Abstract
The patient was a 59-year-old man. Two years before, he was hospitalized with an unknown cause of pulmonary infarction, deep vein thrombosis and portal vein thrombosis. At this time, he was admitted to the hospital complaining epigastralgia, and was diagnosed with acute pancreatitis. Treatment with fasting and protease inhibitor against pancreatitis was not effective. It was later revealed that he suffered from antiphospholipid antibody syndrome (APS), and induction of anticoagulation and antiplatelet drug led to the pancreatitis being resolved. It is possible that a micro thrombus, due to APS, induced ischemia of the pancreas which then repeatedly led to localized pancreatitis. We report herein a rare case of intractable acute pancreatitis due to antiphospholipid antibody syndrome.