Herquline B, a New Platelet Aggregation Inhibitor Produced by Penicillium herquei Fg-372

YUMI ENOMOTO; KAZURO SHIOMI; MASAHIKO HAYASHI; ROKURO MASUMA; TOMOYA KAWAKUBO; KEIICHI TOMOSAWA; YUZURU IWAI; SATOSHI OMURA

doi:10.7164/antibiotics.49.50

Herquline B, a New Platelet Aggregation Inhibitor Produced by Penicillium herquei Fg-372

YUMI ENOMOTO, KAZURO SHIOMI, MASAHIKO HAYASHI, ROKURO MASUMA, TOMOYA KAWAKUBO, KEIICHI TOMOSAWA, YUZURU IWAI, SATOSHI OMURA

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JOURNAL FREE ACCESS

1996 Volume 49 Issue 1 Pages 50-53

DOI https://doi.org/10.7164/antibiotics.49.50

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Abstract

A new herquline analog, herquline B was isolated from the culture broth of Penicillium herquei Fg-372. Herquline B contains one piperazine and two cyclohexenones. The pyrrolidine ring of herquline A was cleaved to yield herquline B. The IC₅₀ value of herquline B against platelet aggregation induced by ADP and platelet-activating factor were 1.6 and 5.0 μM, respectively.

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