Abstract
A recessive, non-maternal effect, female-specific lethal mutant of Drosophila melanogaster was recovered from a natural population. The mutant, fle(3)100, is located at 3-45±. About one-half of homozygous females show normal development up to the pharate adult stage. Salivary gland chromosomes of third instar homozygous female larvae have normal staining properties in the lactic-aceto-orcein staining, suggesting normal dosage compensation. The results indicate that the fle(3)100 gene forms a new class of sex-specific lethals.