帯状疱疹に対するRo-8181の有効性, 安全性および有用性を検討するため, ヒト血清アルブミンを対照薬として, 二重盲検比較試験を行つた。皮膚症状の観察項目別の改善率では, 水疱·膿疱において投与開始後5日目でRo-8181群70%, placebo群50%で, 両群間に差(p<0.05)が認められた。皮膚症状改善度の推移を著明改善以上の症例についてみると, 投与開始後4日目の著明改善率はRo-8181群8%, placebo群0%であり, Fisherの直接計算法で両群間に差(p<0.05)が認められた。また, 投与開始後5日目の著明改善率はRo-8181群15%, placebo群3%であり, κ² 検定で両群間に差(p<0.05)が認められた。主治医による有効性の判定ではU検定でRo-8181群が優れている傾向が認められた。主治医による安全性の判定では副作用発現率がRo-8181群83%, placebo群14%であり, U検定で両群間に差(p<0.001)が認められた。主治医による有用性の判定ではU検定で両群間に差は認められなかつた。以上の結果より, 帯状疱疹に対し, Ro-8181は皮疹のうち水疱·膿疱に対して有効であり, 主治医判定でも有効性が認められたが, 安全性については本薬剤の耐薬性が示されたものの副作用の発現率が高かつたため, 有用性は高くないと考えられた。

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CTAの行政上の取り扱い、歴史、投資戦略等をまず簡単に説明する。CTAとは金融先物、オプション、スワップを対象とした取り引きに関する投資のアドバイスやサービスを個人、ファンドに提供する個人、または組織に対する金融行政上の用語で、正式名はCommodity trading advisorである。CTAという用語は投資信託、ETFを含むヘッジファンド、プライベートファンドへの投資アドバイスにも適応される。CTAs は米国連邦政府による規制対象であり Commodity Futures Trading Commission (CFTC) への登録と National Futures Association (NFA) のメンバーになることが義務付けられている。また、CTAはヘッジファンドの投資スタイルのひとつ (Global Macro) でもある。

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The Japan Society for Occupational Health (JSOH) recommends the Occupational Exposure Limits (OELs) as reference values for preventing adverse health effects on workers caused by occupational exposure to chemical substances, continuous or intermittent noise, impulsive or impact noise, heat stress, cold stress, whole-body vibration, hand-arm vibration and time-varying electric, magnetic and electromagnetic fields and ultraviolet and ionizing radiation.

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Intracerebral injection of vegetative myxamoebae of strains of Polysphondylium pallidum caused 80 to 100% mortality in mice, whereas a 30 to 50% mortality occurred with strains of Dictyostelium giganteum and D. mucoroides. Death is attributable to an unidentified toxic factor. Histopathologically a giant cell formation was seen in the spleen of mice. This cell was different from Langerhan's or foreign body giant cell. Rats injected intracerebrally behaved similarly. Intranasal instillation of myxamoebae in guinea pigs caused transient pneumonia. Myxamoebae do not multiply in the brain tissues of mice or rats, or in the lungs of guinea pigs.
Intranasal instillation of vegetative myxamoebae is less pathogenic than free living amoebae like Hartmanella culbertsoni, H. rhysodes, Naegleria sp. (Culbertson strain HB-1), or Naegleria aerobia.

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The nd Annual Meeting of Japan Society for Science Education (JSSE) was held on July 29-31, 1998 at Tokyo Gakugei University in western suburb of Tokyo with about 290 registrants under the main theme of "Towards Implementation of Science Curriculum for Construction of Creation and Symbiosis." Number of papers over 210 were presented in both main sessions and general presentations. There were two symposiums, one lecture, one forum, one international forum, one workshop, three sessions of themes set by the steering committee and ten sessions of themes set independently by members of JSSE in main sessions. Also, there were many other general presentations. Many papers were presented coping with the main theme. They were a lecture related to learning and creativity based on advance of brain, and many presentations related to symbiosis such as relation between in-door and out-door school activities, school based research activities such as curriculum development, and way of finding new methodology of research on classroom, consistency of curriculum through elementary to high school, pre-service teacher education, and so on. Contents of claims and discussions in every presentation in main sessions are summarized in this paper.

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A financial market is a diversified dynamical system with many constraints, and price movements are modeled in terms of the micro properties of each transactions and the macro properties of dynamical systems. These two properties must be bridged by the multiplicity. The model forcuses on the size of tick and the number of transactions with the price movement compared with the previous transctions and explains stochastic nature of short-term volatilities and persistently stable long-term volatilities as a results of unique behaviour of heterogeneous market participants.

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DiGeorge syndrome (DGA), velocardiofacial syndrome (VCFS), and conotruncal anomaly face syndrome (CTAF) are frequently associated with q11.2 deletion syndrome. We report two cases of q11.2 deletion syndrome. Two patients had cleft palate, and facial dysmorphism. Fluorescence in situ hybridization (FISH) was used to show deletion of chromosome q11.2. Palatoplasty was performed at about two years of age with the patients under general anesthesia. The postoperative course was uneventful in both patients.

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As a new type of digital currency,

is considered as “future gold” by various scholars. Therefore, this study considers and gold as a group of hedging assets to conduct investment research and it also discusses the investment rules between and gold: prediction of the rise and fall of , comparison of the characteristics of and gold, and the impact of the transaction procedures of and gold on the final trading results, and formulates trading strategies through optimization algorithms. Then, four machine learning algorithms, i.e., LSTM, BP neural network, Adaboost, and Bagging, are introduced to predict the rise and fall of gold and the next day, and then, the entropy weight method is used to synthesize four predicted results to ensure the robustness of the predicted results. To establish the optimal trading strategy, this study considers the maximum expected return as the goal to develop a single-objective optimization model and historical five-day price volatility as a risk factor. In this study, ant colony, simulated annealing, and genetic algorithms are used to solve the single-objective optimization model. Finally, we conclude that , similar to other financial assets, e.g., gold, is sensitive to shocks and volatile and possesses a relatively quiet cycle. When has an asymmetric impact, and gold can equally treat transactions.

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We report three cases of q11.2 deletion syndrome (CATCH; cardiac defects, abnormal faces, thymic hypoplasia, cleft palate and hypocalcemia with chromosome q11.2 deletion) with various complications including hearing loss and nasopharyngeal problems. All three cases we report here had congenital cardiac defects. Two of the three cases had cleft palate, one overt and the other submucoals. Although one of the three cases had a normal hearing level, the other two were almost deaf, one with and the other without inner ear anomalies. The former case was prescribed a hearing aid, and for the latter case, cochlear implantation operation was conducted at the age of three years and seven months. Both of these patients have successfully developed communication skills.
CATCH shows a variety of phenotypes, including hearing loss and nasopharyngeal malformations, either of which may disturb speech ability and thus, furthermore, mental development of the child. However, this condition may be improved by early and adequate intervention. Thus, otolaryngologists should be familiarized with the typical facial abnormality and most frequent manifestations of this syndrome, and be ready to treat patients with q11 deletion, providing them with intensive and individualized prescription at their early stages.

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目的:現在尿路上皮腫瘍のスクリーニング法としては尿細胞診が広く用いられているが細胞異型の弱い腫瘍の場合には検出感度が低く偽陰性が問題となる. 近年開発された尿中腫瘍マーカーのNMPは, 迅速に結果が得られ早期の尿路上皮癌を確認できるとされスクリーニングに広く用いられつつある. 今回われわれは, 尿中NMP値と尿細胞診結果を組織診断および膀胱鏡検査と比較し, 今後の尿路上皮スクリーニング法について検討したので報告する.
材料および方法:2000年7月から2002年4月までに当院泌尿器科より提出された外来自然尿675例について尿細胞診およびNMP (コニカMatritech UNMPテストキットELISA法) を比較検討した.
結果:臨床的および組織学的に31例の癌 (G1: 8例G2: 19例G3: 4例) が確認された. このうちNMPでは陽性が17例, 細胞診では14例, 陰性はNMPでは14例, 細胞診では17例であった. 細胞診では明らかな偽陽性症例 (+) はみられず, 疑陽性症例 (±) 17例に対しNMPでの偽陽性数は96例であった. これらの要因として細胞診で炎症や結石などにより細胞異型を示していたものがあり, NMPでは白血球成分の多い検体で高値を示していた.
考察:今回の検討で尿細胞診では検出感度は低いが特異度が高く診断には欠かせない検査である. 一方, NMPはG1の癌検出が細胞診に比べ優れているが, 膿尿などの白血球成分の多い検体では偽陽性結果が多く細胞診結果と乖離するためNMPと尿細胞診との併用が望ましいと思われる.

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is a crypto currency that is a peer-to-peer(P2P) network systems based on distributed ledger technology and is being used as an alternative payment system. Reliability and safety are very important aspects of payment system. However, in recent years, with an increase in value, crypto currency becomes a target of a malicious users and the attacks that strike the vulnerability of the system are regarded as a problem. Such a problem significantly reduces reliability and safety as a payment system for crypto currency. Therefore, it is necessary to pay attention to cyber security risks inherent in the system, as well as price uctuations usually focused on financial asset prices. In this research, we propose to use information observed in darknet as alternative data. It is useful in evaluating the risk in the crypto currency market. The darknet is a name of an IP address space unallocated by terminals or the like among spaces that can be assigned IP addresses. The darknet is mainly used for observing signs of security incidents. This is useful for investors to grasp potential risks of crypto currency markets and is important for service providers to explain security risks and measures. In addition, the darknet observation information has a prospect of utilizing not only the crypto currency but also the monitoring of the security risk of companys.

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Blockchain – a distributed and public database of transactions – has become a platform for decentralized applications. Despite its increasing popularity, blockchain technology faces a scalability problem: the throughput does not scale with the increasing network size. Thus, in this paper, we propose a scalable blockchain protocol to solve the scalability problem. The proposed method was designed based on a proof of stake (PoS) consensus protocol and a sharding protocol. Instead of transactions being processed by the whole network, the sharding protocol is employed to divide unconfirmed transactions into transaction shards and to divide the network into network shards. The network shards process the transaction shards in parallel to produce middle blocks. Middle blocks are then combined into a final BLOCK in a timestamp recorded on the blockchain. Experiments were performed in a simulation network consisting of 100 Amazon EC2 instances. The latency of the proposed method was approximately 27 s and the maximum throughput achieved was 36 transactions per second for a network containing 100 nodes. The results of the experiments indicate that the throughput of the proposed protocol increases with the network size. This confirms the scalability of the proposed protocol.

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CATCH症候群は,番染色体長腕(q11.2)の部分欠失に起因する隣接遺伝子症候群であり,心血管異常(cardiac defects),異常顔貌(abnormal facies),胸腺低形成(thymic hypoplasia),口蓋裂(cleft palate),低Ca血症(bypocalcaemia)を特徴とする.今回,口蓋裂を伴ったCATCH症候群の1例の麻酔を経験した.本症例では良好な麻酔管理が行えたが,本症は多発合併奇形を有することが多く,術前の十分な検索,評価が必要である.

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Aim: Macrophage-derived chemokine (CCL) is a member of the CC-family of chemokines synthesized by monocyte-derived macrophages. Previous studies have reported a relationship between CCL and atherosclerosis and the role of histamine in this pathway. Histamine ncreases the CCL expression in human monocytes via the H2 receptor. In this study, we investigated the effects of CCL and the role of histamine in mouse monocytes with respect to atherosclerosis.
Methods and Results: The expression of CCL was investigated in apolipoprotein E (apoE)-deficient mice. The mice had high serum concentrations of CCL and their atherosclerotic lesions contained abundant levels of CCL. In addition, when the mouse monocyte cell line (J774A.1 cells) differentiated into macrophage-like cells, the cells showed a similar expression of CCL and reduced expression of H2 receptors. Histamine is synthesized from l-histidine by histidine decarboxylase (HDC) in a single enzymatic step. HDC knockout mice were compared with apoE/HDC double knockout mice. The findings indicated that the expression of CCL in atherosclerosis models is under the influence of histamine. In addition, in vitro studies using J774A.1 cells and an in vivo study using histamine receptor knockout mice showed that histamine stimulates the CCL expression via the histamine H2 receptor.
Conclusions: The current results support our previous CCL studies in the setting of human atherosclerosis and suggest that this molecule is involved in the atherogenic processes in a mouse model of atherosclerosis.

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