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Background: SYMPLICITY HTN-Japan is a prospective, randomized, controlled trial comparing renal denervation (RDN) with standard pharmacologic therapy for treatment of uncontrolled hypertension (HTN).

Methods and Results: Patients enrolled had uncontrolled HTN, defined as

systolic blood pressure (SBP) ≥160 mmHg and 24-h ambulatory SBP ≥135 mmHg, on ≥3 antihypertensive drugs of maximally tolerated dose for at least 6 weeks prior to enrollment. Randomization was 1:1 to RDN or maintenance of current medical therapy (control). Patients were followed every 6 months post-randomization for up to 36 months. There were patients randomized to RDN and 19 to control, and 11 patients were crossed over and received RDN at 6 months post-randomization. For the RDN group (n=), SBP reduction was −32.8±20.1 mmHg and DBP reduction was −15.8±12.6 mmHg at 36 months post-procedure, both P<0.001. For the combined RDN and crossover group (n=33), SBP reduction was −26.7±18.9 mmHg and DBP reduction was −12.7±11.8 mmHg at 30 months post-procedure, both P<0.001. There were no procedural-, device- or treatment-related safety events through 36 months.

Conclusions: SYMPLICITY HTN-Japan is the first randomized controlled trial to evaluate RDN in an Asian population. Despite the

number of enrollments, results show patients who received RDN therapy maintained SBP reduction out to 36 months.

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Food Safety Commission, Cabinet

, Government of Japan (FSCJ) was established in 2003 and marked its 20^th anniversary in 2023. FSCJ held a commemorative ceremony and symposium to celebrate its 20^th anniversary at Mita conference hall (Mita, Minato-ku, Tokyo) on September 1st, 2023, which attracted a total of 164 on-site attendees including six media companies, as well as 460 online viewers. FSCJ Chairperson Dr. YAMAMOTO gave a summary of each session; Session 1 outlined the various future challenges against which risk assessment organizations must prepare. In Session , panelists shared information on the development of new evaluation methodologies and international collaborations in order to meet various global demands and issues. In Session 3, the FSCJ introduced its future initiatives and called for international collaboration in sharing information and expertise to address data gaps and emerging issues, to which all panelists expressed their support. The importance of personnel development to tackle these challenges was also raised. In concluding the seminar, Dr. YAMAMOTO expressed that the common understanding gained from this occasion was the most fruitful achievement, owing to the international colleagues who shared their thought-provoking presentations and insights.

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The WHO International Programme on Chemical Safety (IPCS) framework for analyzing the relevance of a cancer mode of action (MoA) for humans (IPCS cancer-HRF) is an application to assess human relevance of tumorigenic hazards found through rodent bioassays. The chloroacetanilide herbicides, butachlor and alachlor, induced enterochromaffin-like (ECL) cell tumors in rat stomachs, at the highest doses. This study analyzed the human relevance of this tumor by applying the IPCS cancer-HRF using published data. In a postulated MoA, early key events (KEs) included decreased mucosal thickness in the fundic region, due to reduced parietal cells. The following KEs included increased pH of gastric acid and hypergastrinemia, leading to enhanced cell proliferation and hyperplasia, and resulting in the outcome of an ECL cell tumor. The data showed consistencies in dose-response and temporal concordance with the KEs and specificity in the tumor response, providing strengthened evidence of the KEs. While the early KE was not the same, similar MoAs have already been established for omeprazole and ciprofloxacin. The integrated data indicated that the postulated MoAs were biologically plausible. Alternative MoAs were excluded.. Based on sufficient evidence, an MoA was established in rats. When addressing chemically inducible MoAs of human relevance, KEs of hypergastrinemia and trophic ECL cell hyperplasia were judged to not be qualitatively and quantitatively plausible in humans. The MoA in rats is unlikely to be present in humans; however, the potential effects on parietal cells cannot be excluded. Thus, the IPCS cancer-HRF is very useful for assessing human relevance.

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This paper reports the methods and results of the survey for DECC in 2009. We report the units of primary energy consumption from uses of building including , public , hospital, welfare facility, school and so on. In 2009, we gathered data through a questionnaire which included items of standard (level ) database in hopes to develop basic (level 1) database.

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Objectives: To evaluate the effects of a

-month lifestyle intervention for dry eye disease in workers. Methods: Prospective interventional study (randomized controlled study). Forty-one middle-aged Japanese workers (men, ; women, 19; 39.±8.0 years) with definite and probable dry eye disease were enrolled and randomized to an intervention group (n = ) and a control group (n = 19). The intervention aimed at modifying diet, increasing physical activity, and encouraging positive thinking. The primary outcome was change in dry eye disease diagnoses. Secondary outcome was change in disease parameters, including dry eye symptoms, as assessed using the Dry Eye-Related Quality of Life Score, corneal and conjunctival staining scores, tear break-up time, and Schirmer test results. Results: A total of 36 participants (intervention group, 17; control group, 19) completed the study. The number of definite dry eye disease diagnoses decreased from four to none (p =.05), and the dry eye symptom score showed a significant decrease in the intervention group (p =.03). In contrast, the corneal and conjunctival staining scores, tear break-up time, and Schirmer test results did not differ significantly between groups. Conclusions: The -month lifestyle intervention employed in this study improved dry eye disease status among workers, with a considerable decrease in subjective symptoms. Lifestyle intervention may be a promising management option for dry eye disease, although further investigation of long-term effects are required.

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Technical and Vocational Education and Training (TVET) plays an instrumental role in the technological advancement and economic sustainability of many nations. This study offers an analysis regarding the reality of Technical and Higher Education in Timor-Leste. Education in Timor-Leste has never been high on its list of priorities and specially Technical and Higher Education is even less regarded. The first University was established under Indonesia rule in 1986, however the whole system was brought to its knees during the conflicts in 1999. To respond to this reality UNESCO has created a Timor-Leste UNESCO Country Programming Document (TL-UCPD). Following this UNESCO Program, the Timor-Leste Government developed a Strategy Development Plan on Education. Higher education in Timor-Leste is divided into Higher Technical Education and University Education. Government data about Higher and Technical Education shows a work in progress. However, this falls short from meeting the demand required for Educational Institutions, teachers, students and quality of education. All of these aspects of education are necessary for the development of Timor-Leste as a Nation. This paper concludes that a comprehensive and dynamic approach to strengthen TVET delivery in Timor-Leste is absolutely essential in order to achieve stability and growth in the economic development of the nation.

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To evaluate exposure levels of volatile organic compounds (VOCs) in workers for studies of VOCs exposure in indoor air, personal air sampling was conducted in healthy volunteers in Tachikawa Air Base, Japan Air Self-Defense Force, where no aircraft is operated. Active personal air sampler with activated charcoal tube was used for sampling the VOCs on a day shift. There were 6 straight-chain alkanes with a chain length of C9 to C15 and 4 aromatic hydrocarbons including benzene, toluene, ethylbenzen and o-xylene. Higher VOCs levels of toluene (5.8 - 23.1 ppb) was observed in workers of library than in other workers (toluene; 0. - .5ppb), although exposure levels were below the indoor air quality guideline values of the Japan Ministry of Health, Labour and Welfare. These results suggested workers in Tachikawa Air Base may be exposed to lower enough VOCs levels to minimize biological effects.

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DiGeorge syndrome (DGA), velocardiofacial syndrome (VCFS), and conotruncal anomaly face syndrome (CTAF) are frequently associated with q11. deletion syndrome. We report two cases of q11. deletion syndrome. Two patients had cleft palate, and facial dysmorphism. Fluorescence in situ hybridization (FISH) was used to show deletion of chromosome q11.. Palatoplasty was performed at about two years of age with the patients under general anesthesia. The postoperative course was uneventful in both patients.

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Objectives: To investigate the relationships between the self-reported prevalence of musculoskeletal symptoms in the neck, upper back and low back and certain individual, work-related physical and psychosocial factors. Methods: We conducted a cross-sectional survey using a descriptive questionnaire, which was distributed to 2000 workers in 54 workplaces, in Bangkok, registered at the Social Security of Thailand. Results: Returns were 1,428 (71%) questionnaires, and after screening for exclusion criteria, 1,185 workers were found to be eligible for the study. For the head/neck region, frequently working in an uncomfortable posture increased the risk of experiencing head/neck symptoms (adjusted OR=1.81, 95% CI=1.35-.44). For the upper back region, frequent trunk bending during work increased the risk of experiencing upper back symptoms (adjusted OR=1.80, 95% CI=1.32-.44) whereas working in a job that required little interaction with others decreased the risk of experiencing upper back symptoms (adjusted OR=0.42, 95% CI=0.25-0.68). For the low back region, working for >8 h a day showed an elevated risk for low back symptoms (adjusted OR=1.66, 95% CI=1.25-.). Conclusions: Some biopsychosocial factors were associated with the prevalence of musculoskeletal symptoms in the spine among workers. Further research should focus on these factors in order to develop specific strategies to reduce the occurrence of such symptoms in the environment.

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Body Mass Index as a Measure of Health Care for Japanese Male

Office

Workers: Noriyuki NAKANISHI, et al. Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine—Cross-sectional associations between body mass index (BMI) and medical test items in health examinations were examined in , 435 Japanese male workers aged 20 to 59 yr in Osaka, Japan. From the logistic regression analyses, BMI showed a significant dose-relationship for the high levels of systolic blood pressure, diastolic blood pressures (DBP), total cholesterol (T-CHOL), triglyceride, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), gamma glutamyl transpeptidase (γ-GTP), uric acid (UA), and hemoglobin A_1c and the low levels of high-density lipoprotein cholesterol, hemoglobin, and hematocrit, controlling for age and habits of drinking alcohol and smoking. The high levels of DBP, T-CHOL, GOT, GPT, γ-GTP and UA showed significant odds ratios (ORs) for .5 to 23.4 kg/ of BMI compared with 21.5 to .4 kg/ of BMI as the reference level. In the logistic regression analyses using the total number of abnormal findings in medical test items as a dependent variable, ORs for .5 to 23.4 kg/ of BMI relative to 21.5 to .4 kg / of BMI were 1.49 [95% confidence interval (Cl): 1.01-.21] for one, 1.58 (95% Cl: 1.05-.36) for two, 3.31 (95% Cl: 1.86-5.90) for three and 3.56 (95% Cl: 1.89-6.72) for four or more. By contrast, there were no definite associations between the BMI levels of less than 21.5 kg/ and the total number of abnormal findings in medical test items. These results suggest that the optimal BMI level is 21.5 to .4 kg/ or somewhat below for promoting better health in this population.

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Objective: This study aimed to evaluate the efficacy of increased daily walking steps on the 6-month incidence of neck pain among

workers.

Methods: Healthy

workers with high risk of neck pain were recruited into a 6-month prospective cluster-randomized controlled trial. Participants were randomly assigned at the cluster level, into either intervention (n = 50) or control (n = 41) groups. Participants in the intervention group were instructed to increase their daily walking steps to a designated level for a duration of 6 months. Participants in the control group received no intervention. The outcome measures included the 6-month incidence of neck pain as well as its pain intensity and disability level. Analyses were performed using multivariable logistic regression model.

Results: Of the participants in the intervention and control groups,

% and 34% reported a 6-month incidence of neck pain, respectively. After adjusting for confounders, a significant preventive effect of walking intervention was found (adjusted odd ratio 0., 95% confidence interval 0.06-0.75). No significant difference in pain intensity and disability level was found between those in the intervention and control groups.

Conclusion: An intervention to increase daily walking steps reduced onset neck pain in high-risk

workers. However, the walking interventions did not decrease pain intensity and disability in those increasing the number of daily walking steps compared to the control group.

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The study aims to clarify the effect of indoor environments on

workers’ satisfaction with the thermal and air environment. Environmental measurements and questionnaire survey were conducted on buildings and their workers in 2020 and 2021 during the COVID-19 pandemic. Satisfaction with the thermal environment showed a quadratic relationship with temperature and a negative correlation with mass concentration. Also, satisfaction with the air environment indicated a positive correlation with relative humidity and a negative correlation with concentration and mass concentration. Therefore, workers’ satisfaction can be enhanced by maintaining the indoor environments.

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Physical inactivity is revealed as the global health problem that contributes to noncommunicable diseases (NCDs). High technological developments including smart phones or computers can cause of increased sedentary work and decreased leisure time of activities in healthy adults particularly in

workers. Sitting at desk or computer is routine in workers. They did not require moderate or high physical workload. These caused of physical inactivity in workers. Therefore, the facilitating factors or barriers related to physical activity (PA) participation should be identified. The purpose of this study was to assess the level of PA and to determine the facilitating factors and barriers associated to PA participation in workers. Two study design were conducted: cross sectional survey and qualitative research. First, PA was collected by Thai version of short-form International Physical Activity Questionnaire (IPAQ). The participants were classified into high and low level of PA. Second, the facilitating factors and barriers of individual and environmental perspectives associated to PA participation in each level of PA were determined for 15-30 minutes. Data were analyzed by the descriptive statistics and content analysis. Our results found 18 of workers completed the IPAQ. Their mean ages were 32.61±4.62 years and spent 1585.89±1140.74 MET-min/wk. Of 18 workers, from low PA and 4 from moderate to high PA participated the in-depth interview. The health appearances and facilities could facilitate them to participate PA while lack of time and motivation were identified as the barriers. Our findings indicated the factors influenced on PA participation, therefore, it useful for planning the new strategy of PA promotion.

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The paper entitled with “A Formulation of Three Dimensional Wave Activity Flux Describing Wave Propagation on the Mass-Weighted Isentropic Time Mean Equation” by Kinoshita, T., T. Iwasaki, and K. Sato was published in Scientific Online Letters on the Atmosphere (SOLA) (Vol. 12, p. 198-202; http://doi.org/10.2151/sola.2016-040) on August 3rd, 2016. Although the authors intended to submit this paper in the Special Edition on The First Asian Conference on Meteorology (ACM2015) (Vol. 12A) of SOLA and should be published in this special edition, the Editorial

of SOLA has mistakenly processed the proofreading and publication of this paper.

The Editorial

of SOLA sincerely apologizes for causing this and lists the paper by Kinoshita et al. (2016) also in the Special Edition on ACM2015 (Vol. 12A).

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 With a focus on GHQ/SCAP, GS documents, the objective of this study was to clarify the basic facts of the purge to which Mitsuhashi Kikuo was subjected. The findings are as follows:
 1.  Circumstances in the lead-up to Mitsuhashi undergoing review for public qualification and the outcome of the review were clarified.
 1)  After Japan's defeat in the Asia-Pacific War, Mitsuhashi made every effort to restart the field of sports and physical education. He also attempted to run for in the first upper-house elections (March 10, 1947). He underwent a review by the Central Public Qualifications Examination Committee in an effort to qualify as a candidate. His intended “public ” was that of a Diet member.
 )  The review concluded that Mitsuhashi should be subject to a purge under SCAPIN 550, as he had held the post of Director of the Great Japan Industrial Patriotic Association before the war. Although the Committee had initially declared him “passed” (March 17), GHQ did not recognize the Japanese decision and decided to subject Mitsuhashi to a purge under SCAPIN 550 (March 31). The apparent reason was that GHQ emphasized the formal criteria, and thus declared him a Memorandum Case.
 .  The lead-up to Mitsuhashi's appeal for re-review and its outcome was also clarified, in addition to his arguments during the appeal process.
 1)  Working within the system, Mitsuhashi petitioned the Public Service Qualifications Appeal Board for a re-review (April 14). In the re-review process, he submitted 5 memoranda testifying that he had not been influential as a director. In addition, he also testified orally twice before the Board.
 )  He argued that his role was unpaid and merely titular, and that he had not attended meetings or made any positive contributions. He added that his appointment had been a mere formality; he had not intended to utilize the organization, and his contribution merely involved gymnastic instruction.
 Furthermore, he claimed that he was a liberal who had consistently criticized prewar physical education policy as militaristic, and who had studied sports instruction abroad.
 3)  After the re-review, Mitsuhashi was delisted as a subject of the purge under SCAPIN 550 (Dec.). However, GHQ only accepted this decision about 5 months later following appeals from the Japanese government (May , 1948). Though Mitsuhashi's arguments were accepted by the entire Japanese membership of the Committee, it took more than 13 months for GHQ to acknowledge the decision.

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帯状疱疹に対するRo-8181の有効性, 安全性および有用性を検討するため, ヒト血清アルブミンを対照薬として, 二重盲検比較試験を行つた。皮膚症状の観察項目別の改善率では, 水疱·膿疱において投与開始後5日目でRo-8181群70%, placebo群50%で, 両群間に差(p<0.05)が認められた。皮膚症状改善度の推移を著明改善以上の症例についてみると, 投与開始後4日目の著明改善率はRo-8181群8%, placebo群0%であり, Fisherの直接計算法で両群間に差(p<0.05)が認められた。また, 投与開始後5日目の著明改善率はRo-8181群15%, placebo群3%であり, 検定で両群間に差(p<0.05)が認められた。主治医による有効性の判定ではU検定でRo-8181群が優れている傾向が認められた。主治医による安全性の判定では副作用発現率がRo-8181群83%, placebo群14%であり, U検定で両群間に差(p<0.001)が認められた。主治医による有用性の判定ではU検定で両群間に差は認められなかつた。以上の結果より, 帯状疱疹に対し, Ro-8181は皮疹のうち水疱·膿疱に対して有効であり, 主治医判定でも有効性が認められたが, 安全性については本薬剤の耐薬性が示されたものの副作用の発現率が高かつたため, 有用性は高くないと考えられた。

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