AD
500, after which it decreases to the present value. The high intensity at
AD
500 as found in Finland, but not in Bulgaria and Japan, is not a consequence of the applied Thellier technique since we are able to reproduce the known field intensities in the laboratory, and some of the dated bricks yield values which are in broad agreement with Nurmijärvi Magnetic Observatory data. We also show that variations in grain size of the magnetic carriers, cooling rate or magnetic refraction are unlikely to cause systematic errors in intensity larger than a few percent. Based on results of self-made bricks we show that the archaeointensity, however, depends on the angle between the laboratory and ancient field directions. If these are not aligned errors up to ±10% in archaeointensity can occur and are probably caused by anisotropy of remanence or by other factors not yet understood. The high intensity at
AD
500 in Finland can be modelled by a radial nondipole field source at the core-mantle boundary producing enhanced field at higher latitudes (Finland) and relatively weaker fields at lower latitudes (
e
.g. Bulgaria and Japan). Extrapolation of the present field (IGRF 1990) back in time shows similar field behaviour.
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ヒト歯肉上皮細胞のIL-
8
産生に及ぼすHigh Mobility Group Box 1(HMGB1)の影響

*森元陽子, 川原幸一, 菊池清志, 松山孝司, 中島結実子, 小薗（藤崎）清香, 町頭三保, 丸山征郎, 和泉雄一

特定非営利活動法人　日本歯周病学会学術大会プログラムおよび講演抄録集
2007年 2007f 巻 P-12
発行日: 2007年
公開日: 2007/08/31

DOI https://doi.org/10.14833/amjsp.2007f.0.51.0

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Prostaglandin
E
2 Stimulates Adaptive IL-
22
Production and Promotes Allergic Contact Dermatitis

Calum T Robb, Jinju Lee, Jennifer M Felton, Shuh Narumiya, Adriano G Rossi, Sarah
E
Howie, Chengcan Yao

日本薬理学会年会要旨集
2018年 WCP2018 巻 WCP2018_PO1-4-7
発行日: 2018年
公開日: 2020/09/10

DOI https://doi.org/10.1254/jpssuppl.WCP2018.0_PO1-4-7

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BACKGROUND
Atopic dermatitis (
AD
) and allergic contact dermatitis (ACD) are both forms of eczema and are common inflammatory skin diseases with a central role of T cell-derived IL-
22
in their pathogenesis. Although prostaglandin
E
2 (PGE2) is known to promote inflammation, little is known about its role in processes related to
AD
and ACD development, including IL-
22
upregulation.
OBJECTIVES
We set out to investigate whether PGE2 has a role in T cell-derived IL-
22
induction and development of ACD, which has augmented prevalence in patients with
AD
.
METHODS
T cell cultures and in vivo sensitization of mice with powerful haptens (oxazolone and dinitrofluorobenzene) were used to assess the role of PGE2 in IL-
22
production. The involvement of PGE2 receptors and their downstream signals was also examined. The specific effects of PGE2 during ACD pathogenesis were evaluated by using the oxazolone-induced ACD mouse model. Gene expression of PGE2 and IL-
22
signaling pathways was also investigated by using genomic profiling in human lesional
AD
skin biopsies.
RESULTS
PGE2 promotes IL-
22
production from T cells through its receptors,
E
prostanoid receptor 2 (EP2) and EP4. This is mediated by its downstream cAMP-PKA signaling and probably involves the transcription factor aryl hydrocarbon receptor (AHR). Selective deletion of EP4 in T cells prevents hapten-induced adaptive IL-
22
production in vivo. Importantly, blockade of endogenous PGE2 production by a COX inhibitor indomethacin or deletion of EP4 in T cells limit atopic-like skin inflammation in the oxazolone-induced mouse ACD model. Moreover, both PGE2 and IL-
22
pathway genes were coequally upregulated in human
AD
lesional skin but were down-regulated after treatment with betamethasone or ultraviolet
B
(UVB) radiation, both common therapies for
AD
.
CONCLUSIONS
Our results thus define a crucial role for PGE2 in promoting ACD by facilitating T cell-derived IL-
22
production.

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20 オオイソバナ(gorgonian coral)と数種の軟サンゴからのpolyhydroxysterol類の構造(ポスター発表の部)

小林優, 神田扶由子, S. M. D. Kumar, Ch. V. Lakshmana Rao, D. Srinivasa Rao, D. Venkata Rao, C. Bheemasankara Rao

天然有機化合物討論会講演要旨集
1990年 32 巻 20
発行日: 1990/09/25
公開日: 2017/08/18

DOI https://doi.org/10.24496/tennenyuki.32.0_151

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Melithasterols A-D (1-4), isolated from a gorgoinan coral Melithaea ocracea of Okinawa, were shown to be cholestane-, 24-methyl-
22
-dehydrocholestane-,
22
-dehydrocholestane-, and 24-methylenecholestane-derivatives. respectively, having a common 3β,
7
α -dihydroxy-5α, 6α-epoxy-Δ^
8
steroid nucleus. This was confirmed by direct comparison with the authentic sample prepared by lead tetra-acetate oxydation of cholest-6-ene- 3β, 5α,
8
α-triol 3-monoacetate. Twelve new polyhydroxysterols were isolated from an Alcyonium sp. (
7
,
8
,
9
), and Sclerophytum sp. (14,16,19
b
,20,21,
22
a,23,26,28) soft corals collected off the coasts of the Andaman and Nicobar Islands in the Indian Ocean. All the Sclerophytum sp. soft corals contained 17a or its 25-deacetyl derivative. Compounds
7
to
9
were identified as 24-methylenecholest-5-ene- 3β, 16β-diol-3-0-α-L fucoside (
7
) and its
7
β-(
8
) and
7
α-hydroxy (
9
) derivatives. Compound 14 was shown to be 24S-24-methylcholest-5-ene-3β,25ξ,26-triol and was correlated to the known compound 15 by 5α, 6β-glycolation. Compound 16 was shown to be 5β, 6α-isomer of 17
b
, correlating to 17
b
by PCC oxidation followed by dehydration. Compound 19
b
was identified with 25-deacetyl derivative of the known compound lobosterol (19a) by hydrolysis of authentic lobosterol. Compounds 20 and 21 were shown to be
7
-dehydro-(20) and
22
E
-dehydro-(21) derivative of 17a and 17
b
, respectively, by comparisons of their spectral data with reference compounds. Compounds
22
a and 23 were 24S-methylcholestane-3β, 5α 25-triol-6-one 25-monoacetate (
22
a) and its 25-deacetoxyl derivative (23). Partial PCC oxidation of 17a afforded
22
a. Compounds 26 (andamansterol) and 28 (nicobarsterol) were shown to be gorgost-5-ene-3β,
9
α. 11α, 21-tetrol and novel secosteroid, 11,21-cyclo-
B
-homo-11-oxa-
9
, 11-secoergostane-3β, 6α, 12ξ-triol-
9
-one, respectively, by spectral analyses (H-HCOSY, HMQC, HMBC).
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日本における過去3000年の定量的気温復元，西日本編，

*川幡穂高, 松岡めぐみ, 戸上亜美, 原田尚美, 木元克典, 横山祐典, 田中裕一郎, 加　三千宣

日本地球化学会年会要旨集
2012年 59 巻 3D18
発行日: 2012年
公開日: 2012/09/01

DOI https://doi.org/10.14862/geochemproc.59.0.334.0

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高時間解像度で広島市の温度を復元した．過去3000年間のアルケノン水温の最高は24.3℃（827
A.D
.），最低は
22
.2℃（770
B.C
）であった．
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Actinobacillus actinomycetemcomitans の口腔上皮細胞における IL-
8
および ICAM-1 発現に及ぼす影響

*嶋田照子, 菅野直之, 好士亮介, 小幡純, 仙田直樹, 田中一, 落合邦康, 伊藤公一

特定非営利活動法人　日本歯周病学会学術大会プログラムおよび講演抄録集
2007年 2007s 巻 B-8-1020
発行日: 2007年
公開日: 2007/05/07

DOI https://doi.org/10.14833/amjsp.2007s.0.52.0

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Deexcitation of the 931.1 keV
2₂
+-State of Cd¹⁵²

Yasuyuki Gono, Manabu Fujioka, Tamotsu Toriyama

Journal of the Physical Society of Japan
1970年 29 巻 2 号 255-258
発行日: 1970/08/05
公開日: 2007/06/01

DOI https://doi.org/10.1143/JPSJ.29.255

ジャーナル認証あり

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The gamma-ray spectrum and the conversion-electron spectrum are measured in the decay of the Tb¹⁵² activity. The L-subshell electron lines of the 586.
7
keV
2₂
+→2₁⁺ transition are separated by the ion-free beta-ray spectrometer. The M1-
E
2 mixing ratio, δ², and the dimensionless ratio X of
E
0-
E
2 mixing of the 586.
7
keV transition are obtained to be δ²≤0.16 and 0.034≤X≤0.038, respectively. The
E
2 branching ratio
B
(
E
2;
2₂
+→0_g⁺):
B
(
E
2;
2₂
+→2₁⁺):
B
(
E
2;
2₂
+→0₁⁺) is determined to be 0.023 : 1.0 : 5.6.
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Sterol Constituents from Five Edible Mushrooms

Yasunori YAOITA, Keiko AMEMIYA, Hiroyuki OHNUMA, Katsuyuki FURUMURA, Akihiro MASAKI, Toshihiko MATSUKI, Masao KIKUCHI

Chemical and Pharmaceutical Bulletin
1998年 46 巻 6 号 944-950
発行日: 1998/06/15
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.46.944

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Eight new sterols, 5α,
8α
-epidioxy-(
22
E
, 24R)-23-methylergosta-6,
22
-dien-3β-ol (1), 3β, 5α,
9α
-trihydroxy-(
22
E
, 24R)-23-methylergosta-
7
,
22
-dien-6-one (2), 3β, 5α,
9α
-trihydroxy-(24S)-ergost-
7
-en-6-one (3), 3β, 5α,
9α
, 14α-tetrahydroxy-(
22
E
, 24R)-ergosta-
7
,
22
-dien-6-one (4), (
22
E
, 24R)-ergosta-
7
,
22
-diene-3β, 5α, 6α,
9α
-tetrol (5), 5α,
9α
-epidioxy-3β-hydroxy-(
22
E
, 24R)-ergosta-
7
,
22
-dien-6-one (6), 5α,
9α
-epidioxy-3β-hydroxy-(24S)-ergost-
7
-en-6-one (
7
) and 5α, 6α-epoxy-(
22
E
, 24R)-ergosta-
8
,
22
-diene-3β,
7β
, 14α-triol (
8
), have been isolated from five edible mushrooms, Lentinus edodes, Flammulina velutipes, Hypsizigus marmoreus, Pleurotus ostreatus and Pholiota nameko together with fifteen known ones (
9
-23), of which two (16 and 17) are reported for the first time from a fungal source. The structures of these new compounds were elucidated on the basis of their spectral data.
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Sythesis and Stereochemistry of 11-Amino-6, 6a,
7
,
8
,
9
, 10, 10a, 11-octahydrodibenzo[
b
,
e
]thiepines and-oxepines

黒川美貴雄, 糸川彰, 松本純一, 福本吉久, 月原冨武

Chemical and Pharmaceutical Bulletin
1992年 40 巻 9 号 2270-2274
発行日: 1992/09/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.40.2270

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11-Amino-6, 6a,
7
,
8
,
9
, 10, 10a, 11-octahydrodibebenzo[
b
,
e
]thiepines (6a-d) and -oxepines (
7
a-d) were synthesized by the Leuckart reaction of 6, 6a,
7
,
8
,
9
, 10, 10a, 11-octahydro-11-oxodibenzo[
b
,
e
]thiepines (1a,
b
)and -oxepines (2a,
b
) followed by hydrolysis of the reaction products 4a-d and 5a-d, respectively. The four diastereomers, cis(6a-H, 10a-H)-cis(10a-H, 11-H) 6a and
7
a, cis(6a-H, 10a-H)-trans(10a-H, 11-H) 6
b
and
7
b
, trans(6a-H, 10a-H)-trans(10a-H, 11a-H)6c and
7
c, and trans(6a-H, 10a-H)-cis(10a-H, 11-H) 6d and
7
d, were isolated and their configurations and conformations were elucidated by chemical methods together with ¹H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.
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Photochemical Reaction of Ergosta-4, 6,
8
(14),
22
-tetraen-3-one

Nobutoshi TANAKA, Ken-ichi HOSOI, Daizo TANAKA, Mimei TAKAHASHI

Chemical and Pharmaceutical Bulletin
1996年 44 巻 4 号 843-846
発行日: 1996/04/15
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.44.843

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Chemical properties of ergosta-4, 6,
8
(14),
22
-tetraen-3-one (1) were investigated. Though 1 is rather stable to acids or bases, it reacts easily with two moleculres of oxygen on irradiation with UV light to give 6α,
9α
-epidioxy-14α-hydroperoxyergosta-4,
7
,
22
-trien-3-one (2), which is transformed successively to 6α,
7α
;
8α
,
9α
-diepoxy-14α-hydroperoxyergosta-4,
22
-dien-3-one (3) and 14α-hydroperoxy-
9α
-hydroxyergosta-4,
7
,
22
-triene-3, 6-dione (4) under these reaction conditions.
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The Properties of 2112 keV Level in ¹¹⁶Sn

Yukichi Yamaguchi, Jian-zhi Runan(Gen), Teruaki Nagahara

Journal of the Physical Society of Japan
1975年 38 巻 4 号 911-916
発行日: 1975/04/15
公開日: 2007/06/01

DOI https://doi.org/10.1143/JPSJ.38.911

ジャーナル認証あり

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The gamma-ray spectrum and the conversion-electron spectrum are measured in the decay of the ^116mIn activity. Directional correlations are also measured for 818–1293 and 1097–1293 keV cascades. The M1-
E
2 mixing ratio δ, and the
E
0-
E
2 mixing ratio μ_k are obtained for 818.
7
keV
2₂
+→2₁⁺ transition to be δ=1.52_{−0.22
+0.26, and μ_k≤6.1×10⁻⁴ respectively. The E
2 branching ratio B
(E
2; 2₂
+→0_g⁺): B
(E
2; 2₂
+→2₁⁺): B
(E
2; 2₂
+→0₁⁺) is determined to be 0.0158:1.0:5.86.
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