Incidence of gingival overgrowth caused by calcium channel blockers

MAKIKO ONO; NAOKO OHNO; KAZUHIRO HASEGAWA; SHIGEO TANAKA; MASAMICHI KOMIYA; HIROKO MATSUMOTO; AKIRA FUJII; YOSHIAKI AKIMOTO

doi:10.11263/jsotp1982.27.79

MAKIKO ONO, NAOKO OHNO, KAZUHIRO HASEGAWA, SHIGEO TANAKA, MASAMICHI KOMIYA, HIROKO MATSUMOTO, AKIRA FUJII, YOSHIAKI AKIMOTO

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MAKIKO ONO
Departments of Oral Surgery, Nihon University School of Dentistry at Matsudo
NAOKO OHNO
Departments of Oral Surgery, Nihon University School of Dentistry at Matsudo
KAZUHIRO HASEGAWA
Departments of Oral Surgery, Nihon University School of Dentistry at Matsudo
SHIGEO TANAKA
Departments of Oral Surgery, Nihon University School of Dentistry at Matsudo
MASAMICHI KOMIYA
Departments of Oral Surgery, Nihon University School of Dentistry at Matsudo
HIROKO MATSUMOTO
Departments of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo
AKIRA FUJII
Departments of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo
YOSHIAKI AKIMOTO
Departments of Oral Surgery, Nihon University School of Dentistry at Matsudo

Keywords: calcium channel blocker, gingival overgrowth, incidence

JOURNAL FREE ACCESS

2008 Volume 27 Issue 2 Pages 79-85

DOI https://doi.org/10.11263/jsotp1982.27.79

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Abstract

The incidence of gingival overgrowth caused by calcium channel blockers was determined. The overgrowth was found in patients receiving amlodipine, diltiazem, manidipine, nicardipine, nifedipine and nisoldipine. The highest rate of gingival overgrowth was obtained by nifedipine (7.6%), followed by diltiazem (4.1%), manidipine (1.8%), amlodipine (1.l%), nisoldipine (1.1%) and nicardipine (0.5%) . The rate of nifedipine-induced gingival overgrowth was significantly higher than those of amlodipine, manidipine, nicardipine and nisoldipine, but not diltiazem.

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