2019 Volume 71 Issue 2 Pages 142-148
Hepatoid adenocarcinoma (HA) is defined as a tumor that develops outside the liver; it is histologically similar to hepatocellular carcinoma and often produces α-fetoprotein (AFP). We report a case of advanced uterine corpus HA that was successfully treated with paclitaxel and carboplatin (TC) chemotherapy after surgery. A 76-year-old female presented with lower abdominal distention. MRI and PET-CT revealed an enhanced 94 × 67-mm mass in the uterine cavity, and metastases to the pelvic and para-aortic lymph nodes, and lung. Her serum AFP level was elevated: 1476 ng/ml (normal, <10 ng/ml). We performed cytoreduction surgery. The final diagnosis was HA of the uterine corpus, FIGO IVB stage (UICC pT3bN1M1). She received 16 courses of monthly TC therapy (paclitaxel, 175 mg/m2; carboplatin, AUC 5). Her serum AFP level decreased to the normal range, and she remains in complete remission. Advanced HA prognosis may be improved by the treatment involving TC therapy. [Adv Obstet Gynecol, 71(2) : 142-148, 2019 (R1.5)]
