We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group
B
which comprised preeclamptics who were supplemented their diets with vitamins
C
and
E
. MDA increased from
6
.
22
±
2
.
8
(placebo) to
8
.48 ± 1.
2
(A) and
8
.02 ± 1.
8
nmol/gHb (
B
). NO concentrations were enhanced from 19.
3
±
4
.
2
(P) to 23.
8
±
6
.
4
(A) and 24.1 ±
5
.
4
μmol/L (
B
). GSH contents were decreased from 10.42 ±
2
.
81
(P) to
8
.02 ±
2
.92 (A) and
9
.39 ± 1.02 μmol/g Hb (
B
), whereas GSSG concentrations increased from 0.98 ± 0.28 (P) to 1.24 ± 0.29 (A) and 1.08 ± 0.12 μmol/g Hb (
B
). SOD activity decreased 23% in A and 14% in
B
; GRx decreased 27% in A and
5
.
5
% in
B
; GPx decreased 12% in A and
9
.
6
% in
B
. Catalase activity, however, increased 27% in A and 29% in
B
as compared to control. Thus, we conclude that the use of vitamins
C
and
E
should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.
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