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5,106,697件中 1-20の結果を表示しています
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • FRANÇOIS LE GOFFIC, FRÉDÉRIC TANGY, BERNARD MOREAU
    The Journal of Antibiotics
    1979年 32 巻 12 号 1288-1292
    発行日: 1979年
    公開日: 2006/04/12
    ジャーナル フリー
    A sample of [
    3H
    ] tobrarnycin (
    5
    , 000 Ci/Mole) has been synthetized and incubated with
    the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
    two types of binding sites. The primary one is probably responsible for the inhibition of
    protein synthesis whereas the secondary one is probably related to the misreading and reading
    tiirough of the messenger RNA.
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • 琴尾 幸徳, 石川 成実, 田辺 順子, 御園 生尭久
    日本化学会誌(化学と工業化学)
    1980年 1980 巻 9 号 1391-1396
    発行日: 1980/09/10
    公開日: 2011/05/30
    ジャーナル フリー
    Nアルキル
    3
    ,
    4
    :
    9
    ,10-ペリレンテトラカルボン酸モノアンヒドリド=モノイミド[
    4
    a~
    e
    ]と芳香族アミン(アニリン,p-トルイジン,p-アニシジン,
    3
    ,
    5
    -キシリジン,
    4
    -アミノナゾベンゼン,およびo-フェニレンジアミン)を縮合して非対称型
    3
    ,
    4
    :
    9
    ,10-ペリレンビス(ジカルボキシミド)誘導体-N-アルキル-N'-アリール-
    3
    ,
    4
    :
    9
    ,10-ペリレンビス(ジカルボキシミド)(〔
    5
    a~
    e
    〕,〔
    6
    a~
    e
    〕,〔
    7
    a~
    e
    〕,〔
    8
    a~
    e
    〕,〔
    9
    a~
    e
    〕,および〔10a~
    b
    〕)を合成した. これらの各誘導体はすべて赤色系の色相を示し, 顔料試験の結果N-ブチル-N'-アリール-
    3
    ,
    4
    :
    9
    ,10-ペリレンビス(ジカルボキシミド)(たとえば〔
    5
    e
    〕や〔
    6
    e
    〕)がとくにすぐれた耐光性を示した.
  • Cbesseredes HORTS
    Journal of Human Ergology
    1982年 11 巻 Supplement 号 429-440
    発行日: 1982/12/15
    公開日: 2011/02/23
    ジャーナル フリー
  • M. L. GHOSH
    Journal of Physics of the Earth
    1972年 20 巻 2 号 165-186
    発行日: 1972年
    公開日: 2009/04/30
    ジャーナル フリー
    The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.
  • MARIE LAVAULT, ALAIN FOURNET, HELENE GUINAUDEAU, JEAN BRUNETON
    Chemical and Pharmaceutical Bulletin
    1986年 34 巻 3 号 1148-1152
    発行日: 1986/03/25
    公開日: 2008/03/31
    ジャーナル フリー
    Nine isoquinoline alkaloids belonging to the protoberberine, proaporphine and bisbenzyl-isoquinoline series were isolated from Caryomene olivascens (Menispermaceae). Four compounds are new : (-)-2-norlimacine (
    4
    ), (-)-caryolivine (
    6
    ), (+)-1, 2-dehydro-2-norlimacusine (
    9
    ) and N-formylstepharine (
    3
    ). The last one is the first N-formyl derivative to be reported in the proaporphine group. Its biogenetic origin is discussed. Structures were established on the basis of 360 MHz (FT) nuclear magnetic resonance measurements and also by chemical correlation in the case of
    3
    .
  • ―特にアポ蛋白Eの変化について―
    本間 康彦, 三神 美和, 佐藤 美智子, 石原 仁一, 吉川 広, 木下 栄治, 田川 隆介, 星合 充基, 古屋 秀夫, 井出 満, 田辺 晃久, 玉地 寛光, 兼本 成斌, 友田 春夫, 中谷 矩章, 五島 雄一郎
    動脈硬化
    1984年 12 巻 3 号 599-603
    発行日: 1984/08/01
    公開日: 2011/09/21
    ジャーナル フリー
    Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL2 and
    HDL3
    were estimated on the 0th,
    7
    th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
    B
    ,
    C
    -II,
    E
    levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL2 and
    HDL3
    were 15.
    9
    ±
    7
    .
    5
    mg/dl (mean±SD), 150.
    9
    ±58.1mg/dl 43.
    8
    ±
    9
    .
    6
    mg/dl, 16.
    4
    ±
    5
    .
    8
    mg/dl and 24.
    9
    ±
    6
    .
    3
    mg/dl respectively. Plasma apoprotein A-I, A-II,
    B
    ,
    C
    -II and
    E
    levels were
    81
    .
    7
    ±
    22
    .0 mg/dl, 15.1±
    5
    .
    4
    mg/dl, 93.
    7
    ±36.0mg/dl,
    3
    .
    83
    ±1.00mg/dl and
    4
    .29±1.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-
    C
    (r=0.348), HDL2-
    C
    (r=0.612) and
    HDL3
    (r=0.569). Apoprotein
    B
    correlated with total cholesterol (TC) (r=0.610), VLDL-
    C
    (r=0.341), LDL-
    C
    (r=0.726), HDL-
    C
    (r=0.432) and HDL2-
    C
    (r=0.465). Apoprotein
    C
    -II correlated with TC (r=0.765), TG (r=0.679), VLDL-
    C
    (r=0.651), LDL-
    C
    (r=0.461) and HDL2-
    C
    (r=0.326). Apoprotein
    E
    correlated with TC (r=0.580), TG (r=0.575) and VLDL-
    C
    (r=0.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=0.468). Apoprotein
    B
    correlated with apoprotein
    C
    -II (r=0.393). Apoprotein
    C
    -II correlated with apoprotein
    B
    (r=0.393) and
    E
    (r=0.549). Apoprotein
    E
    only correlated with apoprotein
    C
    -II (r=0.549).
  • 増大する資源
    E
    . F. Boswell
    紙パ技協誌
    1998年 52 巻 7 号 885-889
    発行日: 1998/07/01
    公開日: 2009/11/19
    ジャーナル フリー
    The world is in the midst of a huge fundamental shift in fibre supply, demand balances, and policy changes. Governments around the world are introducing policy changes which influence the supply demand balance as the politicians' thoughts are uttered. Government agencies and their bureaucrats are imposing changes on industry even before the legislation is passed by the government in question.
    This ad hoc change process will continue for a time to come until the countries in question show a tough-mindedness with regard to their land use policies. Policies affecting forest areas such as protection areas, Native land claims, the protection of biodiversity and a true goal of sustainable development ; which addresses the combined issues of cultural, environmental, social and economic matters.
    Eventually all of these difficult issues will reach essential closure. Then there will be great new opportunities for investment to meet the growing demand for forest products ; leading to a strengthening competitive position in the more traditional producing areas such as Canada.
  • 黒川 美貴雄, 吉田 耕治, 永井 保嵩, 宇野 準
    Chemical and Pharmaceutical Bulletin
    1983年 31 巻 12 号 4312-4318
    発行日: 1983/12/25
    公開日: 2008/03/31
    ジャーナル フリー
    Two new partially saturated tricyclic ring systems,
    6
    ,
    6
    a,
    7
    ,
    8
    ,
    9
    , 10, 10a, 11-octahydro-11-oxodibenz [
    b
    ,
    e
    ] oxepins (
    3
    a and
    3
    b
    ), and -thiepins (
    4
    a and
    4
    b
    ) were synthesized. Compounds
    4
    a and
    4
    b
    were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10
    b
    ). Deuterated
    4
    a and
    4
    b
    (11a and 11
    b
    ) were prepared starting from butadiene-
    d6
    (12). The stereochemical features of
    3
    a (trans),
    3
    b
    (cis),
    4
    a (trans) and
    4
    b
    (cis) are compared with those of 10a, 10
    b
    , 11a and 11
    b
    on the basis of proton nuclear magnetic resonance data.
  • Philippe Biane
    Publications of the Research Institute for Mathematical Sciences
    1995年 31 巻 1 号 63-79
    発行日: 1995年
    公開日: 2009/04/24
    ジャーナル フリー
  • Yasuhiro SUGIMOTO, Kazuma SAKATOH
    IEICE Transactions on Electronics
    2013年 E96.C 巻 6 号 867-874
    発行日: 2013/06/01
    公開日: 2013/06/01
    ジャーナル 認証あり
    Circuit techniques to enhance the linearity of input-voltage-to-current (V/I) conversion and to increase the output impedance of a current source by compensating for the low intrinsic gain of a transistor were introduced to realize a high-frequency operational transconductance amplifier (OTA) for a low supply voltage using sub-100-nm CMOS processes. Applying these techniques, a MOS
    7
    th-order Gm-
    C
    linear-phase low-pass filter (LPF) was realized using a 65nm CMOS process. A simplified biquad LPF that can serve as a component of a
    7
    th-order LPF was newly developed by replacing OTAs with resistors. As a result, the -
    3
    dB frequency bandwidth, group delay ripple,
    3
    rd-order distortion, and
    3
    rd-order input intercept point (IIP
    3
    ) were 200MHz, 2.2%, ≤ -55dB with a 100MHz input, and +10.
    3
    dBm, respectively, all with a ±0.1Vp-p input signal at each input terminal in the pseudodifferential configuration. The LPF including an output buffer dissipated 60mW in the case of a 1.2V supply. Wide spurious-free dynamic range (SFDR) characteristics were confirmed up to high frequencies.
  • Yao Sun, Jianzhong Ye, Yuanbo Hou, Huale Chen, Jianming Cao, Tieli Zhou
    Japanese Journal of Infectious Diseases
    2017年 70 巻 5 号 485-489
    発行日: 2017年
    公開日: 2017/09/25
    [早期公開] 公開日: 2017/03/28
    ジャーナル フリー

    The aim of the present study was to evaluate the predation efficacy of Bdellovibrio bacteriovorus on multidrug-resistant (MDR) or extensive drug resistant (XDR) gram-negative pathogens and their corresponding biofilms. In this study, we examined the ability of

    B
    . bacteriovorus to prey on MDR and XDR gram-negative clinical bacteria, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Results showed that
    B
    . bacteriovorus
    was able to prey on all planktonic cultures, among which the most efficient predation was observed for drug-resistant
    E
    . coli
    , with a
    3
    .11 log10 reduction in viability. Furthermore,
    B
    . bacteriovorus
    demonstrated promising efficacy in preventing biofilm formation and dispersing the established biofilm. Reductions in biofilm formation of
    E
    . coli, K. pneumoniae, P. aeruginosa
    , and A. baumannii co-cultured with
    B
    . bacteriovorus
    were 65.2%, 37.1%, 44.
    7
    %, and 36.
    8
    %, respectively. Meanwhile, the established biofilms of
    E
    . coli, K. pneumoniae, P. aeruginosa
    , and A. baumannii were significantly reduced by
    83
    .
    4
    %,
    81
    .
    8
    %,
    83
    .1%, and 79.
    9
    %, respectively. A visual analysis supported by scanning electron microscopy demonstrated the role of
    B
    . bacteriovorus
    in removing the established biofilms. This study highlights the potential use of
    B
    . bacteriovorus
    as a biological control agent with the capability to prey on MDR/XDR gram-negative pathogens and eradicate biofilms.

  • I. F. Davies
    Journal of Light & Visual Environment
    1984年 8 巻 1 号 1_9-1_20
    発行日: 1984年
    公開日: 2011/05/20
    ジャーナル フリー
  • CHING-CHUAN HUANG
    SOILS AND FOUNDATIONS
    2009年 49 巻 2 号 249-258
    発行日: 2009年
    公開日: 2011/01/27
    ジャーナル フリー
    The correction factor (ηie) for the ultimate bearing capacity of a footing placed adjacent to a slope, taking into account the combined effect of horizontal and vertical seismic loads, represented by horizontal and vertical seismic coefficients, kh and kv, respectively, was derived using a modified Janbu's slice method. The influence of slope angles ‘α’ on the values of ‘ηie’ are studied here. It was found that the values of ηie can be expressed as an exponential function of ‘kh/(1-kv)’ and ‘α’, with a measurable interdependency between ‘α’ and ‘ηie’. The influence of ‘α’ on the value of ‘ηie’ increases as the input value of ‘kh/(1-kv)’ increases. Equations derived based on the analytical results are proposed to account for this effect. Based on the analyses of 11 near-fault seismographers obtained in the 1999 Chi-Chi earthquake in Taiwan, a ratio between the vertical and the horizontal seismic coefficients, λ, of between ±0.25 is suggested for including the combined effect of vertical and horizontal seismic forces in evaluating the seismic bearing capacity of footings located in near-fault areas.
  • CHING-CHUAN HUANG, WEN-WEI KANG
    SOILS AND FOUNDATIONS
    2008年 48 巻 5 号 641-651
    発行日: 2008年
    公開日: 2011/01/27
    ジャーナル フリー
    At present, analytical or empirical formula for seismic bearing capacity of footings adjacent to slopes is not available. This study uses a pseudo-static-based approach in conjunction with rigorous Janbu's slice method to derive analytical values of seismic bearing capacity factors (Nγ) and correction factors for the effects of inertia of soil mass and load inclinations for a rigid footing adjacent to cohesionless slopes. It is shown that both the bearing capacity factors (Nγ) and the correction factors for the seismic bearing capacity of footings placed on level ground derived herein are comparable with those reported in the literature. Empirical equations regarding the effects of slope angles and load inclinations, expressed using generalized forms of those proposed in the literature, are also derived. It is also found that the empirical equations derived in the present study provide values of correction factors in good agreements with the analytical ones, indicating the validity of using these empirical equations for assessing the bearing capacity of rigid footings situated on the slope subjected to pseudo-static seismic loading.
  • 鈴木 敏弘
    日本内分泌学会雑誌
    1960年 36 巻 6 号 1075-1091,925
    発行日: 1960/09/20
    公開日: 2012/09/24
    ジャーナル フリー
    Metabolism of body fluids and electrolytes which related not only to aldosterone alone but to other corticosteroids, for example, glucocorticoids had mineral action. And the simultaneous administration of aldosterone and corticosterone consistently resulted in a greater potassium diuresis than did the aldosterone alone.
    Therefore, body fluids and electrolytes are aummation of many corticosteroids which had biological action, and can't know by the determination of simple corticosteroids.
    The author report on the systemic determination of aldosterone, Comp.
    B
    , Comp.
    E
    , Comp. F, and the newly separated contaminants.
    Method :
    The 24 hours urine specimen is pooled at
    5
    °
    C
    and acidified to pH 1.
    5
    with conc. HCL, then standing 24 hours at 15°
    C
    .
    Urine was extracted by chloroform and dried. Extract was treated with Florisil column chromatographies and
    4
    consecutered and different paper chromatographies with Chloroform-Formamide System, Bush-
    C
    System,
    E2B
    System, and Bush-
    B
    5
    System, to separated corticosteroid partitions.
    Results :
    1. Recoveries of
    5
    mg/100 ml H2O standard samples after
    5
    times continued extraction by 0.1 volume chloroform, for Comp.
    B
    , Comp.
    E
    , and DOC is
    95
    %, and Comp. F is
    83
    %.
    2. Additional chloroform re-extraction, Comp.
    B
    , Comp.
    E
    , and DOG do not appear in the
    7
    th chloroform extraction, but Comp. F appear in the amount of 60μg in
    8
    th chloroform and
    9
    th extraction is nothing, thus this determination necessitate at least
    8
    consecutered extractions.
    3
    . Comp.
    B
    , Comp.
    E
    , and Comp. F appear in 25% methanol in chloroform fraction by the use of the Florisil column chromatography is made, and recovery is about 100% in condition of 60 drops/minutes.
    4
    . Separate Comp. III, Comp. V, Comp. VI, and Comp. VII from aldosterone partition in Neher-Wettstein's method.
    5
    . New contaminants were discover from Comp.
    E
    and Comp. F partition after Bush-
    C
    System paper chromatography, called Comp.
    E2
    -
    E42
    , Comp. F2 ; and, other conatminants named M1-
    M8
    Z1-
    Z8
    , HC1-
    HC3
    ,
    AC1
    and
    AC2
    in Chloroform-Formamide and Bush-
    C
    System paper chromatography.
    6
    . Examination of the purities of Comp.
    B
    , Comp.
    E
    , Comp. F, and aldosterone partitions is made use of the ultra violet absorption spectrum, and necessitates
    4
    (
    C
    -F→Bush-
    C
    E2B
    →Bush-
    B5
    ), or
    3
    (
    C
    -F→
    E2B
    →Bush-
    B5
    ), paper chromatographies to satisfactorily separate these compounds.
    7
    . The
    H2SO4
    chromogen spectrum of these partition correspond with the standard compounds.
  • S. SICSIC, J. F. LE BIGOT,
    C
    . VINCENT,
    C
    . CERCEAU, F. LE GOFFIC
    The Journal of Antibiotics
    1982年 35 巻 5 号 574-579
    発行日: 1982年
    公開日: 2006/04/12
    ジャーナル フリー
    The activities of tobramycin derivatives acetylated and ethylated on the
    6
    '-N, 2'-N and
    3
    -N positions were examined. The MICs of these derivatives against tobramycin sensitive strains indicated that 2'-N-ethylated and
    6
    '-N-ethylated derivatives have a fairly good activity, and confirmed that the
    3
    -N position is the most important one for antibiotic activity since
    3
    -N derivatives were less active. The MICs of these derivatives against tobramycin resistant strains, and their inactivation by tobramycin modifying enzymes were examined. These results showed that 2'-N or
    6
    '-N ethylation protects the drug against inactivation by AAC(2') or AAC(
    6
    '), respectively, and 2'-N-ethyltobramycin and
    6
    '-N-ethyltobramycin were active against strains containing these modifying enzymes. On the other hand,
    3
    -N ethylation protects the drug against inactivation by AAC(
    3
    ) but
    3
    -N-ethyl tobramycin does not inhibit strains containing this enzyme.
  • 宮北 隆志, 三浦 創, 伊藤 昭好, 山本 剛夫
    産業医学
    1981年 23 巻 6 号 619-631
    発行日: 1981/11/20
    公開日: 2008/04/14
    ジャーナル フリー
    Effects of noise exposure on aural reflex (AR) were investigated. The threshold of AR (ART) was measured in two groups exposed to occupational noise (Group A and
    B
    ) by the electro-acoustic impedance bridge (Madsen, ZO-72). White noise (WN), and pure tones of 1 and
    4
    kHz were selected as activating stimuli for AR, and ARTs for these stimuli (ARTWN, ART1k,
    ART4k
    ) were determined respectively. The results were compared with the ARTs in the normal group (Group
    C
    ) reported by the authors previously. Group A consisted of 31 male workers exposed mainly to steady noise, and Group
    B
    included 65 male workers exposed maily to impulsive noise. Group
    C
    consisted of 50 males and 50 females, who had normal hearing acuity without any history of occupational noise exposure (Fig. 12). Mean age was 37.2 years in Group A, 49.
    9
    in Group
    B
    . Mean period of noise exposure was 13.
    3
    years in Group A, 26.1 in Group
    B
    . In both groups, the hearing loss was observed in the higher frequency region at
    4
    and/or
    8
    kHz, while normal hearing acuity was reserved at 1 kHz (Fig.
    3
    and
    4
    ). Because of no significant difference between Group A and
    B
    in each of the mean ARTs (Table
    3
    ), Groups A and
    B
    were summarized as the exposed group to noise. ARTs for three different stimuli (ARTWN, ART1k,
    ART4k
    ) in the exposed group showed significant differences compared to those in the non-exposed group (Group
    C
    ); i.
    e
    . mean ARTWN was 92.0 dB SPL in the exposed group and
    83
    .
    8
    in Group
    C
    , mean ART1k was 93.
    8
    dB SPL in the exposed group and
    96
    .2 in the non-exposed, mean
    ART4k
    was 102.1 dB SPL in the former and 97.
    5
    in the latter group (Table
    5
    ). There was a significant negative correlation between the hearing level at
    4
    kHz (
    HL4k
    ) and the value of [
    ART4k
    -
    HL4k
    ] (Fig. 14). The difference between ART1k and ARTWN, [ART1k-ARTWN], was significantly reduced in the exposed group; i.
    e
    . 1.
    9
    dB in the exposed group and 12.
    4
    in Group
    C
    (Table
    6
    ). For the purpose of our study, the exposed group was re-classified into another two groups according to their HLs at
    4
    and
    8
    kHz; i.
    e
    . Group D (HL(
    4
    k+
    8
    k)/2
    <25 dB) and Group
    E
    (HL(
    4
    k+
    8
    k)/2
    >__=25 dB). The mean values of ARTs and HLs in Groups D,
    E
    and
    C
    , which are summarized in Table
    7
    , show two interesting points. First, the significant elevation of ARTWN is observed not only in Group
    E
    but also in Group D with normal hearing acuity. Second. the lowering of ART1k is observed in Group
    E
    only. These results indicate that the elevation o ARTWN probably depends upon the exposure history to occupational noise but not upon the hearing loss, and that lowering of ART1k may be caused by the hearing loss of the subjects in the higher frequency region. These estimations may be supported by the fact that [ART1k-ARTWN] was
    3
    .
    7
    dB in group D and 0.
    6
    dB in Group
    E
    (Table
    8
    ). Since damages of outher hair cells (OHC) in the Corti's organ do not always lead to hearing loss, it is conceivable that the reduction of [ART1k-ARTWN] is the results of the widening of the critical band width for AR due largely to the damage of OHC caused by the occupational noise exposure. Under this conception, the value of [ART1k-ARTWN] may be used as a sensitive and objectibe indicator for detecting and evaluating the early stages of noise-induced hearing impairment and individual susceptibility to noise.
  • FRANÇOIS LE GOFFIC, MARIE-LOUISE CAPMAU, ERÉDÉRIC TANGY, ELIANE CAMINADE
    The Journal of Antibiotics
    1980年 33 巻 8 号 895-899
    発行日: 1980年
    公開日: 2006/04/12
    ジャーナル フリー
    (
    3H
    ) Tobramycin was used as a probe to determine the relationship between the structure of aminoglycoside antibiotics and their ability to remove this drug from its higher affinity binding site on the ribosome. The dissacharide moieties (neamine, tobramine, gentamine) appeared to have a common binding site, whereas the kanosamine, garosamine and ribose moieties determined the specificity of this binding. Amikacin and butikacin behaved in an anomalous manner in spite of their close structural relationship to tobramycin.
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