Abstract
We conducted a pharmacokinetic and clinical study of cefluprenam (CFLP) against the cases with infectious diseases in otorhinolaryngological field. The results obtained were as follows.
1. The concentration ratios of CFLP in tissue versus serum were 25.7% for palatine tonsil (n=18), 36.8% for maxillary sinus mucosa (n=3), 52.0% for submandibular gland (n=6) and 36.2% for parotid gland (n=3) after i. v. injection of CFLP at a dose of one gram.
2. In the clinical study, patients were given CFLP at a dose of 1 g twice a day by intravenous or drip infusion. In 19 patients with otorhinolaryngological infectious diseases, the overall efficacy rate was 94.1%: excellent in 11 cases, good in 5 cases, fair in 1 case and unevaluable in 1 case. The bacteriological eradication rate was 100%. In laboratory findings, an elevation in GOT and GPT was observed in one case. No adverse drug reactions were observed in all cases.
