Abstract
Objectives: Human papillomavirus (HPV) DNA testing was done as an adjunct to cervical cytology to evaluate its usefulness in cervical cancer screening.
Study Design: Between May 2004 and March 2006, 33790 women living in Kanazawa City were screened based on Bethesda cytological classification. In cases with ASC (ASC-US and ASC-H), HPV DNA testing was done using Hybrid Capture-II. Cytology-ASC-and HPV-positive women underwent colposcopy to determine the histological diagnosis.
Results: Of these 33790, 1565 (4.6%) had ASC cytology. HPV DNA was positive in 221 (14.1%) of the 1565. Of these 221, 169 (76.5%) underwent biopsy. Of these 169, 27 had disease exceeding CIN 2.
Conclusions: HPV DNA testing, combined with cytology significantly improved CIN screening efficacy and avoided unnecessary biopsies.
