ALTEMICIDIN, A NEW ACARICIDAL AND ANTITUMOR SUBSTANCE II. STRUCTURE DETERMINATION

ATSUSHI TAKAHASHI; DAISHIRO IKEDA; HIKARU NAKAMURA; HIROSHI NAGANAWA; SHOGO KURASAWA; YOSHIRO OKAMI; TOMIO TAKEUCHI; YOICHI IITAKA

doi:10.7164/antibiotics.42.1562

ALTEMICIDIN, A NEW ACARICIDAL AND ANTITUMOR SUBSTANCE

II. STRUCTURE DETERMINATION

ATSUSHI TAKAHASHI, DAISHIRO IKEDA, HIKARU NAKAMURA, HIROSHI NAGANAWA, SHOGO KURASAWA, YOSHIRO OKAMI, TOMIO TAKEUCHI, YOICHI IITAKA

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JOURNAL FREE ACCESS

1989 Volume 42 Issue 11 Pages 1562-1566

DOI https://doi.org/10.7164/antibiotics.42.1562

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Abstract

The structure of altemicidin, a new acaricidal and antitumor agent, was determined to be (1R, 2S, 3aR, 7aS)-4-carbamoyl-2-hydroxy-6-methyl-1-(sulfamoylacetamido)-2, 3, 3a, 6, 7, 7ahexahydro-6-azaindene-1-carboxylic acid by a combination of spectroscopic and X-ray crystallographic analysis of its derivatives. Altemicidin is a monoterpene alkaloid.

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