In addition to the three furanoid-norditerpenoids, diosbulbin-A (1), -B (2) and- (3), reported previously, four related compounds, diosbulbin-D (_<19>H_<20>O_, mp 226-°), - (_<19>H_<>O_, mp 235.5-236.5°), -F (_<20>H_<24>O_7, mp 201-203.5°) and -G (_<19>H_<>O_, mp 215-216.5°), were isolated from the root tubers of Dioscorea bulbifera L. forma spontanea Makino et Nemoto. On the basis of their chemical and spectral data and correlation of D with others they are assigned the structures 4, 5, and 7, respectively.

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B型慢性肝炎症例612例中, -100抗体陽性であつた24例の肝炎ウイルスマーカーと臨床的特徴につき検討した. 抗原陽性, 陰性別にみると, -100抗体陽性例は, 抗原陽性例例中2例 (0.%) と少なく, これに対して抗原陰性例385例中例(5.7%)と, 抗原陰性例に有意に多く認められた(p<0.01). HCV RNA陽性例も, 抗原陰性例, DNA-polymerase 低値例に高率に認められた. また, 抗原から抗体に seroconversion (SC) した症例では, SC後にHCV RNAが持続陽性となつた. 以上より, B型, 型肝炎ウイルスは同一個体に感染しうるが, SC後に型肝炎ウイルスが優勢に増殖すると考えられた. これは, 合併例の治療上, 考慮すべき知見と思われた.

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In this paper, I reexamine a notorious passage in Plato's Sophist 253d-

in order to establish a new relationship between the Method of Division practiced in the scene of denning sophist and the Separation in the scene of the (συμπλοκη των ειδων. The passage begins with following introductory remarks(253d1-2). Το κατα γενη διαιρεισθαι (Intr. 1) και μητε αυτον ειδο&b.sigmav; ετερον ηγησασθαι και μητε ετερον ον ταυτον (Intr. 2) These two items belong to the Knowledge of Dialectic, and someone who is equipped with them discerns sufficiently the followings(ibid. d7 ιλανω&b.sigmav; διαισθανται). (1) μιαν ιδεαν δια πολλων, ενο&b.sigmav; εκαστου κειμνου χωρι&b.sigmav;, παντη διατεταμενην (2) πολλα&b.sigmav; ετερα&b.sigmav; αλληλων υπο μια&b.sigmav; εξωθεν περιεχομενα&b.sigmav; (3) μιαν δι' ολων πολλων εν ενι συνημμενην (4) πολλα&b.sigmav; χωρι&b.sigmav; παντη διωρισμενα&b.sigmav;(ibid. d5-1) Among various interpretations on this passage, we can see two tendencies. On the one hand, some scholars think that this passage refers to the Method of Division, and hold that Plato intended here to describe the genus-species relationship in the world of Idea. On the other hand, some scholars reject this kind of view and claim that it refers to the Dialectic in the scene of συμπλοκη which they treat as a grasp of consistency and inconsistency between Forms. It seems, however, to me that both of these tendencies have a common fault that they cannot help supposing in one and the same dialogue two kinds of Dialectic which are totally different from each other. So in our interpretation these two types of Dialectic should have some suitable relationship. My general strategy is as follows. At the first stage of my interpretation, I investigate the passage in relation to the Method of Division. And among four items cited above, I take (1) as the Collection(219-7, 2265-), (2) as the Separation(226, 5, 267d1), (3) as the Connection(224, 2525, 268), and (4) as the Repetition of a set of those three(2231-4, 226a-8, 2315), respectively. Although most of scholars have took the expression of (2) to mean the Collection in combination with that of (1), I don't commit myself to this kind of view. At the second stage, I connect the passage to the Dialectic in the scene of συμπλοκη by means of interpreting the phrase ιχανω&b.sigmav; διαισθανεται cited above as a grasp of the foundation of the Method of Division(cf. 253a ικανω&b.sigmav;, ibid. 3 αιτια). In other words, I regard the Dialectic in the συμπλοκη as the foundation of the Method of Division, and think, accordingly, that there is a certain kind of hierarchy between the two. For example, as far as (2) is concerned, I think two types of separation in this dialogue. One is the separation in the scene of defining sophist. In this scene the Stranger distinguishes one Form from the other exclusive Form, such as the cleansing of soul from that of body(5 αφορισασθαι). I call this type of separation Separation 1, and take the expression of Intr. 1 to refer to the Separation 1. The other is the separation in the scene of συμπλοχη. In this scene the Stranger distinguishes one Form from many Forms which are comprehended by the former one, such as Being from Rest and Motion(250b8-4). And in another passage of the text this type of separation seems to be said in other words that Being is the same as itself but different from any other Forms(254d4-15, 257a1-, 259b1-4). So I call both of these Separation 2. Depending upon this classification, I consider the relationship between the two types of separation. Indeed many cleansings concerning body are tied up as similar things(cf. b3 ομοιοτητα) in comparison with many cleansings concerning soul. But this doesn't mean that the many cleansings about body are the same as the one Form which ties up them. So, strictly

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魚市場およびと畜場のドブネズミにおけるStaphylococcus auresの保有率はそれぞれ74.% (44/59), 34.% (/26) であった. 魚市場のネズミ由来S. aureus104株の生物型は型81株 (77.%), B型16株 (15.4%), A型株 (5.8%), 型別不能1株 (1%) で, と畜場由来株はG型8株 (.%), B型1株 (11.1%) であった. 魚市場のネズミ由来株のコアグラーゼ型は, VIII型 (26.%), 1型 (.1%), VII型 (13.5%), IV型 (8.7%), II型 (5.8%), III型 (2.%), V型 (2.%), VI型 (2.%), 同定不能 (14.4%) で, と畜場由来株は, VIII型 (44.4%), V型 (.2%), VI [型 (.2%), 同定不能 (11.1%) であった.魚市場のネズミ匹由来の12株からはエンテロトキシンA (11株) およびB (1株) が産生された.

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Six full-length cDNAs encoding pig cytochrome P450 (CYP) enzymes, CYP1A1, CYP2A19, CYP2B, CYP233v4, CYP249, and CYP21, were isolated and sequenced. The cDNA sequences of pig CYP1A1, CYP2A19, CYP2B, CYP249, and CYP21 showed high similarity to human CYP1A1 (85.4%), CYP2A13 (.%), (81.1%), (85.3%), and (82.5%), respectively, and pig cDNA showed high similarity to rat (79.2%). Reverse transcription-polymerase chain reaction (RT-PCR) assays revealed hepatic gene expression of all these pig CYP enzymes: the order of expression was and > > CYP1A1 and CYP2A19 > . In the kidney, the gene was expressed at the same level as in the liver, but the CYP1A1, CYP2A19, and genes were expressed at lower levels than in the liver. Little renal gene expression of CYP249 and CYP21 was observed. We revealed for the first time the full-length cDNA sequences encoding pig CYP1A1 and five CYP enzymes belonging to the CYP2 gene family, thus making it possible to examine the gene expression levels of these CYP enzymes in pig tissues by RT-PCR.

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A bubble collapse phenomenon in water is photographically investigated using a high-speed framing camera (200, 000 frames/sec).The bubble was generated by focusing the beam of a pulsed ruby laser ( nsec, 0. J, 40MW). It was found that the total collapse time of the bubble (initially 2.5mm in radius) is about 200 μsec, providing a reasonably good agreement with the collapse time μsec obtained through the RAYLEIGH's analytical solution.

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Circuit techniques to enhance the linearity of input-voltage-to-current (V/I) conversion and to increase the output impedance of a current source by compensating for the low intrinsic gain of a transistor were introduced to realize a high-frequency operational transconductance amplifier (OTA) for a low supply voltage using sub-100-nm CMOS processes. Applying these techniques, a MOS 7th-order Gm- linear-phase low-pass filter (LPF) was realized using a 65nm CMOS process. A simplified biquad LPF that can serve as a component of a 7th-order LPF was newly developed by replacing OTAs with resistors. As a result, the -3dB frequency bandwidth, group delay ripple, 3rd-order distortion, and 3rd-order input intercept point (IIP3) were 200MHz, 2.2%, ≤ -55dB with a 100MHz input, and +10.3dBm, respectively, all with a ±0.1Vp-p input signal at each input terminal in the pseudodifferential configuration. The LPF including an output buffer dissipated 60mW in the case of a 1.2V supply. Wide spurious-free dynamic range (SFDR) characteristics were confirmed up to high frequencies.

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体外成熟－体外受精によって作出した牛胚を第１卵割時期に従って分類し，これらの2-細胞期胚のその後の脱出胚盤胞までの発生と性について体外培養とPCRによる性判別によって検討した．体外受精に供した669個の胚のうち，媒精後，26，30および44時間で選んだ卵割胚はそれぞれ124，，および65個であった．これらの胚を卵丘細胞層の拡がった同じ培地に別々に移して10日間共培養した．媒精後，26，30 および44時間で選んだ胚の脱出胚盤胞への発生率はそれぞれ56.5，40.1，21.および4.%となり，これらの間には統計学的な有意な差がみられた（P<0.05）．さらに，早く卵割した胚（媒精後および26時間）では遅く卵割した胚（媒精後30および44時間）に較べて脱出胚盤胞の最初の出現あるいはピークが早かった．性判別のためにPCRに供した183個の脱出胚盤胞のうち，171個で性を判定することができ，全体での性比は51.5%（/171）であった．早く卵割した胚および遅く卵割した胚から発生した脱出胚盤胞の性比はそれぞれ49.7%（74/149）および63.%（14/）となり，第１卵割時期に関係していなかった．以上の結果から，媒精から第１卵割の終了までの時間は性差についてではなく，胚のその後の発生に大きく影響することが示唆された．

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Some patients who showed a 50% or greater narrowing of at least one major coronary artery in the first study underwent recatheterization at a mean interval of 35. months. Coronary arterial lesions and the degree of narrowing [i.., normal (absent), 25%, 50%, 75%, 90%, 99% and complete occlusion (100%)] were classified in accordance with the AHA reporting system. When the lesions in the second study showed a change of equal or more than 2 in the above 7 stages in comparison with the first study, either progression or regression was determined. Of the patients, progression occurred in 73 (32%) and regression was found in 7 (3%). In the aggravated group in symptom, progression was noted in 58%, and even in the stabilized group, progression was observed in %. As a result of the second study, 15 (21%) out of 73 patients showing progression underwent surgical treatment, and more than half of these cases (/15) were constituted by the stabilized group. During the above following-up periods, myocardial infarction occurred subsequently in 14 (19%) out of 73 patients showing progression. Up to the present time, sudden deaths occurred in 8 patients, and 5 out of 8 patients were also of the stabilized group. The authors wish to emphasize from these findings the necessity of aggressively pursuing restudy even in stabilized cases showing symptoms of ischemic disease.

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A procedure for limit equilibrium slope analysis based on a realistic consideration of the mobilized interslice shear forces is presented in this paper. This new approach ensures that solutions are kinematically admissible and the possibility of convergence problems, often associated with numerical solutions, is minimized. The proposed approach recognizes the importance of slip surface geometry in estimating interslice shear forces whether vertical or non-vertical slices are used in a limit equilibrium analysis. Illustrative examples are presented and the results shown to be reasonable. The calculated factors of safety based on the new method compare very well with values based on recognized methods of analysis. Yet the method is more direct and enables a proper visualization of the transfer of mobilized normal and shear forces through a sloping soil mass above a potential slip surface. The method also gives consistent results with non-vertical slices even if the shape of non-vertical slices is varied.

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Rectal contents of beef cattle and pigs were collected between October 2010 and February 2011 in Japan. Campylobacter jejuni were isolated from 36.0% (90/250) of beef cattle from .0% (/25) of beef farms.

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. coli were isolated from 3.% (/250) of beef cattle from 16.0% (4/25) of beef farms and from 42.4% (106/250) of pigs from all 25 pig farms. As to enrofloxacin, 40.0% (36/90) of

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. jejuni isolates and 66.7% (/) of

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. coli isolates from beef cattle and 44.3% (47/106) of

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. coli isolates from pigs were resistant. Additionally, 15.1% (16/106) of

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. coli isolates from pigs were resistant to erythromycin and enrofloxacin. The high prevalence of Campylobacter carriers and significant antimicrobial resistance of the isolates were found.

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