SYNTHESIS AND β-LACTAMASE INHIBITORY ACTIVITY OF 6-[(1-HETEROARYLTHIOETHYL-1, 2, 3-TRIAZOL-4-YL)-METHYLENE]PENAM SULFONES

Abstract

The synthesis of β-lactamase inhibitory activity of a series of sodium 6-[(1-heteroarylthioethyl-1, 2, 3-triazol-4-yl)methylene]pemcillanate 1, 1-dioxides are described. Their activity was compared with tazobactam and sulbactam. The Z-isomers were more active than the E-isomers. The in vitro activity of the Z-isomers of the phenylthiadiazole derivatives (13a and 15a) was better than sulbactam against the tested β-lactamases and comparable to tazobactam especially against TEM-2 and cephalosporinase. But their synergistic activity with five antibiotics was inferior to tazobactam.