Treatment strategy for Parkinson's disease considering brain network abnormalities

Abstract

In Parkinson's disease, the progression of the clarification of cortico–basal ganglia loop based on the firing rate model has dramatically contributed to the development of not only medical and surgical treatments but also an understanding of side effects. On the other hand, progress in recent research has clarified the limitations of the firing frequency model and has shown the relationship between abnormal β band oscillations and pathological conditions that complements the limitations of the firing rate model. Besides, research on the elucidation of new pathological conditions using resting–state functional MRI analysis has also been in progress. This review summarizes recent advances in treatment strategies for Parkinson's disease that take into account brain network abnormalities.