1997 Volume 73 Issue 1 Pages 93-96
The effect of ovariectomy and continuous subcutaneous replacement of 17β-estradiol was examined in female Wistar rats. Tail skin temperature significantly increased in ovariectomized rats 6 days after ovariectomy, and the elevated level was sustained until 21 days after ovariectomy. 17β-Estradiol at doses of 0.3 and 1.0 μg/body/day suppressed the increases in tail skin temperature. In the forced swimming test, the ovariectomized control rats showed significantly prolonged immobility time in comparison with sham-ovariectomized rats 14 days after ovariectomy. The duration of immobility of ovariectomized rats treated with 17β-estradiol (0.3, 1.0, 3.0 μg/body/day)or maprotiline (0.6 mg/body/day)was significantly shorter than that of ovariectomized control rats.