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The production of nematode-immobilizing secretory cells by Climacodon septentrionalis

Joey
B
. Tanney, Leonard J. Hutchison

Mycoscience
2012年 53 巻 1 号 31-35
発行日: 2012年
公開日: 2023/03/31

DOI https://doi.org/10.1007/s10267-011-0128-1

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The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

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The Properties of 2112 keV Level in ¹¹⁶Sn

Yukichi Yamaguchi, Jian-zhi Runan(Gen), Teruaki Nagahara

Journal of the Physical Society of Japan
1975年 38 巻 4 号 911-916
発行日: 1975/04/15
公開日: 2007/06/01

DOI https://doi.org/10.1143/JPSJ.38.911

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The gamma-ray spectrum and the conversion-electron spectrum are measured in the decay of the ^116mIn activity. Directional correlations are also measured for 818–1293 and 1097–1293 keV cascades. The M1-
E
2 mixing ratio δ, and the
E
0-
E
2 mixing ratio μ_k are obtained for 818.
7
keV
2₂
+→2₁⁺ transition to be δ=1.52_{−0.22
+0.26, and μ_k≤6.1×10^{−4
respectively. The E
2 branching ratio B
(E
2; 2₂
+}→0_g⁺): B
(E
2; 2₂
+→2₁⁺): B
(E
2; 2₂
+→0₁⁺) is determined to be 0.0158:1.0:5.86.
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(
22E
, 24S)
5α
-Stigmasta-3,
22
-dien-6-one: An Intermediate of the Isomerization of (
22E
, 24S)-3α,
5
-Cyclo-
5α
-stigmast-
22
-en-6-one into (
22E
, 24S)-
5α
-Stigmasta-2,
22
-dien-6-one

Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE

Agricultural and Biological Chemistry
1988年 52 巻 12 号 3217-3218
発行日: 1988年
公開日: 2006/04/05

DOI https://doi.org/10.1271/bbb1961.52.3217

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Stimulative Effects of (
22E
,24R)-Ergosta-
7
,
22
-diene-3β,
5α
,6β-triol from Fruiting Bodies of Tricholoma auratum, on a Mouse Osteoblastic Cell Line, MC3T3-
E
1

Keishi Hata, Fuyuki Sugawara, Naganori Ohisa, Saori Takahashi, Kazuyuki Hori

Biological and Pharmaceutical Bulletin
2002年 25 巻 8 号 1040-1044
発行日: 2002年
公開日: 2002/08/01

DOI https://doi.org/10.1248/bpb.25.1040

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We screened the differentiation-inducing activities of 39 mushroom extracts from Akita prefecture, Japan, on the mouse osteoblastic cell line, MC3T3-
E
1. Sixteen phosphate buffered saline (PBS), 8 boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MC3T3-
E
1 cell differentiation. The enzyme activities were markedly induced by extracts of Tricholoma auratum, and we isolated the active compound from methanol extracts of this mushroom. Physical data for the isolated active compound were identical to those for (
22E
,24R)-ergosta-
7
,
22
-diene-3β,
5α
,6β-triol (1). 1 induced ALP activities of MC3T3-
E
1 cells and promoted cell proliferation. To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MC3T3-
E
1 cells by 1, ergosterol (2), ergocalciferol (3), cholesta-3β,
5α
,6β-triol (
4
),
7
-dehydrocholesterol (
5
) and cholecalciferol (6) were tested. The enzyme activities of MC3T3-
E
1 cells were increased 3.0-fold by 10 μM 1 and 2.
4
-fold by 10 μM
4
. However, 2, 3,
5
and 6 did not induce MC3T3-
E
1 cell ALP activity at 0.1—10 μM. These results suggested that the OH groups at C-
5
and/or C-6 of 1 and
4
played an important role in their differentiation-inducing activities on MC3T3-
E
1 cells. Furthermore, 1 suppressed induction of MC3T3-
E
1 cell apoptosis by serum starvation.
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Deexcitation of the 931.1 keV
2₂
+-State of Cd¹⁵²

Yasuyuki Gono, Manabu Fujioka, Tamotsu Toriyama

Journal of the Physical Society of Japan
1970年 29 巻 2 号 255-258
発行日: 1970/08/05
公開日: 2007/06/01

DOI https://doi.org/10.1143/JPSJ.29.255

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The gamma-ray spectrum and the conversion-electron spectrum are measured in the decay of the Tb¹⁵² activity. The L-subshell electron lines of the 586.
7
keV
2₂
+→2₁⁺ transition are separated by the ion-free beta-ray spectrometer. The M1-
E
2 mixing ratio, δ², and the dimensionless ratio X of
E
0-
E
2 mixing of the 586.
7
keV transition are obtained to be δ²≤0.16 and 0.034≤X≤0.038, respectively. The
E
2 branching ratio
B
(
E
2;
2₂
+→0_g⁺):
B
(
E
2;
2₂
+→2₁⁺):
B
(
E
2;
2₂
+→0₁⁺) is determined to be 0.023 : 1.0 :
5
.6.
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An Efficient Preparation of (
22E
, 24S)-
5α
-Stigmasta-2,
22
-dien-6-one from (
22E
, 24S)-3α,
5
-Cyclo-
5α
-stigmast-
22
-en-6-one

Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE, Kiyomi KOBAYASHI, Suguru TAKATSUTO

Agricultural and Biological Chemistry
1988年 52 巻 8 号 2117-2118
発行日: 1988年
公開日: 2006/04/05

DOI https://doi.org/10.1271/bbb1961.52.2117

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右房室弁の形態学的検索

その所属腱索および乳頭筋について

島田博

日本医科大学雑誌
1981年 48 巻 6 号 779-789
発行日: 1981/12/15
公開日: 2010/10/14

DOI https://doi.org/10.1272/jnms1923.48.779

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Although there have been numerous articles concerning the anatomy of the atrioventricular valve in man, only a few publications have recorded the relationship between the chordae tendineae and the papillary muscles. The purpose of this paper is to study the relationship among the shape and size of the atrioventricular valve, the chordae tendineae and the papillary muscles. 50 subjects, as listed in Table 1, were analyzed by the Taniya-Hashimoto Method.
The results obtained were as follows:
1) The right atrioventricular valve was classified into two types: 33 cases (66%) of three irregularly shaped cusps, i.
e
. type I, and 17 cases (34%) of four or five cusps, i.
e
. type II.
2) The average circumference of the right atrioventricular orifice (ostium atrioventriculare dextrum) was 11.96cm (9.63.15.06cm) in type I and 12.19cm (9.52.15.
22
cm) in type H. There existed no significant difference in the circumference of the atrioventricular orifice between type I and II.
3) The average length of the cusp-fundus (the length of the fixed margin of the cusp) was as follows:
type I: anterior cusp…………
4
.13cm (2.03-6.96cm)
posterior cusp…………3.62cm (1.21-
5
.44cm)
septalcusp……………
4
.21cm (3.11-6.08cm)
type II: anterior cusp…………
4
.10cm (2.68-
5
.42cm)
posterior cusp…………3.67cm (0.
94
-
5
.70cm)
septal cusp……………
4
.43cm (2.96-6.53cm)
4
) The average width of the cusp (the maximum distance between the apex and the fundus of the cusp) was as follows:
type I: anterior cusp…………1.86cm (1.26-2.29cm)
posterior cusp…………1.62cm (0.62-2.
94
cm)
septal cusp……………1.76cm (1.15-2.72 cm)
type II: anterior cusp…………1.92cm (1.40-2.34cm)
posterior cusp…………1.72cm (0.
94
-2.42cm)
septal cusp……………1.
84
cm (1.14-2.53cm)
The length or width of the cusp in type I was similar to that in type II.
5
) The papillary muscles consisted of five groups, which were named the anterior, postlateral, postmedial, postseptal and septal muscles. The average number of the papillary muscles per right ventricle was
5
.
7
(2.0.9.0). The chordae tendineae from the anterior papillarymuscles were attached to the anterior and posterior cusps and those from the postlateral and postmedial muscles were attached to the posterior and septal cusps. The chordae tendineae from the postseptal muscles were linked only to the septal cusp and those from the septal muscles were connected to the septal and anterior cusps.
6) The average number of the stems of the chordae tendineae from the papillary muscles were as follows:
From the anterior papillary muscles………
7
.2 (2.0-14.0)
the postlateral papillary muscles……3.
5
(1.0-8.0)
the postmedial papillary muscles……
4
.0 (1.0-8.0) the postseptal papillary muscles……
4
.
5
(1.0-13.0) the septal papillary muscles………
5
.
7
(2.0-12.0)
The average n umber of the stems of the chordae tendineae per right ventricle was 24.
4
(16.0-35.0).
7
) The tip of the chordae tendineae are attached to the fixed margin of the valve cusp, i.
e
. type A, to the ventricular surface, i.
e
. type
B
and to the free margin, i.
e
. type C. The average number of them were 23.
4
(14.0-32.0) in type A, 19.2 (
4
.0-37.0) in type
B
and 68.1 (31.0-105.0) in type C. The average number of the apexes of the chordae tendineae per right ventricle was 110.
7
(53.0-166.0).
8) The average number of the chordae tendineae for the anterior cusp was 34.9 (12.0-64.0), for the posterior cusp 30.
5
(
5
.0-65.0) and for the septal cusp 45.3 (23.0-68.0).
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Purines. XLI. : An Alternative Synthesis and the Chemical Behavior of
7
, 9-Dialkyladeninium Salts

斎藤徹, 井上勲, 藤井澄三

Chemical and Pharmaceutical Bulletin
1990年 38 巻 6 号 1536-1547
発行日: 1990/06/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.38.1536

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A full account is given of the chemical behavior observed for
7
, 9-dialkyladeninium salts (16). On treatment with boiling 1N aqueous NaOH for 60min, 16a,
b
, d,
e
(X=I), 16c (X=Br), and 16f (X=
ClO₄
) rearranged to isomeric N⁶,
7
-dialkyladenines (21a-f) in 50-91% yields. Treatment of the salts with 0.
5
N aqueous Na₂CO₃ at room temperature for 30-90min or with Amberlite CG-400 (OH^-) in H₂O at room temperature gave the ring-opened derivatives
22
a-f (in the trans-formamide form) in 56-83% yields, and rate constants for the ring-opening reactions of 16a,
b
, d-g (X=
ClO₄
) and 16c (X=Br) leading to
22
a-g were determined in H₂O at pH 9.
84
and ionic strength 0.50 at 25°C. Cyclization of
22
a with NaH in AcNMe₂ at room temperature or with boiling 1N aqueous NaOH produced 21a in
84
% or 72% yield, respectively.In solution, the trans-formamides
22
seemed to transform slowly into the cis-formamides 23, attaining equilibria. The existence of such an equilibrium in D₂O or Me₂SO-d₆ at 25°C or in H₂O at pH 9.
84
and ionic strength 0.50 at 25°C was kinetically confirmed in the case of
22
a, and the mechanism of the rearrangement of 16 to 21 through
22
is discussed on the basis of the above kinetic results and Deslongchamps' theory of stereoelectronic control. On treatment with
NaBH₄
in MeOH at room temperature, 16a (X=I) furnished the
7
, 8-dihydro derivative 28 (
84
% yield), which slowly decomposed in H₂O at 60°C to give
22
a in 49% yield.The
7
, 9-dialkyladeninium salts (16) were found to be obtainable from N'-alkoxy-1-alkyl-
5
-formamidoimidazole-
4
-carboxamidines (9) through an alternative synthetic route : Alkylations of 9 with alkyl halides in HCONMe₂ in the absence of base, followed by hydrogenolysis of the N'-alkoxy group and cyclizatio (or vice versa) produced 16 in acceptable yields. In order to interpret the proton nuclear magnetic resonance spectrum of
22
a, the 2-deuterated species 26 was also synthesized from 24 via 25 and 27.
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Interaction of Glycophorin with Lipid Bilayer Studied by Calorimetry, Densitometry, Static Light Scattering, and Electron Microscopy

Sen-fang Sui, Erich Sackmann

The Journal of Biochemistry
1992年 111 巻 1 号 129-138
発行日: 1992年
公開日: 2008/11/18

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In the first part of the present work the interaction of glycophorin with dimyristoylphosphatidylcholine (DMPC) is studied by freeze fracture electron microscopy, densitometry, calorimetry, and 90° static light scattering. An exothermic lipid/protein interaction energy of W_P=190 kJ•mol^-1 was found by application of the well known Van Laar relation for the displacement of the freezing point and the Gibbs-Duhem relationship. Secondly, the effects of Ca²⁺ on the lipid/protein interaction were studied. Following Ca²⁺ addition a remarkable decoupling of the interaction of the glycophorin head group with the bilayer surface was revealed by densitometry and gold-labeling electron microscopy. It is estimated that about 80% of lipid once disturbed by the adsorption of glycophorin head groups is decoupled after addition of Ca²⁺. Thirdly, the selective interaction of glycophorin with binary lipid mixtures was studied, including the mixtures of DMPC with dimyristoylphosphatidylserine (DMPS) and dilauroylphosphatidylcholine (DLPC), and the mixture of dipalmitoylphosphatidylcholine (DPPC) with DLPC.
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e
-
22
. The Effects of
5
-FU against Brain Tumors

Kazuo TAKEUCHI, Masayuki ATSUCHI, Shoji ODA, Minoru JINBO, Takeshi MASUI, Motohide OGASHIWA

Neurologia medico-chirurgica
1968年 10 巻 132-133
発行日: 1968年
公開日: 2007/08/17

DOI https://doi.org/10.2176/nmc.10.132

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Short-Step Synthesis of Plant Growth-Promoting Brassinosteroids

高津戸秀, 池川信夫

Chemical and Pharmaceutical Bulletin
1984年 32 巻 5 号 2001-2004
発行日: 1984/05/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.32.2001

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Brassinolide analogues, (
22
R, 23R, 24R)-2α, 3α,
22
, 23-tetrahydroxy-
B
-homo-
7
-oxa-
5α
-ergostan-6-one (24-epibrassinolide) (10) and (
22
S, 23S, 24R)-2α, 3α,
22
, 23-tetrahydroxy-
B
-homo-
7
-oxa-
5α
-ergostan-6-one (9), were synthesized from brassicasterol (3a) in five steps and with ca. 20% overall yield. The key steps are the direct formation of (
22
E
, 24R)-3α,
5
-cyclo-
5α
-ergost-
22
-en-6-one (
4
) from brassicasterol mesylate (3
b
), the acid-catalyzed rearrangement of
4
to (
22
E
, 24R)-
5α
-ergosta-2,
22
-dien-6-one (6), and the Baeyer-Villiger oxidation of the tetrahydroxy
5α
-ergostan-6-ones
7
and 8.
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Optical Energy-Levels of Cu⁺

Yosizo YAMAMOTO

Nippon Sugaku-Buturigakkwai Kizi Dai 3 Ki
1940年 22 巻 12 号 1048-1052
発行日: 1940年
公開日: 2009/06/09

DOI https://doi.org/10.11429/ppmsj1919.22.12_1048

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The numerical values of the intervals betrween optieal levels are competed for the configurations
1s²2s²2p⁸3s²3p⁸3
*^{94s
, 5
s, 6s and 7
s of Cu⁺, according to the general expression of energy-levels derived in the previous paper The self-consistent field radial functions computed by Hartree adn Hartree are used for1s, 2s, 2p, 3s, 3p and 3d. Those of 4
s, 5
s, e.s and are ealenlated from Hartree Hartree's core-functions by the numerical integrations. The calculated results are shown in Table I.The agreement with experiment is satisfactory
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P-
22
酵素機能を利用する高立体選択的キラルシントンの合成とその天然物合成への応用(ポスター発表の部)

陳政宇, 南雲紳史, 梅澤勲, 尾能満智子, 秋田弘幸

天然有機化合物討論会講演要旨集
1994年 36 巻 P-22
発行日: 1994/09/20
公開日: 2017/08/18

DOI https://doi.org/10.24496/tennenyuki.36.0_549

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One of the most efficient method to synthesize optically pure natural products is to start off with chiral synthon. We synthesized three new chiral synthons (2R,3R)-
4
, (
4
R,
5
S)-27, and (S)-(-)-34 on the basis of the following two concepts; (1) to utilize the highly stereoselective chemical method to establish the relative configuration, (2) to carry out the kinetic resolution of racemates by ester-cleaving enzymes (lipase) at the next step. The Zn(BH_
4
)_2 reduction of β-keto ester (±)-3 afforded the alcohol (±)-syn-1 in high diastereoselectivity. The saponification of the corresponding acetate (±)-
4
using the lipase "Amano A" proceeded enantioselectively to give acetate (2R,3R)-
4
(48% yield, >99%ee) and alcohol (2S,3S)-1 (51% yield,
94
%ee). The epoxidation of methyl sorbate followed by addition of thiophenol provided (±)-
22
stereospecifically. The enantioselective esterification of (±)-
22
using the lipase "PL266" in the presence of isopropenyl acetate gave alcohol (
4
R,
5
S)-
22
(49.
7
%, >99%ee) and acetate (
4
S,
5
R)-23 (50.2%, 98%ee). The successful conversion of C-S into C-O bond at C_
4
chiral center in stereo retentive manner was carried out to give (
4
S,
5
S)-21 which was converted into ketal (
4
R,
5
S)-27 via three steps. The coupling reaction of methyl
4
,
5
-epoxy-(2
E
)-pentenoate 33 and m-methoxy toluene in the presence of lewis acid provided two alcohols 34 (23%) and 35 (49%). The enantioselective hydrolysis of acetate (±)-36 derived from 34 using the lipase "MY-30" gave alcohol (S)-(-)-34 (85%ee). The enzymatic esterification of this chiral compound using same lipase achieved the enrichment of optical purity. In result, we obtained (S)-(-)-36 (
94
%ee). These chiral compound were applicable to the syntheses of (-)-Oudemansins A,
B
and X, L-Acosamine, and (S)-(+)-Curcudiol.
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熱力学諸量の測定とその結果を用いた化学熱力学計算によるNi-Mo-
B
およびNi-W-
B
3成分系状態図の決定

香山滉一郎, 森下政夫, 張国鋒

粉体および粉末冶金
2006年 53 巻 5 号 419-429
発行日: 2006年
公開日: 2006/12/19

DOI https://doi.org/10.2497/jjspm.53.419

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The phase diagrams of the Ni-Mo-
B
and Ni-W-
B
ternary systems in the region of less than 50mol%
B
were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
E₁
:L (1365K, 71.
5
mol%Ni-6.0mol%Mo-
22
.
5
mol%
B
)=(Ni)+
Ni₃B
+
NiMo₂B₂

E₂
:L (1355K, 62.
5
mol%Ni-2.
5
mol%Mo-30.
5
mol%
B
)=
Ni₃B
+
Ni₂B
+
NiMo₂B₂

E₃
:L (1445K, 42.0mol%Ni-30.6mol%Mo-10.3mol%
B
)=(Ni)+NiMo+
NiMo₂B₂

P₁:L (1812K, 34.9mol%Ni-42.3mol%Mo-
22
.8mol%
B
)+MoB=
Mo₂B
+
NiMo₂B₂

P₂:L (1633K, 42.3mol%Ni-40.
4
mol%Mo-17.3mol%
B
)+Mo=
Mo₂B
+
NiMo₂B₂

P₃:L (1812K, 53.
5
mol%Ni-33.
7
mol%Mo-12.8mol%
B
)+Mo=NiMo+
NiMo₂B₂

E₁
:L (1622K, 51.0mol%Ni-31.6mol%W-17.
4
mol%
B
)=(Ni)+W+
NiW₂B₂

E₂
:L (1260K, 71.0mol%Ni-
7
.0mol%W-
22
.0mol%
B
)=(Ni)+
Ni₃B
+
NiW₂B₂

E₃
:L (1291K, 65.
4
mol%Ni-
4
.8mol%W-29.8mol%
B
)=
Ni₂B
+
Ni₃B
+
NiW₂B₂

P₁:L (2115K, 23.8mol%Ni-43.1mol%W-33.1mol%
B
)+WB=
W₂B
+
NiW₂B₂

P₂:L (1657K, 48.9mol%Ni-33.1mol%W-18.0mol%
B
)+
W₂B
=W+
NiW₂B₂

The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
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23pSM-6 Isoscalar and Isotensor π-π Scattering Lengths from K^+_<π3> Decays

T BAKER, C. RANGACHARYULU

日本物理学会講演概要集
1999年 54.2.1 巻 23pSM-6
発行日: 1999/09/13
公開日: 2018/03/04

DOI https://doi.org/10.11316/jpsgaiyo.54.2.1.0_16_3

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Magnetism of β′-Gd₂(
MoO₄
)₃ and photoluminescence of β′-Eu₂(
MoO₄
)₃ crystallized in rare-earth molybdenum borate glasses

Yong WANG, Tsuyoshi HONMA, Yoshihiro DOI, Yukio HINATSU, Takayuki KOMATSU

Journal of the Ceramic Society of Japan
2013年 121 巻 1410 号 230-235
発行日: 2013/02/01
公開日: 2013/02/01

DOI https://doi.org/10.2109/jcersj2.121.230

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Ferroelastic β′-Gd₂(
MoO₄
)₃ and β′-Eu₂(
MoO₄
)₃ crystals were synthesized through the crystallization of 21.25Gd₂O₃–63.75MoO₃–
15B₂O₃
glass and
22.5Eu₂O₃
–
47.5MoO₃
–
30B₂O₃
glass, respectivelty, and their magnetism and photoluminescence properties were examined. It was demonstrated from the temperature dependence of the magnetic susceptibility and specific heat down to T = 1.8 K that the magnetic state of Gd³⁺ ions in the crystallized samples, i.
e
., in the β′-Gd₂(
MoO₄
)₃ crystals and the residual glasses, is paramagnetic and any magnetic interaction is not formed among Gd³⁺ ions down to T = 1.8 K, i.
e
., the effective magnetic moment of µ_eff =
7
.
94
µ_B and Weiss constant of θ = –0.3 K. Photoluminescence (PL) of Eu³⁺ ions was clearly observed in the crystallized samples, although the melt-quenched glass did not show any photoluminescence. The present study proposes that the concentration quenching among Eu³⁺ ions in β′-Eu₂(
MoO₄
)₃ crystals is small and β′-RE₂(
MoO₄
)₃ crystals would be good hosts for PL emissions of RE³⁺.
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40 五味子の新dibenzocyclooctadiene型リグナンの構造と反応

田口平八郎, 池谷幸信, 吉岡一郎

天然有機化合物討論会講演要旨集
1979年 22 巻 40
発行日: 1979/09/20
公開日: 2017/08/18

DOI https://doi.org/10.24496/tennenyuki.22.0_299

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Three new dibenzocyclooctadiene lignans, epigomisin O(1), gomisin
E
(
7
) and angeloylgomisin Q(26), were isolated from the fruits of Schizandra chinensis BAILL.(Schizandraceae), which are used as an antitussive and a tonic under the names of "Hoku-gomisi" in Japan and "Wu-wei-zi" in China. 1) The structure of epigomisin O(1) was elucidated by correlation with known lignans, gomisins O(2) and N(
4
). 2) Oxidation of
4
with KMnO_
4
in a mixture of 2% NaOH and pyridine gave compounds 3 and
5
. Further oxidation of 3 with KMnO_
4
gave
5
. Reduction of
5
with NaBH_
4
afforded deangeloylgomisin
B
(6). The structure of gomisin
E
(
7
) was elucidated by the same reaction to correlate with a known lignan, gomisin D(8). 3) The cleavage of the methylenedioxy group on the aromatic ring with Pb(OAc)_
4
in dry benzene into diphenol was studied(19-
22
→19
b
-
22
b
). The structure of angeloylgomisin Q(26) was elucidated by the use of the above reaction to correlate with 6.
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High Plasma Estradiol-17β Levels in Dogs with Benign Prostatic Hyperplasia and Azoospermia

Eiichi KAWAKAMI, Eri AMEMIYA, Kenji NAMIKAWA, Chikako KASHIWAGI, Tatsuya HORI, Toshihiko TSUTSUI

Journal of Veterinary Medical Science
2001年 63 巻 4 号 407-412
発行日: 2001年
公開日: 2001/05/10

DOI https://doi.org/10.1292/jvms.63.407

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The semen quality of
22
dogs (
4
to
7
years old) with benign prostatic hyperplasia (BPH) was examined at the hospital of our university, and
4
of the
22
BPH dogs were diagnosed as azoospermic. The mean peripheral plasma estradiol-17β (
E₂
) level (17.3 pg/ml) of the 18 BPH dogs with spermatogenic function was higher than that of
5
normal male dogs and their mean T level (1.
7
ng/ml) was lower. The mean
E₂
level (27.3 pg/ml) of the
4
BPH dogs with azoospermia was significantly higher than the value in the BPH dogs with spermatogenic function (P<0.01), and the mean T level (1.1 ng/ml) was significantly lower (P<0.05). Five normal male dogs were given 10 intramuscular injections of estradiol benzoate (
E₂B
)
5
μg/kg, at 3-day intervals to investigate the relationship between high plasma
E₂
levels and the cause of the BPH and azoospermia. Their testes and prostates were measured and biopsied both before and 30 days after the start of
E₂B
injections. At 30 days after the start of the
E₂B
injections, the mean peripheral plasma T levels had decreased by half, and the mean testicular volume had decreased to 88% of original volume. The numbers of spermatocytes, spermatids, and spermatozoa in the seminiferous tubules of all of the dogs were significantly lower (P<0.05, 0.01). In addition, the mean prostatic volume increased to 130%, the mean height of the glandular epithelium decreased, and the glandular lumen became increased in diameter. These findings indicate that both BPH and serious spermatogenic dysfunction may be simultaneously induced by protracted high plasma
E₂
levels in dogs.
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Streptococcus mutans 溶菌酵素産生菌の分布と 1 菌株の産生する酵素の活性

福岡隆俊

九州歯科学会雑誌
1983年 37 巻 1 号 101-113
発行日: 1983/02/25
公開日: 2017/12/22

DOI https://doi.org/10.2504/kds.37.101_1

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Distribution of bacteria which produce enzyme capable of lysing Str. mutans
E
49 strain in human dental plaques was investigated on adults of age 20 to
22
. The activity of the enzyme (MLE) produced by an isolated strain (FDC-63) was also investigated. The results obtained are summarized as follows. 1. MLE producing bacteria were detected in 43 samples (37.1%) out of 116 samples of dental plaques obtained from adults of age 20 to
22
. 2. Twenty four samples had MLE producing bacteria at the rate of over
5
% of total number of bacteria in each sample. 3. The 40 strains isolated were composed of 92.
5
% of Gram positive cocci, 2.
5
% of Gram negative cocci and
5
% of Gram positive rods.
4
. Most of the isolates (
84
.6%) showed lytic activity against living cells of
E
49 on GAM agar plates.
5
. The MLE produced by FDC-63 had lytic activity against both living and heat killed cells of
E
49 under aerobic or anaerobic condition. 6. The activity of the MLE was rather weak against purified cell walls of
E
49.
7
. Optimal pH in the activity of the MLE was 6.0 and optimal temperature 37℃. The activity of the MLE was lost by heating at 60℃ for 60 min. 8. FDC-63 was identified as Streptococcus milleri.
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Prevalence and molecular characterization of extended-spectrum β-lactamase (ESBL) and plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli in dogs

Özkan ASLANTAŞ, Ebru Şebnem YILMAZ

Journal of Veterinary Medical Science
2017年 79 巻 6 号 1024-1030
発行日: 2017年
公開日: 2017/06/16
[早期公開] 公開日: 2017/04/27

DOI https://doi.org/10.1292/jvms.16-0432

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This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant
E
. coli isolates were detected in 95 (
22
.2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: bla_CTX-M-15 (62), bla_{TEM-1b
(42), bla_CMY-2 (22
), bla_CTX-M-3 (16), bla_CTX-M-1 (15), bla_OXA-1 (9) and bla_SHV-12 (3) alone or in combination. The most frequently encountered phylogenetic group was group A₁ (35.8%), followed by group D₂ (22
.1%), B
1 (15.8%), D₁ (9.5
%), A₀ (7
.4
%), B2₂
(5
.3%) and B2₃
(4
.2%), respectively. PMQR genes, aac(6’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.3, 10.5
and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.8% for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE, f17a-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing E
. coli clone O25b
:ST131/B
2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing E
. coli isolates among dogs in Turkey.
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