Plasma Tissue Factor Antigen Level in Patients with Disseminated Intravascular Coagulation

Abstract

Plasma tissue factor (TF) antigen level and hemostatic markers were measured in 55 patients with disseminated intravascular coagulation (DIC), 15 patients suspected with DIC and 10 patients without DIC. Plasma TF antigen was detected in normal volunteers and it was significantly higher in patients with DIC than in patients suspected with DIC and without DIC. But in some patients with DIC plasma TF antigen level was within normal range. Plasma TF antigen level in patients with DIC significantly decreased after therapy compared with before. And it was not correlated with organ failure and its prognosis. Plasma TF antigen level in patients with DIC was slightly positively correlated with thrombin-antithrombinIII complex but not correlated with other hemostatic markers. In hematopoietic neoplasma with DIC plasma TF antigen level showed a tendency to increase in nonlymphoid leukemia as compared to lymphoid tumor. It was suggested that TF was implicated in occurrence and progression of DIC.