STUDIES ON THE BIOSYNTHESIS OF BASIC 16-MEMBERED MACROLIDE ANTIBIOTICS, PLATENOMYCINS. II PRODUCTION, ISOLATION AND STRUCTURES OF 3-O-PROPIONYL-5-OMYCAMINOSYL PLATENOLIDES I AND II, 9-DEHYDRO DEMYCAROSYL PLATENOMYCIN AND DEMYCAROSYL PLATENOMYCIN

TAMOTSU FURUMAI; MAKOTO SUZUKI

doi:10.7164/antibiotics.28.775

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

STUDIES ON THE BIOSYNTHESIS OF BASIC 16-MEMBERED MACROLIDE ANTIBIOTICS, PLATENOMYCINS. II

PRODUCTION, ISOLATION AND STRUCTURES OF 3-O-PROPIONYL-5-OMYCAMINOSYL PLATENOLIDES I AND II, 9-DEHYDRO DEMYCAROSYL PLATENOMYCIN AND DEMYCAROSYL PLATENOMYCIN

TAMOTSU FURUMAI, MAKOTO SUZUKI

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JOURNAL FREE ACCESS

1975 Volume 28 Issue 10 Pages 775-782

DOI https://doi.org/10.7164/antibiotics.28.775

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Abstract

Four basic glycosides have been isolated from the fermentation broth of the blocked mutants of Streptomyces platensis subsp. malvinus MCRL 0388. These compounds isolated and purified by solvent extraction and column chromatography were identified as 3-O-propionyl-5-O-mycaminosyl platenolides I (PPL-I-MC) and II (PPL-II-MC), 9-dehydro demycarosyl platenomycin (DDM-PLM) and demycarosyl platenomycin (DM-PLM).

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